| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Bertrand, W Lechowicz, G M Szpak, J Dymeck. [Morphometric assessment of lesions in the dopaminergic nigrostriatal system in Parkinson disease]. Neurologia i neurochirurgia polska. vol 30. issue 5. 1997-05-12. PMID:9148173. |
the qualitative study indicated that melanin depletion in dopaminergic cells of substantia nigra in parkinson's disease is diffuse and it is located mainly in the lateral alfa layer. |
1997-05-12 |
2023-08-12 |
human |
| E Bertrand, W Lechowicz, G M Szpak, J Dymeck. [Morphometric assessment of lesions in the dopaminergic nigrostriatal system in Parkinson disease]. Neurologia i neurochirurgia polska. vol 30. issue 5. 1997-05-12. PMID:9148173. |
the morphometric evaluation revealed that depletion of dopaminergic neurons in substantia nigra in parkinson's disease is 73%, on average, while in vta it remains under 5%. |
1997-05-12 |
2023-08-12 |
human |
| V Blanchard, P Anglade, G Dziewczapolski, M Savasta, Y Agid, R Raisman-Vozar. Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra. Brain research. vol 709. issue 2. 1997-05-01. PMID:8833770. |
dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra. |
1997-05-01 |
2023-08-12 |
rat |
| H Moukhles, O Bosler, J P Bolam, A Vallée, D Umbriaco, M Geffard, G Douce. Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra. Neuroscience. vol 76. issue 4. 1997-04-29. PMID:9027876. |
they indicate that this dense serotonin input to the substantia nigra is very precisely organized, acting through both "non-junctional" and "junctional" modes of neurotransmission in the pars compacta, which projects to the neostriatum and the limbic system, whereas the predominant mode of serotonin transmission appears to be of the "junctional" type in the pars reticulata, where serotonin can finely control the motor output of the basal ganglia by acting on the gaba projection neurons either directly or through the local release of dopamine by dopaminergic dendrites. |
1997-04-29 |
2023-08-12 |
rat |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
the neurotoxin mptp has been used to create an animal model of parkinson's disease in the mouse, in part, because it causes a significant loss of dopaminergic neurons in the substantia nigra (nucleus a9). |
1997-04-24 |
2023-08-12 |
mouse |
| E C Hirsch, B Faucheux, P Damier, A Mouatt-Prigent, Y Agi. Neuronal vulnerability in Parkinson's disease. Journal of neural transmission. Supplementum. vol 50. 1997-04-24. PMID:9120427. |
although parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra not all dopaminergic neurons degenerate in this disease. |
1997-04-24 |
2023-08-12 |
Not clear |
| M Naoi, W Maruyama, P Dostert, Y Hashizum. N-methyl-(R)salsolinol as a dopaminergic neurotoxin: from an animal model to an early marker of Parkinson's disease. Journal of neural transmission. Supplementum. vol 50. 1997-04-24. PMID:9120428. |
n-methyl-(r)salsolinol depleted dopamine neurons in the rat substantia nigra without necrotic tissue reaction, which may be due to the apoptotic death process, as proved by its induction of dna damage in dopaminergic neuroblastoma sh-sy5y cells. |
1997-04-24 |
2023-08-12 |
human |
| M J Marti, C J James, T F Oo, W J Kelly, R E Burk. Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 6. 1997-04-07. PMID:9045731. |
that dopaminergic neurons of the substantia nigra may depend on their target, the striatum, during development is suggested by the presence of a natural apoptotic cell death event in these neurons that can be augmented by an early developmental axon-sparing striatal injury. |
1997-04-07 |
2023-08-12 |
Not clear |
| P K Sonsalla, N D Jochnowitz, G D Zeevalk, J A Oostveen, E D Hal. Treatment of mice with methamphetamine produces cell loss in the substantia nigra. Brain research. vol 738. issue 1. 1997-03-25. PMID:8949944. |
studies were conducted to determine if treatment of mice with methamphetamine (meth) would produce a loss of dopaminergic cells in the substantia nigra. |
1997-03-25 |
2023-08-12 |
mouse |
| D W Eyles, K M Avent, T J Stedman, S M Pon. Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem. Life sciences. vol 60. issue 8. 1997-03-25. PMID:9042387. |
hpp+ was present in all regions (except for substantia nigra in one patient and globus pallidus in another); the amount/g ranged from 1.6-8.3 pmol but there was no preferential sequestration of the metabolite in dopaminergic regions. |
1997-03-25 |
2023-08-12 |
Not clear |
