| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D E Schmidt, M H Ebert, J C Lynn, W O Whetsel. Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451719. |
one approach is to use organotypic tissue cultures of the canine substantia nigra (csn) which permit administration of precise concentrations of pharmacological agents directly to mature, well-developed and metabolically active dopaminergic neurons. |
1998-02-26 |
2023-08-12 |
Not clear |
| A I Gorbachevskai. [The projections of the amygdaloid body, ventral tegmental area and substantia nigra to different segments of the nucleus accumbens in the canine brain]. Morfologiia (Saint Petersburg, Russia). vol 112. issue 5. 1998-02-25. PMID:9460675. |
medical segment receives projection fibers only from amygdala basal nucleus and tegmental ventral field, i. e. from structures related to limbic system, while lateral one--from all dopaminergic parts of substantia nigra, associated with regulation of locomotor behavior as well. |
1998-02-25 |
2023-08-12 |
dog |
| S Chapman, D M Michaelso. Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453565. |
in contrast, the nerve terminal density of the dopaminergic neurons that project from the substantia nigra to the striatum was unaffected and was similar to that of the controls. |
1998-02-24 |
2023-08-12 |
mouse |
| M d'Ischia, G Prot. Biosynthesis, structure, and function of neuromelanin and its relation to Parkinson's disease: a critical update. Pigment cell research. vol 10. issue 6. 1998-02-03. PMID:9428003. |
no longer dismissed as just a mere curiosity in the family of melanin pigments, neuromelanin is attracting increasing interest as a central constituent of certain populations of dopaminergic neurons in the human substantia nigra, which may hold the key for the understanding of neuron functioning and degeneration in aging and in parkinson's disease. |
1998-02-03 |
2023-08-12 |
human |
| E Floor, M G Wetze. Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422371. |
the dopaminergic phenotype of neurons in human substantia nigra deteriorates during normal aging, and loss of these neurons is prominent in parkinson's disease. |
1998-02-02 |
2023-08-12 |
human |
| G M Gonzalez, L L Werlin. Release of [3H]dopamine from guinea pig striatal slices is modulated by sigma1 receptor agonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 4. 1998-01-21. PMID:9349631. |
their location in guinea pig striatum, a terminal field of dopaminergic projections arising from the substantia nigra, suggested that this tissue would be a logical choice in which to examine physiological properties of sigma receptor activation. |
1998-01-21 |
2023-08-12 |
rat |
| A Alfahel-Kakunda, W F Silverma. Calcium-binding proteins in the substantia nigra and ventral tegmental area during development: correlation with dopaminergic compartmentalization. Brain research. Developmental brain research. vol 103. issue 1. 1998-01-21. PMID:9370056. |
calcium-binding proteins in the substantia nigra and ventral tegmental area during development: correlation with dopaminergic compartmentalization. |
1998-01-21 |
2023-08-12 |
Not clear |
| F Tamar. Disturbances in higher function in Parkinson's disease. European neurology. vol 38 Suppl 2. 1998-01-20. PMID:9387801. |
as the activity of these circuits can be modulated at the striatum by the nigrostriatal dopaminergic system, cognitive function can be influenced by the pathological change in the substantia nigra in parkinson's disease. |
1998-01-20 |
2023-08-12 |
Not clear |
| X Lu, T Hag. Glial cell line-derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats. The Journal of comparative neurology. vol 388. issue 3. 1998-01-14. PMID:9368855. |
here, we show that gdnf (3 micrograms per day and higher) can promote the survival of all (retrogradely labeled) axotomized nigrostriatal dopaminergic neurons of adult rats when continuously infused for 2 weeks close to the substantia nigra, compared to only approximately 30% survival with control infusions. |
1998-01-14 |
2023-08-12 |
rat |
| K Nish. Expression of c-Jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Brain research. vol 771. issue 1. 1998-01-09. PMID:9383016. |
expression of c-jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated mice. |
1998-01-09 |
2023-08-12 |
