| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Yang, Wei-Hua Yang, Sha-Sha Chen, Bao-Feng Ma, Bin Li, Tao Lu, Ting-Yu Qu, Ronald L Klein, Li-Ru Zhao, Wei-Ming Dua. Pre-immunization with an intramuscular injection of AAV9-human erythropoietin vectors reduces the vector-mediated transduction following re-administration in rat brain. PloS one. vol 8. issue 5. 2013-12-17. PMID:23667683. |
we have recently demonstrated that adeno-associated virus serotype 9 (aav9)-mediated human erythropoietin (hepo) gene delivery into the brain protects dopaminergic (da) neurons in the substantia nigra in a rat model of parkinson's disease. |
2013-12-17 |
2023-08-12 |
human |
| Flavia di Michele, Sabina Luchetti, Giorgio Bernardi, Elena Romeo, Patrizia Longon. Neurosteroid and neurotransmitter alterations in Parkinson's disease. Frontiers in neuroendocrinology. vol 34. issue 2. 2013-12-16. PMID:23563222. |
parkinson's disease (pd) is associated with a massive loss of dopaminergic cells in the substantia nigra leading to dopamine hypofunction and alteration of the basal ganglia circuitry. |
2013-12-16 |
2023-08-12 |
human |
| P Giuliani, S Romano, P Ballerini, R Ciccarelli, N Petragnani, S Cicchitti, M Zuccarini, S Jiang, M P Rathbone, F Caciagli, P Di Iori. Protective activity of guanosine in an in vitro model of Parkinson's disease. Panminerva medica. vol 54. issue 1 Suppl 4. 2013-12-09. PMID:23241934. |
parkinson's disease (pd) is a pathological condition characterized by a progressive neurodegeneration of dopaminergic neurons with the consequent reduction of dopamine content in the substantia nigra. |
2013-12-09 |
2023-08-12 |
human |
| O Sydow, P Hansson, D Young, B Meyerson, E O Backlund, T Ebendal, L O Farnebo, R Freedman, B Hamberger, B Hoffer, A Seiger, I Strömberq, L Olso. Long-term beneficial effects of adrenal medullary autografts supported by nerve growth factor in Parkinson's disease. European journal of neurology. vol 2. issue 5. 2013-12-03. PMID:24283725. |
adrenal medullary transplants were tried initially, because of the biochemical relationship between chromaffin cells of the medulla and dopaminergic neurons of the substantia nigra. |
2013-12-03 |
2023-08-12 |
mouse |
| Pablo Garcia-Reitboeck, Oleg Anichtchik, Jeffrey W Dalley, Natalia Ninkina, George K Tofaris, Vladimir L Buchman, Maria Grazia Spillantin. Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. Experimental neurology. vol 248. 2013-11-27. PMID:23933574. |
endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. |
2013-11-27 |
2023-08-12 |
mouse |
| Pablo Garcia-Reitboeck, Oleg Anichtchik, Jeffrey W Dalley, Natalia Ninkina, George K Tofaris, Vladimir L Buchman, Maria Grazia Spillantin. Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. Experimental neurology. vol 248. 2013-11-27. PMID:23933574. |
we show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type c57bl/6j mice compared with c57bl/6s mice with a spontaneous deletion of the α-synuclein gene or c57bl/6j mice with a targeted deletion of the α-synuclein gene. |
2013-11-27 |
2023-08-12 |
mouse |
| Fabia Febbraro, Kathrine J Andersen, Vanesa Sanchez-Guajardo, Noemie Tentillier, Marina Romero-Ramo. Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model. Experimental neurology. vol 247. 2013-11-26. PMID:23531432. |
several lines of data support a role for iron in parkinson's disease: iron is present in lewy bodies, iron accumulates in the dopaminergic neurons in the substantia nigra, and parkinson's disease is correlated with polymorphisms of several genes implicated in iron metabolism. |
2013-11-26 |
2023-08-12 |
rat |
| Scott Mackey, Yu Jing, Joseph Flores, Katie Dinelle, Doris J Doude. Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry. Experimental neurology. vol 247. 2013-11-26. PMID:23557600. |
stereological cell counting of tyrosine hydroxylase immunoreactive cells in the substantia nigra and the ventral tegmental area indicated a dose dependent loss of dopaminergic neurons. |
2013-11-26 |
2023-08-12 |
rat |
| Han-Sam Cho, Mal-Soon Shin, Wook Song, Tae-Won Jun, Baek-Vin Lim, Young-Pyo Kim, Chang-Ju Ki. Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamine-induced Parkinson's rats. Journal of exercise rehabilitation. vol 9. issue 3. 2013-11-26. PMID:24278884. |
progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of parkinson's disease. |
2013-11-26 |
2023-08-12 |
rat |
| Han-Sam Cho, Mal-Soon Shin, Wook Song, Tae-Won Jun, Baek-Vin Lim, Young-Pyo Kim, Chang-Ju Ki. Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamine-induced Parkinson's rats. Journal of exercise rehabilitation. vol 9. issue 3. 2013-11-26. PMID:24278884. |
in the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. |
2013-11-26 |
2023-08-12 |
rat |
| Chang-Youl Park, Shin-Ho Lee, Bo-Kyun Kim, Mal-Soon Shin, Chang-Ju Kim, Hong Ki. Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats. Journal of exercise rehabilitation. vol 9. issue 4. 2013-11-26. PMID:24278893. |
