| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Dhanushkodi, E O Akano, E E Roguski, Y Xue, S K Rao, S G Matta, T S Rex, M P McDonal. A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism. Genes, brain, and behavior. vol 12. issue 2. 2013-08-09. PMID:23190369. |
analysis of th-positive fibers in the striatum showed normalized density in mptp-lesioned mice pretreated with raav.epos71e, suggesting that enhanced sprouting induced by epos71e may have been responsible for normal behavior and dopaminergic tone in these mice. |
2013-08-09 |
2023-08-12 |
mouse |
| John P M Finber. Pharmacology of Rasagiline, a New MAO-B Inhibitor Drug for the Treatment of Parkinson's Disease with Neuroprotective Potential. Rambam Maimonides medical journal. vol 1. issue 1. 2013-08-05. PMID:23908775. |
although the exact distribution of mao isoforms in different neurons and tissues is not known, dopamine behaves largely as a mao-a substrate in vivo, but following loss of dopaminergic axonal varicosities from the striatum, metabolism by glial mao-b becomes increasingly important. |
2013-08-05 |
2023-08-12 |
human |
| Trent U Steidinger, Sunny R Slone, Huiping Ding, David G Standaert, Talene A Yacoubia. Angiogenin in Parkinson disease models: role of Akt phosphorylation and evaluation of AAV-mediated angiogenin expression in MPTP treated mice. PloS one. vol 8. issue 2. 2013-07-29. PMID:23409128. |
we found that angiogenin overexpression using this approach does not reduce the mptp-induced degeneration of dopaminergic cells in the substantia nigra, nor limit the depletion of dopamine and its metabolites in the striatum. |
2013-07-29 |
2023-08-12 |
mouse |
| Y Zhao, J Xiao, S Gong, J A Clara, M S Ledou. Neural expression of the transcription factor THAP1 during development in rat. Neuroscience. vol 231. 2013-07-25. PMID:23219941. |
in addition to purkinje cells in the cerebellum, thap1-ir was also localized to pyramidal neurons in the cerebral cortex, relay neurons in the thalamus, medium spiny and cholinergic neurons in the striatum, dopaminergic neurons in the substantia nigra, and pyramidal and interneurons in the hippocampus. |
2013-07-25 |
2023-08-12 |
rat |
| Marian E Berryhill, Martin Wiener, Jaclyn A Stephens, Falk W Lohoff, H Branch Coslet. COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383291. |
these findings link wm performance with slower dopaminergic metabolism in the prefrontal cortex as well as a greater density of dopamine receptors in the striatum. |
2013-07-17 |
2023-08-12 |
human |
| O M Littrell, J L Fuqua, A D Richardson, J Turchan-Cholewo, E R Hascup, P Huettl, F Pomerleau, L H Bradley, D M Gash, G A Gerhard. A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function. Neuropeptides. vol 47. issue 1. 2013-07-16. PMID:22981157. |
a major consequence of parkinson's disease (pd) involves the loss of dopaminergic neurons in the substantia nigra (sn) and a subsequent loss of dopamine (da) in the striatum. |
2013-07-16 |
2023-08-12 |
rat |
| Noelia Granado, Isabel Lastres-Becker, Sara Ares-Santos, Idaira Oliva, Eduardo Martin, Antonio Cuadrado, Rosario Moratall. Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Glia. vol 59. issue 12. 2013-07-08. PMID:21882243. |
nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. |
2013-07-08 |
2023-08-12 |
Not clear |
| David Devos, Caroline Moreau, Arnaud Delval, Kathy Dujardin, Luc Defebvre, Regis Borde. Methylphenidate : a treatment for Parkinson's disease? CNS drugs. vol 27. issue 1. 2013-07-03. PMID:23160937. |
given that the loss of dopamine in the striatum is the primary pathochemical hallmark in pd, pharmacological treatment of the disease has focused on restoring dopaminergic neurotransmission. |
2013-07-03 |
2023-08-12 |
Not clear |
| S Ares-Santos, N Granado, R Moratall. The role of dopamine receptors in the neurotoxicity of methamphetamine. Journal of internal medicine. vol 273. issue 5. 2013-07-02. PMID:23600399. |
genetic inactivation of dopamine d1 or d2 receptors protects against the loss of dopaminergic fibres in the striatum and loss of dopaminergic neurons in the substantia nigra. |
2013-07-02 |
2023-08-12 |
mouse |
| A Abi-Dargha. Recent evidence for dopamine abnormalities in schizophrenia. European psychiatry : the journal of the Association of European Psychiatrists. vol 17 Suppl 4. 2013-07-01. PMID:23573603. |
the evidence from pet and spect studies suggests that there is excess dopamine release subcortically, in the striatum, and that dopaminergic transmission may be abnormal in the cortex also, because of an upregulation in d1 receptors. |
2013-07-01 |
2023-08-12 |
Not clear |
