| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L J Martin, C D Blackstone, A I Levey, R L Huganir, D L Pric. AMPA glutamate receptor subunits are differentially distributed in rat brain. Neuroscience. vol 53. issue 2. 1993-06-11. PMID:8388083. |
glur1 co-localizes with most dopaminergic neurons within the substantia nigra. |
1993-06-11 |
2023-08-12 |
rat |
| P A Lapchak, K D Beck, D M Araujo, I Irwin, J W Langston, F Heft. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:8098137. |
the medial forebrain lesions decreased the following markers of striatal dopaminergic function: [3h]opamine uptake (65%), tyrosine hydroxylase activity (79%), dopamine content (80%) and [3h]mazindol binding site density (52%), induced a pronounced loss of tyrosine hydroxylase-positive cell bodies within the substantia nigra and also reduced tyrosine hydroxylase messenger rna levels. |
1993-06-08 |
2023-08-12 |
human |
| P A Lapchak, K D Beck, D M Araujo, I Irwin, J W Langston, F Heft. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:8098137. |
chronic intranigral brain-derived neurotrophic factor treatment did not attenuate nor did it exacerbate the medial forebrain bundle lesion-induced decreases of dopaminergic parameters in either the substantia nigra or striatum. |
1993-06-08 |
2023-08-12 |
human |
| Y S Zhu, S B Jones, R E Burke, S O Franklin, C E Inturris. Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions. Life sciences. vol 52. issue 19. 1993-06-01. PMID:8097862. |
expression of the striatal proenkephalin gene is modulated by dopaminergic input from the substantia nigra (sn). |
1993-06-01 |
2023-08-12 |
rat |
| P Hantraye, M Varastet, M Peschanski, D Riche, P Cesaro, J C Willer, M Mazier. Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:8469305. |
neuropathological examination of caudate nucleus, putamen, substantia nigra and ventral tegmental area in brain sections stained for tyrosine hydroxylase showed a typical uneven striatal dopamine fibre loss and a neuronal depletion in the dopaminergic mesencephalic cell groups that reproduce those observed in idiopathic parkinson's disease. |
1993-05-12 |
2023-08-12 |
Not clear |
| B L Roland, C V Grijalv. Gastric mucosal erosions induced by lateral hypothalamic damage: neuronal and dopaminergic mechanisms. Brain research. vol 605. issue 1. 1993-05-10. PMID:8096786. |
in experiments 2 and 3, electrolytic lesions were used to destroy cell bodies in the substantia nigra and their dopaminergic fibers (some of which pass through the lh area). |
1993-05-10 |
2023-08-12 |
Not clear |
| C Yokoyama, H Okamura, Y Ibat. Resistance of hypothalamic dopaminergic neurons to neonatal 6-hydroxydopamine toxicity. Brain research bulletin. vol 30. issue 5-6. 1993-04-26. PMID:8096162. |
we studied the effects of neonatal intracisternal administration of the 6-hydroxydopamine (6-ohda) following desipramine pretreatment on dopaminergic (da) neurons in the rat hypothalamus and substantia nigra by immunocytochemistry with an antiserum against tyrosine hydroxylase (th). |
1993-04-26 |
2023-08-12 |
rat |
| D C German, S G Speciale, K F Manaye, M Sade. Opioid receptors in midbrain dopaminergic regions of the rat. I. Mu receptor autoradiography. Journal of neural transmission. General section. vol 91. issue 1. 1993-04-22. PMID:8383984. |
the purpose of this study was to map and quantify the density of the mu opioid receptor subtype relative to the location of the dopaminergic (da) neurons in the retrorubral field (nucleus a8), substantia nigra (nucleus a9), and ventral tegmental area and related nuclei (nucleus a10) in the rat. |
1993-04-22 |
2023-08-12 |
rat |
| A Elverfors, J Jonason, G Jonason, G Leonsson, H Nissbrand. Determination of release of endogenous dopamine from superfused substantia nigra slices. Journal of neuroscience methods. vol 45. issue 3. 1993-04-09. PMID:1363484. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic neuronal pathway but also from cell bodies and dendrites in the substantia nigra (sn). |
1993-04-09 |
2023-08-11 |
Not clear |
| E Ronken, F L Van Muiswinkel, A H Mulder, A N Schoffelmee. Opioid receptor-mediated inhibition of evoked catecholamine release from cultured neurons of rat ventral mesencephalon and locus coeruleus. European journal of pharmacology. vol 230. issue 3. 1993-04-01. PMID:8095023. |
the effects of selective opioid agonists on the evoked release of [3h]dopamine and [3h]noradrenaline were studied in cultured dopaminergic neurons of the ventral mesencephalon (containing the substantia nigra and ventral tegmental area) and in cultured neurons of the noradrenergic locus coeruleus, respectively. |
1993-04-01 |
2023-08-12 |
human |
| C Moret, M Brile. Does 5-carboxamidotryptamine-induced turning in guinea-pigs involve 5-HT1D autoreceptors? European journal of pharmacology. vol 230. issue 3. 1993-04-01. PMID:8440314. |
