| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Nicole, D Santiard-Baron, I Ceballos-Pico. Direct evidence for glutathione as mediator of apoptosis in neuronal cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 52. issue 9. 1999-02-19. PMID:9856280. |
particularly, a decrease in the level of the powerful antioxidant glutathione (gsh) and death of dopaminergic neurons in substantia nigra are prominent features in parkinson's disease. |
1999-02-19 |
2023-08-12 |
mouse |
| T Nakazato, A Akiyam. Differential time courses of exogenous 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine and its metabolite MPP+ in the rat striatum and nucleus accumbens measured using in vivo voltammetry. Brain research. vol 812. issue 1-2. 1999-02-10. PMID:9813295. |
the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (mptp) has been shown to affect nigrostriatal projection neurons to a greater extent than substantia nigra neurons that project to the nucleus accumbens. |
1999-02-10 |
2023-08-12 |
rat |
| V Seutin, L Massotte, J Scuvée-Moreau, A Dress. Spontaneous apamin-sensitive hyperpolarizations in dopaminergic neurons of neonatal rats. Journal of neurophysiology. vol 80. issue 6. 1999-02-10. PMID:9862933. |
intracellular recordings from substantia nigra slices revealed the existence of spontaneous hyperpolarizations (amplitude 2-8 mv, duration 100-400 ms) at -60 mv in most dopaminergic neurons of neonatal (9-15 days) but not adult rats. |
1999-02-10 |
2023-08-12 |
rat |
| J H Son, H S Chun, T H Joh, S Cho, B Conti, J W Le. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 1. 1999-02-05. PMID:9870933. |
the major pathological lesion of parkinson's disease (pd) is the selective cell death of dopaminergic (da) neurons in substantia nigra (sn). |
1999-02-05 |
2023-08-12 |
mouse |
| D L Choi-Lundberg, Q Lin, T Schallert, D Crippens, B L Davidson, Y N Chang, Y L Chiang, J Qian, L Bardwaj, M C Boh. Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878166. |
previously, we observed that an adenoviral (ad) vector encoding human glial cell line-derived neurotrophic factor (gdnf), injected near the rat substantia nigra (sn), protects sn dopaminergic (da) neuronal soma from 6-hydroxydopamine (6-ohda)-induced degeneration. |
1999-02-04 |
2023-08-12 |
human |
| A Mura, J Feldon, M Mint. Reevaluation of the striatal role in the expression of turning behavior in the rat model of Parkinson's disease. Brain research. vol 808. issue 1. 1999-01-08. PMID:9795128. |
in the present study, we tested the contribution of the substantia nigra vs. that of the striatum, in the expression of contralateral turning induced by l-dopa in rats with unilateral dopaminergic depletion. |
1999-01-08 |
2023-08-12 |
rat |
| A I Gorbachevskaia, O G Chivilëv. [The spatial organization of the afferent projections in the canine nucleus accumbens]. Morfologiia (Saint Petersburg, Russia). vol 114. issue 4. 1998-12-30. PMID:9826812. |
the differences between projections of nucleus accumbens studied are that apart from the above-mentioned common afferents medial segment receives projections from allocortical (entorhinal, periamygdalar) fields and subicular portion of hippocampal formation while lateral segment receives projections from all dopaminergic portions of substantia nigra. |
1998-12-30 |
2023-08-12 |
dog |
| Y Sanvarinda, L Phivthongngam, P Govitrapon. Alterations of striatal cholinergic receptors after lesioning of the substantia nigra. Neurochemistry international. vol 33. issue 2. 1998-12-11. PMID:9761463. |
in the present study we examined the changes in striatal dopaminergic and cholinergic receptors in unilateral substantia nigra lesioned rats that showed vigorous ipsilateral rotation (total turns > 300) in response to apomorphine (1 mg kg(-1) ip). |
1998-12-11 |
2023-08-12 |
rat |
| M D Bevan, P A Booth, S A Eaton, J P Bola. Selective innervation of neostriatal interneurons by a subclass of neuron in the globus pallidus of the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 22. 1998-12-11. PMID:9801382. |
descending collaterals of pallidostriatal neurons were also found to make synaptic contact with dopaminergic and gabaergic neurons of the substantia nigra. |
1998-12-11 |
2023-08-12 |
rat |
| K J Elliott, J M Jones, A I Sacaan, G K Lloyd, J Corey-Naev. 6-hydroxydopamine lesion of rat nigrostriatal dopaminergic neurons differentially affects nicotinic acetylcholine receptor subunit mRNA expression. Journal of molecular neuroscience : MN. vol 10. issue 3. 1998-12-08. PMID:9770646. |
nicotinic acetylcholine receptor (nachr) subunit mrna expression in the rat substantia nigra (sn) was assayed by semiquantitative rt-pcr following 6-hydroxydopamine (6-ohda) lesion of nigrostriatal dopaminergic neurons. |
1998-12-08 |
2023-08-12 |
rat |
| H Li, X M Shen, G Dryhurs. Brain mitochondria catalyze the oxidation of 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1) to intermediates that irreversibly inhibit complex I and scavenge glutathione: potential relevance to the pathogenesis of Parkinson's disease. Journal of neurochemistry. vol 71. issue 5. 1998-11-30. PMID:9798930. |
