| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shangqi Sun, Liqin Huang, Gege Jiang, Guanfeng Xie, Xiaoyi Li, Xiufeng Wang, Hongxiu Guo, Cailin Wang, Siyi Zheng, Gang Li, Jing Xion. Neuroprotective effects of lixisenatide against propagation of α-synuclein pathology in Parkinson's disease. Neural regeneration research. 2025-03-27. PMID:40145958. |
additionally, lixisenatide treatment alleviated motor dysfunction and dopaminergic cell neurodegeneration 20 weeks after stereotactic injection of α-synuclein preformed fibrils into the striatum of wild-type mice. |
2025-03-27 |
2025-03-30 |
mouse |
| Yongmei Wu, Qiang Guo, Jinfan Gan, Linghan Duan, Haixia Zhao, Haoran Tai, Chan Yang, Yunzhu Li, Zhen Xu, Yue Yao, Zheng Nie, Ming Yang, Shurong Li, Jun Li, Bingyin S. Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson's disease. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 58. 2025-03-26. PMID:40136228. |
axons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of parkinson's disease (pd), with axonal degeneration preceding the loss of cell bodies. |
2025-03-26 |
2025-03-28 |
zebrafish |
| Daniela Mercatelli, Alberto Brugnoli, Anna Di Maio, Federica Albanese, Derya R Shimshek, Alessandro Usiello, Michele Morar. Enhancement of D1 dopaminergic responses in aged LRRK2 G2019S knock-in mice. Neurobiology of disease. 2025-03-22. PMID:40120831. |
we conclude that the lrrk2 g2019s mutation is associated with age-dependent enhancement of d1 dopaminergic responses, possibly due to elevated endogenous d1 transmission in striatum, that might be instrumental to sustain motor and cognitive function over ageing and help explain the slower and more benign course of g2019s-associated parkinson's disease. |
2025-03-22 |
2025-03-26 |
mouse |
| Andrea L Rosso, Emma M Baillargeon, Nico I Bohnen, Brian J Lopresti, Theodore J Huppert, Lana M Chahine, Erin Jacobsen, Caterina Rosan. Nigrostriatal dopaminergic integrity in relation to prefrontal cortex activity and gait performance during dual-task walking in older adults. medRxiv : the preprint server for health sciences. 2025-03-17. PMID:40093203. |
to compare nigrostriatal dopaminergic integrity across groups, we assessed binding of the type-2 vesicular monoamine transporter (vmat2) density in the sensorimotor and associative striatum using [ |
2025-03-17 |
2025-03-20 |
Not clear |
| Kaisa N Bornhoft, Julianna Prohofsky, Timothy J O'Neal, Amy R Wolff, Benjamin T Saunder. Striatal dopamine represents valence on dynamic regional scales. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025-03-17. PMID:40097183. |
cue-guided behavior depends on a network of brain systems, including dopaminergic projections to the striatum. |
2025-03-17 |
2025-03-20 |
rat |
| Auderlan M de Gois, José M M Bispo, Edson R Santos, Marina F Souza, João E C Melo, Mylaine S Mendonça, Thiago H Almeida-Souza, Enilton A Camargo, Katty A A L Medeiros, Pollyana C Leal, Heitor F Santos, Lívia C R F Lins, Alessandra M Ribeiro, Regina H Silva, José R Santo. β-2 agonist and antagonist adrenoceptors induce neuroprotection in a progressive model of parkinsonism. Neuropharmacology. vol 271. 2025-03-06. PMID:40023440. |
in immunohistochemical analysis both salbutamol and propranolol prevented dopaminergic damage in the substantia nigra pars compacta (snpc), ventral tegmental area (vta), striatum and noradrenergic damage in locus coeruleus (lc). |
2025-03-06 |
2025-03-09 |
rat |
| Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo, Veronica Ghiglieri, Paolo Calabres. Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease. Current neuropharmacology. 2025-02-24. PMID:39988779. |
since both serotonergic and dopaminergic afferents densely innervate many parts of the central nervous system, intact crosstalk between serotonin (5-ht) and dopamine (da) transmission is essential for regulating synaptic plasticity in the striatum (str), prefrontal cortex (pfc), and hippocampus (hpc).. |
2025-02-24 |
2025-02-26 |
Not clear |
| Manpreet Kaur, Khadga Raj Ara. Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson's disease. Metabolic brain disease. vol 40. issue 2. 2025-02-11. PMID:39932604. |
in this context, nrf2 exhibits neuroprotective action by preserving dopaminergic neurons in the striatum and retarding the disease progression; thus, nrf2 activation plays a crucial role in pd. |
2025-02-11 |
2025-02-13 |
Not clear |
| Axel Chemla, Giuseppe Arena, Ginevra Sacripanti, Kyriaki Barmpa, Alise Zagare, Pierre Garcia, Vyron Gorgogietas, Paul Antony, Jochen Ohnmacht, Alexandre Baron, Jaqueline Jung, Frida Lind-Holm Mogensen, Alessandro Michelucci, Anne-Marie Marzesco, Manuel Buttini, Thorsten Schmidt, Anne Grünewald, Jens C Schwamborn, Rejko Krüger, Cláudia Saraiv. Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss. Brain : a journal of neurology. 2025-02-06. PMID:39913247. |
knock-in mice expressing p.r285q miro1 (the orthologue of the human p.r272q mutation) displayed accumulation of phosphorylated α-synuclein in the striatum and a significant loss of dopaminergic neurons in the substantia nigra, accompanied by behavioral alterations. |
