| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E K Richfiel. Quantitative autoradiography of the dopamine uptake complex in rat brain using [3H]GBR 12935: binding characteristics. Brain research. vol 540. issue 1-2. 1991-07-31. PMID:1829013. |
lesioning of the dopaminergic median forebrain bundle resulted in a dramatic loss of the dopamine uptake complex in the striatum, nucleus accumbens, olfactory tubercle, and substantia nigra. |
1991-07-31 |
2023-08-11 |
rat |
| T M Dawson, V L Dawson, F H Gage, L J Fisher, M A Hunt, J K Wamsle. Downregulation of muscarinic receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants. Brain research. vol 540. issue 1-2. 1991-07-31. PMID:1905173. |
the autoradiographic distribution and density of muscarinic receptors was studied in the neostriatum of rats with long-term unilateral 6-hydroxydopamine (6-ohda) lesions of the nigrostriatal dopaminergic pathway and in lesioned rats who had additionally received embryonic substantia nigra grafts in the dopamine denervated striatum. |
1991-07-31 |
2023-08-11 |
rat |
| M Gupta, M H Stoler, L H Fossom, A W Tan. Tyrosine hydroxylase mRNA in the dopaminergic neurons of young adult and aged mice by in situ hybridization. Neuroscience letters. vol 119. issue 1. 1991-07-19. PMID:1982959. |
tyrosine hydroxylase (th) mrna in the dopaminergic neurons of the substantia nigra (sn) and the ventral tegmental area (vta) in young adult and aged mice was detected and quantitated using in situ hybridization. |
1991-07-19 |
2023-08-11 |
mouse |
| T J Mahalik, G H Clayto. Specific outgrowth from neurons of ventral mesencephalic grafts to the catecholamine-depleted striatum of adult hosts. Experimental neurology. vol 113. issue 1. 1991-07-12. PMID:1710572. |
grafts of fetal ventral mesencephalon including substantia nigra have been used to correct some motor deficits produced by unilateral destruction of the dopaminergic nigrostriatal pathway in rats. |
1991-07-12 |
2023-08-11 |
rat |
| J L Neisewander, I Lucki, P McGonigl. Behavioral and neurochemical effects of chronic administration of reserpine and SKF-38393 in rats. The Journal of pharmacology and experimental therapeutics. vol 257. issue 2. 1991-06-24. PMID:2033524. |
however, chronic administration of the agonist in reserpinized animals decreased d1 receptor density in the nucleus accumbens, but not in the caudate-putamen or substantia nigra, demonstrating that this partial agonist can selectively down-regulate d1 receptors when endogenous dopaminergic tone is removed. |
1991-06-24 |
2023-08-11 |
rat |
| J Caboche, M Rogard, M J Besso. Comparative development of D1-dopamine and mu opiate receptors in normal and in 6-hydroxydopamine-lesioned neonatal rat striatum: dopaminergic fibers regulate mu but not D1 receptor distribution. Brain research. Developmental brain research. vol 58. issue 1. 1991-05-22. PMID:1849802. |
the possible influence of dopaminergic (da) fibers originating from the substantia nigra on the postnatal distribution of striatal d1 and mu receptors was also examined by producing an early 6-hydroxydopamine (6-ohda) lesion of da fibers. |
1991-05-22 |
2023-08-11 |
rat |
| A Depaulis, M Vergnes, Z Liu, E Kempf, C Marescau. Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat. Neuroscience. vol 39. issue 2. 1991-05-22. PMID:2128373. |
after selective destruction of dopaminergic neurons within the substantia nigra with 6-hydroxydopamine (5 micrograms/side) or hemisection of the ascending nigral output, bilateral intranigral injection of muscimol (2 ng/side) still significantly suppressed generalized non-convulsive seizures. |
1991-05-22 |
2023-08-11 |
rat |
| N J Riachi, W D Dietrich, S I Hari. Effects of internal carotid administration of MPTP on rat brain and blood-brain barrier. Brain research. vol 533. issue 1. 1991-05-20. PMID:2085733. |
unlike primates, rats are resistant to systemic 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (mptp) neurotoxicity, but direct infusion of mptp into rat substantia nigra causes specific destruction of dopaminergic neurons. |
1991-05-20 |
2023-08-11 |
rat |
| S Usui, H Fukuda, O Hikosak. [Spontaneous saccades in MPTP-induced hemi-parkinsonian monkeys]. Rinsho shinkeigaku = Clinical neurology. vol 30. issue 11. 1991-05-17. PMID:2085922. |
