| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Yantiri, J K Anderse. The role of iron in Parkinson disease and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. IUBMB life. vol 48. issue 2. 2000-05-25. PMID:10794588. |
parkinson disease (pd) involves the specific degeneration of dopaminergic neurons of the pars compacta of the substantia nigra. |
2000-05-25 |
2023-08-12 |
Not clear |
| E Lewandowska, I Kurkowska-Jastrzebska, W Lechowicz, A Członkowska, A Członkowsk. Ultrastructural changes in substantia nigra and striatum observed on a mouse model of Parkinson's disease induced by MPTP administration. Folia neuropathologica. vol 37. issue 4. 2000-04-27. PMID:10705644. |
the study was carried out on a mouse model of parkinson's disease induced by the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-neurotoxin which damages dopaminergic neurons in substantia nigra. |
2000-04-27 |
2023-08-12 |
mouse |
| Y He, T Lee, S K Leon. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700609. |
6-hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. |
2000-04-25 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700609. |
the pathologic hallmark of parkinson's disease is the dopaminergic cell death in the substantia nigra (sn). |
2000-04-25 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700609. |
tyrosine hydroxylase immunohistochemistry and haematoxylin staining further revealed that these apoptotic cells are dopaminergic cells in the substantia nigra. |
2000-04-25 |
2023-08-12 |
rat |
| E C Hirsc. Nigrostriatal system plasticity in Parkinson's disease: effect of dopaminergic denervation and treatment. Annals of neurology. vol 47. issue 4 Suppl 1. 2000-04-21. PMID:10762138. |
this article reviews data on biochemical and morphological changes induced by treatment, the lesion, or both, in dopaminergic neurons themselves, postsynaptic striatal tissue, and afferent fibers to dopaminergic neurons in the substantia nigra. |
2000-04-21 |
2023-08-12 |
Not clear |
| M B Feany, W W Bende. A Drosophila model of Parkinson's disease. Nature. vol 404. issue 6776. 2000-04-13. PMID:10746727. |
parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (lewy bodies) and an extrapyramidal movement disorder. |
2000-04-13 |
2023-08-12 |
human |
| L Zou, J Xu, J Jankovic, Y He, S H Appel, W L. Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice. Neuroscience letters. vol 281. issue 2-3. 2000-04-05. PMID:10704769. |
pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in c57bl/6 mice. |
2000-04-05 |
2023-08-12 |
mouse |
| B Drukarch, F L van Muiswinke. Drug treatment of Parkinson's disease. Time for phase II. Biochemical pharmacology. vol 59. issue 9. 2000-04-04. PMID:10704931. |
at the cellular level, pd is characterized by degeneration of neuromelanin-containing dopaminergic neurons in the substantia nigra. |
2000-04-04 |
2023-08-12 |
human |
| I Aubert, I Ghorayeb, E Normand, B Bloc. Phenotypical characterization of the neurons expressing the D1 and D2 dopamine receptors in the monkey striatum. The Journal of comparative neurology. vol 418. issue 1. 2000-03-27. PMID:10701753. |
the striatum is regulated by dopaminergic inputs from the substantia nigra. |
2000-03-27 |
2023-08-12 |
monkey |
| J L Venero, M L Vizuete, M Revuelta, C Vargas, J Cano, A Machad. Upregulation of BDNF mRNA and trkB mRNA in the nigrostriatal system and in the lesion site following unilateral transection of the medial forebrain bundle. Experimental neurology. vol 161. issue 1. 2000-03-23. PMID:10683272. |
the disposition of bdnf mrna expressing cells at this postlesion time in substantia nigra mimicked that of the dopaminergic neurons expressing the mrna for the dopamine transporter. |
2000-03-23 |
2023-08-12 |
Not clear |
