| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David G Le Couteur, Michael Muller, Maria C Yang, George D Mellick, Allan J McLea. Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Reviews on environmental health. vol 17. issue 1. 2002-12-24. PMID:12088093. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by dopaminergic cell death and deposition of lewy bodies within the substantia nigra of the midbrain. |
2002-12-24 |
2023-08-12 |
Not clear |
| Alice Guyon, Laurence Cathala, Danièle Paupardin-Tritsch, Daniel Eugèn. Furosemide modulation of GABA(A) receptors in dopaminergic neurones of the rat substantia nigra. Neuropharmacology. vol 43. issue 4. 2002-12-24. PMID:12367620. |
furosemide modulation of gaba(a) receptors in dopaminergic neurones of the rat substantia nigra. |
2002-12-24 |
2023-08-12 |
rat |
| Mimoun Azzouz, Enca Martin-Rendon, Robert D Barber, Kyriacos A Mitrophanous, Emma E Carter, Jonathan B Rohll, Susan M Kingsman, Alan J Kingsman, Nicholas D Mazaraki. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451130. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra. |
2002-12-23 |
2023-08-12 |
rat |
| A Nicotra, S Parve. Apoptotic molecules and MPTP-induced cell death. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200191. |
mptp administered in vivo to mice causes selective loss of dopaminergic neurons in the substantia nigra (sn), as in this disease. |
2002-12-19 |
2023-08-12 |
mouse |
| K L Double, D Ben-Shachar, M B H Youdim, L Zecca, P Riederer, M Gerlac. Influence of neuromelanin on oxidative pathways within the human substantia nigra. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200193. |
neuromelanin (nm) is a dark-coloured pigment produced in the dopaminergic neurons of the human substantia nigra (sn). |
2002-12-19 |
2023-08-12 |
human |
| S Bharat, B C Cochran, M Hsu, J Liu, B N Ames, J K Anderse. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Neurotoxicology. vol 23. issue 4-5. 2002-12-16. PMID:12428720. |
oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons in the substantia nigra (sn) of parkinson's disease (pd) patients. |
2002-12-16 |
2023-08-12 |
Not clear |
| Xavier Emonds-Alt, Vincenzo Proietto, Régis Steinberg, Charles Advenier, Samira Daoui, Emmanuel Naline, Christiane Gueudet, Jean-Claude Michaud, Florence Oury-Donat, Martine Poncelet, Pol Vilain, Gérard Le Fur, Jean-Pierre Maffrand, Philippe Soubrié, Marc Pasca. Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Canadian journal of physiology and pharmacology. vol 80. issue 5. 2002-12-10. PMID:12056557. |
senktide (30 nm) induced firing rate increase of noradrenergic neurons in the guinea pig locus coeruleus and dopaminergic neurons in the guinea pig substantia nigra was also blocked by ssr 146977 (50 and 100 nm, respectively). |
2002-12-10 |
2023-08-12 |
human |
| S Tam, D P Barry, L Beaman, B L Beama. Neuroinvasive Nocardia asteroides GUH-2 induces apoptosis in the substantia nigra in vivo and dopaminergic cells in vitro. Experimental neurology. vol 177. issue 2. 2002-11-26. PMID:12429191. |
neuroinvasive nocardia asteroides guh-2 induces apoptosis in the substantia nigra in vivo and dopaminergic cells in vitro. |
2002-11-26 |
2023-08-12 |
Not clear |
| S Tam, D P Barry, L Beaman, B L Beama. Neuroinvasive Nocardia asteroides GUH-2 induces apoptosis in the substantia nigra in vivo and dopaminergic cells in vitro. Experimental neurology. vol 177. issue 2. 2002-11-26. PMID:12429191. |
n. asteroides strain guh-2 invades the brains of experimentally infected animals and selectively affects dopaminergic neurons of the substantia nigra (sn), causing an l-dopa-responsive movement disorder resembling parkinsonism. |
2002-11-26 |
2023-08-12 |
Not clear |
| Miwako Ozaki, Tsutomu Hashikawa, Kazutaka Ikeda, Yukie Miyakawa, Tomio Ichikawa, Yoshihiro Ishihara, Toshiro Kumanishi, Ryoji Yan. Degeneration of pontine mossy fibres during cerebellar development in weaver mutant mice. The European journal of neuroscience. vol 16. issue 4. 2002-11-22. PMID:12270032. |
in weaver mutant mice, substitution of an amino acid residue in the pore region of girk2, a subtype of the g-protein-coupled inwardly rectifying k+ channel, changes the properties of the homomeric channel to produce a lethal depolarized state in cerebellar granule cells and dopaminergic neurons in substantia nigra. |
2002-11-22 |
2023-08-12 |
mouse |
| Miwako Ozaki, Tsutomu Hashikawa, Kazutaka Ikeda, Yukie Miyakawa, Tomio Ichikawa, Yoshihiro Ishihara, Toshiro Kumanishi, Ryoji Yan. Degeneration of pontine mossy fibres during cerebellar development in weaver mutant mice. The European journal of neuroscience. vol 16. issue 4. 2002-11-22. PMID:12270032. |
