| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Eaton, K P Gudehithlu, T Quach, C P Silvia, M Hadjiconstantinou, N H Nef. Distribution of aromatic L-amino acid decarboxylase mRNA in mouse brain by in situ hybridization histology. The Journal of comparative neurology. vol 337. issue 4. 1994-02-24. PMID:7904615. |
after treatment with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), the signal disappeared in the substantia nigra, decreased somewhat in the ventral tegmental area, and remained unchanged in the dorsal raphe nucleus. |
1994-02-24 |
2023-08-12 |
mouse |
| R M Lindsay, C A Altar, J M Cedarbaum, C Hyman, S J Wiegan. The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease. Experimental neurology. vol 124. issue 1. 1994-02-16. PMID:8282068. |
parkinson's disease, characterized by the progressive loss of dopaminergic neurons of the substantia nigra, is one of the most well-characterized neurodegenerative disorders from both an anatomical and biochemical standpoint, but as yet the etiology of this disease remains poorly understood. |
1994-02-16 |
2023-08-12 |
human |
| C Hyman, M Juhasz, C Jackson, P Wright, N Y Ip, R M Lindsa. Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 1. 1994-02-16. PMID:8283241. |
taken together, our results indicate that bdnf and nt-3 have broadly similar effects in promoting the survival and differentiated phenotype of both dopaminergic and gabaergic neurons of the developing substantia nigra. |
1994-02-16 |
2023-08-12 |
rat |
| I Marey-Semper, M Gelman, M Lévi-Straus. The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopaminergic neurons from the substantia nigra. The European journal of neuroscience. vol 5. issue 8. 1994-02-15. PMID:7904221. |
the high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopaminergic neurons from the substantia nigra. |
1994-02-15 |
2023-08-12 |
mouse |
| S N Mitchell, K M Smith, M H Joseph, J A Gra. Increases in tyrosine hydroxylase messenger RNA in the locus coeruleus after a single dose of nicotine are followed by time-dependent increases in enzyme activity and noradrenaline release. Neuroscience. vol 56. issue 4. 1994-02-14. PMID:7904333. |
we have found that a single systemic injection of nicotine (0.8 mg/kg) increases messenger rna for the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase, two to six days later in the noradrenergic cell body region, the locus coeruleus (and not in the dopaminergic cell body regions, substantia nigra and ventral tegmental area). |
1994-02-14 |
2023-08-12 |
rat |
| H Sauer, W Fischer, G Nikkhah, S J Wiegand, P Brundin, R M Lindsay, A Björklun. Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts. Brain research. vol 626. issue 1-2. 1994-02-14. PMID:8281451. |
brain-derived neurotrophic factor (bdnf) has been shown to promote the survival of dopaminergic neurons from the substantia nigra in cell culture. |
1994-02-14 |
2023-08-12 |
rat |
| M I Martínez-Mir, H Pollard, J Moreau, E Traiffort, M Ruat, J C Schwartz, J M Palacio. Loss of striatal histamine H2 receptors in Huntington's chorea but not in Parkinson's disease: comparison with animal models. Synapse (New York, N.Y.). vol 15. issue 3. 1994-02-09. PMID:7904088. |
similar losses of binding sites were observed in the quinolinic acid lesioned striatal intrinsic neurons in the guinea pig, whereas lesioning dopaminergic cell bodies in the substantia nigra with 6-hydroxydopamine did not produce any significant change. |
1994-02-09 |
2023-08-12 |
human |
| A Benazzouz, C Gross, J Féger, T Boraud, B Bioula. Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys. The European journal of neuroscience. vol 5. issue 4. 1994-01-27. PMID:8261116. |
in parkinson's disease the loss of dopaminergic neurons in the substantia nigra is associated with global disorganization of basal ganglia activity and, in particular, with increased activity of the excitatory glutamatergic neurons of the subthalamic nucleus. |
1994-01-27 |
2023-08-12 |
monkey |
| M T Herrero, E C Hirsch, F Javoy-Agid, J A Obeso, Y Agi. Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum. Brain research. vol 624. issue 1-2. 1994-01-13. PMID:7902770. |
parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. |
1994-01-13 |
2023-08-12 |
monkey |
| N B Saul'skay. The influence of injections of 6-hydroxydopamine into the nucleus accumbens and the substantia nigra on the behavior of rats. Neuroscience and behavioral physiology. vol 23. issue 5. 1993-12-17. PMID:8232865. |
bilateral injections of 6-hydroxydopamine into the nucleus accumbens of rats with destroyed dopaminergic neurons of the substantia nigra leads to an increase in the horizontal motoric activity in the open field and accelerates the appearance of conditioned reflex responses in the course of the postoperative restoration of the skill as compared with these indices in rats in which the neurotoxin was injected only into the substantia nigra. |
