| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Louis, P Burnham, S Varo. Neurite outgrowth from cultured CNS neurons is promoted by inhibitors of protein and RNA synthesis. Journal of neurobiology. vol 25. issue 2. 1994-08-04. PMID:7517438. |
inhibitor-induced neurite outgrowth was observed (1) from dopaminergic neurons in mixed cultures of the rat substantia nigra or (2) in pure cultures of rat and chick neurons grown on a polyornithine/laminin substratum. |
1994-08-04 |
2023-08-12 |
rat |
| K B Seroogy, K H Lundgren, T M Tran, K M Guthrie, P J Isackson, C M Gal. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. The Journal of comparative neurology. vol 342. issue 3. 1994-08-04. PMID:7912699. |
we have shown that mrnas for brain-derived neurotrophic factor and neurotrophin-3 are localized to specific ventral mesencephalic regions containing dopaminergic cell bodies, including the substantia nigra and ventral tegmental area. |
1994-08-04 |
2023-08-12 |
rat |
| B G Dickie, S A Greenfiel. Raphé nucleus-evoked release of acetylcholinesterase from guinea-pig substantia nigra. Neuroreport. vol 5. issue 7. 1994-07-29. PMID:8018847. |
acetylcholinesterase (ache) is released from dopaminergic dendrites in the guinea-pig substantia nigra. |
1994-07-29 |
2023-08-12 |
Not clear |
| M A Päivärinta, M Röyttä, V Hukkanen, R J Marttila, U K Rinn. Nervous system inflammatory lesions and viral nucleic acids in rabbits with herpes simplex virus encephalitis-induced rotational behaviour. Acta neuropathologica. vol 87. issue 3. 1994-07-20. PMID:8009958. |
no hsv-specific nucleic acids or neural destruction were observed in the regions of the serotoninergic raphe or dopaminergic substantia nigra. |
1994-07-20 |
2023-08-12 |
Not clear |
| K Unsicke. Growth factors in Parkinson's disease. Progress in growth factor research. vol 5. issue 1. 1994-07-07. PMID:8199355. |
several molecules, most of which occur in the striatum and the substantia nigra, have been identified that protect lesioned dopaminergic nigrostriatal neurons in culture or in animal models of parkinson's disease. |
1994-07-07 |
2023-08-12 |
human |
| A G Kanthasamy, J L Borowitz, G Pavlakovic, G E Iso. Dopaminergic neurotoxicity of cyanide: neurochemical, histological, and behavioral characterization. Toxicology and applied pharmacology. vol 126. issue 1. 1994-06-10. PMID:7910421. |
tyrosine hydroxylase (th) immunohistochemical examination of brains from cyanide-treated animals showed a reduced number of th-positive cells in substantia nigra, indicating a loss of dopaminergic neurons. |
1994-06-10 |
2023-08-12 |
mouse |
| B Heppelmann, R Señaris, P C Emso. Combination of alkaline phosphatase in situ hybridization with immunohistochemistry: colocalization of calretinin-mRNA with calbindin and tyrosine hydroxylase immunoreactivity in rat substantia nigra neurons. Brain research. vol 635. issue 1-2. 1994-06-09. PMID:7909717. |
calbindin- and tyrosine hydroxylase-like immunoreactivity was found in the majority of calretinin mrna-containing cells within the substantia nigra, pars compacta, indicating that in this nucleus a proportion of the dopaminergic neurons contain both calcium binding proteins calbindin and calretinin. |
1994-06-09 |
2023-08-12 |
rat |
| J Zhang, L A Chiodo, A S Freema. Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra. The Journal of pharmacology and experimental therapeutics. vol 269. issue 1. 1994-06-02. PMID:7513359. |
influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra. |
1994-06-02 |
2023-08-12 |
rat |
| J Zhang, L A Chiodo, A S Freema. Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra. The Journal of pharmacology and experimental therapeutics. vol 269. issue 1. 1994-06-02. PMID:7513359. |
in vivo electrophysiological recording methods were used to evaluate the effects of selective and nonselective agonists for excitatory amino acid (eaa) receptor subtypes on the activity of dopaminergic (da) and nondopaminergic (non-da) neurons in the substantia nigra of chloral hydrate-anesthetized rats. |
1994-06-02 |
2023-08-12 |
rat |
| J A Angulo, B S McEwe. Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. Brain research. Brain research reviews. vol 19. issue 1. 1994-06-01. PMID:7909470. |
dopaminergic transmission emanating from midbrain dopaminergic cell bodies of the substantia nigra and the ventral tegmentum regulates striatal and accumbens neuropeptide levels and their mrnas. |
1994-06-01 |
2023-08-12 |
Not clear |
| F Zhang, G Dryhurs. Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease. Journal of medicinal chemistry. vol 37. issue 8. 1994-05-24. PMID:7909337. |
this hypothesis proposes that in response to some form of chronic brain insult, the activity of gamma-glutamyltranspeptidase is upregulated leading to an increased rate of translocation of glutathione (gsh) into the cytoplasm of dopaminergic cell bodies in the substantia nigra (sn) para compacta. |
1994-05-24 |
2023-08-12 |
mouse |
