| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' K Wedzony, A Czyrak, M Ma\\xc4\\x87kowiak, K Fija\\xc5\\x8. The impact of a competitive and a non-competitive NMDA receptor antagonist on dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra. Naunyn-Schmiedeberg\'s archives of pharmacology. vol 353. issue 5. 1996-10-08. PMID:8740145.' |
the impact of a competitive and a non-competitive nmda receptor antagonist on dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra. |
1996-10-08 |
2023-08-12 |
rat |
| b' K Wedzony, A Czyrak, M Ma\\xc4\\x87kowiak, K Fija\\xc5\\x8. The impact of a competitive and a non-competitive NMDA receptor antagonist on dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra. Naunyn-Schmiedeberg\'s archives of pharmacology. vol 353. issue 5. 1996-10-08. PMID:8740145.' |
the study compares effects of the competitive and non-competitive nmda receptor antagonists, cgp 40116 and mk-801 respectively, on the metabolism of dopamine and on the density of d-1 and d-2 dopaminergic receptors in the rat ventral tegmental area and substantia nigra. |
1996-10-08 |
2023-08-12 |
rat |
| b' K Wedzony, A Czyrak, M Ma\\xc4\\x87kowiak, K Fija\\xc5\\x8. The impact of a competitive and a non-competitive NMDA receptor antagonist on dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra. Naunyn-Schmiedeberg\'s archives of pharmacology. vol 353. issue 5. 1996-10-08. PMID:8740145.' |
it is concluded that competitive nmda receptor antagonists in doses which evoke hyperlocomotion and stereotypy-like activity, may have a substantial impact on the dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra, similar to that described for mk-801, a non-competitive nmda receptor antagonist. |
1996-10-08 |
2023-08-12 |
rat |
| J Ge, N M Barne. Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders. European journal of pharmacology. vol 297. issue 3. 1996-08-08. PMID:8666063. |
the present results indicate that the reduction of angiotensin at1 and/or at2 receptor recognition site levels in the caudate nucleus, putamen and substantia nigra correlates with the principal neuropathology associated with parkinson's disease and as such indicates that at least a significant population of angiotensin at1 and at2 receptors are located on the human dopaminergic nigrostriatal pathway. |
1996-08-08 |
2023-08-12 |
human |
| M Trupp, E Arenas, M Fainzilber, A S Nilsson, B A Sieber, M Grigoriou, C Kilkenny, E Salazar-Grueso, V Pachnis, U Arumä. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature. vol 381. issue 6585. 1996-08-01. PMID:8657281. |
moreover, high levels of c-ret mrna expression were found in dopaminergic neurons of the adult substantia nigra, where exogenous gdnf protected ret-positive neurons from 6-hydroxydopamine-induced cell death. |
1996-08-01 |
2023-08-12 |
Not clear |
| T F Oo, C Henchcliffe, R E Burk. Apoptosis in substantia nigra following developmental hypoxic-ischemic injury. Neuroscience. vol 69. issue 3. 1996-04-18. PMID:8596657. |
we have previously observed that either hypoxic-ischemic or excitotoxic striatal injury during development is associated with a reduction in the adult number of dopaminergic neurons in the substantia nigra. |
1996-04-18 |
2023-08-12 |
Not clear |
| X L Chen, F J Roisen, M Gupt. The effect of prior in vitro exposure of donor cells to trophic factors in neurotransplantation. Experimental neurology. vol 138. issue 1. 1996-04-11. PMID:8593897. |
transplantation of ngf-naive pc12 cells leads to a significant increase in the number of dopaminergic neurons in the host substantia nigra (sn) compared to mptp-treated animals. |
1996-04-11 |
2023-08-12 |
mouse |
| V Steffen, M Santiago, C P de la Cruz, E Revilla, A Machado, J Can. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Human & experimental toxicology. vol 14. issue 11. 1996-03-28. PMID:8588946. |
the neurotoxic action of mpp+ injected intracerebroventricularly (icv) in the rat has been studied, using dopaminergic systems in the substantia nigra, striatum, olfactory bulb, median eminence and hypophysis. |
1996-03-28 |
2023-08-12 |
rat |
| V Steffen, M Santiago, C P de la Cruz, E Revilla, A Machado, J Can. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Human & experimental toxicology. vol 14. issue 11. 1996-03-28. PMID:8588946. |
however, olfactory bulb and substantia nigra were not affected; (3) mpp+ by icv administration produced neurotoxic effect on the dopaminergic system. |
1996-03-28 |
2023-08-12 |
rat |
| B A Faucheux, M T Herrero, J Villares, R Levy, F Javoy-Agid, J A Obeso, J J Hauw, Y Agid, E C Hirsc. Autoradiographic localization and density of [125I]ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinson's disease and MPTP-lesioned monkeys. Brain research. vol 691. issue 1-2. 1996-03-25. PMID:8590043. |