1993-12-17 |
2023-08-12 |
rat |
| G Yadid, K Pacak, E Golomb, J D Harvey-White, D M Lieberman, I J Kopin, D S Goldstei. Glycine stimulates striatal dopamine release in conscious rats. British journal of pharmacology. vol 110. issue 1. 1993-12-14. PMID:8220914. |
the results suggest that dopaminergic cells in the substantia nigra synthesize strychnine-sensitive glycine receptors and transport the receptors to terminals in the striatum. |
1993-12-14 |
2023-08-12 |
rat |
| M M Giacobini, I Strömberg, S Almström, Y Cao, L Olso. Fibroblast growth factors enhance dopamine fiber formation from nigral grafts. Brain research. Developmental brain research. vol 75. issue 1. 1993-12-10. PMID:7693370. |
the presence of fgf-1 and -2 (fgf-1, acidic fgf; fgf-2, basic fgf) has recently been demonstrated in the dopaminergic cells of substantia nigra in rat and fgf-2 has been shown to be able to increase survival and promote neurite outgrowth of cultured mesencephalic neurons. |
1993-12-10 |
2023-08-12 |
rat |
| S Kato, M Oda, H Tanab. Diminution of dopaminergic neurons in the substantia nigra of sporadic amyotrophic lateral sclerosis. Neuropathology and applied neurobiology. vol 19. issue 4. 1993-12-09. PMID:7901781. |
diminution of dopaminergic neurons in the substantia nigra of sporadic amyotrophic lateral sclerosis. |
1993-12-09 |
2023-08-12 |
Not clear |
| S Kato, M Oda, H Tanab. Diminution of dopaminergic neurons in the substantia nigra of sporadic amyotrophic lateral sclerosis. Neuropathology and applied neurobiology. vol 19. issue 4. 1993-12-09. PMID:7901781. |
the number of dopaminergic neurons was diminished in the substantia nigra of seven cases. |
1993-12-09 |
2023-08-12 |
Not clear |
| R H Edward. Neural degeneration and the transport of neurotransmitters. Annals of neurology. vol 34. issue 5. 1993-12-06. PMID:7902065. |
the toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) reproduces the selective degeneration of dopaminergic neurons in the substantia nigra characteristic of parkinson's disease. |
1993-12-06 |
2023-08-12 |
Not clear |
| T Alexi, F Heft. Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture. Neuroscience. vol 55. issue 4. 1993-12-02. PMID:7901801. |
transforming growth factor alpha messenger rna and protein levels are highest in the striatum, the target area of mesencephalic dopaminergic neurons of the substantia nigra, suggesting a role as a target-derived neurotrophic factor for these cells. |
1993-12-02 |
2023-08-12 |
rat |
| P Mailleux, J J Vanderhaeghe. Dopaminergic regulation of cannabinoid receptor mRNA levels in the rat caudate-putamen: an in situ hybridization study. Journal of neurochemistry. vol 61. issue 5. 1993-11-29. PMID:7901331. |
we found, in a first set of experiments, that unilateral 6-hydroxydopamine dopaminergic deafferentation of the striatum (characterized by a contralateral turning behavior in response to apomorphine, the almost complete disappearance of the tyrosine hydroxylase hybridization signal in the substantia nigra, and an increase of preproenkephalin a mrna level in the striatum) was associated with significantly increased (45%) cannabinoid receptor mrna levels in the homolateral caudate-putamen. |
1993-11-29 |
2023-08-12 |
rat |
| A Albanese, R Granata, B Gregori, M P Piccardi, C Colosimo, P Tonal. Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to monkeys: behavioural, morphological and biochemical correlates. Neuroscience. vol 55. issue 3. 1993-11-23. PMID:8105418. |
(3) morphological analysis showed that the density of midbrain dopaminergic neurons located in the substantia nigra was unchanged in group a monkeys, but was reduced by 6.8% in mptp-treated monkeys of group b. |
1993-11-23 |
2023-08-12 |
monkey |
| J G Sheng, L M McShane, R J Plunkett, A C Cummins, E H Oldfield, I J Kopin, M A Palmatie. Dopaminergic neuronal sprouting and behavioral recovery in hemi-parkinsonian rats after implantation of amnion cells. Experimental neurology. vol 123. issue 2. 1993-11-22. PMID:8405285. |
to determine if these cells could induce sprouting of dopaminergic nerve fibers in vivo, the substantia nigra of rats was lesioned unilaterally with 6-hydroxydopamine and live-rat-term amnion cells, or killed-rat-term amnion cells were implanted into the denervated striata. |
1993-11-22 |
2023-08-12 |
human |
| A Zainos-Rosales, R Aguilar-Roblero, J L Mendoza-Ramírez, R Drucker-Colí. 2-Deoxyglucose autoradiographic evidence that fetal substantia nigra grafts exert contralateral effects in 6-hydroxydopamine-lesioned animals who recover motor asymmetries. Neuroscience letters. vol 156. issue 1-2. 1993-11-16. PMID:8414199. |
fetal substantia nigra grafts decrease turning behavior induced by dopaminergic agonists in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal system. |
1993-11-16 |
2023-08-12 |
rat |