| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Cui, Yun Shi, Hui Hong, Yu Zhou, Chenmeng Qiao, Liping Zhao, Xuebing Jia, Weijiang Zhao, Yanqin She. 5-HT4 Receptor is Protective for MPTP-induced Parkinson's Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-10-02. PMID:37782386. |
in addition, gr 125487 pretreatment exacerbated the loss of dopaminergic neurons probably by suppressing jak2/pka/creb signaling pathway and increased reactive glia and neuroinflammation in the striatum. |
2023-10-02 |
2023-10-07 |
mouse |
| Jingbo Wang, Sabitha Joseph, Siv Vingill, Ekrem Dere, Lars Tatenhorst, Anja Ronnenberg, Paul Lingor, Christian Preisinger, Hannelore Ehrenreich, Jörg B Schulz, Judith Stegmülle. Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects. Journal of neurochemistry. 2023-09-27. PMID:37753846. |
nex-cre;fbxo7fl/fl mice revealed an increase in striatal dopamine concentrations, changes in the glutamatergic, gabaergic and dopaminergic pathways, astrogliosis and microgliosis and little or no neuronal loss in the striatum. |
2023-09-27 |
2023-10-07 |
mouse |
| Shirley D Wenker, María Isabel Farias, Victoria Gradaschi, Corina Garcia, Juan Beauquis, María Celeste Leal, Carina Ferrari, Xianmin Zeng, Fernando J Pitoss. Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors. PloS one. vol 18. issue 9. 2023-09-26. PMID:37751438. |
we first observed that transplanted human dopaminergic precursors into the striatum of immunosuppressed rats elicited an early and sustained activation of astroglial and microglial cells after 15 days' post-transplant. |
2023-09-26 |
2023-10-07 |
human |
| Brittany Liebenow, Thomas Wilson, Benjamin Maas, Emily Aladnani, Rosalyn J Moran, Jason White, Terry Lohrenz, Ihtsham Ul Haq, Mustafa S Siddiqui, Adrian W Laxton, Stephen B Tatter, P Read Montague, Kenneth T Kishid. Sub-second Dopamine Signals during Risky Decision-Making in Patients with Impulse Control Disorder. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745618. |
prior research implicates changes in striatal function and heightened dopaminergic activity in the dorsal striatum of patients with icd. |
2023-09-25 |
2023-10-07 |
Not clear |
| Meng Ji, Shi-Qin Niu, He-Yin Mi, Peng Jiang, Yue L. Vinpocetine improves dyskinesia in Parkinson's disease rats by reducing oxidative stress and activating the Wnt/β-catenin signaling pathway. Chemical biology & drug design. 2023-09-25. PMID:37749299. |
besides, h&e staining was applied to observe the changes of dopaminergic neurons in the striatum. |
2023-09-25 |
2023-10-07 |
rat |
| Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan, Jie Za. FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA. Journal of translational medicine. vol 21. issue 1. 2023-09-22. PMID:37737187. |
parkinson's disease (pd), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment. |
2023-09-22 |
2023-10-07 |
human |
| Emily K DiMarco, Renata Sadibolova, Angela Jiang, Brittany Liebenow, Rachel E Jones, Ihtsham U Haq, Mustafa S Siddiqui, Devin B Terhune, Kenneth T Kishid. Time perception reflects individual differences in motor and non-motor symptoms of Parkinson's disease. Parkinsonism & related disorders. vol 114. 2023-09-04. PMID:37595329. |
notably, dopaminergic signaling in the striatum has been shown to play a critical role in the perception of time. |
2023-09-04 |
2023-09-07 |
Not clear |
| Louisa A Christie, Nicola L Brice, Anna Rowland, Louise Dickson, Rishi Anand, Martin Teall, Kevin J Doyle, Lakshminarayana Narayana, Christine Mitchell, Jenna R M Harvey, Victoria Mulligan, Lee A Dawson, Stephanie J Cragg, Mark Carlton, Roland W Bürl. Discovery of Journal of medicinal chemistry. 2023-08-31. PMID:37651656. |
discovery of nicotinic acetylcholine receptor (nachr) α6 subunit rna expression is relatively restricted to midbrain regions and is located presynaptically on dopaminergic neurons projecting to the striatum. |
2023-08-31 |
2023-09-07 |
Not clear |
| Peter van Ruitenbeek, Luisa Franzen, Natasha Leigh Mason, Peter Stiers, Johannes G Ramaeker. Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective. Frontiers in psychiatry. vol 14. 2023-08-21. PMID:37599874. |
both disorders are characterized by maladaptive goal-directed behavior, impaired cognitive control, hyperactive phasic dopaminergic neurotransmission in the striatum, prefrontal hypoactivation, and reduced frontal cortex gray matter volume/density. |
2023-08-21 |
2023-09-07 |
Not clear |
