| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z H Qin, B Weis. Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra. European journal of pharmacology. vol 269. issue 1. 1995-02-21. PMID:7828655. |
to study the influence of dopaminergic activity on the expression of dopamine d2 receptors and glutamic acid decarboxylase in substantia nigra, mice were treated daily for several days with an irreversibly acting dopamine d1 and dopamine d2 receptor antagonist n-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (eedq) or with a selective irreversible d2 dopamine receptor antagonist fluphenazine-n-mustard. |
1995-02-21 |
2023-08-12 |
mouse |
| K D Beck, J Valverde, T Alexi, K Poulsen, B Moffat, R A Vandlen, A Rosenthal, F Heft. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature. vol 373. issue 6512. 1995-02-17. PMID:7830767. |
glial-cell-line-derived neurotrophic factor (gdnf) promotes survival of embryonic dopaminergic neurons in culture, and its expression pattern suggests a role as a transient target-derived trophic factor for dopaminergic neurons of the substantia nigra. |
1995-02-17 |
2023-08-12 |
rat |
| R M Wu, K P Mohanakumar, D L Murphy, C C Chiue. Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline). Annals of the New York Academy of Sciences. vol 738. 1995-02-17. PMID:7832430. |
in addition, the present studies also clearly demonstrate that deprenyl can substantially protect dopaminergic neurons against mpp+ toxicity in the substantia nigra zona compacta in vivo. |
1995-02-17 |
2023-08-12 |
rat |
| K P Mohanakumar, A de Bartolomeis, R M Wu, K J Yeh, L M Sternberger, S Y Peng, D L Murphy, C C Chiue. Ferrous-citrate complex and nigral degeneration: evidence for free-radical formation and lipid peroxidation. Annals of the New York Academy of Sciences. vol 738. 1995-02-17. PMID:7832447. |
iron-complex-induced damage of dopaminergic neurons in the substantia nigra, might have resulted from a sequence of cytotoxic events including the .oh generation and lipid peroxidation as demonstrated in this study. |
1995-02-17 |
2023-08-12 |
Not clear |
| J J Dally, S A Greenfiel. The release of acetylcholinesterase in vivo is regulated by dopaminergic systems in the guinea-pig substantia nigra. Neurochemistry international. vol 25. issue 4. 1995-02-16. PMID:7820067. |
the release of acetylcholinesterase in vivo is regulated by dopaminergic systems in the guinea-pig substantia nigra. |
1995-02-16 |
2023-08-12 |
Not clear |
| M Hajós, S A Greenfiel. Synaptic connections between pars compacta and pars reticulata neurones: electrophysiological evidence for functional modules within the substantia nigra. Brain research. vol 660. issue 2. 1995-02-16. PMID:7820690. |
in contrast to the response of dopaminergic pars compacta neurones, pars reticulata neurones responded to stimulation over wide areas of substantia nigra, without any clear site-specific selectivity. |
1995-02-16 |
2023-08-12 |
Not clear |
| M Hajós, S A Greenfiel. Synaptic connections between pars compacta and pars reticulata neurones: electrophysiological evidence for functional modules within the substantia nigra. Brain research. vol 660. issue 2. 1995-02-16. PMID:7820690. |
it is concluded that within the substantia nigra, dopaminergic neurones are arranged in functional modules such that most inhibition is derived from a highly local circuit with the collaterals of adjacent pars reticulata cells. |
1995-02-16 |
2023-08-12 |
Not clear |
| J A St-Pierre, P J Bédar. Intranigral but not intrastriatal microinjection of the NMDA antagonist MK-801 induces contralateral circling in the 6-OHDA rat model. Brain research. vol 660. issue 2. 1995-02-16. PMID:7820694. |
these results show that the non-competitive nmda antagonist can induce motor activity in the presence or in the absence of the dopaminergic pathway and that in the latter case its action is exerted predominantly at the level of the substantia nigra, perhaps through suppression of the excitatory subthalamic drive. |
1995-02-16 |
2023-08-12 |
rat |
| G J Sengstock, C W Olanow, A J Dunn, S Barone, G W Arendas. Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. Experimental neurology. vol 130. issue 1. 1995-02-14. PMID:7529713. |
progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. |
1995-02-14 |
2023-08-12 |
rat |
| G J Sengstock, C W Olanow, A J Dunn, S Barone, G W Arendas. Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. Experimental neurology. vol 130. issue 1. 1995-02-14. PMID:7529713. |
we recently reported that intranigral fe infusion into the rat substantia nigra (sn) induces dose-dependent sn neurodegeneration and associated reductions in striatal dopaminergic (da) markers. |