we determined the effects of treadmill exercise on survival of dopamine neurons in the substantia nigra and dopaminergic fibers in the striatum after hypoxic ischemia brain injury. |
2013-11-26 |
2023-08-12 |
rat |
| Chang-Youl Park, Shin-Ho Lee, Bo-Kyun Kim, Mal-Soon Shin, Chang-Ju Kim, Hong Ki. Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats. Journal of exercise rehabilitation. vol 9. issue 4. 2013-11-26. PMID:24278893. |
in this study, hypoxic ischemia injury caused loss of dopamine neurons in the substantia nigra and dopaminergic fibers in the striatum. |
2013-11-26 |
2023-08-12 |
rat |
| Christoph Scherfler, Regina Esterhammer, Michael Nocker, Philipp Mahlknecht, Heike Stockner, Boris Warwitz, Sabine Spielberger, Bernadette Pinter, Eveline Donnemiller, Clemens Decristoforo, Irene Virgolini, Michael Schocke, Werner Poewe, Klaus Sepp. Correlation of dopaminergic terminal dysfunction and microstructural abnormalities of the basal ganglia and the olfactory tract in Parkinson's disease. Brain : a journal of neurology. vol 136. issue Pt 10. 2013-11-25. PMID:24014521. |
this study reports a significant association between increased mean diffusivity signal and decreased 6-[(18)f] fluorolevodopa uptake, indicating that microstructural degradation of the substantia nigra and the olfactory tract parallels progression of putaminal dopaminergic dysfunction in parkinson's disease. |
2013-11-25 |
2023-08-12 |
human |
| Jenny U Johansson, Suraj Pradhan, Ludmila A Lokteva, Nathaniel S Woodling, Novie Ko, Holden D Brown, Qian Wang, Christina Loh, Egle Cekanaviciute, Marion Buckwalter, Amy B Manning-Bog, Katrin I Andreasso. Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 40. 2013-11-25. PMID:24089506. |
suppression of microglial ep2 signaling also increased numbers of dopaminergic (da) neurons in the substantia nigra independent of mptp treatment, suggesting that microglial ep2 may influence development or survival of da neurons. |
2013-11-25 |
2023-08-12 |
mouse |
| J A Priebe, P Rieckmann, S Lautenbache. [Central pain processing and Parkinson's disease. Epidemiology, physiology, and experimental results issuing pain processing]. Schmerz (Berlin, Germany). vol 26. issue 6. 2013-11-19. PMID:23052966. |
parkinson's disease (pd) is caused by degeneration of the dopaminergic neurons in the substantia nigra (sn) and a resulting dysfunction of the nigrostriatal pathways including the basal ganglia. |
2013-11-19 |
2023-08-12 |
Not clear |
| b' Nadia Schendzielorz, Juha-Pekka Oinas, Timo T My\\xc3\\xb6h\\xc3\\xa4nen, Ilkka Reenil\\xc3\\xa4, Atso Raasmaja, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. PloS one. vol 8. issue 4. 2013-11-14. PMID:23613844.' |
this study utilized dopaminergic and noradrenergic toxins to assess the presence of comt in the presynaptic neurons originating from the substantia nigra, ventral tegmental area or locus coeruleus. |
2013-11-14 |
2023-08-12 |
rat |
| Patrick P Michel, Damien Toulorge, Serge Guerreiro, Etienne C Hirsc. Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23699175. |
parkinson disease (pd) is a degenerative brain disorder characterized by motor symptoms that are unequivocally associated with the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2013-11-12 |
2023-08-12 |
Not clear |
| Na Wu, Lu Song, Xinxin Yang, Weien Yuan, Zhenguo Li. NMDA receptor regulation of levodopa-induced behavior and changes in striatal G protein-coupled receptor kinase 6 and β-arrestin-1 expression in parkinsonian rats. Clinical interventions in aging. vol 8. 2013-11-04. PMID:23569367. |
parkinson's disease is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. |
2013-11-04 |
2023-08-12 |
rat |
| Anamitra Ghosh, Hariharan Saminathan, Arthi Kanthasamy, Vellareddy Anantharam, Huajun Jin, Gautam Sondarva, Dilshan S Harischandra, Ziqing Qian, Ajay Rana, Anumantha G Kanthasam. The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of biological chemistry. vol 288. issue 30. 2013-11-04. PMID:23754278. |
parkinson disease (pd) is a chronic neurodegenerative disease characterized by a slow and progressive degeneration of dopaminergic neurons in substantia nigra. |
2013-11-04 |
2023-08-12 |
mouse |
| Anamitra Ghosh, Hariharan Saminathan, Arthi Kanthasamy, Vellareddy Anantharam, Huajun Jin, Gautam Sondarva, Dilshan S Harischandra, Ziqing Qian, Ajay Rana, Anumantha G Kanthasam. The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of biological chemistry. vol 288. issue 30. 2013-11-04. PMID:23754278. |
to our surprise we observed a dramatic up-regulation of pin1 mrna and protein levels in dopaminergic mn9d neuronal cells treated with the parkinsonian toxicant 1-methyl-4-phenylpyridinium (mpp(+)) as well as in the substantia nigra of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse model. |
2013-11-04 |
2023-08-12 |
mouse |