| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Herroelen, J P De Backer, N Wilczak, A Flamez, G Vauquelin, J De Keyse. Autoradiographic distribution of D3-type dopamine receptors in human brain using [3H]7-hydroxy-N,N-di-n-propyl-2-aminotetralin. Brain research. vol 648. issue 2. 1994-11-21. PMID:7922537. |
the presence of d3 receptors in non-limbic parts of the neostriatum and substantia nigra suggests that they also play a role in the dopaminergic control of motor processes. |
1994-11-21 |
2023-08-12 |
human |
| J Thomas, J Wang, H Takubo, J Sheng, S de Jesus, K S Bankiewic. A 6-hydroxydopamine-induced selective parkinsonian rat model: further biochemical and behavioral characterization. Experimental neurology. vol 126. issue 2. 1994-11-17. PMID:7925817. |
the main focus of the present study was to define the rotational response of 6-hydroxydopamine-lesioned rats to dopaminergic agonists to separate the partially lesioned rats from those having complete substantia nigra (sn) and ventral tegmental area (vta) lesions. |
1994-11-17 |
2023-08-12 |
rat |
| S Ohno, Y Adachi, M Koumori, K Mizukoshi, M Nagasaka, K Ichihara, E Kat. Synthesis and structure-activity relationships of new (5R,8R,10R)-ergoline derivatives with antihypertensive or dopaminergic activity. Chemical & pharmaceutical bulletin. vol 42. issue 7. 1994-11-15. PMID:7923470. |
a series of new (5r,8r,10r)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were tested in conscious spontaneously hypertensive rats and in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra. |
1994-11-15 |
2023-08-12 |
rat |
| B Bowery, L A Rothwell, G R Seabroo. Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921615. |
comparison of these data with the binding affinity for cloned dopamine receptors demonstrates that the responses to quinpirole on dopaminergic neurones in both the a9 (substantia nigra) and a10(ventral tegmental area) brain areas are consistent with the activation of predominantly d2, and not d3 or d4 dopamine receptors. |
1994-11-09 |
2023-08-12 |
rat |
| D G Cole, L A Kobierski, C Konradi, S E Hyma. 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 20. 1994-10-27. PMID:7937819. |
because expression of the c-fos gene in response to camp- and ca2+/calmodulin-regulated protein kinases depends on phosphorylation of camp-response element-binding protein (creb) at ser-133, we examined creb phosphorylation after dopaminergic stimulation in cultured striatal neurons and in the striatum of rats after unilateral 6-hydroxydopamine ablation of the substantia nigra. |
1994-10-27 |
2023-08-12 |
rat |
| D J Clarke, A P Payn. Neuroanatomical characterization of a new mutant rat with dopamine depletion in the substantia nigra. The European journal of neuroscience. vol 6. issue 5. 1994-10-03. PMID:7915606. |
we here report that tyrosine hydroxylase immunocytochemistry demonstrates that these mutants have profound depletions in dopaminergic systems in the substantia nigra and corresponding areas of neostriatum. |
1994-10-03 |
2023-08-12 |
rat |
| B Lavoie, A Paren. Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigra. The Journal of comparative neurology. vol 344. issue 2. 1994-10-03. PMID:7915727. |
furthermore, the fact that some neurons of the ppn display both chat and glutamate immunoreactivity indicates that single neurons in the mesopontine tegmentum may exert a two-fold effect upon dopaminergic neurons of the substantia nigra. |
1994-10-03 |
2023-08-12 |
monkey |
| B Lavoie, A Paren. Pedunculopontine nucleus in the squirrel monkey: projections to the basal ganglia as revealed by anterograde tract-tracing methods. The Journal of comparative neurology. vol 344. issue 2. 1994-10-03. PMID:8077458. |
the labeled fibers in the substantia nigra are thin and varicose and arborize almost exclusively in the pars compacta, where they closely surround the soma and proximal dendrites of dopaminergic neurons. |
1994-10-03 |
2023-08-12 |
squirrel_monkey |
| E K O'Malley, B A Sieber, R S Morrison, I B Black, C F Dreyfu. Nigral type I astrocytes release a soluble factor that increases dopaminergic neuron survival through mechanisms distinct from basic fibroblast growth factor. Brain research. vol 647. issue 1. 1994-09-26. PMID:8069707. |
our studies have been directed to the identification of local, naturally-occurring molecules that support substantia nigra (sn) dopaminergic (da) neuron survival. |
1994-09-26 |
2023-08-12 |
Not clear |
| V Silani, D Mariani, F M Donato, C Ghezzi, F Mazzucchelli, M Buscaglia, G Pardi, G Scarlat. Development of dopaminergic neurons in the human mesencephalon and in vitro effects of basic fibroblast growth factor treatment. Experimental neurology. vol 128. issue 1. 1994-09-23. PMID:7915238. |
the origin and development of the mesencephalic dopaminergic (mesda) neurons within the substantia nigra were characterized in human embryos from postconception (pc) week 5.0 to 12.0. |