we have proposed that a very early step in the pathogenesis of idiopathic parkinson's disease is the elevated translocation of l-cysteine into neuromelanin-pigmented dopaminergic neurons in the substantia nigra. |
1998-11-30 |
2023-08-12 |
rat |
| b' M T Corasaniti, M C Strongoli, D Rotiroti, G Bagetta, G Nistic\\xc3\\xb. Paraquat: a useful tool for the in vivo study of mechanisms of neuronal cell death. Pharmacology & toxicology. vol 83. issue 1. 1998-11-25. PMID:9764419.' |
our observations have demonstrated that paraquat causes evident neurotoxic effects after intracerebroventricular or intracerebral injection in experimental animals; however, it seems that the herbicide does not exibit a selective neurotoxicity towards the dopaminergic nigro-striatal system since potent behavioural and electrocortical changes are induced by paraquat after injection in brain areas other than the substantia nigra and caudate nucleus. |
1998-11-25 |
2023-08-12 |
rat |
| J F Dormont, H Condé, D Fari. The role of the pedunculopontine tegmental nucleus in relation to conditioned motor performance in the cat. I. Context-dependent and reinforcement-related single unit activity. Experimental brain research. vol 121. issue 4. 1998-11-23. PMID:9746146. |
the reinforcement-related activity, preferentially evidenced in broad spike neurons presumed to be cholinergic, is speculated to be associated with cholinergic projection of pptg neurons to the dopaminergic neurons of the substantia nigra. |
1998-11-23 |
2023-08-12 |
cat |
| M Merad-Boudia, A Nicole, D Santiard-Baron, C Saillé, I Ceballos-Pico. Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease. Biochemical pharmacology. vol 56. issue 5. 1998-11-06. PMID:9783733. |
in parkinson's disease (pd), dopaminergic cell death in the substantia nigra was associated with a profound glutathione (gsh) decrease and a mitochondrial dysfunction. |
1998-11-06 |
2023-08-12 |
Not clear |
| M J Millan, A Newman-Tancredi, M Brocco, A Gobert, F Lejeune, V Audinot, J M Rivet, R Schreiber, A Dekeyne, M Spedding, J P Nicolas, J L Peglio. S 18126 ([2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl]), a potent, selective and competitive antagonist at dopamine D4 receptors: an in vitro and in vivo comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2, 3b]pyridine) and raclopride. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765336. |
as regards postsynaptic dopaminergic receptors, raclopride potently (0.01-0.3 mg/kg s.c.) reduced rotation elicited by quinpirole in rats with unilateral lesions of the substantia nigra, antagonized induction of hypothermia by pd 128, 907, blocked amphetamine-induced hyperlocomotion and was effective in six further models of potential antipsychotic activity. |
1998-11-05 |
2023-08-12 |
human |
| K Thorré, S Sarre, I Smolders, G Ebinger, Y Michott. Dopaminergic regulation of serotonin release in the substantia nigra of the freely moving rat using microdialysis. Brain research. vol 796. issue 1-2. 1998-10-29. PMID:9689460. |
dopaminergic regulation of serotonin release in the substantia nigra of the freely moving rat using microdialysis. |
1998-10-29 |
2023-08-12 |
rat |
| H Boudin, D Pélaprat, W Rostène, V M Pickel, A Beaude. Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 20. 1998-10-23. PMID:9763490. |
neurotensin (nt) produces various stimulatory effects on dopaminergic neurons of the rat substantia nigra. |
1998-10-23 |
2023-08-12 |
rat |
| K X Huang, D A Bergstrom, D N Ruskin, J R Walter. N-methyl-D-aspartate receptor blockade attenuates D1 dopamine receptor modulation of neuronal activity in rat substantia nigra. Synapse (New York, N.Y.). vol 30. issue 1. 1998-10-22. PMID:9704877. |
therefore, nmda receptor blockade markedly reduces the ability of d1 receptor stimulation to modulate firing rates of both dopaminergic and non-dopaminergic cells in the substantia nigra. |
1998-10-22 |
2023-08-12 |
rat |
| F Georges, E Normand, B Bloch, C Le Moin. Opioid receptor gene expression in the rat brain during ontogeny, with special reference to the mesostriatal system: an in situ hybridization study. Brain research. Developmental brain research. vol 109. issue 2. 1998-10-22. PMID:9729374. |
by g15, kappa-opioid receptor mrna was detectable in the nucleus accumbens and dorsal striatum, and in the substantia nigra and ventral tegmental area, suggesting an early expression of the corresponding receptor on dopaminergic terminal fibers. |
1998-10-22 |
2023-08-12 |
rat |
| M Gu, A D Owen, S E Toffa, J M Cooper, D T Dexter, P Jenner, C D Marsden, A H Schapir. Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases. Journal of the neurological sciences. vol 158. issue 1. 1998-10-15. PMID:9667773. |
oxidative stress and complex i deficiency have both been identified in the substantia nigra in parkinson's disease but their place in the sequence of events resulting in dopaminergic cell death is uncertain. |
1998-10-15 |
2023-08-12 |
Not clear |