| Ahmad Salti, Roxana Nat, Sonya Neto, Zoe Puschban, Gregor Wenning, Georg Dechan. Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. Stem cells and development. vol 22. issue 3. 2013-06-27. PMID:22889265. |
the profiles were applied to discrete stages of in vitro differentiation of mouse embryonic stem cells toward the dopaminergic lineage and after transplantation into the striatum of 6-hydroxy-dopamine-lesioned rats. |
2013-06-27 |
2023-08-12 |
mouse |
| Sonya Carvalho Neto, Ahmad Salti, Zoe Puschban, Nadia Stefanova, Roxana Nat, Georg Dechant, Gregor K Wennin. Cell fate analysis of embryonic ventral mesencephalic grafts in the 6-OHDA model of Parkinson's disease. PloS one. vol 7. issue 11. 2013-06-24. PMID:23209667. |
evidence from carefully conducted open label clinical trials suggested that therapeutic benefit can be achieved by grafting fetal dopaminergic (daergic) neurons derived from ventral mesencephalon (vm) into the denervated striatum of parkinson's disease (pd) patients. |
2013-06-24 |
2023-08-12 |
mouse |
| Takashi Konishi, Satoshi Kono, Masaya Fujimoto, Tatsuhiro Terada, Kozo Matsushita, Yasuomi Ouchi, Hiroaki Miyajim. Benign hereditary chorea: dopaminergic brain imaging in patients with a novel intronic NKX2.1 gene mutation. Journal of neurology. vol 260. issue 1. 2013-06-14. PMID:22825795. |
the dopaminergic pet studies in the two patients revealed decreased raclopride binding in the striatum, while the cft binding was not altered. |
2013-06-14 |
2023-08-12 |
Not clear |
| Despina Ziavra, Georgia Makri, Panagiotis Giompres, Stavros Taraviras, Dimitra Thomaidou, Rebecca Matsas, Ada Mitsacos, Elias D Kouvela. Neural stem cells transplanted in a mouse model of Parkinson's disease differentiate to neuronal phenotypes and reduce rotational deficit. CNS & neurological disorders drug targets. vol 11. issue 7. 2013-06-13. PMID:23131156. |
over-expression of the cell cycle exit and neuronal differentiation protein cend1 in npcs enhances the generation of gabaergic, but not dopaminergic, neuronal phenotypes after grafting in the lesioned striatum. |
2013-06-13 |
2023-08-12 |
mouse |
| Peizhou Jiang, Ming Gan, Shu-Hui C Ye. Dopamine prevents lipid peroxidation-induced accumulation of toxic α-synuclein oligomers by preserving autophagy-lysosomal function. Frontiers in cellular neuroscience. vol 7. 2013-06-12. PMID:23754979. |
the formation of lewy bodies containing α-synuclein (α-syn), prominent loss of dopaminergic neurons and dopamine (da) deficiency in substantia nigra and striatum are histopathological and biochemical hallmarks of parkinson's disease (pd). |
2013-06-12 |
2023-08-12 |
human |
| Mariana Raineri, Betina Gonzalez, Belen Goitia, Edgar Garcia-Rill, Irina N Krasnova, Jean Lud Cadet, Francisco J Urbano, Veronica Bisagn. Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum. PloS one. vol 7. issue 10. 2013-06-11. PMID:23056363. |
the aim of the present study was to investigate if modafinil could counteract methamphetamine-induced neuroinflammatory processes, which occur in conjunction with degeneration of dopaminergic terminals in the mouse striatum. |
2013-06-11 |
2023-08-12 |
mouse |
| Ioannis U Isaias, Jens Volkmann, Alberto Marzegan, Giorgio Marotta, Paolo Cavallari, Gianni Pezzol. The influence of dopaminergic striatal innervation on upper limb locomotor synergies. PloS one. vol 7. issue 12. 2013-06-11. PMID:23236504. |
dopaminergic innervation of the striatum was measured by fp-cit and spect. |
2013-06-11 |
2023-08-12 |
human |
| Michael C Reed, H Frederik Nijhout, Janet Bes. Computational studies of the role of serotonin in the basal ganglia. Frontiers in integrative neuroscience. vol 7. 2013-06-10. PMID:23745108. |
dopaminergic projections to the striatum inhibit the medium spiny neurons (msn) in the striatopalladal (indirect) pathway and excite msns in the striatonigral (direct) pathway. |
2013-06-10 |
2023-08-12 |
Not clear |
| Emelie Stenman, Asa Lilj. Increased monoaminergic neurotransmission improves compliance with physical activity recommendations in depressed patients with fatigue. Medical hypotheses. vol 80. issue 1. 2013-06-05. PMID:23127500. |
the prefrontal cortex, striatum and cerebellum) that control movement and initiative receive dopaminergic and noradrenergic projections. |
2013-06-05 |
2023-08-12 |
Not clear |
| Xuefeng Tan, Lei Zhang, JianBing Qin, Meiling Tian, Huixia Zhu, Chuanming Dong, Heyan Zhao, Guohua Ji. Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 1. 2013-05-30. PMID:23085081. |
the results showed that overexpression of nurr1 promoted nscs to differentiate into dopaminergic neurons in vivo, increased the level of dopamine (da) neurotransmitter in the striatum, resulting in behavioral improvement of pd rats. |
2013-05-30 |
2023-08-12 |
rat |