| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenji Abe, Toshiaki Saitoh, Yoshie Horiguchi, Iku Utsunomiya, Kyoji Taguch. Synthesis and neurotoxicity of tetrahydroisoquinoline derivatives for studying Parkinson's disease. Biological & pharmaceutical bulletin. vol 28. issue 8. 2005-11-30. PMID:16079473. |
parkinson's disease involves the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2005-11-30 |
2023-08-12 |
Not clear |
| Glenda M Halliday, Anita Ophof, Melissa Broe, Poul H Jensen, Emma Kettle, Heidi Fedorow, Michael I Cartwright, Francine M Griffiths, Claire E Shepherd, Kay L Doubl. Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease. Brain : a journal of neurology. vol 128. issue Pt 11. 2005-11-28. PMID:16000336. |
to determine early intracellular changes in regions where cell loss is most marked (dopaminergic a9 substantia nigra) versus regions with lewy bodies but where cell loss is limited, we assessed 13 patients with definite parkinson's disease at various disease stages in comparison with controls. |
2005-11-28 |
2023-08-12 |
Not clear |
| Raffaella Geracitano, Alessandro Tozzi, Nicola Berretta, Fulvio Florenzano, Ezia Guatteo, Maria Teresa Viscomi, Barbara Chiolo, Marco Molinari, Giorgio Bernardi, Nicola B Mercur. Protective role of hydrogen peroxide in oxygen-deprived dopaminergic neurones of the rat substantia nigra. The Journal of physiology. vol 568. issue Pt 1. 2005-11-28. PMID:16002440. |
protective role of hydrogen peroxide in oxygen-deprived dopaminergic neurones of the rat substantia nigra. |
2005-11-28 |
2023-08-12 |
rat |
| C L Parish, J Nunan, D I Finkelstein, F N McNamara, J Y Wong, J L Waddington, R M Brown, A J Lawrence, M K Horne, J Drag. Mice lacking the alpha4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16077034. |
given the known effects of nachrs on dopaminergic neurotransmission, we assessed the ability of the alpha4 nachr subunit to regulate arbor size of dopaminergic neurons by comparing responses of wild-type and alpha4 nachr subunit knockout [alpha4(-/-)] mice to long-term exposure to cocaine, amphetamine, nicotine, and haloperidol, and after substantia nigra neurotoxic lesioning. |
2005-11-28 |
2023-08-12 |
mouse |
| A Hurtado-Lorenzo, E Millan, V Gonzalez-Nicolini, D Suwelack, M G Castro, P R Lowenstei. Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration. Molecular therapy : the journal of the American Society of Gene Therapy. vol 10. issue 3. 2005-11-22. PMID:15336651. |
the neurotoxin 6-hydroxydopamine was used to lesion the nigrostriatal dopaminergic innervation; rad-shhn and rad-gli-1 protected dopaminergic neuronal cell bodies in the substantia nigra, but not axonal terminals in the striatum, from 6-ohda-induced cell death, while rad-nurr-1 was ineffective in protecting either cell bodies or axons. |
2005-11-22 |
2023-08-12 |
rat |
| S M Cardoso, P I Moreira, P Agostinho, C Pereira, C R Oliveir. Neurodegenerative pathways in Parkinson's disease: therapeutic strategies. Current drug targets. CNS and neurological disorders. vol 4. issue 4. 2005-11-15. PMID:16101557. |
parkinson's disease (pd), considered one of the major neurological disorders, is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by the presence of intraneuronal cytoplasmic inclusions called lewy bodies. |
2005-11-15 |
2023-08-12 |
human |
| Pao-Chi Liao, Yu-Min Kuo, Hen-Chia Hsu, Chienfang G Cherng, Lung Y. Local proteins associated with methamphetamine-induced nigrostriatal dopaminergic neurotoxicity. Journal of neurochemistry. vol 95. issue 1. 2005-11-08. PMID:16181420. |
infusion of anisomycin into striatum and substantia nigra both abolished the ma-induced striatal dopamine (da) and dihydroxyphenylacetic acid (dopac) depletions, indicating a critical role of local protein synthesis in determining such dopaminergic toxicity. |
2005-11-08 |
2023-08-12 |
Not clear |
| Hyman M Schippe. Heme oxygenase expression in human central nervous system disorders. Free radical biology & medicine. vol 37. issue 12. 2005-11-03. PMID:15544918. |
in parkinson disease, ho-1 decorates lewy bodies of affected dopaminergic neurons and is highly overexpressed in astrocytes residing within the substantia nigra. |
2005-11-03 |
2023-08-12 |
human |
| Angela De Iuliis, Jessica Grigoletto, Alessandra Recchia, Pietro Giusti, Paola Arsla. A proteomic approach in the study of an animal model of Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 357. issue 2. 2005-11-01. PMID:15946658. |
the aetiology of parkinson's disease (pd), an age-related disorder characterized by a progressive degeneration of dopaminergic neurons of the substantia nigra (sn) pars compacta, remains unclear. |
2005-11-01 |
2023-08-12 |
rat |
