| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Gates, T F O'Brien, A Faissner, D A Steindle. Neuron-glial interactions during the in vivo and in vitro development of the nigrostriatal circuit. Journal of chemical neuroanatomy. vol 6. issue 4. 1993-11-15. PMID:7691083. |
in particular, using in vivo manipulations of the dopaminergic projections from the midbrain substantia nigra, as well as an in vitro model of the developing nigrostriatal circuit, we look at the reciprocal interactions between growing dopaminergic axons and astrocyte-derived ecm molecules in the striatum. |
1993-11-15 |
2023-08-12 |
Not clear |
| I Mendez, K Elisevich, B A Flumerfel. GABAergic synaptic interactions in the substantia nigra. Brain research. vol 617. issue 2. 1993-10-29. PMID:8104661. |
the present study analyzes the synaptic connections of gabaergic and dopaminergic neurons in each of the divisions of the substantia nigra by employing a double-labeling immunocytochemical technique at the light and electron microscope levels. |
1993-10-29 |
2023-08-12 |
Not clear |
| N Corvaja, G Doucet, J P Bola. Ultrastructure and synaptic targets of the raphe-nigral projection in the rat. Neuroscience. vol 55. issue 2. 1993-10-20. PMID:7690910. |
since dopaminergic neurons of the substantia nigra are known to be responsive to stimulation of the raphe and to applied 5-hydroxytryptamine, sections that contained anterogradely labelled terminals were further processed to reveal tyrosine hydroxylase immunoreactivity to determine whether the raphe input makes direct synaptic contact with dopaminergic neurons. |
1993-10-20 |
2023-08-12 |
rat |
| N Corvaja, G Doucet, J P Bola. Ultrastructure and synaptic targets of the raphe-nigral projection in the rat. Neuroscience. vol 55. issue 2. 1993-10-20. PMID:7690910. |
it is concluded that dendrites of dopaminergic neurons in the substantia nigra pars reticulata represent at least one of the synaptic targets of the raphe-nigral projection and that these contacts provide an anatomical substrate for the effects of the dorsal raphe, and presumably 5-hydroxytryptamine, on dopaminergic systems in the substantia nigra. |
1993-10-20 |
2023-08-12 |
rat |
| L L Ventrell. Effect of intracerebroventricular infusion of epidermal growth factor in rats hemitransected in the nigro-striatal pathway. Journal of neurosurgical sciences. vol 37. issue 1. 1993-10-07. PMID:8103556. |
among diverse growth factors epidermal growth factor (egf) is active in vitro on axonal regeneration of dopaminergic cells of the substantia nigra. |
1993-10-07 |
2023-08-12 |
rat |
| B J Snow, I Tooyama, E G McGeer, T Yamada, D B Calne, H Takahashi, H Kimur. Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363349. |
postmortem counts of dopaminergic cell densities in the substantia nigra (5 subjects) and striatal levels of dopamine (da) and its metabolites (6 subjects) were determined on 1 parkinsonian (pd), 3 progressive supranuclear palsy (psp), 1 amyotrophic lateral sclerosis, and 1 alzheimer's case who had been positron emission tomography scanned with 6-[18f]fluorodopa during life. |
1993-09-30 |
2023-08-12 |
human |
| A Kastner, E C Hirsch, M T Herrero, F Javoy-Agid, Y Agi. Immunocytochemical quantification of tyrosine hydroxylase at a cellular level in the mesencephalon of control subjects and patients with Parkinson's and Alzheimer's disease. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8103078. |
parkinson's disease is characterized by massive degeneration of the melanized dopaminergic neurons in the substantia nigra. |
1993-09-27 |
2023-08-12 |
human |
| K O Schoeps, C Halldin, K Någren, C G Swahn, P Karlsson, H Hall, L Fard. Preparation of [1-11C]dopamine, [1-11C]p-tyramine and [1-11C]m-tyramine. Autoradiography and PET examination of [1-11C]dopamine in primates. Nuclear medicine and biology. vol 20. issue 5. 1993-09-27. PMID:8358354. |
autoradiographic examination of [11c]dopamine binding on human brain section post-mortem demonstrated specific binding in the caudate putamen and the substantia nigra, regions with a dense dopaminergic innervation. |
1993-09-27 |
2023-08-12 |
human |
| S M Sorensen, J H Kehne, G M Fadayel, T M Humphreys, H J Ketteler, C K Sullivan, V L Taylor, C J Schmid. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8102646. |
mdl 100,907 blocked the slowing of ventral tegmental area (a10) dopaminergic neurons by amphetamine but, like clozapine, produced only small increases in the number of active substantia nigra zona compacta (a9) and a10 dopamine neurons after acute administration. |
1993-09-17 |
2023-08-12 |
mouse |
| D A Lewis, D S Melchitzky, J W Haycoc. Four isoforms of tyrosine hydroxylase are expressed in human brain. Neuroscience. vol 54. issue 2. 1993-08-26. PMID:8101641. |