degeneration of the nigro-striatal dopaminergic neurons occurring in parkinson's disease is associated with an increase in iron concentrations in the substantia nigra. |
1996-03-25 |
2023-08-12 |
human |
| C Verney, A Febvret-Muzerelle, P Gaspa. Early postnatal changes of the dopaminergic mesencephalic neurons in the weaver mutant mouse. Brain research. Developmental brain research. vol 89. issue 1. 1996-03-14. PMID:8575083. |
in adult weaver (wv) mutant mice up to 70% of the mesostriatal dopaminergic neurons are lost and major alterations of the dopaminergic dendrites of the substantia nigra have been described. |
1996-03-14 |
2023-08-12 |
mouse |
| W de Jong, A C Linthorst, H G Verstee. The nigrostriatal dopamine system and the development of hypertension in the spontaneously hypertensive rat. Archives des maladies du coeur et des vaisseaux. vol 88. issue 8. 1996-03-04. PMID:8572872. |
this normalization of dopaminergic activity may be the causal factor underlying the attenuation of the development of hypertension in shr after bilateral lesioning of the pars compacta, of the substantia nigra. |
1996-03-04 |
2023-08-12 |
rat |
| L Pozzi, L Trabace, R Invernizzi, R Samani. Intranigral GR-113808, a selective 5-HT4 receptor antagonist, attenuates morphine-stimulated dopamine release in the rat striatum. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548313. |
the results suggest that 5-ht4 receptors in the substantia nigra modulate the activity of the dopaminergic nigrostriatal system only when the neurons are activated. |
1996-02-20 |
2023-08-12 |
rat |
| Y Agi. [Aging, disease and nerve cell death]. Bulletin de l'Academie nationale de medecine. vol 179. issue 6. 1996-02-14. PMID:8542348. |
in order to distinguish the biochemical abnormalities underlying dysfunction of neurons during aging, neuronal loss during neurodegeneration (parkinson's disease) and nerve cell death, we searched for morphological and biochemical signs of apoptosis in dopaminergic neurons of the substantia nigra of parkinsonian patients and controls. |
1996-02-14 |
2023-08-12 |
human |
| S K Yeghiayan, A E Kelle. Serotonergic stimulation of the ventrolateral striatum induces orofacial stereotypy. Pharmacology, biochemistry, and behavior. vol 52. issue 3. 1996-02-14. PMID:8545465. |
in addition to dopaminergic projections from the substantia nigra, the striatum receives serotonergic (5-ht) inputs arising from the raphe nuclei. |
1996-02-14 |
2023-08-12 |
Not clear |
| J M Trugma. D1/D2 actions of dopaminergic drugs studied with [14C]-2-deoxyglucose autoradiography. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 5. 1996-02-07. PMID:8539420. |
to define the neural circuits activated by dopaminergic stimulation in rat models of parkinsonism, the author studied the effects of l-dopa and selective d1 and d2 agonists on rcgu in rats with unilateral 6-ohda substantia nigra lesions. |
1996-02-07 |
2023-08-12 |
rat |
| S Prisco, E Esposit. Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area. British journal of pharmacology. vol 116. issue 2. 1996-02-01. PMID:8528581. |
electrophysiological techniques were used to study the effects of fluoxetine and citalopram on the basal activity of dopaminergic neurones in the ventral tegmental area (vta) and substantia nigra, pars compacta (snc) of rats. |
1996-02-01 |
2023-08-12 |
rat |
| G Torre. Fenfluramine-induced c-fos in the striatum and hypothalamus: a tract-tracing study. Neuroreport. vol 6. issue 12. 1996-01-26. PMID:8527740. |
to ascertain whether the dopaminergic nigrostriatal system coordinated transcriptional effects on the cpu, discrete microinjections of dextran into the substantia nigra (cell group a9) were evaluated for retrograde axonal transport. |
1996-01-26 |
2023-08-12 |
rat |
| S A Bayer, K V Wills, L C Triarhou, J D Thomas, B Ghett. Systematic differences in time of dopaminergic neuron origin between normal mice and homozygous weaver mutants. Experimental brain research. vol 105. issue 2. 1996-01-18. PMID:7498373. |
in the retrorubral field and substantia nigra, weaver homozygotes had substantial losses of dopaminergic neurons and had a greater deficit in the proportion of neurons generated late while, in the ventral tegmental area and interfascicular nucleus, there were slight losses of dopaminergic neurons and only slight deficits in the proportion of late-generated neurons. |
1996-01-18 |
2023-08-12 |
mouse |
| Y Akaneya, M Takahashi, H Hatanak. Survival of and 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity against dopaminergic neurons in coculture of rat mesencephalon with their target on non-target regions. Neuroscience research. vol 23. issue 1. 1996-01-18. PMID:7501301. |
it is known that dopaminergic neurons in the substantia nigra of the mesencephalon mainly project to the corpus striatum and neocortex, while the hippocampus receives major cholinergic projection from the septum. |
1996-01-18 |
2023-08-12 |
rat |