| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Ulfig, M Setzer, F Neudörfer, U Saretzk. Changing distribution patterns of synaptophysin-immunoreactive structures in the human dorsal striatum of the fetal brain. The Anatomical record. vol 258. issue 2. 2000-02-18. PMID:10645967. |
this pattern may correspond to the early dopaminergic innervation from the substantia nigra which is known to reach the developing patches. |
2000-02-18 |
2023-08-12 |
human |
| H Katsuki, T Kume, S Kaneko, A Akaik. [Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629879. |
we utilized organotypic midbrain slice cultures for the assessment of survival and degeneration of dopaminergic neurons in the substantia nigra. |
2000-02-16 |
2023-08-12 |
Not clear |
| M Smiałowska, M Bajkowska, B Prezewłocka, M Maj, J Turchan, R Przewłock. Effect of 6-hydroxydopamine on neuropeptide Y and corticotropin-releasing factor expression in rat amygdala. Neuroscience. vol 94. issue 4. 2000-02-14. PMID:10625052. |
the influence of dopaminergic denervation on neuropeptide y and corticotropin-releasing factor-containing neurons in the amygdala was investigated in rats by examining the effects of a selective, unilateral 6-hydroxydopamine lesion of mesencephalic dopaminergic neurons in both the substantia nigra and the ventral tegmental area on these peptides and their messenger rna expression, observed eight to 10 days after the lesion. |
2000-02-14 |
2023-08-12 |
rat |
| M Brinley-Reed, A J McDonal. Evidence that dopaminergic axons provide a dense innervation of specific neuronal subpopulations in the rat basolateral amygdala. Brain research. vol 850. issue 1-2. 2000-02-03. PMID:10629756. |
dopaminergic inputs from the ventral tegmental area and substantia nigra are involved in numerous emotional and behavioral functions mediated by the amygdala. |
2000-02-03 |
2023-08-12 |
rat |
| D Koziorowski, J Jaszta. [Factors which can play important role in pathogenesis of Parkinson disease]. Neurologia i neurochirurgia polska. vol 33. issue 4. 2000-02-02. PMID:10612105. |
degeneration of dopaminergic neurons that project from substantia nigra to striatum is the primary mechanism that causes parkinson disease (pd). |
2000-02-02 |
2023-08-12 |
Not clear |
| A Charara, T C Heilman, A I Levey, Y Smit. Pre- and postsynaptic localization of GABA(B) receptors in the basal ganglia in monkeys. Neuroscience. vol 95. issue 1. 2000-01-31. PMID:10619469. |
in the striatum, interneurons were more strongly stained than medium-sized projection neurons while in the substantia nigra, dopaminergic neurons of the pars compacta were much more intensely labeled than gabaergic neurons of the pars reticulata. |
2000-01-31 |
2023-08-12 |
monkey |
| K Honda, J Riehl, E Mignot, S Nishin. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619672. |
we further assessed the roles of the mesostriatal dopaminergic system and found that local perfusion of quinpirole and 7-oh-dpat into the substantia nigra (sn) significantly aggravated cataplexy, while perfusion of a d2/d3 antagonist significantly reduced cataplexy. |
2000-01-19 |
2023-08-12 |
Not clear |
| E M Nikulina, R P Hammer, K A Miczek, R M Krea. Social defeat stress increases expression of mu-opioid receptor mRNA in rat ventral tegmental area. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549815. |
because opioids mediate significant regulatory activities of brain dopamine neurons, dopaminergic loci in the ventral tegmental area (vta) and substantia nigra (sn) were selected for analysis. |
2000-01-04 |
2023-08-12 |
rat |
| K Honda, J Riehl, E Mignot, S Nishin. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep [corrected]. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549832. |
we further assessed the roles of the mesostriatal dopaminergic system and found that local perfusion of quinpirole and 7-oh-dpat into the substantia nigra (sn) significantly aggravated cataplexy, while perfusion of a d2/d3 antagonist significantly reduced cataplexy. |
2000-01-04 |
2023-08-12 |
Not clear |
| J A Aguirre, A Cintra, J Hillion, J A Narváez, A Jansson, T Antonelli, L Ferraro, F A Rambert, K Fux. A stereological study on the neuroprotective actions of acute modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse. Neuroscience letters. vol 275. issue 3. 2000-01-04. PMID:10580713. |
the data provide morphological evidence, based on unbiased stereological analysis, for a potential neuroprotective role of modafinil, not only in dopaminergic neurons, but also with a similar magnitude in the non-da nerve cell population of the substantia nigra after mptp lesion. |
