| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Piallat, A Benazzouz, A L Benabi. Neuroprotective effect of chronic inactivation of the subthalamic nucleus in a rat model of Parkinson's disease. Journal of neural transmission. Supplementum. vol 55. 1999-08-03. PMID:10335494. |
as subthalamic nucleus neurons send direct glutamatergic projections to the substantia nigra, we studied the effects of kainic acid lesion of this nucleus on the degeneration of dopaminergic neurons induced by microinjection of 6-hydroxydopamine in the striatum of rat done one week after the first lesion. |
1999-08-03 |
2023-08-12 |
rat |
| M Revuelta, J L Venero, A Machado, J Can. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366014. |
we have previously studied changes in the serotoninergic and dopaminergic nigrostriatal systems following transection of the medial forebrain bundle and found a long-term axotomy-induced increase in the levels of serotonin and its main metabolite, 5-hydroxyindolacetic acid in substantia nigra [venero et al. |
1999-08-02 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. Time-course and localization of transferrin receptor expression in the substantia nigra of 6-hydroxydopamine-induced parkinsonian rats. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366015. |
parkinson's disease is a neurodegenerative disease characterized by dopaminergic cell death in the substantia nigra. |
1999-08-02 |
2023-08-12 |
rat |
| A Guyon, S Laurent, D Paupardin-Tritsch, J Rossier, D Eugèn. Incremental conductance levels of GABAA receptors in dopaminergic neurones of the rat substantia nigra pars compacta. The Journal of physiology. vol 516 ( Pt 3). 1999-07-29. PMID:10200421. |
molecular and biophysical properties of gabaa receptors of dopaminergic (da) neurones of the pars compacta of the rat substantia nigra were studied in slices and after acute dissociation. |
1999-07-29 |
2023-08-12 |
rat |
| J Kulisevsky, B Pascual-Sedan. [Parkinson disease and cognition]. Neurologia (Barcelona, Spain). vol 14 Suppl 1. 1999-07-28. PMID:10377731. |
however, in parkinson's disease patients pure subcortical alterations are able to produce a severe cognitive impairment, such as lost of dopaminergic neurones from substantia nigra to caudate nucleus and frontal areas. |
1999-07-28 |
2023-08-12 |
Not clear |
| W Duan, M P Mattso. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398297. |
parkinson's disease (pd) is an age-related disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (sn) and corresponding motor deficits. |
1999-07-28 |
2023-08-12 |
mouse |
| H Yang, W Cai, K Zhan. [Long-term survival of fetal substantia nigra grafts in striatum of PD rats: an observation of tyrosine hydroxylase immunohistochemistry and western blot]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 35. issue 1. 1999-07-27. PMID:10374499. |
by using immunohistochemistry and western blot, we observed the varied patterns of survival, development and growth of dopaminergic neurons after intrastriatal transplantation of fetal substantia nigra. |
1999-07-27 |
2023-08-12 |
rat |
| P A Starr, T Wichmann, C van Horne, R A Baka. Intranigral transplantation of fetal substantia nigra allograft in the hemiparkinsonian rhesus monkey. Cell transplantation. vol 8. issue 1. 1999-07-15. PMID:10338274. |
this pilot study examined the morphological features and behavioral effects of fetal dopaminergic neuronal allografts placed into the substantia nigra of three 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated hemiparkinsonian rhesus monkeys. |
1999-07-15 |
2023-08-12 |
human |
| C A Paladini, J M Teppe. GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Synapse (New York, N.Y.). vol 32. issue 3. 1999-07-15. PMID:10340627. |
these data demonstrate that dopaminergic neurons in vivo are under tonic gabaergic inhibition mediated by gaba(a) receptors and suggest that gabaergic afferents to substantia nigra comprise a major pathway by which the firing pattern of dopaminergic neurons is controlled in vivo. |
1999-07-15 |
2023-08-12 |
rat |
| C Sommer, M Sabel, W H Oertel, M Kiessling, J Sautte. Temporo-spatial expression of bFGF and TGFbeta2 in embryonic dopaminergic grafts in a rat model of Parkinson's disease. Brain research. Molecular brain research. vol 69. issue 1. 1999-07-12. PMID:10350637. |
lack of both bfgf and tgfbeta2 expression in grafted dopaminergic neurons compared to their normal expression in the adult rat substantia nigra indicates that these transplanted neurons do not develop their complete physiological phenotype. |
