| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fuyuki Karube, Yang Yang, Kenta Kobayashi, Fumino Fujiyam. Anterograde trans-neuronal labeling of striatal interneurons in relation to dopamine neurons in the substantia nigra pars compacta. Frontiers in neuroanatomy. vol 18. 2024-03-14. PMID:38482378. |
using immunofluorescence against neurotransmitter transporters, almost all axons in the striatum visualized using this approach were confirmed to be dopaminergic. |
2024-03-14 |
2024-03-16 |
Not clear |
| Wan-Hsuan Chang, Hung-Te Hsu, Chih-Cheng Lin, Li-Mei An, Chien-Hsing Lee, Horng-Huey Ko, Chih-Lung Lin, Yi-Ching L. Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473763. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta (snpc), resulting in reduced dopamine levels in the striatum and eventual onset of motor symptoms. |
2024-03-13 |
2024-03-15 |
Not clear |
| Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng H. Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 127. 2024-03-12. PMID:38471370. |
parkinson's disease (pd), a neurodegenerative disorder, is characterized by motor symptoms due to the progressive loss of dopaminergic neurons in the substantia nigra (sn) and striatum (str), alongside neuroinflammation. |
2024-03-12 |
2024-03-15 |
Not clear |
| Raul Izidoro Ribeiro, Gustavo Almeida Carvalho, Raphaela Almeida Chiareli, Isabel Vieira de Assis Lima, Paula Maria Quaglio Bellozi, Onésia Cristina Oliveira Lima, Ágatha Oliveira Giacomelli, Alexander Birbrair, Renato Santiago Gomez, Antônio Carlos Pinheiro de Oliveira, Henning Ulrich, Mauro Cunha Xavier Pint. Glycine transporter-1 inhibition by NFPS promotes neuroprotection against striatal damage models. Neuroscience letters. 2024-03-09. PMID:38460902. |
the results indicated that nfps pre-treatment conferred significant neuroprotection, reducing neuronal degeneration, protecting dopaminergic neurons, and preserving dendritic spines within the striatum. |
2024-03-09 |
2024-03-12 |
Not clear |
| Kanika Bhardwaj, Neelu Kanwar Rajawat, Nupur Mathu. Development of Alpha-Synuclein protein model against therapeutic aspects of Parkinson's disease. Indian journal of pharmacology. vol 56. issue 1. 2024-03-08. PMID:38454587. |
journal/ijpha/04.03/01363791-202456010-00007/figure1/v/2024-03-07t095025z/r/image-tiff parkinson's disease (pd) is the most common neurodegenerative disease caused by the steady depletion of dopamine in the striatum due to the loss of dopaminergic neurons. |
2024-03-08 |
2024-03-10 |
Not clear |
| Samir Ranjan Panda, Pallabi Panja, Ujjawal Soni, V G M Naid. Neurobehavioral Analysis to Assess Olfactory and Motor Dysfunction in Parkinson's Disease. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427259. |
the striatum, a structure essential for motor control, is impaired in function due to the significant loss of dopaminergic neurons in the substantia nigra and the development of lewy bodies in the surviving nigral dopaminergic neurons. |
2024-03-01 |
2024-03-03 |
Not clear |
| Alagudurai Krishnamoorthy, Riddhi Upadhyay, Murugan Sevana. Chrysin for Neurotrophic and Neurotransmitter Balance in Parkinson's Disease. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427256. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) has a direct impact on the dopaminergic neurons in the substantia nigra pars compacta (snpc), dopamine in the striatum (st), homovanillic acid (hva), neurotrophic factors of the snpc, and st regions leading to parkinson's disease (pd). |
2024-03-01 |
2024-03-03 |
mouse |
| Mingjie Zhang, Congyan Duan, Weifang Lin, Honghua Wu, Lu Chen, Hong Guo, Minyu Yu, Qi Liu, Yaling Nie, Hong Wang, Shaoxia Wan. Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease. Molecules (Basel, Switzerland). vol 29. issue 4. 2024-02-24. PMID:38398662. |
in vivo experiments further corroborated these findings, demonstrating that la mitigated the death of th-positive dopaminergic neurons and reduced microglia activation in the ventral snpc brain region of the midbrain and the striatum. |
2024-02-24 |
2024-02-26 |
Not clear |
| Lingling Zhang, Hao Yan. Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson's disease. Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400887. |
parkinson's disease (pd) is a neurodegenerative disease, the most characteristic pathological feature is the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compactus (snpc) of the mesencephalon, along with reduced dopamine content in the striatum. |
2024-02-24 |
2024-02-27 |
Not clear |
| Ashley Centner, Isabella Del Priore, Nicole Chambers, Sophie R Cohen, Michelle L Terry, Michael Coyle, John Glinski, Anna C Stoll, Joseph R Patterson, Christopher J Kemp, Kathryn M Miller, Michael Kubik, Nathan Kuhn, Kelvin C Luk, Caryl E Sortwell, Christopher Bisho. Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study. The European journal of neuroscience. 2024-02-15. PMID:38356120. |
our studies provide insight into the time course and magnitude of pff-induced extracellular dopaminergic deficits in the striatum. |
2024-02-15 |
2024-02-17 |
rat |
| Arianna R S Lark, Sara R Nass, Yun K Hahn, Benlian Gao, Ginger L Milne, Pamela E Knapp, Kurt F Hause. HIV-1 Tat and morphine interactions dynamically shift striatal monoamine levels and exploratory behaviors over time. Journal of neurochemistry. 2024-02-03. PMID:38308495. |
