| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philipp J Kahle, Christian Haas. How does parkin ligate ubiquitin to Parkinson's disease? EMBO reports. vol 5. issue 7. 2005-02-18. PMID:15229644. |
recessive mutations in the human parkin gene are the most common cause of hereditary parkinsonism, which arises from the degeneration of dopaminergic neurons in the substantia nigra. |
2005-02-18 |
2023-08-12 |
mouse |
| C Marin, J Bové, J Serrats, R Cortés, G Mengod, E Tolos. The kappa opioid agonist U50,488 potentiates 6-hydroxydopamine-induced neurotoxicity on dopaminergic neurons. Experimental neurology. vol 191. issue 1. 2005-02-18. PMID:15589511. |
degeneration of dopaminergic neurons in the substantia nigra is the pathological hallmark of parkinson's disease. |
2005-02-18 |
2023-08-12 |
rat |
| Z Xu, D Cawthon, K A McCastlain, W Slikker, S F Al. Selective alterations of gene expression in mice induced by MPTP. Synapse (New York, N.Y.). vol 55. issue 1. 2005-02-17. PMID:15499605. |
real time rt-pcr was used to examine selective genes of the dopaminergic system in the substantia nigra. |
2005-02-17 |
2023-08-12 |
mouse |
| Sandrine Bretaud, Susie Lee, Su Gu. Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicology and teratology. vol 26. issue 6. 2005-02-10. PMID:15451049. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra and movement defects, including bradykinesia, tremor, and postural imbalance. |
2005-02-10 |
2023-08-12 |
zebrafish |
| Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Norio Ogaw. Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism. Acta medica Okayama. vol 58. issue 5. 2005-02-08. PMID:15666991. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by dopaminergic neuron-specific degeneration in the substantia nigra. |
2005-02-08 |
2023-08-12 |
Not clear |
| Hiroyuki Kato, Rumiko Kurosaki, Chie Oki, Tsutomu Arak. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice. Brain research. vol 1030. issue 1. 2005-02-03. PMID:15567338. |
the mptp-injected animals exhibited an 87% loss of tyrosine hydroxylase-containing dopaminergic neurons in the substantia nigra after 7 days, but the arundic acid-treated mice showed only a 56% reduction (p<0.01). |
2005-02-03 |
2023-08-12 |
mouse |
| Renee M Miller, Linda M Callahan, Cindy Casaceli, Linlin Chen, Gretchen L Kiser, Buena Chui, Tamma M Kaysser-Kranich, Timothy J Sendera, Chockalingam Palaniappan, Howard J Federof. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 34. 2005-01-26. PMID:15329391. |
parkinson's disease pathogenesis proceeds through several phases, culminating in the loss of dopaminergic neurons of the substantia nigra (sn). |
2005-01-26 |
2023-08-12 |
mouse |
| M Shamoto-Nagai, W Maruyama, Y Akao, T Osawa, F Tribl, M Gerlach, F A Zucca, L Zecca, P Riederer, M Nao. Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 10-11. 2005-01-26. PMID:15480837. |
we examined the effects of nm isolated from the human substantia nigra on the proteasome activity in human dopaminergic sh-sy5y cells. |
2005-01-26 |
2023-08-12 |
human |
| J L W Bosboom, D Stoffers, E Ch Wolter. Cognitive dysfunction and dementia in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 10-11. 2005-01-26. PMID:15480840. |
parkinson's disease (pd) is a slowly progressive neurodegenerative disorder mainly characterized by degeneration of dopaminergic neurons in the substantia nigra and the ventral tegmental area, in combination with a varying loss of central noradrenergic (locus coeruleus), cholinergic (nucleus basalis of meynert) and serotonergic (dorsal raphe nuclei) integrity, leading to a multitude of motor and non-motor behavioral disturbances. |
2005-01-26 |
2023-08-12 |
Not clear |
| J L W Bosboom, D Stoffers, E Ch Wolter. Cognitive dysfunction and dementia in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 10-11. 2005-01-26. PMID:15480840. |
pd-related dopaminergic deficiency in the nucleus caudatus and mesocortical areas (due to degeneration of projections from the substantia nigra and ventral tegmental area) and cholinergic deficiency in the cortex (due to degeneration of ascending projections from the nucleus basalis of meynert), combined with additional alzheimer-pathology and cortical lewy bodies, may greatly contribute to dementia. |
2005-01-26 |
2023-08-12 |
Not clear |
| Coro Paisán-Ruíz, Shushant Jain, E Whitney Evans, William P Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martínez Gil, Naheed Khan, Janel Johnson, Javier Ruiz Martinez, David Nicholl, Itxaso Martí Carrera, Amets Saénz Pena, Rohan de Silva, Andrew Lees, José Félix Martí-Massó, Jordi Pérez-Tur, Nick W Wood, Andrew B Singleto. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron. vol 44. issue 4. 2005-01-21. PMID:15541308. |
