| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vandana Zaman, Matthew E Nelson, Greg A Gerhardt, Baerbel Rohre. Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530873. |
to further evaluate the role of trkb in the nigrostriatal pathway, we studied neurotrophin levels, dopamine metabolism, and morphology of dopaminergic neurons of the substantia nigra (sn-da) in young adult hypomorphic trkb mice (trkbfbz/fbz), which express only approximately 25% of wild type levels of trkb. |
2004-12-29 |
2023-08-12 |
mouse |
| John Woulfe, Doug Gray, Wendy Prichett-Pejic, David G Munoz, Michel Chretie. Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia protein. Journal of neuropathology and experimental neurology. vol 63. issue 11. 2004-12-29. PMID:15581187. |
traditionally considered non-pathological entities, more recent studies have indicated that mbs are associated with the age-associated degenerative changes in the substantia nigra and striatal loss of dopaminergic terminals. |
2004-12-29 |
2023-08-12 |
human |
| Bala V Manyam, Muralikrishnan Dhanasekaran, Theodore A Har. Neuroprotective effects of the antiparkinson drug Mucuna pruriens. Phytotherapy research : PTR. vol 18. issue 9. 2004-12-23. PMID:15478206. |
this additional finding of a neurorestorative benefit by mucuna pruriens cotyledon powder on the degenerating dopaminergic neurons in the substantia nigra may be due to increased complex-i activity and the presence of nadh and coenzyme q-10. |
2004-12-23 |
2023-08-12 |
rat |
| E Bálint, T Kitka, G Zachar, A Adám, H C Hemmings, A Csilla. Abundance and location of DARPP-32 in striato-tegmental circuits of domestic chicks. Journal of chemical neuroanatomy. vol 28. issue 1-2. 2004-12-22. PMID:15363488. |
these varicose fibers innervated the ventral tegmental area and substantia nigra and were often juxtaposed to dopaminergic neurons and dendrites. |
2004-12-22 |
2023-08-12 |
chicken |
| A K Wright, J F Atherton, L Norrie, G W Arbuthnot. Death of dopaminergic neurones in the rat substantia nigra can be induced by damage to globus pallidus. The European journal of neuroscience. vol 20. issue 7. 2004-12-22. PMID:15379994. |
death of dopaminergic neurones in the rat substantia nigra can be induced by damage to globus pallidus. |
2004-12-22 |
2023-08-12 |
rat |
| A K Wright, J F Atherton, L Norrie, G W Arbuthnot. Death of dopaminergic neurones in the rat substantia nigra can be induced by damage to globus pallidus. The European journal of neuroscience. vol 20. issue 7. 2004-12-22. PMID:15379994. |
parkinson's disease is a debilitating disorder that results from the death of dopaminergic neurones in the substantia nigra. |
2004-12-22 |
2023-08-12 |
rat |
| A K Wright, J F Atherton, L Norrie, G W Arbuthnot. Death of dopaminergic neurones in the rat substantia nigra can be induced by damage to globus pallidus. The European journal of neuroscience. vol 20. issue 7. 2004-12-22. PMID:15379994. |
here we show that lesions of the rat globus pallidus (a treatment that has been shown to increase subthalamic nucleus neuronal activity) result in a significant reduction of the number of dopaminergic neurones in the substantia nigra. |
2004-12-22 |
2023-08-12 |
rat |
| Davor Stanic, Wanida Tripanichkul, John Drago, David I Finkelstein, Malcolm K Horn. Glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra. Brain research. vol 1023. issue 1. 2004-12-21. PMID:15364022. |
glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra. |
2004-12-21 |
2023-08-12 |
rat |
| Pierre-Olivier Fernagut, Marie-Françoise Chessele. Alpha-synuclein and transgenic mouse models. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474350. |
although none of the lines created display dopaminergic neuronal death in the substantia nigra, the models recapitulate some features of synucleinopathies and are useful to study the potential pathogenic role of alpha-synuclein and its molecular partners. |
2004-12-21 |
2023-08-12 |
mouse |
| Lichuan Yang, Shuei Sugama, Ronald P Mischak, Mahmoud Kiaei, Nicolas Bizat, Emmanuel Brouillet, Tong H Joh, M Flint Bea. A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474362. |
q-vd-oph significantly reduced dopamine depletion in striatum produced by mptp administration and prevented mptp-induced loss of dopaminergic neurons in the substantia nigra. |
2004-12-21 |
2023-08-12 |
Not clear |
