| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiong Zhang, Wenjie Xie, Shen Qu, Tianhong Pan, Xiaotong Wang, Weidong L. Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochemical and biophysical research communications. vol 333. issue 2. 2005-09-07. PMID:15950935. |
our present studies have shown that micro-injection of the proteasome inhibitor lactacystin into the substantia nigra (sn) of c57bl/6 mice causes significant loss of dopaminergic cells and induces intracellular inclusion body formation. |
2005-09-07 |
2023-08-12 |
mouse |
| Stevan R Emmett, Susan A Greenfiel. Correlation between dopaminergic neurons, acetylcholinesterase and nicotinic acetylcholine receptors containing the alpha3- or alpha5-subunit in the rat substantia nigra. Journal of chemical neuroanatomy. vol 30. issue 1. 2005-09-06. PMID:15975762. |
correlation between dopaminergic neurons, acetylcholinesterase and nicotinic acetylcholine receptors containing the alpha3- or alpha5-subunit in the rat substantia nigra. |
2005-09-06 |
2023-08-12 |
rat |
| Stevan R Emmett, Susan A Greenfiel. Correlation between dopaminergic neurons, acetylcholinesterase and nicotinic acetylcholine receptors containing the alpha3- or alpha5-subunit in the rat substantia nigra. Journal of chemical neuroanatomy. vol 30. issue 1. 2005-09-06. PMID:15975762. |
the aim of this study was to investigate the relationship between the cells possessing the alpha3 or alpha5 nicotinic acetylcholine receptor subunits and the enzyme acetylcholinesterase, with respect to tyrosine hydroxylase immunoreactive dopaminergic neurons in the rat substantia nigra. |
2005-09-06 |
2023-08-12 |
rat |
| Jason Callio, Tim D Oury, Charleen T Ch. Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15755737. |
dopaminergic neurons of the substantia nigra are susceptible to toxin-based insults. |
2005-09-02 |
2023-08-12 |
mouse |
| Sarah A Baker, Lianne E Stanford, Richard E Brown, Theo Hag. Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice. Brain research. vol 1039. issue 1-2. 2005-08-30. PMID:15781060. |
bdnf-/- mice (p14 and p21 only) had fewer dopaminergic dendrites in the substantia nigra, suggesting that bdnf plays a role in phenotypic maturation, but not in neuronal birth or survival. |
2005-08-30 |
2023-08-12 |
mouse |
| P Mohapel, H Frielingsdorf, J Häggblad, O Zachrisson, P Brundi. Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837137. |
both in the striatum and in the substantia nigra there were no indications of any newly born cells differentiating into dopaminergic neurons following growth factor treatment, such that brdu-labeled cells never co-expressed tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2005-08-30 |
2023-08-12 |
rat |
| Yeung-Kee Kim, Hyung-Ho Lim, Yun-Kyung Song, Hee-Hyuk Lee, Sabina Lim, Seung-Moo Han, Chang-Ju Ki. Effect of acupuncture on 6-hydroxydopamine-induced nigrostratal dopaminergic neuronal cell death in rats. Neuroscience letters. vol 384. issue 1-2. 2005-08-22. PMID:15893426. |
immunostaining for tyrosine hydroxylase demonstrated a dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. |
2005-08-22 |
2023-08-12 |
rat |
| Sarah L Maxwell, Hsin-Yi Ho, Eva Kuehner, Suling Zhao, Meng L. Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Developmental biology. vol 282. issue 2. 2005-08-22. PMID:15950611. |
pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. |
2005-08-22 |
2023-08-12 |
mouse |
| L E Bartlett, I Mende. Dopaminergic reinnervation of the globus pallidus by fetal nigral grafts in the rodent model of Parkinson's disease. Cell transplantation. vol 14. issue 2-3. 2005-08-19. PMID:15881421. |
this limitation may be due to an incomplete restoration of the dopaminergic input to other basal ganglia structures such as the external segment of the globus pallidus (gpe, homologue of the rodent gp), which normally receives dopaminergic input from the substantia nigra (sn). |
2005-08-19 |
2023-08-12 |
rat |
| S Siegert, E Bahn, M L Kramer, W J Schulz-Schaeffer, J W Hewett, X O Breakefield, J C Hedreen, K M Rostas. TorsinA expression is detectable in human infants as young as 4 weeks old. Brain research. Developmental brain research. vol 157. issue 1. 2005-08-12. PMID:15939081. |
expression of torsina protein was detectable beginning at 4 to 8 weeks of age postnatally in the cerebellum (purkinje cells), substantia nigra (dopaminergic neurons), hippocampus and basal ganglia. |
2005-08-12 |
2023-08-12 |
human |