the hallmark pathological features of pd are loss of dopaminergic neurons from the substantia nigra and neuronal intracellular lewy body inclusions. |
2005-01-21 |
2023-08-12 |
Not clear |
| Sandrine Thuret, Kambiz N Alavian, Martin Gassmann, C Kent Lloyd, Simone M Smits, Marten P Smidt, Rüdiger Klein, Richard H Dyck, Horst H Simo. The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. Journal of neurochemistry. vol 91. issue 6. 2005-01-21. PMID:15584907. |
degeneration of dopaminergic neurons in the substantia nigra is associated with one of the most prominent human neurological disorders, parkinson's disease. |
2005-01-21 |
2023-08-12 |
mouse |
| Sandrine Thuret, Kambiz N Alavian, Martin Gassmann, C Kent Lloyd, Simone M Smits, Marten P Smidt, Rüdiger Klein, Richard H Dyck, Horst H Simo. The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. Journal of neurochemistry. vol 91. issue 6. 2005-01-21. PMID:15584907. |
we show here that the neuregulin receptor erbb4 is differentially expressed in mesencephalic dopaminergic neurons, found in the substantia nigra and in a subregion of the ventral tegmentum but not in the retrorubral field. |
2005-01-21 |
2023-08-12 |
mouse |
| Matteo Marti, Flora Mela, Remo Guerrini, Girolamo Calò, Clementina Bianchi, Michele Morar. Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release. Journal of neurochemistry. vol 91. issue 6. 2005-01-21. PMID:15584926. |
we recently showed that pharmacological blockade of nociceptin/orphanin fq (n/ofq) peptide (nop) receptors located in the substantia nigra stimulates the nigrostriatal dopaminergic pathway and motor behavior (marti et al. |
2005-01-21 |
2023-08-12 |
rat |
| G Garcia, P Tagliaferro, A Ferri, A M Evangelista de Duffard, R Duffard, A Brusc. Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2,4-dichlorophenoxyacetic Acid. Neurotoxicology. vol 25. issue 6. 2005-01-14. PMID:15474613. |
dopaminergic neurons from the midbrain nuclei substantia nigra (sn; a9) and ventral tegmental area (vta; a10) were investigated by tyrosine hydroxylase (th) immunostaining in neonate rat brains exposed to 2,4-dichlorophenoxyacetic acid (2,4-d) through lactation. |
2005-01-14 |
2023-08-12 |
rat |
| C R Lee, E D Abercrombie, J M Teppe. Pallidal control of substantia nigra dopaminergic neuron firing pattern and its relation to extracellular neostriatal dopamine levels. Neuroscience. vol 129. issue 2. 2005-01-13. PMID:15501605. |
the principal gabaergic inputs to the dopaminergic neurons of the substantia nigra originate from neurons of the neostriatum, globus pallidus and substantia nigra pars reticulata. |
2005-01-13 |
2023-08-12 |
Not clear |
| Oliver Cooper, Ole Isacso. Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 41. 2005-01-12. PMID:15483111. |
consequently, no evidence of dopaminergic (da) neurogenesis was found in the striatum or substantia nigra in any experimental group, and amphetamine-induced behavioral rotations did not improve. |
2005-01-12 |
2023-08-12 |
rat |
| Rumiko Kurosaki, Yasuko Muramatsu, Hiroyuki Kato, Tsutomu Arak. Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 78. issue 1. 2005-01-07. PMID:15159144. |
the immunohistochemical study has shown that the acute treatment with mptp caused severe loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-immunoreactive dopaminergic neurons and marked increase in glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the striatum and the substantia nigra. |
2005-01-07 |
2023-08-12 |
mouse |
| Christelle Monville, Eduardo Torres, Eleri Thomas, Cinzia G Scarpini, Justna Muhith, Jeff Lewis, Jaquie Finn, Chris Smith, Shijie Cai, Stacey Efstathiou, Keith Howard, Stephen B Dunnet. HSV vector-delivery of GDNF in a rat model of PD: partial efficacy obscured by vector toxicity. Brain research. vol 1024. issue 1-2. 2005-01-06. PMID:15451362. |
both constructs induced a significant protection of the dopaminergic neurons in the substantia nigra from the lesions, whereas only one induced a transient behavioural recovery in amphetamine-induced rotation. |
2005-01-06 |
2023-08-12 |
rat |
| Rajappa S Kenchappa, Latha Diwakar, Jayasree Annepu, Vijayalakshmi Ravindranat. Estrogen and neuroprotection: higher constitutive expression of glutaredoxin in female mice offers protection against MPTP-mediated neurodegeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 10. 2005-01-05. PMID:15132975. |
administration of mptp to male mice results in loss of dopaminergic neurons in substantia nigra, whereas female mice are unaffected. |
2005-01-05 |
2023-08-12 |
mouse |