| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V G Sidyakin, V B Pavlenko, A M Kulichenko, E V Gorelova, O M Pavlenk. Activity of substantia nigra neurons in the cat brain during a self-initiated behavioral act. Neuroscience and behavioral physiology. vol 28. issue 3. 1998-10-05. PMID:9682227. |
activity was recorded from 50 dopaminergic neurons (identified in terms of their low frequency of background activity and long action potentials) and 67 nondopaminergic neurons of the substantia nigra and adjacent region. |
1998-10-05 |
2023-08-12 |
cat |
| M Dai, J M Teppe. Do silent dopaminergic neurons exist in rat substantia nigra in vivo? Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681948. |
do silent dopaminergic neurons exist in rat substantia nigra in vivo? |
1998-10-01 |
2023-08-12 |
rat |
| M Dai, J M Teppe. Do silent dopaminergic neurons exist in rat substantia nigra in vivo? Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681948. |
a subpopulation of inactive or "silent" dopaminergic neurons has been reported to exist in vivo in rat substantia nigra, comprising up to 50% of nigral dopaminergic neurons. |
1998-10-01 |
2023-08-12 |
rat |
| M Dai, J M Teppe. Do silent dopaminergic neurons exist in rat substantia nigra in vivo? Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681948. |
in sharp contrast to previous reports, these data suggest that silent neurons do not comprise a substantial proportion of the total number of dopaminergic neurons in the substantia nigra. |
1998-10-01 |
2023-08-12 |
rat |
| M Dai, J M Teppe. Do silent dopaminergic neurons exist in rat substantia nigra in vivo? Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681948. |
reverse chi2 analysis revealed that, if they exist at all, silent dopaminergic neurons make up less than 2% of the dopaminergic cells in the substantia nigra. |
1998-10-01 |
2023-08-12 |
rat |
| P J Kramer, J Caldwell, A Hofmann, P Tempel, G Weiss. Neurotoxicity risk assessment of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) as a synthetic impurity of drugs. Human & experimental toxicology. vol 17. issue 5. 1998-09-16. PMID:9663939. |
it selectively destroys dopaminergic neurons in the substantia nigra and the globus pallidus. |
1998-09-16 |
2023-08-12 |
Not clear |
| J Zhang, J O Price, D G Graham, T J Montin. Secondary excitotoxicity contributes to dopamine-induced apoptosis of dopaminergic neuronal cultures. Biochemical and biophysical research communications. vol 248. issue 3. 1998-09-08. PMID:9704010. |
dopamine (da) and related catechols may contribute to selective degeneration of dopaminergic neurons in the substantia nigra in parkinson's disease. |
1998-09-08 |
2023-08-12 |
Not clear |
| J S Kim, J H Im, S U Kwon, J H Kang, M C Le. Micrographia after thalamo-mesencephalic infarction: evidence of striatal dopaminergic hypofunction. Neurology. vol 51. issue 2. 1998-09-08. PMID:9710055. |
the patient's micrographia may be related to a dysfunctional nigrostriatal dopaminergic system secondary to ischemic damage to the substantia nigra. |
1998-09-08 |
2023-08-12 |
Not clear |
| D G Walker, K Terai, A Matsuo, T G Beach, E G McGeer, P L McGee. Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases. Brain research. vol 794. issue 2. 1998-08-27. PMID:9622624. |
the use of neurotrophic growth factors as a means of preventing loss of the dopaminergic (da) neurons in the substantia nigra (sn) is becoming an accepted treatment strategy for parkinson's disease (pd). |
1998-08-27 |
2023-08-12 |
human |
| S Maisonnette, J P Huston, M Brandao, R K Schwartin. Behavioral asymmetries and neurochemical changes after unilateral lesions of tuberomammillary nucleus or substantia nigra. Experimental brain research. vol 120. issue 3. 1998-08-27. PMID:9628414. |
the ibotenic acid lesions of the pars reticulata did not deplete neostriatal dopamine, indicating that they spared the dopaminergic output of the substantia nigra. |
1998-08-27 |
2023-08-12 |
rat |
| J Haavik, K Tosk. Tyrosine hydroxylase and Parkinson's disease. Molecular neurobiology. vol 16. issue 3. 1998-08-21. PMID:9626667. |
a consistent neurochemical abnormality in parkinson's disease (pd) is degeneration of dopaminergic neurons in substantia nigra, leading to a reduction of striatal dopamine (da) levels. |
1998-08-21 |
2023-08-12 |
Not clear |
