| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T B Freeman, M S Spence, B D Boss, D H Spector, R E Strecker, C W Olanow, J H Kordowe. Development of dopaminergic neurons in the human substantia nigra. Experimental neurology. vol 113. issue 3. 1991-11-19. PMID:1680741. |
a series of 29 human embryonic brains were examined in order to characterize the ontogeny of dopaminergic neurons within the developing substantia nigra. |
1991-11-19 |
2023-08-11 |
human |
| J F Chen, Z H Qin, F Szele, G Bai, B Weis. Neuronal localization and modulation of the D2 dopamine receptor mRNA in brain of normal mice and mice lesioned with 6-hydroxydopamine. Neuropharmacology. vol 30. issue 9. 1991-11-06. PMID:1833662. |
further, the evidence that lesions of striatum and substantia nigra induced with 6-hydroxydopamine greatly reduced the d2 receptor mrna signal in the substantia nigra, without concomitantly increasing the d2 receptor mrna in the striatum, suggests that the increase in dopamine receptor binding in the striatum that is ipsilateral to the lesion with 6-hydroxydopamine and the enhanced behavioral sensitivity to dopaminergic agonists, cannot be accounted for solely by an increase in d2 receptor mrna. |
1991-11-06 |
2023-08-11 |
mouse |
| C Beyer, C Pilgrim, I Reisert, U Misgel. Cells from embryonic rat striatum cocultured with mesencephalic glia express dopaminergic phenotypes. Neuroscience letters. vol 128. issue 1. 1991-11-05. PMID:1681474. |
it is concluded that glia from substantia nigra but not glia from neostriatum is capable of inducing development or promoting survival of dopaminergic cells. |
1991-11-05 |
2023-08-11 |
rat |
| K D Anderson, E J Karle, A Reine. Ultrastructural single- and double-label immunohistochemical studies of substance P-containing terminals and dopaminergic neurons in the substantia nigra in pigeons. The Journal of comparative neurology. vol 309. issue 3. 1991-11-04. PMID:1717517. |
ultrastructural single- and double-label immunohistochemical studies of substance p-containing terminals and dopaminergic neurons in the substantia nigra in pigeons. |
1991-11-04 |
2023-08-11 |
Not clear |
| K D Anderson, E J Karle, A Reine. Ultrastructural single- and double-label immunohistochemical studies of substance P-containing terminals and dopaminergic neurons in the substantia nigra in pigeons. The Journal of comparative neurology. vol 309. issue 3. 1991-11-04. PMID:1717517. |
to help clarify the role of striatonigral projection neurons, we conducted electron microscopic single- and double-label immunohistochemical studies of sp+ terminals and/or dopaminergic neurons (labeled with either anti-dopamine, da, or anti-tyrosine hydroxylase, th) in pigeons to determine: (1) the synaptic organization of sp+ terminals, (2) the synaptic organization of th+ perikarya and/or dendrites, and (3) the synaptic relationship between sp+ terminals and th+ neurons in the substantia nigra. |
1991-11-04 |
2023-08-11 |
Not clear |
| K D Anderson, E J Karle, A Reine. Ultrastructural single- and double-label immunohistochemical studies of substance P-containing terminals and dopaminergic neurons in the substantia nigra in pigeons. The Journal of comparative neurology. vol 309. issue 3. 1991-11-04. PMID:1717517. |
the presence of contacts between sp+ terminals and dopaminergic dendrites in the substantia nigra was directly demonstrated in tissue double-labeled for sp (by the peroxidase-antiperoxidase procedure, or pap, with diaminobenzidine) and th (by either the silver-intensified immunogold procedure or the pap procedure with benzidine dihydrochloride). |
1991-11-04 |
2023-08-11 |
Not clear |
| T Hattori, M Takada, T Moriizumi, D Van der Koo. Single dopaminergic nigrostriatal neurons form two chemically distinct synaptic types: possible transmitter segregation within neurons. The Journal of comparative neurology. vol 309. issue 3. 1991-11-04. PMID:1717519. |
previous studies have shown that anterograde transport of tritiated labeled proteins from the substantia nigra to the striatum over short survival times primarily labels asymmetric synapses (and that these asymmetric synapses are preferentially vulnerable to selective dopaminergic neurotoxins such as 6-hydroxydopamine). |
1991-11-04 |
2023-08-11 |
rat |
| T Hattori, M Takada, T Moriizumi, D Van der Koo. Single dopaminergic nigrostriatal neurons form two chemically distinct synaptic types: possible transmitter segregation within neurons. The Journal of comparative neurology. vol 309. issue 3. 1991-11-04. PMID:1717519. |
thus, we suggest that single dopaminergic neurons in the substantia nigra make two types of synaptic contact with striatal cells: 1) symmetric synapses en passant, which can be stained with tyrosine hydroxylase and dopamine and which contact dendritic spine necks, and 2) asymmetric terminal boutons of unknown chemical nature which end on dendritic spine heads. |
1991-11-04 |
2023-08-11 |
rat |
| G L Bernardini, X Gu, E Viscardi, D C Germa. Amphetamine-induced and spontaneous release of dopamine from A9 and A10 cell dendrites: an in vitro electrophysiological study in the mouse. Journal of neural transmission. General section. vol 84. issue 3. 1991-10-04. PMID:1679335. |