contralateral turning induced by unilateral injection of 5-carboxamidotryptamine (5-ct) into guinea-pig substantia nigra could result from unilaterally reduced inhibition of the dopaminergic pathway as a consequence of a decreased release of inhibitory 5-hydroxytryptamine (5-ht) through stimulation of 5-ht1d autoreceptors. |
1993-04-01 |
2023-08-12 |
Not clear |
| P Damier, E C Hirsch, P Zhang, Y Agid, F Javoy-Agi. Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience. vol 52. issue 1. 1993-03-15. PMID:8433802. |
hyperoxidation phenomena are suspected to be involved in dopaminergic cell death in parkinson's disease, which affects preferentially the neuromelanin-containing dopaminergic neurons of the substantia nigra. |
1993-03-15 |
2023-08-12 |
human |
| P Miu, F Karoum, G Toffano, J W Commission. Regulatory aspects of nigrostriatal dopaminergic neurons. Experimental brain research. vol 91. issue 3. 1993-02-16. PMID:1483521. |
in the urethane-anesthetized rat, electrical stimulation (10 hz, 30 s, 250 microa) of the medial forebrain bundle (mfb), at 20-min intervals over an 8-h period, combined with intracerebral microdialysis in the striatum caused: an undiminished increase in the release of dopamine (da) with each stimulation episode; a decreased efflux of 3,4-dihydroxyphenylacetic acid (dopac) and 4-hydroxy-3-methoxyphenylacetic acid (hva) after the first stimulation only; a delayed increased efflux of dopac with no change in hva; and a poststimulation depression of firing of dopaminergic neurons in the substantia nigra (before, 3.1 +/- 0.7 hz; after, 1.9 +/- 1.0 hz; p < 0.05). |
1993-02-16 |
2023-08-11 |
rat |
| C Nitsch, G Wolfrum, F Schaefer, A L Scotti, J Unge. Opposite effects of intranigral ibotenic acid and 6-hydroxydopamine on motor behavior and on striatal neuropeptide Y neurons. Brain research bulletin. vol 30. issue 1-2. 1993-02-12. PMID:8420631. |
in the present investigation, the effects of an interruption of the striato-nigro-thalamic loop by ibotenic acid (ibo)-induced lesions of total substantia nigra (sn) on circling behavior and on striatal neuropeptide y (npy) neurons were compared with those after the selective destruction of the dopaminergic nigrostriatal projection with 6-hydroxydopamine (6-ohda). |
1993-02-12 |
2023-08-12 |
rat |
| b' M T Corasaniti, G Bagetta, P Rodin\\xc3\\xb2, S Gratteri, G Nistic\\xc3\\xb. Neurotoxic effects induced by intracerebral and systemic injection of paraquat in rats. Human & experimental toxicology. vol 11. issue 6. 1993-01-21. PMID:1361145.' |
similarly, microinfusion of paraquat (0.2-0.4 mumol) into the locus coeruleus, substantia nigra or into the raphe nuclei, where noradrenergic, dopaminergic and serotonergic neurons are present, respectively, elicited potent excitotoxic effects (n = 6 rats per dose and area). |
1993-01-21 |
2023-08-11 |
rat |
| D Ben-Shachar, M B Youdi. Iron, melanin and dopamine interaction: relevance to Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 1. 1993-01-21. PMID:8416600. |
interaction between iron and melanin may provide a reasonable explanation for the vulnerability of the melanin containing dopaminergic neurons in the substantia nigra (sn) to neurodegeneration in parkinson's disease (pd). |
1993-01-21 |
2023-08-12 |
rat |
| I D Smith, A A Grac. Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity. Synapse (New York, N.Y.). vol 12. issue 4. 1993-01-19. PMID:1465742. |
the influence of subthalamic nucleus (stn) afferents on dopaminergic (da) neurons of the rat substantia nigra (sn) was investigated. |
1993-01-19 |
2023-08-11 |
rat |
| A Sato, Y Sat. Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain. Neuroscience research. vol 14. issue 4. 1993-01-14. PMID:1334245. |
we also briefly review the influence of other central noradrenergic fibers originating in the locus ceruleus, serotonergic fibers originating in the dorsal raphe nucleus, dopaminergic fibers originating in the substantia nigra, and peripheral sympathetic and parasympathetic nerve fibers upon regulation of regional cerebral blood flow. |
1993-01-14 |
2023-08-11 |
Not clear |
| M Bokor, A Faragó, R Schnabel, T Gara. Relationship between the immune system and the diseases of the central nervous system. Therapia Hungarica (English edition). vol 40. issue 2. 1993-01-12. PMID:1462276. |
considering the eventual role of non-specific cell-mediated immune reactions in the pathogenesis of parkinson's syndrome based on the destruction of dopaminergic cells of the substantia nigra the killer cell activity of patients suffering from this disease has been examined. |
1993-01-12 |
2023-08-11 |
Not clear |
| N B Mercuri, F Stratta, P Calabresi, G Bernard. A voltage-clamp analysis of NMDA-induced responses on dopaminergic neurons of the rat substantia nigra zona compacta and ventral tegmental area. Brain research. vol 593. issue 1. 1993-01-08. PMID:1360865. |
a voltage-clamp analysis of nmda-induced responses on dopaminergic neurons of the rat substantia nigra zona compacta and ventral tegmental area. |
1993-01-08 |
2023-08-11 |
rat |