| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K E Bowenkamp, A F Hoffman, G A Gerhardt, M A Henry, P T Biddle, B J Hoffer, A C Granhol. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. The Journal of comparative neurology. vol 355. issue 4. 1995-09-14. PMID:7636027. |
in order to determine if there is a positive effect of gdnf on injured adult midbrain dopaminergic neurons in situ, we have carried out experiments in which a single dose of gdnf was injected into the substantia nigra following a unilateral lesion of the nigrostriatal system. |
1995-09-14 |
2023-08-12 |
rat |
| L J Furmidge, A W Duggan, G W Arbuthnot. In vivo detection of immunoreactive neurokinin A release within rat substantia nigra and its dependency on a dopaminergic input. Brain research. vol 679. issue 2. 1995-09-12. PMID:7633884. |
in vivo detection of immunoreactive neurokinin a release within rat substantia nigra and its dependency on a dopaminergic input. |
1995-09-12 |
2023-08-12 |
rat |
| M Amalric, H Moukhles, A Nieoullon, A Daszut. Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat. The European journal of neuroscience. vol 7. issue 5. 1995-08-23. PMID:7613632. |
this lesion model, the induction of a partial dopamine denervation of the striatum (74% depletion of dopamine striatal tissue content) with a retrograde degeneration of dopamine cell bodies in the substantia nigra, sparing the mesolimbic dopaminergic pathway, closely approximates the neuronal degeneration observed in human idiopathic parkinson's disease. |
1995-08-23 |
2023-08-12 |
human |
| H Sauer, V Wong, A Björklun. Brain-derived neurotrophic factor and neurotrophin-4/5 modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum. Neuroscience. vol 65. issue 4. 1995-08-22. PMID:7617169. |
disruption of dopaminergic neurotransmission in the striatum by neurotoxic lesions of the substantia nigra leads to increases in glutamic acid decarboxylase and proenkephalin messenger rna expression, and to decreases in preprotackykinin (the precursor molecule for substance p) messenger rna expression in the two populations of striatal medium-sized spiny projection neurons. |
1995-08-22 |
2023-08-12 |
rat |
| T Himi, M Cao, N Mor. Reduced expression of the molecular markers of dopaminergic neuronal atrophy in the aging rat brain. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 50. issue 4. 1995-08-18. PMID:7614230. |
expression of mrnas encoding the dopamine transporter (dat) and tyrosine hydroxylase (th) in dopaminergic neurons of the substantia nigra (sn) was examined in young and aged fischer 344 rats by in situ hybridization. |
1995-08-18 |
2023-08-12 |
rat |
| K Campbell, A Björklun. Neurotransmitter-related gene expression in intrastriatal striatal transplants. III. Regulation by host cortical and dopaminergic afferents. Brain research. Molecular brain research. vol 29. issue 2. 1995-08-15. PMID:7609615. |
grafted striatal neurons have previously been shown to receive innervation from both the host cerebral cortex and dopaminergic substantia nigra. |
1995-08-15 |
2023-08-12 |
Not clear |
| M Zareba, A Bober, W Korytowski, L Zecca, T Sarn. The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems. Biochimica et biophysica acta. vol 1271. issue 2-3. 1995-08-14. PMID:7605801. |
neuromelanin is an amorphous pigment of the catecholamine origin that accumulates in certain dopaminergic neurons of the substantia nigra of human brain. |
1995-08-14 |
2023-08-12 |
human |
| J C Linder, S J Young, P M Grove. Electron microscopic evidence for neurotoxicity in the basal ganglia. Neurochemistry international. vol 26. issue 2. 1995-08-07. PMID:7599540. |
the dopaminergic projection from the substantia nigra to the neostriatum is vulnerable to several neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), amphetamine, and 5-hydroxydopamine. |
1995-08-07 |
2023-08-12 |
mouse |
| M J Heeringa, E D Abercrombi. Biochemistry of somatodendritic dopamine release in substantia nigra: an in vivo comparison with striatal dopamine release. Journal of neurochemistry. vol 65. issue 1. 1995-07-26. PMID:7790860. |
the somatodendritic release of dopamine in substantia nigra previously has been suggested to be nonvesicular in nature and thus to differ from the classical, exocytotic release of dopamine described for the dopaminergic nerve terminal in striatum. |
1995-07-26 |
2023-08-12 |
rat |
| D L Rosin, K Melia, A M Knorr, E J Nestler, R H Roth, R S Duma. Chronic imipramine administration alters the activity and phosphorylation state of tyrosine hydroxylase in dopaminergic regions of rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 12. issue 2. 1995-07-20. PMID:7779239. |