d-amphetamine (d-amp) is a potent releaser of dopamine (da), and its central nervous system stimulant action is mediated primarily through its effect on the substantia nigra and ventral tegmental area dopaminergic neurons (nuclei a9 and a10, respectively). |
1991-10-04 |
2023-08-11 |
mouse |
| J Guridi, M T Herrero, M R Luquin, J A Obes. [Cellular transplants for Parkinson's disease]. Neurologia (Barcelona, Spain). vol 6. issue 5. 1991-09-26. PMID:1873045. |
in rats with a lesion of the dopaminergic nigrostriatal pathway induced by 6-hydroxydopamine (6-ohda), the histologic and functional viability of the striatal implant of fetal mesencephalic substantia nigra has been demonstrated. |
1991-09-26 |
2023-08-11 |
rat |
| J P Bolam, C M Francis, Z Henderso. Cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1678502. |
cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. |
1991-09-13 |
2023-08-11 |
rat |
| J P Bolam, C M Francis, Z Henderso. Cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1678502. |
in order to determine whether the cholinergic fibres that innervate the substantia nigra make synaptic contact with dopaminergic neurons of the substantia nigra pars compacta, a double immunocytochemical study was carried out in the rat and ferret. |
1991-09-13 |
2023-08-11 |
rat |
| J P Bolam, C M Francis, Z Henderso. Cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1678502. |
it is concluded that at least one of the synaptic targets of cholinergic terminals in the substantia nigra are the dendrites and perikarya of dopaminergic neurons and that in the ferret at least, the dendrites of dopaminergic neurons that descend into the pars reticulata receive multiple synaptic inputs from individual cholinergic axons. |
1991-09-13 |
2023-08-11 |
rat |
| T Galli, G Godeheu, F Artaud, J M Desce, A Pittaluga, L Barbeito, J Glowsinki, A Chéram. Specific role of N-acetyl-aspartyl-glutamate in the in vivo regulation of dopamine release from dendrites and nerve terminals of nigrostriatal dopaminergic neurons in the cat. Neuroscience. vol 42. issue 1. 1991-08-30. PMID:1861773. |
n-acetyl-aspartyl-glutamate interacted with dopaminergic neurons not only presynaptically in the caudate nucleus but also in the substantia nigra since a marked increase in [3h]dopamine release was observed both from local dendrites and from nerve terminals in the ipsilateral caudate nucleus when n-acetyl-aspartyl-glutamate (10(-7) m) was infused locally into the substantia nigra pars compacta. |
1991-08-30 |
2023-08-11 |
cat |
| M A Smith, L S Brady, J Glowa, P W Gold, M Herkenha. Effects of stress and adrenalectomy on tyrosine hydroxylase mRNA levels in the locus ceruleus by in situ hybridization. Brain research. vol 544. issue 1. 1991-08-29. PMID:1677301. |
restraint stress increased tyrosine hydroxylase mrna in the locus ceruleus but not in dopaminergic nuclei such as the substantia nigra or ventral tegmental area. |
1991-08-29 |
2023-08-11 |
rat |
| C Humpel, A Saria, D Regol. Injection of tachykinins and selective neurokinin receptor ligands into the substantia nigra reticulata increases striatal dopamine and 5-hydroxytryptamine metabolism. European journal of pharmacology. vol 195. issue 1. 1991-08-15. PMID:1712305. |
the changes after high doses in the dorsal and ventral striatum may be due to actions on dopaminergic neurons in the substantia nigra as well as in the ventral tegmental area, since there was considerable diffusion from the site of injection. |
1991-08-15 |
2023-08-11 |
Not clear |
| M Corio, J Peute, H W Steinbusc. Distribution of serotonin- and dopamine-immunoreactivity in the brain of the teleost Clarias gariepinus. Journal of chemical neuroanatomy. vol 4. issue 2. 1991-08-02. PMID:2059346. |
in the midbrain of clarias gariepinus, no dopaminergic homologue of the substantia nigra was observed. |
1991-08-02 |
2023-08-11 |
Not clear |
| B Bjelke, K Andersson, S O Ogren, P Bolm. Asphyctic lesion: proliferation of tyrosine hydroxylase-immunoreactive nerve cell bodies in the rat substantia nigra and functional changes in dopamine neurotransmission. Brain research. vol 543. issue 1. 1991-08-01. PMID:1675922. |
furthermore, asphyxia resulted in an increased number of th-ir nerve cell bodies indicative of a proliferation of dopaminergic neurons in the zona compacta of the substantia nigra. |
1991-08-01 |
2023-08-11 |
rat |
| G S Robertson, A Fine, H A Robertso. Dopaminergic grafts in the striatum reduce D1 but not D2 receptor-mediated rotation in 6-OHDA-lesioned rats. Brain research. vol 539. issue 2. 1991-07-31. PMID:1675908. |
rats received fetal dopaminergic neuronal grafts in the striatum and/or substantia nigra ipsilateral to a 6-hydroxydopamine (6-ohda) lesion of the medial forebrain bundle (mfb). |
1991-07-31 |
2023-08-11 |
rat |
| G S Robertson, A Fine, H A Robertso. Dopaminergic grafts in the striatum reduce D1 but not D2 receptor-mediated rotation in 6-OHDA-lesioned rats. Brain research. vol 539. issue 2. 1991-07-31. PMID:1675908. |
fetal dopaminergic grafts in the ipsilateral substantia nigra (sn) did not augment the decreases in turning produced by concomitant ipsilateral dopaminergic grafts in the striatum in response to skf 38393. |
1991-07-31 |
2023-08-11 |
rat |