1995-02-14 |
2023-08-12 |
rat |
| C Martin, I Rubio, M F Burckhart, M Fatom. Effects of neutron-gamma irradiation on striatal D1 and D2 receptor distribution. Neuroscience letters. vol 178. issue 1. 1995-02-06. PMID:7816316. |
one hour after exposure at the dose of 8.4 gy, an increase of d1 (+21%) and d2 (+25%) receptor density was observed in the striatum, located at the most anterior levels, containing the richest plexus of dopaminergic fibers afferent from the substantia nigra. |
1995-02-06 |
2023-08-12 |
Not clear |
| J H Ryu, K Yanai, T Watanab. Marked increase in histamine H3 receptors in the striatum and substantia nigra after 6-hydroxydopamine-induced denervation of dopaminergic neurons: an autoradiographic study. Neuroscience letters. vol 178. issue 1. 1995-02-06. PMID:7816330. |
marked increase in histamine h3 receptors in the striatum and substantia nigra after 6-hydroxydopamine-induced denervation of dopaminergic neurons: an autoradiographic study. |
1995-02-06 |
2023-08-12 |
rat |
| J H Ryu, K Yanai, T Watanab. Marked increase in histamine H3 receptors in the striatum and substantia nigra after 6-hydroxydopamine-induced denervation of dopaminergic neurons: an autoradiographic study. Neuroscience letters. vol 178. issue 1. 1995-02-06. PMID:7816330. |
these results strongly suggest that h3 receptors in the striatum and substantia nigra are influenced by tonic dopaminergic inputs. |
1995-02-06 |
2023-08-12 |
rat |
| S Ohno, M Koumori, Y Adachi, K Mizukoshi, M Nagasaka, K Ichihar. Synthesis and structure-activity relationships of new (5R,8S,10R)-ergoline derivatives with antihypertensive or dopaminergic activity. Chemical & pharmaceutical bulletin. vol 42. issue 10. 1995-02-01. PMID:7805128. |
a series of new (5r,8s,10r)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were evaluated in conscious spontaneously hypertensive rats and in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra, respectively. |
1995-02-01 |
2023-08-12 |
rat |
| I Tooyama, E G McGeer, T Kawamata, H Kimura, P L McGee. Retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrasts with loss in Parkinson's disease. Brain research. vol 656. issue 1. 1995-01-31. PMID:7804831. |
retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrasts with loss in parkinson's disease. |
1995-01-31 |
2023-08-12 |
Not clear |
| M B Youdim, L Lavi. Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease. Life sciences. vol 55. issue 25-26. 1995-01-18. PMID:7527888. |
in the absence of identification of either an endogenously or an exogenously derived dopaminergic neurotoxin, the most valid hypothesis currently envisaged for etiopathology of parkinson's disease (pd) is selective oxidative stress (os) in substantia nigra (sn). |
1995-01-18 |
2023-08-12 |
Not clear |
| A Heinz, L G Schmidt, F M Reischie. Anhedonia in schizophrenic, depressed, or alcohol-dependent patients--neurobiological correlates. Pharmacopsychiatry. vol 27 Suppl 1. 1995-01-04. PMID:7984706. |
the dopaminergic reward system is functionally and anatomically closely connected with the ascending extrapyramidal pathways from the substantia nigra to the dorsal striatum. |
1995-01-04 |
2023-08-12 |
Not clear |
| T Wu, H L Wan. CCK-8-evoked cationic currents in substantia nigra dopaminergic neurons are mediated by InsP3-induced Ca2+ release. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7526297. |
our recent study demonstrated that by activating cck-a receptors, cck-8 excites substantia nigra (sn) dopaminergic (da) neurons via increasing a non-selective cationic conductance. |
1994-12-29 |
2023-08-12 |
Not clear |
| B Landwehrmeyer, J M Palacio. Alterations of neurotransmitter receptors and neurotransmitter transporters in progressive supranuclear palsy. Journal of neural transmission. Supplementum. vol 42. 1994-12-22. PMID:7525868. |
densities of dopamine uptake sites and neurotensin receptors were significantly reduced in striatum and substantia nigra consistent with a localization of these binding sites on degenerating dopaminergic nigrostriatal projection neurons. |
1994-12-22 |
2023-08-12 |
Not clear |
| G M Gonzalez-Alvear, L L Werlin. Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands. The Journal of pharmacology and experimental therapeutics. vol 271. issue 1. 1994-11-25. PMID:7965717. |
sigma receptors have been located in several areas of the brain that control motor function, including on the dopaminergic projections from substantia nigra to striatum. |
1994-11-25 |
2023-08-12 |
rat |