| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeongmin Park, Jeong Heon Gong, Yubing Chen, Thu-Hang Thi Nghiem, Sonam Chandrawanshi, Eunyeong Hwang, Chae Ha Yang, Byung-Sam Kim, Jeong Woo Park, Stefan W Ryter, Byungyong Ahn, Yeonsoo Joe, Hun Taeg Chung, Rina Y. Activation of ROS-PERK-TFEB by Filbertone Ameliorates Neurodegenerative Diseases via Enhancing the Autophagy-Lysosomal Pathway. The Journal of nutritional biochemistry. 2023-03-23. PMID:36958418. |
we also demonstrate that filbertone prevented the loss of dopaminergic neurons in the substantia nigra and striatum of mice on high-fat diet (hfd). |
2023-03-23 |
2023-08-14 |
mouse |
| Emily DiMarco, Renata Sadibolova, Angela Jiang, Brittany Liebenow, Rachel E Jones, Ihtsham Ul Haq, Mustafa S Siddiqui, Devin B Terhune, Kenneth T Kishid. Time perception reflects individual differences in motor and non-motor symptoms of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909605. |
dopaminergic signaling in the striatum has been shown to play a critical role in the perception of time. |
2023-03-13 |
2023-08-14 |
Not clear |
| Sarah Amato, Monica Averna, Diego Guidolin, Cristina Ceccoli, Elena Gatta, Simona Candiani, Marco Pedrazzi, Michela Capraro, Guido Maura, Luigi F Agnati, Chiara Cervetto, Manuela Marcol. Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902106. |
in conclusion, roles for astrocytic d2-otr in the control of glutamatergic synapse functioning through modulation of astrocytic glutamate release should be taken into consideration when considering interactions between oxytocinergic and dopaminergic systems in striatum. |
2023-03-11 |
2023-08-14 |
rat |
| Giulia Costa, Marcello Serra, Riccardo Maccioni, Maria Antonietta Casu, Sanjay B Kasture, Elio Acquas, Micaela Morell. Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 161. 2023-03-11. PMID:36905810. |
thereafter, immunohistochemistry was performed to evaluate in the substantia nigra pars compacta (snc) and striatum the levels of tyrosine hydroxylase (th), as marker of dopaminergic degeneration, and of glial fibrillary acidic protein (gfap) and tmem119, as markers of astrogliosis or microgliosis, respectively. |
2023-03-11 |
2023-08-14 |
mouse |
| Hongli Li, Min Gao, Ziyu Chen, Zhenyu Zhou, Wei Li, Xiaoyang Zhang, Xi Jiang, Lingling Luo, Fei Li, Gaorui Wang, Yu Zhang, Xingxu Huang, Jingning Zhu, Shengjie Fan, Xiaojun Wu, Cheng Huan. Hordenine improves Parkinsonian-like motor deficits in mice and nematodes by activating dopamine D2 receptor-mediated signaling. Phytotherapy research : PTR. 2023-03-08. PMID:36883794. |
parkinson's disease (pd) is a chronic neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and the striatum, leading to dopamine (da) deficiency in the striatum and typical motor symptoms. |
2023-03-08 |
2023-08-14 |
mouse |
| Jayantee Kalita, Abhilasha Tripathi, Mahesh Jadhav, Ravindra S Thakur, Devendra K Pate. A Study of Dopaminergic Pathway in Neurologic Wilson Disease with Movement Disorder. Molecular neurobiology. 2023-03-06. PMID:36879138. |
the central nervous system dopaminergic pathway is not enhanced in nwd, which may be due to structural damage to the corpus striatum and/or substantia nigra. |
2023-03-06 |
2023-08-14 |
Not clear |
| Sandeep, Manas Ranjan Sahu, Linchi Rani, Arun S Kharat, Amal Chandra Monda. Could Vitamins Have a Positive Impact on the Treatment of Parkinson's Disease? Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831815. |
pathophysiologically, it is characterized by intracytoplasmic aggregates of α-synuclein protein in the lewy body and loss of dopaminergic neurons from substantia nigra pars compacta and striatum regions of the brain. |
2023-02-25 |
2023-08-14 |
Not clear |
| Ashley L Holloway, Michael D Schaid, Talia N Lerne. Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-02-22. PMID:36810463. |
chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms. |
2023-02-22 |
2023-08-14 |
mouse |
| Roger A Barker, Anders Björklun. Restorative cell and gene therapies for Parkinson's disease. Handbook of clinical neurology. vol 193. 2023-02-21. PMID:36803812. |
as such, there has been much interest in trying to better reconstitute the dopaminergic nigrostriatal pathway using either factors to regrow it, cells to replace it, or gene therapies to restore dopamine transmission in the striatum. |