in the caudate nucleus and putamen, the terminal zones of the dopaminergic projection from the substantia nigra, all four isoforms were detected, although in immunocytochemical studies type 1 appeared to be the predominant isoform present in axons and terminals. |
1993-08-26 |
2023-08-12 |
human |
| X Guitart, L Lumeng, T K Li, E J Nestle. Alcohol-preferring and nonpreferring rats display different levels of neurofilament proteins in the ventral tegmental area. Alcoholism, clinical and experimental research. vol 17. issue 3. 1993-08-19. PMID:8101433. |
no strain difference in nf levels was seen in the substantia nigra (which like the vta is a major dopaminergic nucleus in brain), locus coeruleus (which is a major noradrenergic nucleus in brain), or spinal cord (which is enriched in nf proteins). |
1993-08-19 |
2023-08-12 |
rat |
| T Hagg, S Varo. Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 13. 1993-08-06. PMID:8101002. |
thus, cntf has potent neurotrophic effects for injured adult rat dopaminergic substantia nigra neurons, whose degeneration plays a major causative role in parkinson disease. |
1993-08-06 |
2023-08-12 |
human |
| K Hayashi, E Chihara, T Sawa, Y Tanak. Clinical features of neuroleptic malignant syndrome in basal ganglia disease. Spontaneous presentation in a patient with Hallervorden-Spatz disease in the absence of neuroleptic drugs. Anaesthesia. vol 48. issue 6. 1993-08-03. PMID:8322990. |
hallervorden-spatz disease is a rare autosomal recessive disorder in which dopaminergic deficiency in the substantia nigra and its nigrostriatal projection has been identified. |
1993-08-03 |
2023-08-12 |
Not clear |
| P Schmitt, J Pequignot, C Garcia, J F Pujol, J M Pequigno. Regional specificity of the long-term regulation of tyrosine hydroxylase in some catecholaminergic rat brainstem areas. I. Influence of long-term hypoxia. Brain research. vol 611. issue 1. 1993-07-29. PMID:8100175. |
th protein quantity was also measured in a dopaminergic structure, the substantia nigra (sn). |
1993-07-29 |
2023-08-12 |
rat |
| A M Palmer, S T DeKosk. Monoamine neurons in aging and Alzheimer's disease. Journal of neural transmission. General section. vol 91. issue 2-3. 1993-07-16. PMID:8099796. |
loss of dopaminergic innervation of the neostriatum is a prominent age-related change, which corresponds with the age-related loss of dopaminergic cell bodies from the substantia nigra. |
1993-07-16 |
2023-08-12 |
Not clear |
| D C German, K F Manay. Midbrain dopaminergic neurons (nuclei A8, A9, and A10): three-dimensional reconstruction in the rat. The Journal of comparative neurology. vol 331. issue 3. 1993-07-16. PMID:8514911. |
the dopaminergic neurons in the midbrain of the rat are located in three cell groups: nucleus a8 cells in the retrorubral field, nucleus a9 cells in the substantia nigra, and nucleus a10 cells in the ventral tegmental area and related nuclei. |
1993-07-16 |
2023-08-12 |
rat |
| G J Sengstock, C W Olanow, R A Menzies, A J Dunn, G W Arendas. Infusion of iron into the rat substantia nigra: nigral pathology and dose-dependent loss of striatal dopaminergic markers. Journal of neuroscience research. vol 35. issue 1. 1993-07-15. PMID:7685399. |
infusion of iron into the rat substantia nigra: nigral pathology and dose-dependent loss of striatal dopaminergic markers. |
1993-07-15 |
2023-08-12 |
rat |
| N Yoshimura, E Mizuta, S Kuno, M Sasa, O Yoshid. The dopamine D1 receptor agonist SKF 38393 suppresses detrusor hyperreflexia in the monkey with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8098860. |
these results indicate that, in parkinsonism, the degeneration of dopaminergic neurons in the substantia nigra leads to the detrusor hyperreflexia, probably due to a failure of activation of dopamine d1 receptors. |
1993-06-21 |
2023-08-12 |
monkey |
| B A Faucheux, E C Hirsch, J Villares, F Selimi, A Mouatt-Prigent, F Javoy-Agid, J J Hauw, Y Agi. Distribution of 125I-ferrotransferrin binding sites in the mesencephalon of control subjects and patients with Parkinson's disease. Journal of neurochemistry. vol 60. issue 6. 1993-06-15. PMID:8492137. |
these results show that in the mesencephalon the regional density of transferrin binding sites is lowest in the dopaminergic cell groups, which are the most vulnerable to pd, and suggest that iron does not accumulate through an increased density of transferrin receptors at the level of the substantia nigra. |
1993-06-15 |
2023-08-12 |
human |
| A Kastner, E C Hirsch, Y Agid, F Javoy-Agi. Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease. Brain research. vol 606. issue 2. 1993-06-14. PMID:8098254. |
to analyze the roles of transcriptional and post-transcriptional regulatory mechanisms of tyrosine hydroxylase (th) gene expression during dopaminergic denervation in parkinson's disease (pd), the cellular content of th messenger rna (mrna) and th protein in the substantia nigra were compared in control subjects and patients with pd. |
1993-06-14 |
2023-08-12 |
human |