1994-09-23 |
2023-08-12 |
human |
| J M Tepper, M Damlama, F Tren. Postnatal changes in the distribution and morphology of rat substantia nigra dopaminergic neurons. Neuroscience. vol 60. issue 2. 1994-09-23. PMID:7915412. |
by day 7 the density of tyrosine hydroxylase positive neurons decreased markedly in ventral substantia nigra, and a dopaminergic pars compacta and a non-dopaminergic pars reticulata could be more clearly distinguished. |
1994-09-23 |
2023-08-12 |
rat |
| M G Rosales, G Flores, S Hernández, D Martínez-Fong, J Aceve. Activation of subthalamic neurons produces NMDA receptor-mediated dendritic dopamine release in substantia nigra pars reticulata: a microdialysis study in the rat. Brain research. vol 645. issue 1-2. 1994-09-21. PMID:8062095. |
here we have studied whether the activation of the subthalamic neurons induces the release of dopamine (da) from dopaminergic dendrites in the pars reticulata of the substantia nigra. |
1994-09-21 |
2023-08-12 |
rat |
| Q P Ma, Y Zhou, J S Ha. Electroacupuncture accelerated the expression of c-Fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat. The International journal of neuroscience. vol 70. issue 3-4. 1994-09-20. PMID:8063541. |
electroacupuncture stimulation significantly increased the number of fos-positive dopaminergic neurons in the ventral tegmental area (vta), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (sn). |
1994-09-20 |
2023-08-12 |
rat |
| D M Bronstein, H Ye, K R Pennypacker, P M Hudson, J S Hon. Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat. Brain research. Molecular brain research. vol 23. issue 3. 1994-09-12. PMID:7914658. |
d1 dopamine (da) receptor agonists induce the expression of the opioid peptide dynorphin (dyn) in the striatum, an effect accentuated several fold by removing the dopaminergic innervation to the striatum (e.g., by lesioning the da cell bodies in the substantia nigra [sn]). |
1994-09-12 |
2023-08-12 |
rat |
| T Wu, H L Wan. CCK-8 excites substantia nigra dopaminergic neurons by increasing a cationic conductance. Neuroscience letters. vol 170. issue 2. 1994-09-12. PMID:8058194. |
using the whole-cell patch-clamp technique, we investigated electrophysiological effects of cholecystokinin on acutely isolated dopaminergic (da) neurons of rat substantia nigra (sn). |
1994-09-12 |
2023-08-12 |
rat |
| A Kastner, M T Herrero, E C Hirsch, J Guillen, M R Luquin, F Javoy-Agid, J A Obeso, Y Agi. Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys: effect of levodopa and GM1 ganglioside therapy. Annals of neurology. vol 36. issue 2. 1994-09-06. PMID:7914399. |
parkinson's disease is characterized by the degeneration of melanized dopaminergic neurons of the substantia nigra. |
1994-09-06 |
2023-08-12 |
monkey |
| A Kastner, M T Herrero, E C Hirsch, J Guillen, M R Luquin, F Javoy-Agid, J A Obeso, Y Agi. Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys: effect of levodopa and GM1 ganglioside therapy. Annals of neurology. vol 36. issue 2. 1994-09-06. PMID:7914399. |
the loss of dopaminergic neurons in the mesencephalon of the mptp-intoxicated monkeys was severe in the substantia nigra, intermediate in cell groups a8 and a10, and almost undetectable in the central gray substance. |
1994-09-06 |
2023-08-12 |
monkey |
| A Kastner, M T Herrero, E C Hirsch, J Guillen, M R Luquin, F Javoy-Agid, J A Obeso, Y Agi. Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys: effect of levodopa and GM1 ganglioside therapy. Annals of neurology. vol 36. issue 2. 1994-09-06. PMID:7914399. |
after both subacute and chronic treatment, the cellular content of tyrosine hydroxylase was reduced by 40% in the surviving neurons of the lesioned substantia nigra, but by less in the other mesencephalic dopaminergic regions. |
1994-09-06 |
2023-08-12 |
monkey |
| H Miyata, N Hironaka, K Ando, T Yanagit. [Rotational behavior induced by methamphetamine and cocaine in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopamine system]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 14. issue 2. 1994-08-24. PMID:8042345. |
the purpose of this study was to compare the ability of intravenously administered methamphetamine and cocaine to facilitate dopaminergic transmission, based on the ability of these drugs to induce rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. |
1994-08-24 |
2023-08-12 |
rat |
| P P Michel, S Vyas, P Anglade, M Ruberg, Y Agi. Morphological and molecular characterization of the response of differentiated PC12 cells to calcium stress. The European journal of neuroscience. vol 6. issue 4. 1994-08-11. PMID:7912984. |
the mechanisms that lead ultimately to neuronal death in pathological ageing of the brain remain mostly unknown as in the case of parkinson's disease where there is a progressive and selective loss of dopaminergic neurons within the substantia nigra. |
1994-08-11 |
2023-08-12 |
Not clear |