| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
we conclude that the gain-of-function weaver phenotype of dopaminergic substantia nigra neurons is mediated by coactivation of wvgirk2 and sur1/kir6. |
1999-10-28 |
2023-08-12 |
mouse |
| Y He, T Lee, S K Leon. Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning. Free radical research. vol 31. issue 2. 1999-10-27. PMID:10490239. |
time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-ohda) lesioning. |
1999-10-27 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning. Free radical research. vol 31. issue 2. 1999-10-27. PMID:10490239. |
parkinson's disease is characterized by dopaminergic cell death in the substantia nigra. |
1999-10-27 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning. Free radical research. vol 31. issue 2. 1999-10-27. PMID:10490239. |
though there are increasing lines of evidence showing iron accumulation in the parkinsonian substantia nigra, it still remains obscure whether increased iron is the primary cause of dopaminergic cell death, or just a consequence of the pathological process. |
1999-10-27 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning. Free radical research. vol 31. issue 2. 1999-10-27. PMID:10490239. |
the results showed that iron was increased after the significant nigral dopaminergic cell death induced by 6-hydroxydopamine injection into the rat substantia nigra. |
1999-10-27 |
2023-08-12 |
rat |
| J Han, F C Cheng, Z Yang, G Dryhurs. Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501216. |
in this investigation, microdialysis has been used to study the effects of 1-methyl-4-phenylpyridinium (mpp+), an inhibitor of mitochondrial complex i and alpha-ketoglutarate dehydrogenase and the active metabolite of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), on extracellular concentrations of glutathione (gsh) and cysteine (cysh) in the rat striatum and substantia nigra (sn). |
1999-10-14 |
2023-08-12 |
human |
| E H van Vulpen, C R Yang, R Nissen, L P Renau. Hypothalamic A14 and A15 catecholamine cells provide the dopaminergic innervation to the supraoptic nucleus in rat: a combined retrograde tracer and immunohistochemical study. Neuroscience. vol 93. issue 2. 1999-10-07. PMID:10465451. |
occasional double-labelled cells were seen in the medial and lateral hypothalamus and bed nucleus of the stria terminalis, but rarely in other known dopaminergic cell groups, notably the ventral tegmental area (a10), zona incerta (a13) and substantia nigra. |
1999-10-07 |
2023-08-12 |
rat |
| C Bentlage, G Nikkhah, M G Cunningham, A Björklun. Reformation of the nigrostriatal pathway by fetal dopaminergic micrografts into the substantia nigra is critically dependent on the age of the host. Experimental neurology. vol 159. issue 1. 1999-10-07. PMID:10486186. |
reformation of the nigrostriatal pathway by fetal dopaminergic micrografts into the substantia nigra is critically dependent on the age of the host. |
1999-10-07 |
2023-08-12 |
rat |
| S J Lokwan, P G Overton, M S Berry, D Clar. Stimulation of the pedunculopontine tegmental nucleus in the rat produces burst firing in A9 dopaminergic neurons. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392847. |
in the present study, single-pulse electrical stimulation applied to this nucleus (and other sites in the rostral pons) was found to elicit responses in the majority of substantia nigra (a9) dopaminergic neurons. |
1999-10-06 |
2023-08-12 |
rat |
| N S Kolomeets, N A Uranov. Synaptic contacts in schizophrenia: studies using immunocytochemical identification of dopaminergic neurons. Neuroscience and behavioral physiology. vol 29. issue 2. 1999-10-04. PMID:10432512. |
the ultrastructure of synaptic contacts on dopaminergic (tyrosine hydroxylase immunopositive (tp) cells) neurons was investigated in the substantia nigra in the brains of four patients with schizophrenia and three mentally healthy subjects (controls). |
1999-10-04 |
2023-08-12 |
human |
| N S Kolomeets, N A Uranov. Synaptic contacts in schizophrenia: studies using immunocytochemical identification of dopaminergic neurons. Neuroscience and behavioral physiology. vol 29. issue 2. 1999-10-04. PMID:10432512. |