| A C Jones, Y Yamamura, L Almasy, S Bohlega, B Elibol, J Hubble, S Kuzuhara, M Uchida, T Yanagi, D E Weeks, T G Nygaar. Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: detailed genetic mapping of the linked region. American journal of human genetics. vol 63. issue 1. 1998-08-13. PMID:9634534. |
parkinson disease (pd) is a common neurodegenerative condition associated with degeneration of dopaminergic neurons in the zona compacta of the substantia nigra. |
1998-08-13 |
2023-08-12 |
Not clear |
| M Ruberg, V France-Lanord, B Brugg, N Lambeng, P P Michel, P Anglade, S Hunot, P Damier, B Faucheux, E Hirsch, Y Agi. [Neuronal death caused by apoptosis in Parkinson disease]. Revue neurologique. vol 153. issue 8-9. 1998-08-10. PMID:9683999. |
in addition, recent ultrastructural studies of dopaminergic neurons in patients with parkinson's disease have shown that these neurons die by apoptosis, and immunocytochemical studies have shown that the cytokine tnf-alpha, observed in microglial cells in the substantia nigra of patients post-mortem, might play a role, as might the transcription factor nf-kappa b, which is translocated into the nucleus of dopaminergic neurons in patients, a sign of its activation. |
1998-08-10 |
2023-08-12 |
Not clear |
| A Paren. The brain in evolution and involution. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 75. issue 6. 1998-08-06. PMID:9599655. |
for example, a typical substantia nigra composed of numerous dopaminergic neurons that project to the striatum already exists in the brain of reptiles. |
1998-08-06 |
2023-08-12 |
Not clear |
| F C Cheng, J S Kuo, L G Chia, G Dryhurs. Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: possible markers for and potential insights into the pathoetiology of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 4. 1998-07-28. PMID:9617787. |
the high 5-s-cys-da/hva ratio observed in the csf of pd-lw patients also provides support for the hypothesis that the translocation of glutathione or l-cysteine into neuromelanin-pigmented dopaminergic cell bodies in the substantia nigra might represent an early event in the pathogenesis of pd. |
1998-07-28 |
2023-08-12 |
Not clear |
| M F Mazurek, S M Savedia, R S Bobba, S Garside, P I Rosebus. Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal. Journal of neurology, neurosurgery, and psychiatry. vol 64. issue 6. 1998-07-23. PMID:9647315. |
this prompted a study of the effect of an eight week course of haloperidol (hal) followed by two week withdrawal, on dopaminergic neurons of the substantia nigra in rats. |
1998-07-23 |
2023-08-12 |
rat |
| D G Walker, T G Beach, R Xu, J Lile, K D Beck, E G McGeer, P L McGee. Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593897. |
in this study, tissue sections of human substantia nigra (sn) from normal and pd cases were examined to determine the pattern of ret expression in this region, and whether there was continued ret expression in surviving dopaminergic neurons in pd cases. |
1998-07-20 |
2023-08-12 |
human |
| I Nagatsu, K Ikemoto, T Takeuchi, R Arai, N Karasawa, T Fujii, T Nagats. Phenylethanolamine-N-methyltransferase - immunoreactive nerve terminals afferent to the mouse substantia nigra. Neuroscience letters. vol 245. issue 1. 1998-07-14. PMID:9596351. |
these results suggest that dopaminergic neurons in the substantia nigra receive pnmt-ir, adrenergic afferents from the c1 region of the medulla oblongata. |
1998-07-14 |
2023-08-12 |
mouse |
| L Blanco, N Pavón, P Alvaŕez, C Díaz, O Castellano, L Castillo, K de la Cuétara, R Macía. [Transplantation of fetal dopaminergic cells simultaneously to the corpus striatum and pars reticularis of the substantia nigra in hemi-parkinsonian rats]. Revista de neurologia. vol 26. issue 151. 1998-07-02. PMID:9585942. |
[transplantation of fetal dopaminergic cells simultaneously to the corpus striatum and pars reticularis of the substantia nigra in hemi-parkinsonian rats]. |
1998-07-02 |
2023-08-12 |
rat |
| A Lee, A E Wissekerke, D L Rosin, K R Lync. Localization of alpha2C-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system. Neuroscience. vol 84. issue 4. 1998-06-23. PMID:9578397. |
in the midbrain, alpha2c-adrenergic receptor immunoreactivity was detected in most tyrosine hydroxylase-immunoreactive cells in dopaminergic regions (63% in the retrorubral field, 77-83% in substantia nigra, 67% in ventral tegmental area). |
1998-06-23 |
2023-08-12 |
rat |