from these results, we conclude that projecting neurons in the pontine nuclei, as well as cerebellar granule cells and dopaminergic neurons in substantia nigra, strongly degenerate in weaver mutant mice, resulting in elimination of pontocerebellar mossy fibres during cerebellar development. |
2002-11-22 |
2023-08-12 |
mouse |
| Susanne Petri, Klaus Krampfl, Reinhard Dengler, Johannes Bufler, Adolf Weindl, Thomas Arzberge. Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra. The Journal of comparative neurology. vol 452. issue 4. 2002-11-15. PMID:12355418. |
human gaba a receptors on dopaminergic neurons in the pars compacta of the substantia nigra. |
2002-11-15 |
2023-08-12 |
human |
| Susanne Petri, Klaus Krampfl, Reinhard Dengler, Johannes Bufler, Adolf Weindl, Thomas Arzberge. Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra. The Journal of comparative neurology. vol 452. issue 4. 2002-11-15. PMID:12355418. |
the gamma-aminobutyric acid a (gaba(a)) receptor subunit expression of the dopaminergic cells of the substantia nigra (sn) was investigated in the present study. |
2002-11-15 |
2023-08-12 |
human |
| N Pavón-Fuentes, R Macías-González, L Blanco-Lezcano, L Alvarez-González, L Martínez-Martí, L Castillo-Díaz, K De La Cuétara Bernal, C Díaz, L Lorigados-Pedre, Y Coro, A Y García-Varona, J C Rosillo, E Día. [Effects of simultaneous transplant of foetal mesencephalic cells in the striatum and the subthalamic nucleus of hemiparkinsonian rats]. Revista de neurologia. vol 34. issue 10. 2002-11-12. PMID:12134319. |
however, when the dopaminergic cells in the substantia nigra degenerate, not only is the dopaminergic innervation of the striatum affected but also other nuclei: globus pallidus, substantia nigra, substantia nigra pars reticulata and subthalamic nucleus. |
2002-11-12 |
2023-08-12 |
rat |
| Z-H Feng, T-G Wang, D-D Li, P Fung, B C Wilson, B Liu, Syed F Ali, R Langenbach, J-S Hon. Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183047. |
cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra. |
2002-10-28 |
2023-08-12 |
mouse |
| Srinivas Bharath, Michael Hsu, Deepinder Kaur, Subramanian Rajagopalan, Julie K Anderse. Glutathione, iron and Parkinson's disease. Biochemical pharmacology. vol 64. issue 5-6. 2002-10-17. PMID:12213603. |
parkinson's disease (pd) is a progressive neurodegenerative disease involving neurodegeneration of dopaminergic neurons of the substantia nigra (sn), a part of the midbrain. |
2002-10-17 |
2023-08-12 |
Not clear |
| Yi He, Wei-Dong Le, Stanley H Appe. Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra. Experimental neurology. vol 176. issue 2. 2002-10-17. PMID:12359173. |
immunoglobulin g (igg) from patients with pd can induce injury of dopaminergic neurons following stereotaxic injection into rat substantia nigra (sn). |
2002-10-17 |
2023-08-12 |
human |
| F Brischoux, B Griffond, D Fellmann, P Y Risol. Early and transient ontogenetic expression of the cocaine- and amphetamine-regulated transcript peptide in the rat mesencephalon: correlation with tyrosine hydroxylase expression. Journal of neurobiology. vol 52. issue 3. 2002-10-16. PMID:12210105. |
in particular, our observations suggest that cart-expressing neurons might help the migration of the dopaminergic neurons of the substantia nigra. |
2002-10-16 |
2023-08-12 |
rat |
| C H Tsai, S K Lo, L C See, H Z Chen, R S Chen, Y H Weng, F C Chang, C S L. Environmental risk factors of young onset Parkinson's disease: a case-control study. Clinical neurology and neurosurgery. vol 104. issue 4. 2002-10-08. PMID:12140099. |
while the cause of parkinson's disease (pd) remains unknown, recent evidence suggests certain environmental factors, such as well water drinking, herbicides and pesticides exposure, and neurotoxins, may trigger the chain of oxidative reactions culminating in the death of dopaminergic neurons in substantia nigra to cause parkinsonism. |
2002-10-08 |
2023-08-12 |
Not clear |
| Isaac Antolín, Juan Carlos Mayo, Rosa María Sainz, María de los Angeles del Brío, Federico Herrera, Vanesa Martín, Carmen Rodrígue. Protective effect of melatonin in a chronic experimental model of Parkinson's disease. Brain research. vol 943. issue 2. 2002-09-27. PMID:12101038. |
parkinson's disease is a chronic condition characterized by cell death of dopaminergic neurons mainly in the substantia nigra. |
2002-09-27 |
2023-08-12 |
mouse |