| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Theodore, W A Cass, W F Marago. Methamphetamine and human immunodeficiency virus protein Tat synergize to destroy dopaminergic terminals in the rat striatum. Neuroscience. vol 137. issue 3. 2006-04-12. PMID:16338084. |
the results indicate that methamphetamine and tat interact to produce an enhanced injury to dopaminergic nerve terminals in the striatum with sparing of the substantia nigra by a mechanism involving oxidative stress. |
2006-04-12 |
2023-08-12 |
human |
| Ji Won Um, Do Sik Min, Hyewhon Rhim, Jongsun Kim, Seung R Paik, Kwang Chul Chun. Parkin ubiquitinates and promotes the degradation of RanBP2. The Journal of biological chemistry. vol 281. issue 6. 2006-04-11. PMID:16332688. |
parkinson disease (pd) is a common neurodegenerative disorder, which involves the deterioration of dopaminergic neurons in the pars compacta of the substantia nigra. |
2006-04-11 |
2023-08-12 |
Not clear |
| Nils Freundlieb, Chantal François, Dominique Tandé, Wolfgang H Oertel, Etienne C Hirsch, Günter U Höglinge. Dopaminergic substantia nigra neurons project topographically organized to the subventricular zone and stimulate precursor cell proliferation in aged primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 8. 2006-04-11. PMID:16495459. |
dopaminergic substantia nigra neurons project topographically organized to the subventricular zone and stimulate precursor cell proliferation in aged primates. |
2006-04-11 |
2023-08-12 |
Not clear |
| Krishnan Sriram, Diane B Miller, James P O'Callagha. Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16405514. |
here, we showed that administration of a single low dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) or methamphetamine (meth), a paradigm that causes selective degeneration of striatal dopaminergic nerve terminals without affecting the cell body in substantia nigra, increased the expression of mrnas encoding microglia-associated factors f4/80, interleukin (il)-1alpha, il-6, monocyte chemoattractant protein-1 (mcp-1, ccl2) and tumor necrosis factor (tnf)-alpha. |
2006-03-30 |
2023-08-12 |
mouse |
| Renee M Miller, Gretchen L Kiser, T M Kaysser-Kranich, Randall J Lockner, Chockalingam Palaniappan, Howard J Federof. Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiology of disease. vol 21. issue 2. 2006-03-29. PMID:16143538. |
we hypothesize that specific differential gene expression underlies important pathogenic processes in parkinson's disease, which is characterized by the gradual loss of dopaminergic neurons in the substantia nigra and consequent loss of dopamine in the striatum. |
2006-03-29 |
2023-08-12 |
human |
| Kelly J Conn, Wenwu Gao, Ann McKee, Michael S Lan, M David Ullman, Patricia B Eisenhauer, Richard E Fine, John M Well. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353226. |
pathological hallmarks of the disease include the loss of dopaminergic neurons from the substantia nigra (sn) and the presence of lewy bodies (lbs) (alpha-synuclein and ubiquitin-positive, eosinophilic, cytoplasmic inclusions) in many of the surviving neurons. |
2006-03-23 |
2023-08-12 |
human |
| Fiona M Menzies, Sarat C Yenisetti, Kyung-Tai Mi. Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Current biology : CB. vol 15. issue 17. 2006-03-23. PMID:16139214. |
the loss of dopaminergic neurons in the substantia nigra is the pathological hallmark of parkinson's disease (pd). |
2006-03-23 |
2023-08-12 |
human |
| Jun Huang, Huaqing Liu, Wangwen Gu, Zhou Yan, Zhenghong Xu, Yongxin Yang, Xingzu Zhu, Yaping L. A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease. Biomaterials. vol 27. issue 6. 2006-03-21. PMID:16118017. |
the rotenone microspheres (9 mg/kg) produced typical pd symptoms in rats, for example, the cataleptic behavior test demonstrated a obviously prolonged descent latency compared with control animals after administration, and the tyrosine hydroxylase (th) immunohistochemistry tests showed typical histological evidence of selective degeneration of the nigrostriatal dopaminergic system (striatum and substantia nigra) in rotenone microspheres-treated rats. |
2006-03-21 |
2023-08-12 |
rat |
| Pablo Ibáñez, Suzanne Lesage, Ebba Lohmann, Stéphane Thobois, Giuseppe De Michele, Michel Borg, Yves Agid, Alexandra Dürr, Alexis Bric. Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa. Brain : a journal of neurology. vol 129. issue Pt 3. 2006-03-15. PMID:16401616. |
parkinson's disease is a frequent disorder caused primarily by the loss of dopaminergic neurons of the substantia nigra. |
2006-03-15 |
2023-08-12 |
Not clear |