mouse |
| K Nish. Expression of c-Jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Brain research. vol 771. issue 1. 1998-01-09. PMID:9383016. |
both age groups exhibited reduction in the number of dopaminergic neurons in the substantia nigra after administration of mptp. |
1998-01-09 |
2023-08-12 |
mouse |
| K Nish. Expression of c-Jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Brain research. vol 771. issue 1. 1998-01-09. PMID:9383016. |
there was a significant difference in the magnitude of decrease in the number of dopaminergic neurons between the two groups, as has previously been reported, and the older mice exhibited more extensive loss of dopaminergic neurons in the substantia nigra after mptp administration than did the young mice. |
1998-01-09 |
2023-08-12 |
mouse |
| A Migheli, R Piva, J Wei, A Attanasio, S Casolino, M E Hodes, S R Dlouhy, S A Bayer, B Ghett. Diverse cell death pathways result from a single missense mutation in weaver mouse. The American journal of pathology. vol 151. issue 6. 1998-01-02. PMID:9403713. |
between p14 and p21, when dopaminergic neurons start to degenerate, staining for isel, c-jun, and pcna in weaver substantia nigra was the same as in controls. |
1998-01-02 |
2023-08-12 |
mouse |
| A H Rajput, M e Fenton, S Birdi, R Macaula. Is levodopa toxic to human substantia nigra? Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 5. 1997-11-07. PMID:9380042. |
levodopa (ld) is the most effective drug for symptomatic control of parkinson's disease, but has been suspected to be toxic to substantia nigra (sn) dopaminergic neurons. |
1997-11-07 |
2023-08-12 |
human |
| H Li, G Dryhurs. Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease. Journal of neurochemistry. vol 69. issue 4. 1997-10-27. PMID:9326282. |
based on a number of lines of evidence, we have proposed recently that a very early step in the pathogenesis of idiopathic parkinson's disease might be elevated translocation of l-cysteine into neuromelanin-pigmented dopaminergic cell bodies in the substantia nigra. |
1997-10-27 |
2023-08-12 |
rat |
| H Li, G Dryhurs. Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease. Journal of neurochemistry. vol 69. issue 4. 1997-10-27. PMID:9326282. |
formation of dhbt-1 requires only dopamine, l-cysteine, and an oxidizing environment, conditions that may well exist in the cytoplasm of neuromelanin-pigmented dopaminergic neurons in the parkinsonian substantia nigra. |
1997-10-27 |
2023-08-12 |
rat |
| H Li, G Dryhurs. Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease. Journal of neurochemistry. vol 69. issue 4. 1997-10-27. PMID:9326282. |
the results of this study raise the possibility that dhbt-1 might be an endotoxin formed specifically in pigmented dopaminergic neurons that can contribute to irreversible damage to mitochondrial complex i and substantia nigra cell death in parkinson's disease. |
1997-10-27 |
2023-08-12 |
rat |
| C L Veenma. Pigeon basal ganglia: insights into the neuroanatomy underlying telencephalic sensorimotor processes in birds. European journal of morphology. vol 35. issue 4. 1997-10-23. PMID:9290931. |
furthermore, the striatum receives a massive projection from dopaminergic neurons of the ventral tegmental area and substantia nigra in the midbrain tegmentum. |
1997-10-23 |
2023-08-12 |
pigeon |
| J L Eberling, K S Bankiewicz, S Jordan, H F VanBrocklin, W J Jagus. PET studies of functional compensation in a primate model of Parkinson's disease. Neuroreport. vol 8. issue 12. 1997-10-23. PMID:9295108. |
positron emission tomography (pet) studies of rhesus macaques at various time points following unilateral mptp administration demonstrated a different time course of degeneration in the dopaminergic terminals in the putamen and in the cell bodies in the substantia nigra, consistent with other evidence of retrograde degeneration. |
1997-10-23 |
2023-08-12 |
Not clear |
| J L Eberling, K S Bankiewicz, S Jordan, H F VanBrocklin, W J Jagus. PET studies of functional compensation in a primate model of Parkinson's disease. Neuroreport. vol 8. issue 12. 1997-10-23. PMID:9295108. |
in addition, the substantia nigra showed a transient upregulation in dopaminergic function in the lesioned hemisphere indicating functional compensation. |
1997-10-23 |
2023-08-12 |
Not clear |