first, dopaminergic denervation due to mptp in the caudate nucleus may suppress the activity of neurons projecting to the pars reticulata of the substantia nigra. |
1991-05-17 |
2023-08-11 |
monkey |
| M N Castel, D Faucher, F Cuiné, P Dubédat, A Boireau, P M Laduro. Identification of intact neurotensin in the substantia nigra after its retrograde axonal transport in dopaminergic neurons. Journal of neurochemistry. vol 56. issue 5. 1991-05-16. PMID:2013766. |
identification of intact neurotensin in the substantia nigra after its retrograde axonal transport in dopaminergic neurons. |
1991-05-16 |
2023-08-11 |
Not clear |
| E K O'Malley, I B Black, C F Dreyfu. Local support cells promote survival of substantia nigra dopaminergic neurons in culture. Experimental neurology. vol 112. issue 1. 1991-05-14. PMID:1672852. |
to examine the regulation of neuronal survival, we have studied the substantia nigra (sn) dopaminergic (da) system, in dissociated cell culture. |
1991-05-14 |
2023-08-11 |
Not clear |
| P J Sweene. New concepts in Parkinson's disease. Hospital practice (Office ed.). vol 26. issue 4. 1991-05-07. PMID:1672693. |
as research has focused on environmental factors toxic to dopaminergic neurons of the substantia nigra, new therapies have emerged. |
1991-05-07 |
2023-08-11 |
Not clear |
| C Hyman, M Hofer, Y A Barde, M Juhasz, G D Yancopoulos, S P Squinto, R M Lindsa. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. vol 350. issue 6315. 1991-04-19. PMID:2005978. |
bdnf is a neurotrophic factor for dopaminergic neurons of the substantia nigra. |
1991-04-19 |
2023-08-11 |
cattle |
| C Hyman, M Hofer, Y A Barde, M Juhasz, G D Yancopoulos, S P Squinto, R M Lindsa. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. vol 350. issue 6315. 1991-04-19. PMID:2005978. |
here we report the effects of bdnf on the survival of dopaminergic neurons of the developing substantia nigra. |
1991-04-19 |
2023-08-11 |
cattle |
| J De Keyser, J P De Backer, G Vauquelin, G Ebinge. D1 and D2 dopamine receptors in human substantia nigra: localization and the effect of aging. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:1825842. |
since nigrostriatal dopaminergic neurons degenerate with aging, these results suggest either that the nigral d2 receptors are up-regulated in response to a progressive depletion of dopamine in the substantia nigra or that, in contrast to the rat, they are not located on dopaminergic neurons. |
1991-04-15 |
2023-08-11 |
human |
| D Ben-Shachar, G Eshel, J P Finberg, M B Youdi. The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:1900527. |
the ability of iron chelators to retard dopaminergic neurodegeneration in the substantia nigra may indicate a new therapeutic strategy in the treatment of parkinson's disease. |
1991-04-15 |
2023-08-11 |
rat |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
the gaba and substance p input to dopaminergic neurones in the substantia nigra of the rat. |
1991-03-19 |
2023-08-11 |
rat |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
in order to examine the synaptic input to dopaminergic neurones in the substantia nigra from gabaergic terminals and terminals that contain substance p, double and triple immunocytochemical studies were carried out at the light and electron microscopic levels in the rat. |
1991-03-19 |
2023-08-11 |
rat |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
in a first series of experiments sections of the substantia nigra were incubated to reveal axon terminals containing either substance p or glutamate decarboxylase and then incubated to reveal dopaminergic neurones using tyrosine hydroxylase immunocytochemistry. |
1991-03-19 |
2023-08-11 |
rat |
| J P Bolam, Y Smit. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain research. vol 529. issue 1-2. 1991-03-19. PMID:1704287. |
the results of the present study: (1) demonstrate that dopaminergic neurones in the substantia nigra receive symmetrical synaptic input from gabaergic and substance p-containing terminals, (2) show that a proportion of these terminals contain both substance p and gaba and (3) suggest that the major synaptic input to dopaminergic neurones is from gabaergic terminals and that a part of this innervation is derived from the striatum. |
1991-03-19 |
2023-08-11 |
rat |