these changes to terminals were located mostly on the distal (small and intermediate) tp dendrites in the compact zone of the substantia nigra, where nearly all the dendrites detected belonged to dopaminergic neurons and the altered terminals formed asymmetrical contacts with short active zones. |
1999-10-04 |
2023-08-12 |
human |
| K Ishihara, M Sas. Mechanism underlying the therapeutic effects of electroconvulsive therapy (ECT) on depression. Japanese journal of pharmacology. vol 80. issue 3. 1999-09-24. PMID:10461762. |
in contrast, ect decreases the auto-receptor functions in noradrenergic and dopaminergic neurons in the locus coeruleus and substantia nigra, respectively, resulting in an increase in release of noradrenaline and dopamine. |
1999-09-24 |
2023-08-12 |
Not clear |
| Y Iribe, K Moore, K C Pang, J M Teppe. Subthalamic stimulation-induced synaptic responses in substantia nigra pars compacta dopaminergic neurons in vitro. Journal of neurophysiology. vol 82. issue 2. 1999-09-23. PMID:10444687. |
the subthalamic nucleus (stn) is one of the principal sources of excitatory glutamatergic input to dopaminergic neurons of the substantia nigra, yet stimulation of the stn produces both excitatory and inhibitory effects on nigral dopaminergic neurons recorded extracellularly in vivo. |
1999-09-23 |
2023-08-12 |
Not clear |
| B Szabo, T Müller, H Koc. Effects of cannabinoids on dopamine release in the corpus striatum and the nucleus accumbens in vitro. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461898. |
the lack of a presynaptic effect on terminals of nigrostriatal and mesolimbic dopaminergic neurons is in accord with the anatomical distribution of cannabinoid receptors: the perikarya of these neurons in the substantia nigra and the ventral tegmental area do not synthesize mrna, and hence protein, for cb1 and cb2 cannabinoid receptors. |
1999-09-14 |
2023-08-12 |
rat |
| V Dror, E Shamir, S Ghanshani, R Kimhi, M Swartz, Y Barak, R Weizman, L Avivi, T Litmanovitch, E Fantino, K Kalman, E G Jones, K G Chandy, J J Gargus, G A Gutman, R Navo. hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Molecular psychiatry. vol 4. issue 3. 1999-09-13. PMID:10395215. |
in situ hybridization reveals abundant hkca3/kcnn3 message localized within the substantia nigra and ventral tegmental area, and along the distributions of dopaminergic neurons from these regions into the nigrostriatal and mesolimbic pathways. |
1999-09-13 |
2023-08-12 |
human |
| A Migheli, R Piva, S Casolino, C Atzori, S R Dlouhy, B Ghett. A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum. The American journal of pathology. vol 155. issue 2. 1999-08-31. PMID:10433930. |
cell cycle proteins were not expressed in the substantia nigra, suggesting that nonapoptotic death of mature dopaminergic neurons is not preceded by abortive cell cycle re-entry. |
1999-08-31 |
2023-08-12 |
mouse |
| M C Bohn, D L Choi-Lundberg, B L Davidson, C Leranth, D A Kozlowski, J C Smith, M K O'Banion, D E Redmon. Adenovirus-mediated transgene expression in nonhuman primate brain. Human gene therapy. vol 10. issue 7. 1999-08-26. PMID:10340549. |
in addition, some dopaminergic neurons in the substantia nigra expressed transgene, suggesting retrograde transport of the vector. |
1999-08-26 |
2023-08-12 |
monkey |
| Y Saito, M Ito, S Hanaoka, E Ohama, S Akaboshi, S Takashim. Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Neuropediatrics. vol 30. issue 2. 1999-08-18. PMID:10401687. |
therefore, the cause of the decreased dopaminergic activity in lns may not be involved in the production of tyrosine hydroxylase in the substantia nigra. |
1999-08-18 |
2023-08-12 |
Not clear |
| C Verne. Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses. Microscopy research and technique. vol 46. issue 1. 1999-08-16. PMID:10402270. |
the development and early specification of the dopaminergic neurons expressing calbindin d28k phenotype in the substantia nigra and in the ventral tegmental area are described. |
1999-08-16 |
2023-08-12 |
human |
| S C Conley, J T Kirchne. Parkinson's disease--the shaking palsy. Underlying factors, diagnostic considerations, and clinical course. Postgraduate medicine. vol 106. issue 1. 1999-08-04. PMID:10418573. |
loss of dopaminergic neurons originating in the substantia nigra is the typical pathologic feature. |
1999-08-04 |
2023-08-12 |
Not clear |