| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Naoi, W Maruyama, T Kasamatsu, P Doster. Oxidation of N-methyl(R)salsolinol: involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines. Journal of neural transmission. Supplementum. vol 52. 1998-06-10. PMID:9564615. |
the isoquinolinium ion caused massive necrosis in the striatum, whereas n-methyl(r)salsolinol depleted selectively dopaminergic neurons in the substantia nigra without necrotic tissue reaction. |
1998-06-10 |
2023-08-12 |
human |
| N S Kolomeets, N A Uranov. [Synaptic contacts in schizophrenia: study with immunocytochemical identification of dopaminergic neurons]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 97. issue 12. 1998-06-09. PMID:9591064. |
the ultrastructure of synaptic contacts located on dopaminergic (tyrosine hydroxylase immunopositive--tp) neurons was investigated in substantia nigra (sn) of postmortem brains in 4 schizophrenic patients compared to 3 mentally healthy control cases. |
1998-06-09 |
2023-08-12 |
Not clear |
| J W Błaszczy. Motor deficiency in Parkinson's disease. Acta neurobiologiae experimentalis. vol 58. issue 1. 1998-06-08. PMID:9583191. |
the pathological process behind the motor disabilities of parkinsonism is a progressive degeneration of dopaminergic neurons of the substantia nigra, that results in dopamine depletion in the striatum. |
1998-06-08 |
2023-08-12 |
Not clear |
| R Kötter, M Feizelmeie. Species-dependence and relationship of morphological and electrophysiological properties in nigral compacta neurons. Progress in neurobiology. vol 54. issue 5. 1998-05-28. PMID:9550193. |
the use of animal models in studying disorders of dopaminergic transmission in humans, such as parkinson's disease, depends on the assumption that morphological and electrophysiological properties of dopaminergic neurons in the pars compacta of the substantia nigra are relatively constant from rodents to monkeys and humans. |
1998-05-28 |
2023-08-12 |
rat |
| J Smythie. The functional neuroanatomy of awareness: with a focus on the role of various anatomical systems in the control of intermodal attention. Consciousness and cognition. vol 6. issue 4. 1998-05-19. PMID:9479480. |
but this is constrained by the functional anatomy of the circuits concerned and waking "awareness" is modulated by the many "nonspecific" systems (cholinergic from the basal forebrain, noradrenergic from the locus coeruleus, dopaminergic from the substantia nigra and ventral tegmentum, and serotoninergic from the raphe). |
1998-05-19 |
2023-08-12 |
Not clear |
| M M Winnicka, J J Braszko, K Wiśniewsk. 6-OHDA lesions to amygdala and hippocampus attenuate memory-enhancing effect of the 3-7 fragment of angiotensin II. General pharmacology. vol 30. issue 5. 1998-05-19. PMID:9559338. |
these results suggest that the anatomical substrate of facilitating retrieval of information activity of aii(3-7) is closely related to the dopaminergic projection from the ventral tegmental area and substantia nigra to ca and hi. |
1998-05-19 |
2023-08-12 |
rat |
| A J Levinson, S Garside, P I Rosebush, M F Mazure. Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat. Neuroscience. vol 84. issue 1. 1998-05-08. PMID:9522374. |
we studied the time course of changes in dopaminergic neurons of the substantia nigra and ventral tegmental area following withdrawal of haloperidol. |
1998-05-08 |
2023-08-12 |
rat |
| N Karasawa, I Nagatsu, K Sakai, T Nagatsu, K Watanabe, M Onozuk. Immunocytochemical study of catecholaminergic neurons in the senescence-accelerated mouse (SAM-P8) brain. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 11-12. 1998-04-29. PMID:9503272. |
immunoelectron microscopy revealed progressive degeneration of dopaminergic neurons and their terminal fibers in the substantia nigra as well as in noradrenergic neurons and their proximal dendrites in the locus coeruleus of the sam-p8 mice. |
1998-04-29 |
2023-08-12 |
mouse |
| J Knol. (-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain. Pharmacology & toxicology. vol 82. issue 2. 1998-04-28. PMID:9498233. |
(-)deprenyl enhances superoxide dismutase and catalase activity in the striatum, protects the nigrostriatal dopaminergic neurons against selective neurotoxins (6-hydroxy-dopamine, mptp, 4-n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine) and prevents characteristic age-related morphological changes in the neurocytes of the substantia nigra. |
1998-04-28 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. Effect of 6-OHDA injection on the AMPA glutamate receptor subunits in the substantia nigra of Sprague-Dawley rats. Neuroscience letters. vol 241. issue 1. 1998-04-28. PMID:9502201. |
parkinson's disease (pd) is characterized by the destruction of dopaminergic cells in the substantia nigra (sn). |