evidence suggests that dopaminergic neurotransmission is disrupted by hiv exposure, however, little is known about whether co-exposure to opioids may alter neurotransmitter levels in the striatum and if this in turn influences behavior. |
2024-02-03 |
2024-02-05 |
mouse |
| Chong-Lei Fu, Bo-Cheng Dong, Xi Jiang, Dan Li, Jun Ya. A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson's disease mouse model. Heliyon. vol 10. issue 2. 2024-01-31. PMID:38293351. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the degeneration of dopaminergic (da) neurons in the substantia nigra and loss of da transmission in the striatum, thus making cell transplantation an effective treatment strategy. |
2024-01-31 |
2024-02-02 |
mouse |
| Alexander Blagov, Anton Postnov, Vasily Sukhorukov, Mikhail Popov, Jamol Uzokov, Alexander Orekho. Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease. Frontiers in bioscience (Landmark edition). vol 29. issue 1. 2024-01-30. PMID:38287806. |
parkinson's disease (pd) is characterized by the degeneration of the dopaminergic neurons of the corpus striatum, which can be caused by the disruption of processes of mitochondrial homeostasis, including mitophagy, mitochondrial fusion and division, mitochondrial transport, accumulation of reactive oxygen species (ros), and calcium signaling. |
2024-01-30 |
2024-02-01 |
Not clear |
| Ignacio Serrano-Martínez, Marta Pedreño, Julia Castillo-González, Viviane Ferraz-de-Paula, Pablo Vargas-Rodríguez, Irene Forte-Lago, Marta Caro, Jenny Campos-Salinas, Javier Villadiego, Pablo Peñalver, Juan Carlos Morales, Mario Delgado, Elena González-Re. Cortistatin as a Novel Multimodal Therapy for the Treatment of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255772. |
we observed that treatment with cortistatin mitigated the mptp-induced loss of dopaminergic neurons in the substantia nigra and their connections to the striatum. |
2024-01-23 |
2024-01-25 |
mouse |
| Ramasamy Thangavel, Harleen Kaur, Iuliia Dubova, Govindhasamy Pushphavathi Selvakumar, Mohammad Ejaz Ahmed, Sudhanshu P Raikwar, Raghav Govindarajan, Duraisamy Kempura. Parkinson's Disease Dementia Patients: Expression of Glia Maturation Factor in the Brain. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256254. |
we detected a large number of gmf-positive glial fibrillary acidic protein (gfap) reactive astrocytes, especially abundant in areas with degenerating dopaminergic neurons within the sn and striatum in pdd. |
2024-01-23 |
2024-01-25 |
human |
| Adam Wojtas, Krystyna Gołembiowsk. Molecular and Medical Aspects of Psychedelics. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203411. |
the data show a significant effect of nbomes on glutamatergic, dopaminergic, serotonergic, and cholinergic neurotransmission in the frontal cortex, striatum, and nucleus accumbens. |
2024-01-11 |
2024-01-13 |
rat |
| Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin O'Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Høegh, Trine Lagerberg, Weiqiu Cheng, Tyler Seibert, Srdjan Djurovic, Anders Dale, Hang Zhou, Howard Edenberg, Joel Gelernter, Olav Smeland, Guy Hindley, Ole Andreasse. Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million Individuals. Research square. 2024-01-10. PMID:38196616. |
loci were mapped to genes enriched for brain regions relevant for aud (striatum, hypothalamus, and prefrontal cortex) and potential drug targets (gabaergic, dopaminergic and serotonergic neurons). |
2024-01-10 |
2024-01-13 |
Not clear |
| Maria João Nunes, Andreia Neves Carvalho, Alexandra I Rosa, Paula A Videira, Maria João Gama, Elsa Rodrigues, Margarida Castro-Calda. Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease. Journal of molecular medicine (Berlin, Germany). 2024-01-10. PMID:38197965. |
importantly, our results show that mptp triggers the presentation of more proteins decorated with slex in mouse cortex and striatum in a time-dependent manner, as well as increased mrna expression of its rate-limiting enzyme fucosyltransferase 7. slex is expressed in neurons, including dopaminergic neurons, and microglia. |
2024-01-10 |
2024-01-13 |
mouse |
| Ge Shi, Chunhui Zhang, Xinghua Bai, Jian Sun, KaiDong Wang, Qi Meng, Yang Li, Guiling Hu, Rong Hu, Qian Cai, Min Huan. A potential mechanism clue to the periodic storm from microglia activation and progressive neuron damage induced by paraquat exposure. Environmental toxicology. 2024-01-08. PMID:38189626. |
in addition, we observed the fluorescence intensity enhancement of iba-1 activated microglia with released pro-inflammatory, all ahead of both the damage of dopaminergic neurons in the substantia nigra and corpus striatum of the brain. |
2024-01-08 |
2024-01-10 |
mouse |
| Sora Kang, Youngjin Noh, Seung Jun Oh, Hye Ji Yoon, Suyeol Im, Hung Taeck Kwon, Youngmi Kim Pa. Neuroprotective Effects of Aldehyde-Reducing Composition in an LPS-Induced Neuroinflammation Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 28. issue 24. 2023-12-23. PMID:38138478. |
oral administration of arc at 10 or 20 units/kg/day for 3 days prior to intraperitoneal injection of lps (10 mg/kg) effectively preserved dopaminergic neurons in the substantia nigra (sn) and striatum by preventing lps-induced cell death. |
2023-12-23 |
2023-12-25 |
Not clear |