| Claire André, Tong T Truong, Jean Francois Robert, Yves C Guillaum. Effect of metals on herbicides-alpha-synuclein association: a possible factor in neurodegenerative disease studied by capillary electrophoresis. Electrophoresis. vol 26. issue 17. 2005-11-01. PMID:16143978. |
the aggregation of alpha-synuclein in the dopaminergic neurons of the substantia nigra is a critical step in the parkinson's disease (pd). |
2005-11-01 |
2023-08-12 |
Not clear |
| Dong-Youn Hwang, Sheila M Fleming, Paul Ardayfio, Taylor Moran-Gates, Hansoo Kim, Frank I Tarazi, Marie-Francoise Chesselet, Kwang-Soo Ki. 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 8. 2005-10-26. PMID:15728853. |
parkinson's disease (pd) is a neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra. |
2005-10-26 |
2023-08-12 |
mouse |
| Rocío M De Pablos, Antonio J Herrera, Ruth F Villarán, Josefina Cano, Alberto Machad. Dopamine-dependent neurotoxicity of lipopolysaccharide in substantia nigra. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 3. 2005-10-25. PMID:15625078. |
these results point out the important contribution of da to the vulnerability and degeneration of dopaminergic neurons of the substantia nigra. |
2005-10-25 |
2023-08-12 |
rat |
| Holly Shill, Mark Stac. Respiratory complications of Parkinson's disease. Seminars in respiratory and critical care medicine. vol 23. issue 3. 2005-10-06. PMID:16088618. |
degeneration of the substantia nigra and subsequent loss of dopaminergic neurons may produce changes in ventilatory parameters. |
2005-10-06 |
2023-08-12 |
Not clear |
| Darren J Moore, Andrew B West, Valina L Dawson, Ted M Dawso. Molecular pathophysiology of Parkinson's disease. Annual review of neuroscience. vol 28. 2005-09-30. PMID:16022590. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. |
2005-09-30 |
2023-08-12 |
Not clear |
| Li Quan, Takaki Ishikawa, Tomomi Michiue, Dong-Ri Li, Dong Zhao, Bao-Li Zhu, Hitoshi Maed. Ubiquitin immunoreactivity in the midbrain as a marker of stress to motor nervous systems in fatal injury. Legal medicine (Tokyo, Japan). vol 7. issue 3. 2005-09-29. PMID:15847823. |
the intranuclear ub-immunopositive inclusion of the pigmented dopaminergic neurons of the substantia nigra (inclusion ub-index) and the granular 'dot-like' ub-immunoreactivity area ('dot-like' ub-area) in the crus cerebri were analyzed. |
2005-09-29 |
2023-08-12 |
human |
| Erin H Norris, Benoit I Giasso. Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders. Antioxidants & redox signaling. vol 7. issue 5-6. 2005-09-27. PMID:15890012. |
parkinson's disease, the most common movement disorder, is characterized by the loss of brainstem neurons, specifically dopaminergic neurons in the substantia nigra, as well as the accumulation of neuronal cytoplasmic filamentous proteinaceous inclusions comprised of polymerized alpha-synuclein. |
2005-09-27 |
2023-08-12 |
Not clear |
| Jin H Son, Hibiki Kawamata, Myung S Yoo, Dae J Kim, Young K Lee, Sooyoul Kim, Ted M Dawson, Hui Zhang, David Sulzer, Lichuan Yang, M Flint Beal, Lorraine A Degiorgio, Hong S Chun, Harriet Baker, Chu Pen. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Journal of neurochemistry. vol 94. issue 4. 2005-09-27. PMID:16092945. |
the regulatory function of septin 5 in dopaminergic (daergic) neurons of substantia nigra (sn), maintained at relatively low levels, has not yet been delineated. |
2005-09-27 |
2023-08-12 |
mouse |
| Jun Peng, Fang Feng Stevenson, Susan R Doctrow, Julie K Anderse. Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. The Journal of biological chemistry. vol 280. issue 32. 2005-09-22. PMID:15946937. |
exposure of mice to the herbicide paraquat has been demonstrated to result in the selective loss of dopaminergic neurons of the substantia nigra, pars compacta (snpc) akin to what is observed in parkinson disease (pd). |
2005-09-22 |
2023-08-12 |
mouse |
| Clive Weller, Norman Oxlade, Sylvia M Dobbs, R John Dobbs, André Charlett, Ingvar T Bjarnaso. Role of inflammation in gastrointestinal tract in aetiology and pathogenesis of idiopathic parkinsonism. FEMS immunology and medical microbiology. vol 44. issue 2. 2005-09-12. PMID:15866206. |
its cardinal features, poverty and slowness of movement, muscle rigidity, postural abnormality and a characteristic tremor, are associated with loss of dopaminergic neurones in the substantia nigra of the brain. |
2005-09-12 |
2023-08-12 |
Not clear |
| R H Andres, A W Huber, U Schlattner, A Pérez-Bouza, S H Krebs, R W Seiler, T Wallimann, H R Widme. Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue. Neuroscience. vol 133. issue 3. 2005-09-07. PMID:15890457. |
parkinson's disease is a disabling neurodegenerative disorder of unknown etiology characterized by a predominant and progressive loss of dopaminergic neurons in the substantia nigra. |
2005-09-07 |
2023-08-12 |
rat |