| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Xiong, Z Zhang, J Huang, C Chen, Z Zhang, M Jia, J Xiong, X Liu, F Wang, X Cao, Z Liang, S Sun, Z Lin, T Wan. VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene therapy. vol 18. issue 4. 2011-07-08. PMID:21107440. |
humsc transplantation ameliorated apomorphine-evoked rotations and reduced the loss of dopaminergic neurons in the lesioned substantia nigra (snc), which was enhanced significantly by vegf expression in humscs. |
2011-07-08 |
2023-08-12 |
human |
| Manuel Garrido, Yuliya Tereshchenko, Zinayida Zhevtsova, Grit Taschenberger, Mathias Bähr, Sebastian Kügle. Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons. Acta neuropathologica. vol 121. issue 4. 2011-07-01. PMID:21191602. |
parkinson's disease is a neurodegenerative disorder characterized by severe motor deficits mainly due to degeneration of dopaminergic neurons in the substantia nigra. |
2011-07-01 |
2023-08-12 |
rat |
| Alexander J Whitwort. Drosophila models of Parkinson's disease. Advances in genetics. vol 73. 2011-06-29. PMID:21310293. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disorder principally affecting the dopaminergic neurons of the substantia nigra. |
2011-06-29 |
2023-08-12 |
drosophila_melanogaster |
| Katharina Schindowski, Oliver von Bohlen und Halbach, Jens Strelau, Dirk A Ridder, Oliver Herrmann, Andreas Schober, Markus Schwaninger, Klaus Unsicke. Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia. Cell and tissue research. vol 343. issue 2. 2011-06-24. PMID:21128084. |
we have previously reported that gdf-15 is a potent neurotrophic factor for lesioned dopaminergic neurons in the substantia nigra, and that gdf-15-deficient mice show progressive postnatal losses of motor and sensory neurons. |
2011-06-24 |
2023-08-12 |
mouse |
| Z-W Zhou, Y Shu, M Li, X Guo, C Pac-Soo, M Maze, D M. The glutaminergic, GABAergic, dopaminergic but not cholinergic neurons are susceptible to anaesthesia-induced cell death in the rat developing brain. Neuroscience. vol 174. 2011-06-21. PMID:21056635. |
in the substantia nigra, 22% of apoptotic cells were dopaminergic neurons. |
2011-06-21 |
2023-08-12 |
rat |
| Chan Lee, Gyu Hwan Park, Jung-Hee Jan. Cellular antioxidant adaptive survival response to 6-hydroxydopamine-induced nitrosative cell death in C6 glioma cells. Toxicology. vol 283. issue 2-3. 2011-06-21. PMID:21397656. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons in the substantia nigra. |
2011-06-21 |
2023-08-12 |
Not clear |
| Zhongwang Yu, Xiaohui Xu, Zhenghua Xiang, Jianfeng Zhou, Zhaohuan Zhang, Chun Hu, Cheng H. Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. PloS one. vol 5. issue 4. 2011-06-16. PMID:20386702. |
nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. |
2011-06-16 |
2023-08-12 |
rat |
| Zhongwang Yu, Xiaohui Xu, Zhenghua Xiang, Jianfeng Zhou, Zhaohuan Zhang, Chun Hu, Cheng H. Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. PloS one. vol 5. issue 4. 2011-06-16. PMID:20386702. |
the pathology of parkinson's disease (pd) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as lewy bodies and lewy neurites in the substantia nigra. |
2011-06-16 |
2023-08-12 |
rat |
| Yoshito Masamizu, Takashi Okada, Hidetoshi Ishibashi, Shin'ichi Takeda, Shigeki Yuasa, Kiyoshi Nakahar. Efficient gene transfer into neurons in monkey brain by adeno-associated virus 8. Neuroreport. vol 21. issue 6. 2011-05-31. PMID:20224455. |
cell typing with immunohistochemistry confirmed efficient aav8-mediated gene transfer into the pyramidal neurons in the cortex, calbindin-positive medium spiny neurons in the striatum and dopaminergic neurons in the substantia nigra. |
2011-05-31 |
2023-08-12 |
monkey |
| Mibel M Pabon, Adam D Bachstetter, Charles E Hudson, Carmelina Gemma, Paula C Bickfor. CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. Journal of neuroinflammation. vol 8. 2011-05-31. PMID:21266082. |
parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. |
2011-05-31 |
2023-08-12 |
rat |
| Tianhong Pan, Xinqun Li, Joseph Jankovi. The association between Parkinson's disease and melanoma. International journal of cancer. vol 128. issue 10. 2011-05-26. PMID:21207412. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a loss of melanin-positive, dopaminergic neurons in the substantia nigra. |
2011-05-26 |