1999-07-12 |
2023-08-12 |
rat |
| M A Piggott, E F Marshall, N Thomas, S Lloyd, J A Court, E Jaros, D Costa, R H Perry, E K Perr. Dopaminergic activities in the human striatum: rostrocaudal gradients of uptake sites and of D1 and D2 but not of D3 receptor binding or dopamine. Neuroscience. vol 90. issue 2. 1999-06-10. PMID:10215149. |
the human striatum, which receives dopaminergic innervation from the substantia nigra and ventral tegmental area (cell groups a8, a9 and a10), has structural and functional subdivisions both rostrocaudally and dorsoventrally. |
1999-06-10 |
2023-08-12 |
human |
| M A Piggott, E F Marshall, N Thomas, S Lloyd, J A Court, E Jaros, D Costa, R H Perry, E K Perr. Dopaminergic activities in the human striatum: rostrocaudal gradients of uptake sites and of D1 and D2 but not of D3 receptor binding or dopamine. Neuroscience. vol 90. issue 2. 1999-06-10. PMID:10215149. |
these relate to motor and non-motor origins of cortical projections and the specific areas of the substantia nigra and ventral tegmental area providing dopaminergic innervation. |
1999-06-10 |
2023-08-12 |
human |
| L R Lucas, J A Angulo, M Le Moal, B S McEwen, P V Piazz. Neurochemical characterization of individual vulnerability to addictive drugs in rats. The European journal of neuroscience. vol 10. issue 10. 1999-06-07. PMID:9786209. |
in this study, we examined the neurobiological basis of dopaminergic hyperactivity by comparing in hrs and lrs the steady-state differences in regulatory inputs to mesencephalic (substantia nigra and ventral tegmental area: vta) dopaminergic neurons. |
1999-06-07 |
2023-08-12 |
rat |
| E Charpantier, P Barnéoud, P Moser, F Besnard, F Sgar. Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804323. |
nicotinic acetylcholine subunit mrna expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area. |
1999-06-07 |
2023-08-12 |
rat |
| E Charpantier, P Barnéoud, P Moser, F Besnard, F Sgar. Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804323. |
using the reverse transcriptase-polymerase chain reaction we have analyzed the mrna for nachr subunits expressed in the substantia nigra (sn) and ventral tegmental area (vta) following unilateral 6-hydroxydopamine lesion of the dopaminergic system. |
1999-06-07 |
2023-08-12 |
rat |
| J Zhang, G Perry, M A Smith, D Robertson, S J Olson, D G Graham, T J Montin. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. The American journal of pathology. vol 154. issue 5. 1999-06-03. PMID:10329595. |
oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (sn) of patients with parkinson's disease (pd). |
1999-06-03 |
2023-08-12 |
Not clear |
| Y Bozzi, E Borrell. Absence of the dopamine D2 receptor leads to a decreased expression of GDNF and NT-4 mRNAs in restricted brain areas. The European journal of neuroscience. vol 11. issue 4. 1999-05-20. PMID:10103122. |
at the level of the substantia nigra, ntfs have been proposed to control dopamine release by regulating the firing rate of dopaminergic cells. |
1999-05-20 |
2023-08-12 |
mouse |
| M Yamada, T Oligino, M Mata, J R Goss, J C Glorioso, D J Fin. Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 7. 1999-05-12. PMID:10097166. |
6-hydroxydopamine (6-ohda) is widely used to selectively lesion dopaminergic neurons of the substantia nigra (sn) in the creation of animal models of parkinson's disease. |
1999-05-12 |
2023-08-12 |
rat |
| A Richter, U Ebert, J N Nobrega, J J Vallbacka, M Fedrowitz, W Lösche. Immunohistochemical and neurochemical studies on nigral and striatal functions in the circling (ci) rat, a genetic animal model with spontaneous rotational behavior. Neuroscience. vol 89. issue 2. 1999-05-07. PMID:10077328. |
the lack of any significant dopaminergic cell loss in the substantia nigra and the locomotor hyperactivity observed in the mutants clearly suggest that the ci rat is not suited as a model of parkinsonism but rather constitutes a model of a hyperkinetic motor syndrome. |
1999-05-07 |
2023-08-12 |
rat |
| A I Brooks, C A Chadwick, H A Gelbard, D A Cory-Slechta, H J Federof. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain research. vol 823. issue 1-2. 1999-05-07. PMID:10095006. |
taken together, these data suggest that systemically absorbed paraquat crosses the blood-brain barrier to cause destruction of dopamine neurons in the substantia nigra, consequent reduction of dopaminergic innervation of the striatum and a neurobehavioral syndrome similar to the well characterized and bona fide dopaminergic toxin mptp. |
1999-05-07 |
2023-08-12 |
mouse |