2025-02-06 |
2025-02-09 |
mouse |
| Ankumoni Dutta, Rubina Roy, Mritunjay Pandey, Sushila Chhetry, Banashree Chetia Phukan, Abhideep Roy, Pallab Bhattacharya, Anupom Bora. Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain. Brain research. 2025-02-05. PMID:39909295. |
in the present study, administration of 20 mg/kg b.w., arsenic for 28 days caused significant loss of dopaminergic neurons and their terminals respectively in the sn and striatum regions of mice brain. |
2025-02-05 |
2025-02-08 |
mouse |
| Mohammad Yasin Zamanian, Zahra Kamran, Marziye Ranjbar Tavakoli, Enwa Felix Oghenemaro, Mohammad Abohassan, Aziz Kubaev, Deepak Nathiya, Parjinder Kaur, Ahmed Hussein Zwamel, Resan Shakir Abdulame. The Role of ΔFosB in the Pathogenesis of Levodopa-Induced Dyskinesia: Mechanisms and Therapeutic Strategies. Molecular neurobiology. 2025-01-31. PMID:39890697. |
Δfosb accumulates within the striatum in response to chronic dopaminergic stimulation, thereby driving maladaptive changes that culminate in dyskinesia. |
2025-01-31 |
2025-02-04 |
Not clear |
| Illia Mushta, Sulev Koks, Anton Popov, Oleksandr Lysenk. Exploring the Potential Imaging Biomarkers for Parkinson's Disease Using Machine Learning Approach. Bioengineering (Basel, Switzerland). vol 12. issue 1. 2025-01-24. PMID:39851285. |
dopamine transporter scan (datscan), based on single-photon emission computed tomography (spect), is commonly used to evaluate the loss of dopaminergic neurons in the striatum. |
2025-01-24 |
2025-01-27 |
Not clear |
| Frederik O Hansen, Karoline Knudsen, Malene F Damholdt, Toke Bek, Per Borghammer, Niels Okkel. Non-motor asymmetry and dopamine degeneration in Parkinson's disease. Brain communications. vol 7. issue 1. 2025-01-23. PMID:39845733. |
asymmetric dopaminergic degeneration of the striatum is a characteristic feature of parkinson's disease, associated with right-left asymmetry in motor function. |
2025-01-23 |
2025-01-25 |
Not clear |
| Adam G O'Mahony, Martina Mazzocchi, Alex Morris, Noelia Morales-Prieto, Caitriona Guinane, Sean L Wyatt, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. The class-IIa HDAC inhibitor TMP269 promotes BMP-Smad signalling and is neuroprotective in in vitro and in vivo 6-hydroxydopamine models of Parkinson's disease. Neuropharmacology. 2025-01-22. PMID:39842624. |
tmp269 also protected dopaminergic neurons in the substantia nigra and their striatal terminals from striatal 6-ohda-induced neurodegeneration and prevented the 6-ohda-induced increases in the numbers of iba1-positive microglia in the striatum and substantia nigra in vivo. |
2025-01-22 |
2025-01-25 |
rat |
| Liqiang Chen, Hiba Douja Chehade, Hong-Yuan Ch. Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation. NPJ Parkinson's disease. vol 11. issue 1. 2025-01-14. PMID:39809792. |
to begin to address this question, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. |
2025-01-14 |
2025-01-17 |
mouse |
| Maria E Bianchetti, Ana Flavia F Ferreira, Luiz R G Britt. Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model. Frontiers in neuroanatomy. vol 18. 2024-12-31. PMID:39736920. |
all animals were euthanized on day 10 and immunohistochemistry techniques were performed to detect tyrosine hydroxylase (th) and iba-1 and thus label dopaminergic neurons and microglia in the snc and striatum (cpu). |
2024-12-31 |
2025-01-02 |
mouse |
| I N Rozhkova, S V Okotrub, E Yu Brusentsev, T A Rakhmanova, D A Lebedeva, V S Kozeneva, N A Shavshaeva, N V Khotskin, S Ya Amstislavsk. Substantia nigra alterations in mice modeling Parkinson's disease. Vavilovskii zhurnal genetiki i selektsii. vol 28. issue 7. 2024-12-26. PMID:39722665. |
the density of neurons in the prefrontal cortex, hippocampus, substantia nigra and striatum in b6.cg-tg mice was assessed in our previous work, but the dopaminergic system was not studied there, although it plays a key role in the development of pd. |
2024-12-26 |
2024-12-29 |
mouse |
| Krishn Kumar Agrawal, Chandra Veer, Yogesh Murti, Sunil Pratap Sing. Lead Phytomolecules for Treating Parkinson's Disease. Central nervous system agents in medicinal chemistry. 2024-12-19. PMID:39698888. |
one percent of persons over 65 years of age suffer from parkinson's disease, a neurological ailment marked by dopaminergic neurons in the nigrostriatal pathway gradually dying and being depleted in the striatum. |
2024-12-19 |
2024-12-21 |
Not clear |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
therefore, we aimed to investigate whether shank3 deficiency (shank3b) leads to changes in the morphology of primary neuronal cell cultures from dopaminergic brain regions of neonatal mouse pups and whether it results in alterations in synaptic proteins in dopaminergic nerve pathway projection areas (striatum, frontal cortex). |
2024-12-09 |
2024-12-12 |
mouse |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
significantly reduced neurite outgrowth was observed in primary dopaminergic neurons from the midbrain and striatum of shank3-deficient compared to wt mice. |
2024-12-09 |
2024-12-12 |
mouse |