chronic administration of imipramine (18 days) decreased levels of th enzyme activity in ventral tegmental area (vta) and substantia nigra (sn), dopaminergic cell body regions, as well as in caudate-putamen (cp), nucleus accumbens (acb), prefrontal cortex (pfc), and olfactory tubercle (ot), dopaminergic terminal fields. |
1995-07-20 |
2023-08-12 |
rat |
| B G Dickie, T C Budd, D Vaux, S A Greenfiel. Uptake of acetylcholinesterase by neurons in the substantia nigra. The European journal of neuroscience. vol 7. issue 3. 1995-07-13. PMID:7773434. |
it is known that acetylcholinesterase is secreted by the dopaminergic neurons of the substantia nigra and has a subsequent action independent of cholinergic transmission. |
1995-07-13 |
2023-08-12 |
human |
| S D Weiser, S L Patrick, S W Mascarella, J Downing-Park, X Bai, F I Carroll, J M Walker, R L Patric. Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of sigma receptor ligands. European journal of pharmacology. vol 275. issue 1. 1995-07-10. PMID:7774655. |
these results indicate that occupancy of sigma receptors in the substantia nigra is associated with an activation of dopamine formation in dopaminergic terminals in the striatum and support the concept that sigma activity in the substantia nigra produces an activation of dopamine-mediated responses in the striatum. |
1995-07-10 |
2023-08-12 |
rat |
| Y Kuga, E E Geisert, T Kono, T Yamamoto, S T Kita. Developmental expression of KG-CAM in the rat neostriatum. Anatomy and embryology. vol 191. issue 3. 1995-06-30. PMID:7539603. |
kg-cam does not appear to be associated with the guidance of dopaminergic axons from the substantia nigra to the striatum, for this pathway is not immunopositive for this member of the ig superfamily. |
1995-06-30 |
2023-08-12 |
rat |
| L Studer, C Spenger, R W Seiler, C A Altar, R M Lindsay, C Hyma. Comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rat substantia nigra. The European journal of neuroscience. vol 7. issue 2. 1995-06-27. PMID:7757259. |
comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rat substantia nigra. |
1995-06-27 |
2023-08-12 |
rat |
| J L Venero, M Romero-Ramos, M Revuelta, A Machado, J Can. Intrastriatal quinolinic acid injections protect against 6-hydroxydopamine-induced lesions of the dopaminergic nigrostriatal system. Brain research. vol 672. issue 1-2. 1995-06-22. PMID:7749737. |
our results suggest that intrastriatal qa injections partially prevent the naturally-occurring retrograde axonal degeneration of substantia nigra cell bodies caused by 6-ohda, and illustrate a target-derived interaction between dopaminergic nerve endings and cell bodies. |
1995-06-22 |
2023-08-12 |
Not clear |
| D A McRitchie, G M Hallida. Calbindin D28k-containing neurons are restricted to the medial substantia nigra in humans. Neuroscience. vol 65. issue 1. 1995-06-21. PMID:7538646. |
although a few calbindin-d28k-positive neurons were found in the medial cell group of the substantia nigra, the vast majority of positive neurons were located in the adjacent a8 and a10 dopaminergic cell groups. |
1995-06-21 |
2023-08-12 |
human |
| G Nikkhah, M G Cunningham, M A Cenci, R D McKay, A Björklun. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. I. Evidence for anatomical reconstruction of the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 5 Pt 1. 1995-06-20. PMID:7538563. |
dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-ohda lesions. |
1995-06-20 |
2023-08-12 |
rat |
| G Nikkhah, M G Cunningham, R McKay, A Björklun. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 5 Pt 1. 1995-06-20. PMID:7751930. |
dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-ohda lesions. |
1995-06-20 |
2023-08-12 |
rat |
| X Liu, P Ernfors, H Wu, R Jaenisc. Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature. vol 375. issue 6528. 1995-06-14. PMID:7746325. |
in contrast, motor neurons of the facial nucleus and sympathetic neurons of the superior cervical ganglion were unaffected, and there was no obvious loss of dopaminergic neurons in the substantia nigra. |
1995-06-14 |
2023-08-12 |
mouse |
| J R Weinstein, S J Gold, D D Cunningham, C M Gal. Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 4. 1995-05-25. PMID:7722637. |
expression of tr mrna by astroglia and dopaminergic neurons was confirmed by colocalization with immunoreactivity for glial fibrillary acidic protein (gfap) in hippocampus and tyrosine hydroxylase in the substantia nigra. |
1995-05-25 |
2023-08-12 |
rat |