| J Booij, G Tissingh, G J Boer, J D Speelman, J C Stoof, A G Janssen, E C Wolters, E A van Roye. [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 62. issue 2. 1997-03-20. PMID:9048712. |
the main neuropathological feature in parkinson's disease is a severe degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of dopamine (da) transporters in the striatum. |
1997-03-20 |
2023-08-12 |
Not clear |
| C C Wrenn, M J Picklo, D A Lappi, D Robertson, R G Wile. Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings. Brain research. vol 740. issue 1-2. 1997-03-19. PMID:8973812. |
dopaminergic neurons of the substantia nigra and ventral tegmental area and serotonergic neurons of the raphé, all monoaminergic neurons that do not express dbh, survived all alpha-dbh-sap doses. |
1997-03-19 |
2023-08-12 |
rat |
| W J Smeets, J R Alonso, A Gonzále. Distribution of NADPH-diaphorase and nitric oxide synthase in relation to catecholaminergic neuronal structures in the brain of the lizard Gekko gecko. The Journal of comparative neurology. vol 377. issue 1. 1997-03-19. PMID:8986877. |
colocalization was observed in numerous cells of the ventral tegmental area, the substantia nigra, and the retrorubral dopaminergic cell group. |
1997-03-19 |
2023-08-12 |
Not clear |
| C A Chapman, J S Yeomans, C D Blaha, J R Blackbur. Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus. Neuroscience. vol 76. issue 1. 1997-03-18. PMID:8971770. |
the cholinergic cells of the tegmental pedunculopontine nucleus monosynaptically excite dopaminergic neurons of the substantia nigra. |
1997-03-18 |
2023-08-12 |
rat |
| H Matsumine, M Saito, S Shimoda-Matsubayashi, H Tanaka, A Ishikawa, Y Nakagawa-Hattori, M Yokochi, T Kobayashi, S Igarashi, H Takano, K Sanpei, R Koike, H Mori, T Kondo, Y Mizutani, A A Schäffer, Y Yamamura, S Nakamura, S Kuzuhara, S Tsuji, Y Mizun. Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27. American journal of human genetics. vol 60. issue 3. 1997-03-18. PMID:9042918. |
an autosomal recessive form of juvenile parkinsonism (ar-jp) (mim 600116) is a levodopa-responsive parkinsonism whose pathological finding is a highly selective degeneration of dopaminergic neurons in the zona compacta of the substantia nigra. |
1997-03-18 |
2023-08-12 |
Not clear |
| L W Klomp, J D Gitli. Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia. Human molecular genetics. vol 5. issue 12. 1997-03-14. PMID:8968753. |
consistent with these observations, in situ hybridization of central nervous system tissue utilizing ceruloplasmin crna probes reveals abundant ceruloplasmin gene expression in specific populations of glial cells associated with the brain microvasculature, surrounding dopaminergic melanized neurons in the substantia nigra and within the inner nuclear layer of the retina. |
1997-03-14 |
2023-08-12 |
human |
| K E Bowenkamp, D David, P L Lapchak, M A Henry, A C Granholm, B J Hoffer, T J Mahali. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Experimental brain research. vol 111. issue 1. 1997-03-11. PMID:8891630. |
6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. |
1997-03-11 |
2023-08-12 |
rat |
| K E Bowenkamp, D David, P L Lapchak, M A Henry, A C Granholm, B J Hoffer, T J Mahali. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Experimental brain research. vol 111. issue 1. 1997-03-11. PMID:8891630. |
intraparenchymal injections of the neurotoxin 6-hydroxydopamine (6-ohda) into the medial forebrain bundle in rats destroys the dopaminergic neurons in the pars compacta of the substantia nigra. |
1997-03-11 |
2023-08-12 |
rat |
| A Gasbarri, M G Packard, A Sulli, C Pacitti, R Innocenzi, V Perciavall. The projections of the retrorubral field A8 to the hippocampal formation in the rat. Experimental brain research. vol 112. issue 2. 1997-03-11. PMID:8951393. |
the dopaminergic neurons in the midbrain of the rat are located in three groups: the ventral tegmental area (vta-a10), substantia nigra (sn-a9), and retrorubral field (rrf-a8). |
1997-03-11 |
2023-08-12 |
rat |
| M Metzger, S Jiang, J Wang, K Brau. Organization of the dopaminergic innervation of forebrain areas relevant to learning: a combined immunohistochemical/retrograde tracing study in the domestic chick. The Journal of comparative neurology. vol 376. issue 1. 1997-03-03. PMID:8946281. |
by combining da immunohistochemistry with retrograde fluorescent tracing, we demonstrated that dopaminergic afferents to the mnh and ndc arise mainly from the area ventralis, whereas the main dopaminergic input to the lpo arises from the substantia nigra. |
1997-03-03 |
2023-08-12 |
chicken |