| Eizo Iseki, Wami Marui, Ryoko Yamamoto, Takashi Togo, Omi Katsuse, Masanori Kato, Takeshi Iwatsubo, Kenji Kosaka, Heii Ara. The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neuroscience letters. vol 380. issue 1-2. 2005-07-28. PMID:15854770. |
we immunohistochemically investigated the degeneration processes of the nigro-striatal and nigro-amygdaloid pathways and the relationship between the loss of dopaminergic neurons and lewy bodies (lb) formation in the substantia nigra using 15 autopsied cases of dementia with lewy bodies (dlb). |
2005-07-28 |
2023-08-12 |
Not clear |
| Eizo Iseki, Wami Marui, Ryoko Yamamoto, Takashi Togo, Omi Katsuse, Masanori Kato, Takeshi Iwatsubo, Kenji Kosaka, Heii Ara. The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neuroscience letters. vol 380. issue 1-2. 2005-07-28. PMID:15854770. |
the results of the present study indicate that the nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in dlb, and suggest that the degeneration of the nigro-amygdaloid pathway more strongly reflects lb formation in dopaminergic neurons of the substantia nigra than that of the nigro-striatal pathway. |
2005-07-28 |
2023-08-12 |
Not clear |
| Eizo Iseki, Wami Marui, Ryoko Yamamoto, Takashi Togo, Omi Katsuse, Masanori Kato, Takeshi Iwatsubo, Kenji Kosaka, Heii Ara. The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neuroscience letters. vol 380. issue 1-2. 2005-07-28. PMID:15854770. |
in addition, they indicate that there is no direct relationship between the loss of dopaminergic neurons and lb formation in the substantia nigra. |
2005-07-28 |
2023-08-12 |
Not clear |
| Serge Przedborsk. Pathogenesis of nigral cell death in Parkinson's disease. Parkinsonism & related disorders. vol 11 Suppl 1. 2005-07-25. PMID:15885625. |
parkinson's disease (pd) is primarily a sporadic condition which results mainly from the death of dopaminergic neurons in the substantia nigra. |
2005-07-25 |
2023-08-12 |
Not clear |
| Serge Przedborsk. Pathogenesis of nigral cell death in Parkinson's disease. Parkinsonism & related disorders. vol 11 Suppl 1. 2005-07-25. PMID:15885625. |
the fate of dopaminergic neurons in pd may also be influenced by additional factors such as excitotoxicity, emanating from the increased glutamatergic input from the subthalamic nucleus to the substantia nigra, and the glial response that arises in the striatum and the substantia nigra. |
2005-07-25 |
2023-08-12 |
Not clear |
| Etienne C Hirsch, Stéphane Hunot, Andreas Hartman. Neuroinflammatory processes in Parkinson's disease. Parkinsonism & related disorders. vol 11 Suppl 1. 2005-07-25. PMID:15885630. |
in parkinson's disease (pd), post-mortem examination reveals a loss of dopaminergic (da) neurons in the substantia nigra (sn) associated with a massive astrogliosis and the presence of activated microglial cells. |
2005-07-25 |
2023-08-12 |
Not clear |
| Shuichi Ueda, Shin-ichi Sakakibara, Kazuhiko Nakadate, Takahiro Noda, Motoo Shinoda, Jeffrey N Joyc. Degeneration of dopaminergic neurons in the substantia nigra of zitter mutant rat and protection by chronic intake of Vitamin E. Neuroscience letters. vol 380. issue 3. 2005-07-20. PMID:15862896. |
degeneration of dopaminergic neurons in the substantia nigra of zitter mutant rat and protection by chronic intake of vitamin e. dopaminergic cell death in the ventral and dorsal tiers of substantia nigra pars copmacta (snc) and their prevention by anti-oxidant diet was immunohistochemically studied in the zitter mutant rats, which are characterized by abnormal metabolism of superoxide. |
2005-07-20 |
2023-08-12 |
rat |
| Yasuhiko Izumi, Hideyuki Sawada, Noriko Sakka, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15712215. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2005-07-15 |
2023-08-12 |
human |
| Andreas Hald, Julie Lothariu. Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869932. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra (sn). |
2005-07-15 |
2023-08-12 |
human |
| Cecilia Gotti, Milena Moretti, Francesco Clementi, Loredana Riganti, J Michael McIntosh, Allan C Collins, Michael J Marks, Paul Whiteake. Expression of nigrostriatal alpha 6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by beta 3 subunit gene deletion. Molecular pharmacology. vol 67. issue 6. 2005-07-14. PMID:15749993. |
mrnas for the neuronal nicotinic acetylcholine receptor (nachr) alpha6 and beta3 subunits are abundantly expressed and colocalized in dopaminergic cells of the substantia nigra and ventral tegmental area. |
2005-07-14 |
2023-08-12 |
mouse |