| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X M Shen, B Xia, M Z Wrona, G Dryhurs. Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease. Chemical research in toxicology. vol 9. issue 7. 1997-02-20. PMID:8902266. |
a very early event in the pathogenesis of idiopathic parkinson's disease (pd) has been proposed to be an elevated translocation of l-cysteine (cysh) and/or glutathione (gsh) into pigmented dopaminergic cell bodies in the substantia nigra (sn) in which cytoplasmic dopamine (da) is normally autoxidized to da-o-quinone as the first step in a reaction leading to black neuromelanin polymer. |
1997-02-20 |
2023-08-12 |
mouse |
| A Mouatt-Prigent, J O Karlsson, Y Agid, E C Hirsc. Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? Neuroscience. vol 73. issue 4. 1997-02-19. PMID:8809817. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra and, to a lesser extent, the ventral tegmental area and catecholaminergic cell group a8. |
1997-02-19 |
2023-08-12 |
Not clear |
| J H Ryu, K Yanai, X L Zhao, T Watanab. The effect of dopamine D1 receptor stimulation on the up-regulation of histamine H3-receptors following destruction of the ascending dopaminergic neurones. British journal of pharmacology. vol 118. issue 3. 1997-02-14. PMID:8762081. |
these results strongly suggest that the expression of histamine h3-receptors in the striatum and substantia nigra is influenced through d1-receptors by tonic nigrostriatal dopaminergic inputs. |
1997-02-14 |
2023-08-12 |
rat |
| G Pezzoli, O Strada, V Silani, A Zecchinelli, L Perbellini, F Javoy-Agid, P Ghidoni, E D Motti, T Masini, G Scarlato, Y Agid, E C Hirsc. Clinical and pathological features in hydrocarbon-induced parkinsonism. Annals of neurology. vol 40. issue 6. 1997-02-13. PMID:9007099. |
pathological examination and immunohistochemical analysis of the brain revealed severe and widespread dopaminergic neuronal loss, associated with severe gliosis, in the substantia nigra, and almost complete loss of tyrosine hydroxylase immunostaining in the striatum. |
1997-02-13 |
2023-08-12 |
Not clear |
| T Götz, U Kraushaar, J Geiger, J Lübke, T Berger, P Jona. Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987749. |
we investigated the functional properties of ampars and nmdars expressed by six main types of basal ganglia neurons in acute rat brain slices (principal neurons and cholinergic interneurons of striatum, gabaergic and dopaminergic neurons of substantia nigra, globus pallidus neurons, and subthalamic nucleus neurons) using fast application of glutamate to nucleated and outside-out membrane patches. |
1997-02-04 |
2023-08-12 |
rat |
| J L Tseng, E E Baetge, A D Zurn, P Aebische. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987758. |
parkinson's disease (pd) is characterized by the progressive loss of the substantia nigra (sn) dopaminergic neurons projecting to the striatum. |
1997-02-04 |
2023-08-12 |
rat |
| N B Mercuri, P Grillner, G Bernard. N-methyl-D-aspartate receptors mediate a slow excitatory postsynaptic potential in the rat midbrain dopaminergic neurons. Neuroscience. vol 74. issue 3. 1997-01-30. PMID:8884774. |
repetitive local application of a short train of stimuli to the rat substantia nigra and ventral tegmental area elicited a predominant depolarizing, slow, long-lasting synaptic response in the dopaminergic cells intracellularly recorded in vitro. |
1997-01-30 |
2023-08-12 |
rat |
| R J Vermeulen, E C Wolters, G Tissingh, J Booij, A G Janssen, J Habraken, E Sokole-Busemann, J C Stoof, E A Van Roye. Evaluation of [123I] beta-CIT binding with SPECT in controls, early and late Parkinson's disease. Nuclear medicine and biology. vol 22. issue 8. 1997-01-17. PMID:8998476. |
the main neuropathological feature in parkinson's disease (pd) is a severe degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of dopamine in the striatum. |
1997-01-17 |
2023-08-12 |
Not clear |
| F Picard, A de Saint-Martin, E Salmon, E Hirsch, C Marescau. Postencephalitic stereotyped involuntary movements responsive to L-Dopa. Movement disorders : official journal of the Movement Disorder Society. vol 11. issue 5. 1997-01-10. PMID:8866499. |
these symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra. |
1997-01-10 |
2023-08-12 |
Not clear |
| J M Campbell, A P Payne, D P Gilmore, J E Byrne, D Russell, J McGadey, D J Clarke, R W Davies, R G Sutcliff. Neostriatal dopamine depletion and locomotor abnormalities due to the Albino Swiss rat agu mutation. Neuroscience letters. vol 213. issue 3. 1997-01-10. PMID:8873142. |
the sub-strain of albino swiss rat (as/agu) is a spontaneous mutation characterised by an ungainly, staggering gait, hindlimb rigidity, whole body tremor and (when symptoms are fully developed) difficulty in initiating movement; it exhibits a progressive decrease in dopaminergic cells within the substantia nigra. |