| Gang Li, Shenggang Sun, Xuebing Cao, Jiangxin Zhong, E'tang Ton. LPS-induced degeneration of dopaminergic neurons of substantia nigra in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 24. issue 1. 2004-12-10. PMID:15165124. |
lps-induced degeneration of dopaminergic neurons of substantia nigra in rats. |
2004-12-10 |
2023-08-12 |
rat |
| Gang Li, Shenggang Sun, Xuebing Cao, Jiangxin Zhong, E'tang Ton. LPS-induced degeneration of dopaminergic neurons of substantia nigra in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 24. issue 1. 2004-12-10. PMID:15165124. |
in order to investigate the neurotoxicity of lipopolysaccharide (lps) on the dopaminergic neurons of substantia nigra and the pathogenesis of parkinson disease, lps was stereotaxically infused into substantia nigra (sn). |
2004-12-10 |
2023-08-12 |
rat |
| Yong-bo Zhao, Bo-min Sun, Dian-you Li, Qiao-shu Wan. Effects of bilateral subthalamic nucleus stimulation on resting-state cerebral glucose metabolism in advanced Parkinson's disease. Chinese medical journal. vol 117. issue 9. 2004-12-09. PMID:15377418. |
the major neuropathological symptoms of parkinson's disease (pd) consist of a loss of pigmented dopaminergic neurons in the substantia nigra and the presence of lewy bodies. |
2004-12-09 |
2023-08-12 |
Not clear |
| D W Hampton, A Seitz, P Chen, E Heber-Katz, J W Fawcet. Altered CNS response to injury in the MRL/MpJ mouse. Neuroscience. vol 127. issue 4. 2004-11-16. PMID:15312895. |
axon regeneration was examined following a cut lesion to the dopaminergic projection from the substantia nigra to the striatum used in previous regeneration experiments. |
2004-11-16 |
2023-08-12 |
mouse |
| Z U Khan, A Gutierre. Distribution of C-terminal splice variant of G alpha i2 in rat and monkey brain. Neuroscience. vol 127. issue 4. 2004-11-16. PMID:15312896. |
hippocampus, cerebral cortex, amygdala, thalamus, striatum, nucleus accumbens, olfactory tubercle and dopaminergic cell groups of substantia nigra, hypothalamus and olfactory bulb showed strong labeling with anti-sgi2. |
2004-11-16 |
2023-08-12 |
rat |
| Masanori Yamada, Takeshi Iwatsubo, Yoshikuni Mizuno, Hideki Mochizuk. Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease. Journal of neurochemistry. vol 91. issue 2. 2004-11-15. PMID:15447678. |
overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in parkinson's disease. |
2004-11-15 |
2023-08-12 |
mouse |
| Masanori Yamada, Takeshi Iwatsubo, Yoshikuni Mizuno, Hideki Mochizuk. Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease. Journal of neurochemistry. vol 91. issue 2. 2004-11-15. PMID:15447678. |
here, we used the recombinant adeno-associated viral (raav) vector system for human alpha-synuclein gene transfer to rat substantia nigra and observed approximately 50% loss of dopaminergic neurons at 13 weeks after infection, which was comparably slower than the progression of neurodegeneration reported in other studies. |
2004-11-15 |
2023-08-12 |
mouse |
| P A Galenko-Yaroshevskii, E V Gurskaya, E A Chikobava, G V Sukoya. Anticataleptic effect of energostim during single treatment with trifluoperazine. Bulletin of experimental biology and medicine. vol 137. issue 3. 2004-11-10. PMID:15232633. |
the protective effect of energostim was associated with its ability to maintain the balance between dopaminergic, cholinergic, and adrenal activity in the substantia nigra and medulla oblongata during administration of neuroleptics. |
2004-11-10 |
2023-08-12 |
Not clear |
| Adam Przybyłkowski, Iwona Kurkowska-Jastrzebska, Ilona Joniec, Agnieszka Ciesielska, Anna Członkowska, Andrzej Członkowsk. Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306248. |
mptp causes an acute damage of dopaminergic neurons especially in the nigrostriatal dopaminergic system, thus diminishing dopamine (da) content in striatum and decreasing the number of dopaminergic cells in the pars compacta of the substantia nigra (sn). |
2004-11-04 |
2023-08-12 |
mouse |
| Antonella Stroppolo, Chai Tian, Barbara Guinea, Vicki Olm, Roxanne Sheffield, John Sommer, Michelle E Ehrlic. 17beta-Estradiol promotes striatal medium size spiny neuronal maturation in vitro. Neuroendocrinology. vol 79. issue 5. 2004-10-22. PMID:15218319. |
it receives a large dopaminergic input from the substantia nigra, and 96% of the msns express darpp-32, a dopamine and cyclic amp-regulated phosphoprotein and key mediator of dopamine function. |
2004-10-22 |
2023-08-12 |
Not clear |