1998-04-28 |
2023-08-12 |
rat |
| A Takeda, J Sawashita, S Takefuta, S Okad. Distribution of zinc in the substantia nigra of rats treated with 6-hydroxydopamine. Biological trace element research. vol 61. issue 1. 1998-04-27. PMID:9498333. |
to study the relationship between tissue accumulation of zinc (zn) and neurodegeneration in the nigrostriatal dopaminergic pathway, 65zn distribution in this pathway was examined after unilateral injection of 6-hydroxydopamine (6-ohda) into the substantia nigra of rats. |
1998-04-27 |
2023-08-12 |
rat |
| I Pérez-Otaño, A Mandelzys, J I Morga. MPTP-Parkinsonism is accompanied by persistent expression of a delta-FosB-like protein in dopaminergic pathways. Brain research. Molecular brain research. vol 53. issue 1-2. 1998-04-20. PMID:9473580. |
parkinson's disease (pd) is characterized by the relatively selective and progressive loss of dopaminergic neurons in the substantia nigra. |
1998-04-20 |
2023-08-12 |
Not clear |
| H M Schipper, A Liberman, E G Stop. Neural heme oxygenase-1 expression in idiopathic Parkinson's disease. Experimental neurology. vol 150. issue 1. 1998-04-14. PMID:9514830. |
in the substantia nigra of both pd and control specimens, moderate ho-1 immunoreactivity was consistently observed in neuromelanin-containing (dopaminergic) neurons. |
1998-04-14 |
2023-08-12 |
human |
| G Radnikow, U Misgel. Dopamine D1 receptors facilitate GABAA synaptic currents in the rat substantia nigra pars reticulata. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 6. 1998-04-13. PMID:9482788. |
the role of dopaminergic d1 receptors located on these fibers was investigated using tight-seal whole-cell recordings from visually identified pars reticulata neurons of rat substantia nigra slices. |
1998-04-13 |
2023-08-12 |
rat |
| G Radnikow, U Misgel. Dopamine D1 receptors facilitate GABAA synaptic currents in the rat substantia nigra pars reticulata. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 6. 1998-04-13. PMID:9482788. |
we conclude that dopamine released from dendrites of dopaminergic neurons enhances gaba release in the pars reticulata of the substantia nigra through d1 receptors presumably located on striatonigral afferents. |
1998-04-13 |
2023-08-12 |
rat |
| C Rosenblad, A Martinez-Serrano, A Björklun. Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience. vol 82. issue 1. 1998-04-09. PMID:9483509. |
in the control group the lesion induced a 75-90% reduction of the dopaminergic innervation in the dorsolateral striatum (assessed by [3h]n-[1-(2-benzo(b)thiopenyl)cyclohexyl]piperidine-labelled dopamine uptake sites), and an approximately 50% reduction in the number of tyrosine hydroxylase-positive cell bodies in the central part of the substantia nigra, accompanied by a significant impairment in spontaneous motor behaviour, as assessed by a forelimb stepping test. |
1998-04-09 |
2023-08-12 |
rat |
| J Wu, L D Partridg. Dissociated dopaminergic neurons from substantia nigra zona compacta in young rats lack functional NMDA receptors. Pflugers Archiv : European journal of physiology. vol 435. issue 5. 1998-04-07. PMID:9479023. |
dissociated dopaminergic neurons from substantia nigra zona compacta in young rats lack functional nmda receptors. |
1998-04-07 |
2023-08-12 |
rat |
| A Laakso, J Bergman, M Haaparanta, H Vilkman, O Solin, J Hietal. [18F]CFT [(18F)WIN 35,428], a radioligand to study the dopamine transporter with PET: characterization in human subjects. Synapse (New York, N.Y.). vol 28. issue 3. 1998-04-06. PMID:9488509. |
we were able to also visualize midbrain dopaminergic neurons (substantia nigra) with [18f]cft in some subjects. |
1998-04-06 |
2023-08-12 |
human |
| I Mendez, M Hon. Reconstruction of the striato-nigro-striatal circuitry by simultaneous double dopaminergic grafts: a tracer study using fluorogold and horseradish peroxidase. Brain research. vol 778. issue 1. 1998-03-13. PMID:9462892. |
re-establishment of the nigrostriatal circuitry and dopaminergic reinnervation of the substantia nigra may be necessary to promote a more complete restoration of function in the dopamine depleted brain and improve the clinical efficacy of dopaminergic transplants. |
1998-03-13 |
2023-08-12 |
Not clear |
| C Apostolides, E Sanford, M Hong, I Mende. Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience. vol 83. issue 2. 1998-03-12. PMID:9460746. |
in the present study, the hypothesis was that treating fetal ventral mesencephalic tissue containing the dopaminergic substantia nigra with glial cell line-derived neurotrophic factor either during storage or at the time of transplantation, would enhance grafted dopaminergic cell survival and functional reinnervation of the host striatum in the unilaterally 6-hydroxydopamine-lesioned rat. |
1998-03-12 |
2023-08-12 |
rat |