| A C Tomac, A Grinberg, S P Huang, C Nosrat, Y Wang, C Borlongan, S Z Lin, Y H Chiang, L Olson, H Westphal, B J Hoffe. Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682708. |
mesencephalic dopaminergic neurons in the substantia nigra and ventral tegmental area appear intact at the time of birth of the mutated mice. |
2000-03-21 |
2023-08-12 |
mouse |
| P Padungchaichot, J Y Wong, A L Natoli, J S Massalas, D I Finkelstein, A L Lawrence, J Drag. Early direct and transneuronal effects in mice with targeted expression of a toxin gene to D1 dopamine receptor neurons. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682709. |
the nigrostriatal pathway in the mutant pups was intact with a normal number of dopaminergic neurons in the substantia nigra and the ventral tegmental area in addition to a normal pattern of striatal dopamine transporter and tyrosine hydroxylase immunoreactivity. |
2000-03-21 |
2023-08-12 |
mouse |
| F M Corrigan, C L Wienburg, R F Shore, S E Daniel, D Man. Organochlorine insecticides in substantia nigra in Parkinson's disease. Journal of toxicology and environmental health. Part A. vol 59. issue 4. 2000-03-20. PMID:10706031. |
these findings are not inconsistent with the hypothesis derived from epidemiological work and animal studies that organochlorine insecticides produce a direct toxic action on the dopaminergic tracts of the substantia nigra and may contribute to the development of pd in those rendered susceptible by virtue of cytochrome p-450 polymorphism, excessive exposure, or other factors. |
2000-03-20 |
2023-08-12 |
Not clear |
| A Csilla. Striato-telencephalic and striato-tegmental circuits: relevance to learning in domestic chicks. Behavioural brain research. vol 98. issue 2. 2000-03-16. PMID:10683111. |
we have demonstrated reciprocal connections between the lpo and dopaminergic (th-positive) neurons of the substantia nigra and ventral tegmentum. |
2000-03-16 |
2023-08-12 |
chicken |
| A M Lin, T Y Luh, C K Chou, L T H. The antioxidative effect of carboxyfullerenes (C3/D3) on iron-induced oxidative injury in CNS. Annals of the New York Academy of Sciences. vol 890. 2000-03-15. PMID:10668440. |
in urethane-anesthetized rats, intranigral infusion of iron degenerated the nigrostriatal dopaminergic system, including as elevation in lipid peroxidation in the infused substantia nigra (sn) and reductions in k(+)-evoked dopamine overflow and dopamine content in the ipsilateral striatum 7 days after the infusion. |
2000-03-15 |
2023-08-12 |
rat |
| J Gervais, C Rouillar. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657038. |
dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. |
2000-03-13 |
2023-08-12 |
rat |
| J M Horowitz, J Myers, M K Stachowiak, G Torre. Identification and distribution of Parkin in rat brain. Neuroreport. vol 10. issue 16. 2000-02-28. PMID:10599851. |
mutations within the amino acid sequence of parkin, the encoded protein of the parkin gene, appear to trigger the degeneration of dopaminergic neurons in the substantia nigra. |
2000-02-28 |
2023-08-12 |
rat |
| B Connor, D A Kozlowski, T Schallert, J L Tillerson, B L Davidson, M C Boh. Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat. Gene therapy. vol 6. issue 12. 2000-02-24. PMID:10637445. |
injection of an adenoviral (ad) vector encoding human glial cell line-derived neurotrophic factor (gdnf) protects dopaminergic (da) neurons in the substantia nigra (sn) of young rats. |
2000-02-24 |
2023-08-12 |
human |
| W Matsuda, K Sugimoto, N Sato, T Watanabe, K Yanaka, A Matsumura, T Nos. [A case of primary brain-stem injury recovered from persistent vegetative state after L-dopa administration]. No to shinkei = Brain and nerve. vol 51. issue 12. 2000-02-24. PMID:10654305. |
the distribution of lesions implied diffuse axonal injury involving dopaminergic systems such as the substantia nigra and the ventral tegmental area. |
2000-02-24 |
2023-08-12 |
Not clear |