| A L Scotti, D Monard, C Nitsc. Re-expression of glia-derived nexin/protease nexin 1 depends on mode of lesion-induction or terminal degeneration: observations after excitotoxin or 6-hydroxydopamine lesions of rat substantia nigra. Journal of neuroscience research. vol 37. issue 2. 1994-05-11. PMID:7908698. |
rat substantia nigra was unilaterally lesioned by stereotaxic application of different toxins: 6-hydroxydopamine, which selectively destroys dopaminergic neurons, the excitotoxic glutamate analog ibotenic acid, or the glutamate receptor agonists n-methyl-d-aspartate and quisqualate, which cause circumscript lesions of the whole substantia nigra. |
1994-05-11 |
2023-08-12 |
rat |
| S Kikuchi, S U Ki. Glutamate neurotoxicity in mesencephalic dopaminergic neurons in culture. Journal of neuroscience research. vol 36. issue 5. 1994-04-29. PMID:7908339. |
these results suggest that 1) glutamate is capable of causing neuronal death in the substantia nigra; 2) gnt on dopaminergic neurons is mainly mediated by the nmda receptor under the conditions of our study; 3) protein kinase c translocation is a key mechanism of gnt; and 4) there is an interplay of a signal transduction system in the pathomechanism of gnt. |
1994-04-29 |
2023-08-12 |
mouse |
| Y Kang, S T Kita. Calcium spike underlying rhythmic firing in dopaminergic neurons of the rat substantia nigra. Neuroscience research. vol 18. issue 3. 1994-04-12. PMID:7907413. |
calcium spike underlying rhythmic firing in dopaminergic neurons of the rat substantia nigra. |
1994-04-12 |
2023-08-12 |
rat |
| J Wang, K S Bankiewicz, R J Plunkett, E H Oldfiel. Intrastriatal implantation of interleukin-1. Reduction of parkinsonism in rats by enhancing neuronal sprouting from residual dopaminergic neurons in the ventral tegmental area of the midbrain. Journal of neurosurgery. vol 80. issue 3. 1994-03-30. PMID:7906726. |
the substantia nigra-lesioned rats showed complete depletion of dopaminergic neurons in the substantia nigra but sparing of those in the ventral tegmental area, whereas the median forebrain bundle-lesioned animals had depletion of dopaminergic cells in the substantia nigra and the ventral tegmental area. |
1994-03-30 |
2023-08-12 |
rat |
| G Engberg, H Nissbrand. gamma-Hydroxybutyric acid (GHBA) induces pacemaker activity and inhibition of substantia nigra dopamine neurons by activating GABAB-receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 5. 1994-03-28. PMID:8114948. |
in the present study the actions of gamma-hydroxybutyric acid (ghba) on dopaminergic neurons in the rat substantia nigra (sn) were pharmacologically analysed utilising extracellular single unit recording techniques. |
1994-03-28 |
2023-08-12 |
rat |
| M Santiago, J Cano, B H Westerin. Are bilateral nigrostriatal dopaminergic pathways functionally linked in the rat brain? A microdialysis study in conscious rats. Brain research. vol 628. issue 1-2. 1994-03-23. PMID:8313146. |
in the present study, we have infused 6 prototypical drugs known to affect nigrostriatal dopaminergic neurons (kainate, baclofen, muscimol (10 mumol/l), picrotoxin (50 mumol/l), tetrodotoxin (ttx) (5 mumol/l) and 1-methyl-4-phenylpyridinium ion (mpp+) (10 mmol/l) via a microdialysis probe unilaterally into the left substantia nigra. |
1994-03-23 |
2023-08-12 |
rat |
| B Landwehrmeyer, A Probst, J M Palacios, G Mengo. Expression of acetylcholinesterase messenger RNA in human brain: an in situ hybridization study. Neuroscience. vol 57. issue 3. 1994-03-17. PMID:8309527. |
however, some noncholinergic neurons like dopaminergic cells in substantia nigra, noradrenergic cells in locus coeruleus, serotoninergic cells in raphé dorsalis, gabaergic cells in thalamic reticular nucleus, granular cells in cerebellar cortex and pontine relay neurons expressed levels comparable to cholinergic neurons in basal forebrain. |
1994-03-17 |
2023-08-12 |
human |
| E S Vizi, I E Tóth, E Orsó, K S Szalay, D Szabó, M Baranyi, G P Vinso. Dopamine is taken up from the circulation by, and released from, local noradrenergic varicose axon terminals in zona glomerulosa of the rat: a neurochemical and immunocytochemical study. The Journal of endocrinology. vol 139. issue 2. 1994-03-11. PMID:8308458. |
da-containing nerves were not seen in the adrenal cortex; however, the same immunocytochemical procedures clearly demonstrated dopaminergic nerve cells and fibres in the substantia nigra and the striatum respectively, and cells of the adrenal medulla. |
1994-03-11 |
2023-08-12 |
human |
| W G Tatto. Selegiline can mediate neuronal rescue rather than neuronal protection. Movement disorders : official journal of the Movement Disorder Society. vol 8 Suppl 1. 1994-03-09. PMID:8302304. |
it was previously shown that the coadministration of selegiline with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) could protect dopaminergic substantia nigra neurons (dsnns) from damage by blocking conversion of mptp to its active radical n-methyl-4-phenylpyridinium (mpp+) by inhibiting mao-b. |
1994-03-09 |
2023-08-12 |
mouse |