| Daphne M Hasbani, Francisco A Perez, Richard D Palmiter, Karen L O'Malle. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221852. |
dopamine (da) has been postulated to play a role in the loss of dopaminergic substantia nigra (sn) neurons in parkinson's disease because of its propensity to oxidize and form quinones and other reactive oxygen species that can alter cellular function. |
2006-03-13 |
2023-08-12 |
mouse |
| Ennio Esposit. Serotonin-dopamine interaction as a focus of novel antidepressant drugs. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475959. |
among the multiple classes of 5-ht receptors described in the central nervous system, much attention has been devoted to the role of 5-ht2 receptor family in the control of central dopaminergic activity, because of the moderate to dense localization of both transcript and protein for 5-ht2a and 5-ht2c receptors in the substantia nigra (sn) and ventral tegmental area (vta), as well as their terminal regions. |
2006-03-10 |
2023-08-12 |
human |
| Geraldine J Kress, Ian J Reynold. Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures. Neurobiology of disease. vol 20. issue 3. 2006-03-09. PMID:15996475. |
we have investigated the properties of the dopaminergic neurotoxins 6-hydroxydopamine, 1-methyl-4-phenylpyridinium and rotenone using an organotypic culture that included slices of substantia nigra, striatum and cortex maintained for about 20 days in vitro. |
2006-03-09 |
2023-08-12 |
Not clear |
| Mar Cuadrado-Tejedor, M Teresa Sesma, José Manuel Giménez-Amaya, Lourdes Orti. Changes in cytoskeletal gene expression linked to MPTP-treatment in Mice. Neurobiology of disease. vol 20. issue 3. 2006-03-09. PMID:16005240. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and a marked reduction of dopamine (da) levels in the striatum. |
2006-03-09 |
2023-08-12 |
mouse |
| Han Seok Ko, Rainer von Coelln, Sathya R Sriram, Seong Who Kim, Kenny K K Chung, Olga Pletnikova, Juan Troncoso, Brett Johnson, Roya Saffary, Eyleen L Goh, Hongjun Song, Bum-Joon Park, Min Jung Kim, Sunghoon Kim, Valina L Dawson, Ted M Dawso. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 35. 2006-03-07. PMID:16135753. |
we further show that adenovirus-mediated overexpression of p38 in the substantia nigra in mice leads to loss of dopaminergic neurons. |
2006-03-07 |
2023-08-12 |
mouse |
| Ana Saavedra, Graça Baltazar, Caetana M Carvalho, Emília P Duart. GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures. Free radical biology & medicine. vol 39. issue 12. 2006-03-07. PMID:16298686. |
in this work we investigated ho-1 expression in rat substantia nigra postnatal cell cultures under conditions mimicking dopamine toxicity and its modulation by glial cell line-derived neurotrophic factor (gdnf), a potent neuroprotective factor for dopaminergic neurons. |
2006-03-07 |
2023-08-12 |
rat |
| Sung-Jin Lee, Dong-Chan Kim, Bo-Hwa Choi, Hyunjung Ha, Kyong-Tai Ki. Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death. The Journal of biological chemistry. vol 281. issue 4. 2006-03-07. PMID:16314418. |
selective cell death of dopaminergic neurons in the substantia nigra is the major cause of parkinson disease. |
2006-03-07 |
2023-08-12 |
Not clear |
| Jordi Clarimon, Georgia Xiromerisiou, Johanna Eerola, Vanesa Gourbali, Olli Hellström, Euthimios Dardiotis, Terhi Peuralinna, Alexandros Papadimitriou, George M Hadjigeorgiou, Pentti J Tienari, Andrew B Singleto. Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients. BMC neurology. vol 5. 2006-02-16. PMID:15967032. |
fibroblast growth factor 20 (fgf20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. |
2006-02-16 |
2023-08-12 |
rat |
| Guo-Hua Fan, Chen Qi, Sheng-Di Che. Heat shock proteins reduce toxicity of 1-methyl-4-phenylpyridinium ion in SK-N-SH cells. Journal of neuroscience research. vol 82. issue 4. 2006-02-16. PMID:16235253. |
the pathology of parkinson's disease (pd) is characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2006-02-16 |
2023-08-12 |
human |
| Shin-ichi Muramats. [Gene therapy and cell transplantation for Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 45. issue 11. 2006-02-15. PMID:16447758. |
in most cases, dopaminergic cells are transplanted ectopically into the striatum instead of the substantia nigra. |
2006-02-15 |
2023-08-12 |
Not clear |
| Zachary C Baquet, Paula C Bickford, Kevin R Jone. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987955. |
reduced expression of bdnf within the substantia nigra accompanies the deterioration of dopaminergic neurons in parkinson's disease (pd) patients. |
2006-02-14 |
2023-08-12 |
mouse |