| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C A Colton, F Pagan, J Snell, J S Colton, A Cummins, D L Gilber. Protection from oxidation enhances the survival of cultured mesencephalic neurons. Experimental neurology. vol 132. issue 1. 1995-05-24. PMID:7720826. |
oxidative stress has been linked to the destruction of dopaminergic neurons in the substantia nigra and may be a significant factor in both parkinson's disease and mptp toxicity. |
1995-05-24 |
2023-08-12 |
rat |
| T Wu, H L Wan. Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons. Neuroscience letters. vol 184. issue 2. 1995-05-23. PMID:7724045. |
whole-cell voltage-clamp recordings were used to investigate the molecular transduction mechanism by which neurotensin decreases the inwardly rectifying potassium conductance of dopaminergic (da) neurons acutely isolated from the rat substantia nigra (sn). |
1995-05-23 |
2023-08-12 |
rat |
| W J Smeets, L Medin. The efferent connections of the nucleus accumbens in the lizard Gekko gecko. A combined tract-tracing/transmitter-immunohistochemical study. Anatomy and embryology. vol 191. issue 1. 1995-05-18. PMID:7536400. |
the projections reach not only the ventral pallidum, the preoptic area, the lateral hypothalamic area and the ventral tegmental area, but also the bed nucleus of the stria terminalis, the dorsomedial thalamic nucleus, the substantia nigra and the retrorubral dopaminergic cell group. |
1995-05-18 |
2023-08-12 |
Not clear |
| E C Wolters, G Tissingh, P L Bergmans, M A Kuipe. Dopamine agonists in Parkinson's disease. Neurology. vol 45. issue 3 Suppl 3. 1995-05-15. PMID:7715794. |
the main pathologic hallmark of parkinson's disease is a degeneration of the dopaminergic cells in the substantia nigra, pars compacta and--to a lesser extent--in the ventral tegmental area. |
1995-05-15 |
2023-08-12 |
Not clear |
| F Vaglini, F Fascetti, F Fornai, R Maggio, G U Corsin. (+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704605. |
the number of th+ neurons in the substantia nigra (sn) of (+)mk-801-pretreated mice was not significantly different from that of control animals, indicating that this treatment specifically antagonized the extensive ddc-induced lesion of dopaminergic cell bodies in this brain area. |
1995-05-10 |
2023-08-12 |
mouse |
| G Bing, Y Zhang, Y Watanabe, B S McEwen, E A Ston. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704612. |
locus coeruleus lesions potentiate neurotoxic effects of mptp in dopaminergic neurons of the substantia nigra. |
1995-05-10 |
2023-08-12 |
mouse |
| G Bing, Y Zhang, Y Watanabe, B S McEwen, E A Ston. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704612. |
the observation that parkinson's disease (pd) is associated with locus coeruleus (lc) noradrenergic neuronal degeneration suggests that the lc noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (sn) dopaminergic neurons in parkinson's disease. |
1995-05-10 |
2023-08-12 |
mouse |
| A Gasbarri, C Verney, R Innocenzi, E Campana, C Pacitt. Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704620. |
in order to evaluate the percentage of dopaminergic (da) cells of ventral tegmental area (vta-a10) and adjacent substantia nigra (sn-a9) projecting to the hf, the retrograde neuronal tracer technique was combined with the tyrosine hydroxylase (th) immunocytochemistry. |
1995-05-10 |
2023-08-12 |
rat |
| S L Stoddar. The adrenal medulla and Parkinson's disease. Reviews in the neurosciences. vol 5. issue 4. 1995-05-04. PMID:7697198. |
parkinson's disease is a neurodegenerative disorder that is characterized primarily by the loss of dopaminergic neurons in the substantia nigra. |
1995-05-04 |
2023-08-12 |
Not clear |
| M Yamada, M Yamada, E Richelso. Heterogeneity of melanized neurons expressing neurotensin receptor messenger RNA in the substantia nigra and the nucleus paranigralis of control and Parkinson's disease brain. Neuroscience. vol 64. issue 2. 1995-04-28. PMID:7700529. |
together with the previous binding data, it is suggested that not only in rat brain, but also in human brain, melanized (possibly dopaminergic) neurons in the substantia nigra and the nucleus paranigralis (ventral tegmental area of rat brain) synthesize neurotensin receptors and express them in their perikarya and the terminal regions. |
1995-04-28 |
2023-08-12 |
human |