2000-01-04 |
2023-08-12 |
mouse |
| K S McNaught, P Jenne. Altered glial function causes neuronal death and increases neuronal susceptibility to 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced toxicity in astrocytic/ventral mesencephalic co-cultures. Journal of neurochemistry. vol 73. issue 6. 1999-12-27. PMID:10582607. |
altered glial function in the substantia nigra in parkinson's disease may lead to the release of toxic substances that cause dopaminergic cell death or increase neuronal vulnerability to neurotoxins. |
1999-12-27 |
2023-08-12 |
Not clear |
| B Cutillas, M Espejo, J Gil, I Ferrer, S Ambrosi. Caspase inhibition protects nigral neurons against 6-OHDA-induced retrograde degeneration. Neuroreport. vol 10. issue 12. 1999-12-21. PMID:10574377. |
the nigral loss of dopaminergic neurons could be prevented by stereotaxical administration of zvad.fmk, a caspase inhibitor, into the substantia nigra, indicating that 6-ohda-induced nigrostriatal degeneration involves caspase activation. |
1999-12-21 |
2023-08-12 |
rat |
| A I Gorbachevskai. [Projections of the substantia nigra, ventral tegmental area and amygdala to the pallidum in dog brain]. Morfologiia (Saint Petersburg, Russia). vol 115. issue 1. 1999-12-14. PMID:10561844. |
neuronal fibres from all dopaminergic portions of substantia nigra and tegmental ventral field were found to project on both structures of dog dorsal pallidum (globus pallidus and entopeduncular nucleus). |
1999-12-14 |
2023-08-12 |
dog |
| M E Olds, D B Jacques, O Kopyo. Subthalamic responses to amphetamine and apomorphine in the behaving rat with a unilateral 6-OHDA lesion in the substantia nigra. Synapse (New York, N.Y.). vol 34. issue 3. 1999-12-10. PMID:10523760. |
the results also show that a unilateral lesion of the substantia nigra with 6-ohda did not block these responses but altered them in a manner consistent with a dopaminergic deafferentation of the basal ganglia. |
1999-12-10 |
2023-08-12 |
rat |
| E Kienzl, K Jellinger, H Stachelberger, W Liner. Iron as catalyst for oxidative stress in the pathogenesis of Parkinson's disease? Life sciences. vol 65. issue 18-19. 1999-12-09. PMID:10576448. |
the mechanisms leading to degeneration of melanized dopaminergic neurons in the brain stem, and particularly in the substantia nigra zona compacta (snzc) in patients with parkinson's disease (pd) are still unknown. |
1999-12-09 |
2023-08-12 |
Not clear |
| H Matsubayashi, T Amano, M Sas. Inhibition by aripiprazole of dopaminergic inputs to striatal neurons from substantia nigra. Psychopharmacology. vol 146. issue 2. 1999-12-02. PMID:10525748. |
inhibition by aripiprazole of dopaminergic inputs to striatal neurons from substantia nigra. |
1999-12-02 |
2023-08-12 |
Not clear |
| M Mogi, A Togari, K Tanaka, N Ogawa, H Ichinose, T Nagats. Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction. Neuroscience letters. vol 268. issue 2. 1999-11-22. PMID:10400088. |
the concentrations of tnf-alpha in the dopaminergic regions (striatum and substantia nigra) on the 6-ohda injection side (right side: r) were significantly higher than those in the regions on the control side (left side: l) (wilcoxon's test, p < 0.05). |
1999-11-22 |
2023-08-12 |
mouse |
| M Mogi, A Togari, K Tanaka, N Ogawa, H Ichinose, T Nagats. Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction. Neuroscience letters. vol 268. issue 2. 1999-11-22. PMID:10400088. |
these results show that tnf-alpha is increased in the striatum and substantia nigra in 6-ohda-injected dopaminergic regions in rats, which finding is similar to the increase in the striatal dopaminergic regions in patients with pd. |
1999-11-22 |
2023-08-12 |
mouse |
| G T Liberatore, D I Finkelstein, J Y Wong, M K Horne, M J Porritt, G A Donnan, D W Howell. Sprouting of dopaminergic axons after striatal injury: confirmation by markers not dependent on dopamine metabolism. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506529. |
the increases in silver staining and dextran-biotin transport provide independent evidence that this increase in dopaminergic activity occurs because of sprouting of new fibers originating in the substantia nigra. |
1999-11-19 |
2023-08-12 |
mouse |
| A M Li. Recovery by NO of the iron-attenuated dopamine dynamics in nigrostriatal system of rat brain. Neuroscience research. vol 34. issue 3. 1999-11-10. PMID:10515255. |
by contrast, infusion of iron in substantia nigra chronically degenerated the nigrostriatal dopaminergic system. |
1999-11-10 |
2023-08-12 |
rat |