| Miguel A Zamora-Ursulo, Job Perez-Becerra, Luis A Tellez, Nadia Saderi, Luis Carrillo-Rei. Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging. PloS one. vol 18. issue 8. 2023-08-20. PMID:37594935. |
we conclude that optical delivery of dopamine in the striatum resembles the motor effects induced by systemic injection of dopaminergic agonists in unilateral dopamine-depleted mice. |
2023-08-20 |
2023-09-07 |
mouse |
| Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
in this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal's repertoire in which the brainstem is strongly involved. |
2023-08-18 |
2023-09-07 |
Not clear |
| Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
we consider what is known about how these structures are related to the basal ganglia, focusing on their projections toward the striatum, dopaminergic neurons and subthalamic nucleus, and explore the functional consequences of those interactions. |
2023-08-18 |
2023-09-07 |
Not clear |
| Akiko Terauchi, Patricia Yee, Erin M Johnson-Venkatesh, Mariel P Seiglie, Lisa Kim, Julia C Pitino, Eli Kritzer, Qiyu Zhang, Jie Zhou, Yulong Li, David D Ginty, Wei-Chung A Lee, Hisashi Umemor. The projection-specific signals that establish functionally segregated dopaminergic synapses. Cell. 2023-08-17. PMID:37591240. |
there are two anatomically and functionally distinct dopaminergic projections connecting the midbrain to striatum: nigrostriatal, which controls movement, and mesolimbic, which regulates motivation. |
2023-08-17 |
2023-09-07 |
mouse |
| Rafael Campos-Martin, Katharina Bey, Björn Elsner, Benedikt Reuter, Julia Klawohn, Alexandra Philipsen, Norbert Kathmann, Michael Wagner, Alfredo Ramire. Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response. Molecular psychiatry. 2023-08-16. PMID:37587247. |
these 12 cpgs are close to or in genes associated with the sweet-compulsive brain hypothesis which proposes that aberrant dopaminergic transmission in the striatum may impair insulin signaling sensitivity among ocd patients. |
2023-08-16 |
2023-09-07 |
Not clear |
| Heba A Farid, Rabab H Sayed, Marwa El-Sayed El-Shamarka, Omar M E Abdel-Salam, Nesrine S El Saye. PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson's disease in rats. Inflammopharmacology. 2023-08-04. PMID:37541971. |
rats treated with roflumilast showed an improvement in motor activity and coordination as well as preservation of dopaminergic neurons in the striatum. |
2023-08-04 |
2023-08-14 |
rat |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
it is well established that midbrain dopaminergic neurons support reinforcement learning (rl) in the basal ganglia by transmitting a reward prediction error (rpe) to the striatum. |
2023-08-01 |
2023-08-14 |
Not clear |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
inspired by the recent observations that besides rpe, the firing rates of midbrain dopaminergic neurons correlate with motor and cognitive variables, we propose a model in which dopamine signal in the striatum carries a vector-valued error feedback signal (a loss gradient) instead of a homogeneous scalar error (a loss). |
2023-08-01 |
2023-08-14 |
Not clear |
| Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang B. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-26. PMID:37495085. |
the higher expression of clec7a was observed in the substantia nigra (sn) and striatum of pd rats with dopaminergic neurons damage and was mainly localized in the microglial. |
2023-07-26 |
2023-08-14 |
rat |
| Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang B. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-26. PMID:37495085. |
adeno-associated virus (aav)-mediated specific knockdown of clec7a in microglial alleviated 6-ohda induced motor deficits and nigrostriatal dopaminergic neuron damage of rats, as evidenced by the increase of tyrosine hydroxylase (th) -positive neurons in sn, as well as dopaminergic nerve fibers in the striatum. |
2023-07-26 |
2023-08-14 |
rat |
| Haoran Peng, Siyuan Chen, Shaopu Wu, Xiaoxue Shi, Jianjun Ma, Hongqi Yang, Xue L. Alpha-synuclein in skin as a high-quality biomarker for Parkinson's disease. Journal of the neurological sciences. vol 451. 2023-07-16. PMID:37454572. |
parkinson's disease (pd), the most common neurological motor system disorder, which characterised by the irreversible loss of dopaminergic neurones in the substantia nigra pars compacta, and leads to the deficiency of dopamine in the striatum. |
2023-07-16 |
2023-08-14 |
human |