| P Remy, A de Recondo, G Defer, C Loc'h, P Amarenco, V Planté-Bordeneuve, M H Dao-Castellana, B Bendriem, C Crouzel, M Clane. Peduncular 'rubral' tremor and dopaminergic denervation: a PET study. Neurology. vol 45. issue 3 Pt 1. 1995-04-27. PMID:7898699. |
lesions causing so-called rubral tremors frequently involve the substantia nigra or the nigrostriatal fibers, suggesting dopaminergic denervation as possibly contributory. |
1995-04-27 |
2023-08-12 |
Not clear |
| H Ichinose, T Ohye, K Fujita, F Pantucek, K Lange, P Riederer, T Nagats. Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia. Journal of neural transmission. Parkinson's disease and dementia section. vol 8. issue 1-2. 1995-04-26. PMID:7893377. |
since the decrease in aadc mrna was comparable to that in th mrna, the alteration of th in parkinson's disease would not be a primary event, but it would reflect the degeneration of dopaminergic neurons in the substantia nigra. |
1995-04-26 |
2023-08-12 |
human |
| C G Charlton, J Mac. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888091. |
the major symptoms of parkinson's disease (pd) are tremors, hypokinesia, rigidity, and abnormal posture, caused by degeneration of dopamine (da) neurons in the substantia nigra (sn) and deficiency of da in the neostriatal dopaminergic terminals. |
1995-04-18 |
2023-08-12 |
rat |
| P Anglade, S Tsuji, F Javoy-Agid, Y Agid, E C Hirsc. Plasticity of nerve afferents to nigrostriatal neurons in Parkinson's disease. Annals of neurology. vol 37. issue 2. 1995-03-07. PMID:7847868. |
the afferents to the dendrites of dopaminergic neurons were analyzed ultrastructurally in the substantia nigra of parkinsonian patients and matched controls, using simultaneous histochemical detection of acetylcholine-like cation and tyrosine hydroxylase. |
1995-03-07 |
2023-08-12 |
human |
| P Anglade, S Tsuji, F Javoy-Agid, Y Agid, E C Hirsc. Plasticity of nerve afferents to nigrostriatal neurons in Parkinson's disease. Annals of neurology. vol 37. issue 2. 1995-03-07. PMID:7847868. |
the size of acetylcholine-like cation-containing terminals in contact with dopaminergic dendrites increased significantly by 38% in the substantia nigra of parkinsonian patients; whereas their number per section of dopaminergic dendrite showed an increase of 60%, although not reaching statistical significance. |
1995-03-07 |
2023-08-12 |
human |
| P Anglade, S Tsuji, F Javoy-Agid, Y Agid, E C Hirsc. Plasticity of nerve afferents to nigrostriatal neurons in Parkinson's disease. Annals of neurology. vol 37. issue 2. 1995-03-07. PMID:7847868. |
the number of the terminals devoid of acetylcholine-like cation per section of dopaminergic dendrite decreased significantly by 52% in the substantia nigra of parkinsonian patients. |
1995-03-07 |
2023-08-12 |
human |
| P Engels, M Sullivan, T Müller, H Lübber. Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). FEBS letters. vol 358. issue 3. 1995-03-03. PMID:7843419. |
we have recently reported increased survival of dopaminergic substantia nigra neurons by inhibition of phosphodiesterase type iv enzymes. |
1995-03-03 |
2023-08-12 |
human |
| E F Ball, P J Shaw, P G Ince, M Johnso. The distribution of excitatory amino acid receptors in the normal human midbrain and basal ganglia with implications for Parkinson's disease: a quantitative autoradiographic study using [3H]MK-801, [3H]glycine, [3H]CNQX and [3H]kainate. Brain research. vol 658. issue 1-2. 1995-03-02. PMID:7834343. |
in pd, glutamate receptor activation may contribute to cell death of dopaminergic neurones in the substantia nigra. |
1995-03-02 |
2023-08-12 |
human |
| T J Feuerstei. [Ketamine inhibits n-methyl-d-aspartate (NMDA) receptor mediated acetylcholine release from rabbit caudate nucleus slices]. Der Anaesthesist. vol 43 Suppl 2. 1995-03-02. PMID:7840414. |
at the neuropathologic level, parkinson's disease is characterized by an overshoot of striatal cholinergic transmission due to the decreased inhibitory dopaminergic input from the substantia nigra. |
1995-03-02 |
2023-08-12 |
rabbit |
| E Oestreicher, G J Sengstock, P Riederer, C W Olanow, A J Dunn, G W Arendas. Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. Brain research. vol 660. issue 1. 1995-02-21. PMID:7828004. |
degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. |
1995-02-21 |
2023-08-12 |
rat |