2023-08-12 |
human |
| Beate Winner, Roberto Jappelli, Samir K Maji, Paula A Desplats, Leah Boyer, Stefan Aigner, Claudia Hetzer, Thomas Loher, Marçal Vilar, Silvia Campioni, Christos Tzitzilonis, Alice Soragni, Sebastian Jessberger, Helena Mira, Antonella Consiglio, Emiley Pham, Eliezer Masliah, Fred H Gage, Roland Rie. In vivo demonstration that alpha-synuclein oligomers are toxic. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 10. 2011-05-26. PMID:21325059. |
we developed α-syn mutants that promote oligomer or fibril formation and tested the toxicity of these mutants by using a rat lentivirus system to investigate loss of dopaminergic neurons in the substantia nigra. |
2011-05-26 |
2023-08-12 |
rat |
| Beate Winner, Roberto Jappelli, Samir K Maji, Paula A Desplats, Leah Boyer, Stefan Aigner, Claudia Hetzer, Thomas Loher, Marçal Vilar, Silvia Campioni, Christos Tzitzilonis, Alice Soragni, Sebastian Jessberger, Helena Mira, Antonella Consiglio, Emiley Pham, Eliezer Masliah, Fred H Gage, Roland Rie. In vivo demonstration that alpha-synuclein oligomers are toxic. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 10. 2011-05-26. PMID:21325059. |
the most severe dopaminergic loss in the substantia nigra is observed in animals with the α-syn variants that form oligomers (i.e., e57k and e35k), whereas the α-syn variants that form fibrils very quickly are less toxic. |
2011-05-26 |
2023-08-12 |
rat |
| Yan Ming Huang, Zheng Qin Yi. Minor retinal degeneration in Parkinson's disease. Medical hypotheses. vol 76. issue 2. 2011-05-23. PMID:20933338. |
parkinson's disease is a neurodegenerative disorder with selective and progressive loss of dopaminergic neurons in substantia nigra. |
2011-05-23 |
2023-08-12 |
Not clear |
| Yan Ming Huang, Zheng Qin Yi. Minor retinal degeneration in Parkinson's disease. Medical hypotheses. vol 76. issue 2. 2011-05-23. PMID:20933338. |
studies on parkinson's disease patients and dopamine-depleted animals indicate that dopaminergic neurons in the retina degenerate due to the genetic and environmental factors that cause dopaminergic neuron loss in the substantia nigra. |
2011-05-23 |
2023-08-12 |
Not clear |
| Adria K Martig, Sheri J Y Mizumor. Ventral tegmental area disruption selectively affects CA1/CA2 but not CA3 place fields during a differential reward working memory task. Hippocampus. vol 21. issue 2. 2011-05-06. PMID:20082295. |
hippocampus (hpc) receives dopaminergic (da) projections from the ventral tegmental area (vta) and substantia nigra. |
2011-05-06 |
2023-08-12 |
rat |
| Lir-Wan Fan, Lu-Tai Tien, Baoying Zheng, Yi Pang, Rick C S Lin, Kimberly L Simpson, Tangeng Ma, Philip G Rhodes, Zhengwei Ca. Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicity. Brain, behavior, and immunity. vol 25. issue 2. 2011-05-04. PMID:20875849. |
on the other hand, neonatal lps-induced injury to the dopaminergic system such as the loss of dendrites and reduced tyrosine hydroxylase immunoreactivity in the substantia nigra persisted in p70 rats. |
2011-05-04 |
2023-08-12 |
rat |
| Pamela J McMillan, Sylvia S White, Allyn Franklin, J Lynne Greenup, James B Leverenz, Murray A Raskind, Patricia Szo. Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease. Brain research. vol 1373. 2011-05-03. PMID:21147074. |
in parkinson's disease (pd), there is a significant loss of noradrenergic neurons in the locus coeruleus (lc) in addition to the loss of dopaminergic neurons in the substantia nigra (sn). |
2011-05-03 |
2023-08-12 |
human |
| James A Miller, Briana R Trout, Kelly A Sullivan, Russell A Bialecki, Ruth A Roberts, Ronald B Tjalken. Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-κB reporter mice prior to loss of dopaminergic neurons. Journal of neuroscience research. vol 89. issue 3. 2011-05-03. PMID:21259327. |
no significant loss of dopaminergic neurons in the substantia nigra was apparent at any dose. |
2011-05-03 |
2023-08-12 |
mouse |
| Emily Gale, Meng L. Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells. Molecular brain. vol 1. 2011-05-02. PMID:18826576. |
the midbrain dopaminergic (mda) neurons of the substantia nigra and the ventral tegmental area play a fundamental role in the control of voluntary movement and the regulation of emotion, and are severely affected in parkinson's disease. |
2011-05-02 |
2023-08-12 |
mouse |