1997-01-10 |
2023-08-12 |
rat |
| F Fukamauchi, M Ishimaru, T Hashimoto, K Obat. Neurochemical analysis of the tyrosine hydroxylase expression in methamphetamine-sensitized rats. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959049. |
in situ hybridization revealed that the signals of th mrna were localized to the dopaminergic perikarya of substantia nigra and ventral tegmental area in the midbrain, and northern blot analysis showed that the levels of th mrna in these areas decreased by 37% compared to that in the saline-treated controls. |
1997-01-08 |
2023-08-12 |
rat |
| T Wu, H L Wan. G alpha q/11 mediates cholecystokinin activation of the cationic conductance in rat substantia nigra dopaminergic neurons. Journal of neurochemistry. vol 66. issue 3. 1997-01-07. PMID:8769867. |
using acutely isolated rat substantia nigra neurons, our previous studies indicated that sulfated cholecystokinin octapeptide (cck-8) excites substantia nigra dopaminergic neurons by increasing the cationic conductance and that pertussis toxin-insensitive g proteins mediate cck-8 induction of cationic currents. |
1997-01-07 |
2023-08-12 |
rat |
| M Santiago, A Machado, J Can. Nigral and striatal comparative study of the neurotoxic action of 1-methyl-4-phenylpyridinium ion: involvement of dopamine uptake system. Journal of neurochemistry. vol 66. issue 3. 1997-01-07. PMID:8769882. |
the presence of nomifensine (20 microm) partially prevented the neurotoxic effect of mpp+ (2.5 mm) on dopaminergic cell bodies/ dendrites in the substantia nigra. |
1997-01-07 |
2023-08-12 |
Not clear |
| R Schmidt-Kastner, C Wetmore, L Olso. Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience. vol 74. issue 1. 1997-01-06. PMID:8843085. |
the expression of bdnf in the striatum suggests that this factor could be a target-derived factor for dopaminergic neurons of substantia nigra and/or work as an autocrine/ paracrine factor within the striatum itself. |
1997-01-06 |
2023-08-12 |
rat |
| I Mendez, D Sadi, M Hon. Reconstruction of the nigrostriatal pathway by simultaneous intrastriatal and intranigral dopaminergic transplants. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 22. 1996-12-19. PMID:8929430. |
the present study demonstrates for the first time that simultaneous dopaminergic transplants (double grafts) placed in the substantia nigra and ipsilateral striatum of rats bearing unilateral 6-hydroxydopamine lesions reconstruct the dopaminergic nigrostriatal pathway in the adult rat brain. |
1996-12-19 |
2023-08-12 |
rat |
| C N Svendsen, M V Sofronie. Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging? Perspectives on developmental neurobiology. vol 3. issue 2. 1996-12-16. PMID:8826531. |
similar findings have also been reported for dopaminergic neurons of the substantia nigra. |
1996-12-16 |
2023-08-12 |
Not clear |
| M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
midbrain dopaminergic neurons are known to release dopamine from somata and/or dendrites located in the substantia nigra (sn) and the ventral tegmental area (vta). |
1996-12-13 |
2023-08-12 |
rat |
| W Wesemann, M Solbach, R Nafe, C Grote, K H Sontag, P Riederer, K Jellinger, H D Mennel, H W Clemen. Effect of lazaroid U-74389G on iron-induced reduction of striatal dopamine metabolism. Journal of neural transmission. Supplementum. vol 46. 1996-12-10. PMID:8821053. |
our data indicate that a single iron application into the substantia nigra leads to a progressive loss of dopaminergic activity in the striatum, also observed in parkinson patients. |
1996-12-10 |
2023-08-12 |
rat |
| T F Oo, R Blazeski, S M Harrison, C Henchcliffe, C A Mason, S K Roffler-Tarlov, R E Burk. Neuron death in the substantia nigra of weaver mouse occurs late in development and is not apoptotic. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 19. 1996-12-06. PMID:8815896. |
weaver is a spontaneous mutation in mice characterized by the postnatal loss of external granule cells in the cerebellum and dopaminergic neurons of the midbrain, especially in the substantia nigra. |
1996-12-06 |
2023-08-12 |
mouse |
| T F Oo, R Blazeski, S M Harrison, C Henchcliffe, C A Mason, S K Roffler-Tarlov, R E Burk. Neuron death in the substantia nigra of weaver mouse occurs late in development and is not apoptotic. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 19. 1996-12-06. PMID:8815896. |
we therefore sought to determine whether the loss of dopaminergic neurons in homozygous weaver mice occurs during the period of natural cell death in the substantia nigra and whether it has the morphology of apoptosis. |
1996-12-06 |
2023-08-12 |
mouse |