2023-02-21 |
2023-08-14 |
Not clear |
| Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E Greene, Pietro De Camilli, Mian Ca. Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology. NPJ Parkinson's disease. vol 9. issue 1. 2023-02-15. PMID:36792618. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by defective dopaminergic (daergic) input to the striatum. |
2023-02-15 |
2023-08-14 |
Not clear |
| Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li, Zengfu Liu, Jiayun Zheng, Yunxin Wang, Hanqun Liu, Lijian Wei, Yilin Su, Yuwan Lin, Wei Dai, Zhiling Zhang, Xiang Chen, Liuyan Ding, Wenyuan Guo, Xiaoqin Zhu, Pingyi Xu, Mingshu M. Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease. Frontiers in aging neuroscience. vol 14. 2023-02-06. PMID:36742201. |
parkinson's disease (pd) is a progressive neurodegenerative disease with characteristic pathological abnormalities, including the loss of dopaminergic (da) neurons, a dopamine-depleted striatum, and microglial activation. |
2023-02-06 |
2023-08-14 |
rat |
| Tahereh Sohrabi, Behnaz Mirzaei-Behbahani, Ramin Zadali, Mitra Pirhaghi, Ludmilla A Morozova-Roche, Ali Akbar Merata. Common Mechanisms Underlying α-Synuclein-Induced Mitochondrial Dysfunction in Parkinson's Disease. Journal of molecular biology. 2023-02-03. PMID:36736886. |
parkinson's disease (pd) is the most common neurological movement disorder characterized by the selective and irreversible loss of dopaminergic neurons in substantia nigra pars compacta resulting in dopamine deficiency in the striatum. |
2023-02-03 |
2023-08-14 |
Not clear |
| Liping Zhou, Deqiang Han, Xingzhe Wang, Zhiguo Che. Probiotic Formulation VSL#3 Interacts with Mesenchymal Stromal Cells To Protect Dopaminergic Neurons via Centrally and Peripherally Suppressing NOD-Like Receptor Protein 3 Inflammasome-Mediated Inflammation in Parkinson's Disease Mice. Microbiology spectrum. 2023-02-02. PMID:36728426. |
hmscs, vsl#3 alone, and their combination markedly ameliorated the decreased striatal dopamine content, loss of dopaminergic neurons in the substantia nigra, increased levels of proinflammatory cytokines in serum, as well as tumor necrosis factor alpha (tnf-α) and interleukin-1β (il-1β) mrnas in striatum and peripheral tissues induced by mptp. |
2023-02-02 |
2023-08-14 |
mouse |
| Qionghui Cai, Na Xu, Yan He, Jiamin Zhu, Fenfen Ye, Zhi Luo, Ruojun Lu, Linshan Huang, Feiyang Zhang, Jiang-Fan Chen, Yan L. α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine A International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674880. |
here, we coupled two unique behavioral paradigms with two pd models to reveal the following: (i) focally injecting α-syn fibrils into the dorsolateral striatum (dls) and the transgenic expression of a53t-α-syn in the dopaminergic neurons in the substantia nigra (sn, pitx3-ires2-tta/teto-a53t mice) selectively impaired forelimb fine movements induced by the single-pellet reaching task. |
2023-01-21 |
2023-08-14 |
mouse |
| Yu Guo, Huan Zhu, Yuanyuan Wang, Tingting Sun, Jiajia Xu, Tie Wang, Weijun Guan, Chunjing Wang, Changqing Liu, Caiyun M. Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson's disease model. Cell and tissue research. 2023-01-16. PMID:36645476. |
histological studies showed that the grafted cells could migrate and differentiate into various neurocytes, including gabaergic, dopaminergic neurons, and glial cells in vivo, and many induced dopaminergic neurons extended dense neurites into the host striatum. |
2023-01-16 |
2023-08-14 |
rat |
| Carmen F M van Hooijdonk, Marieke van der Pluijm, Iris Bosch, Therese A M J van Amelsvoort, Jan Booij, Lieuwe de Haan, Jean-Paul Selten, Elsmarieke van de Giesse. The substantia nigra in the pathology of schizophrenia: A review on post-mortem and molecular imaging findings. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 68. 2023-01-14. PMID:36640734. |
despite being one of the main origins of dopaminergic input to the striatum, the (dys)functioning of the substantia nigra (sn) has been relatively understudied in schizophrenia. |
2023-01-14 |
2023-08-14 |
Not clear |
| Anna Kolacheva, Alyona Bannikova, Ekaterina Pavlova, Vsevolod Bogdanov, Michael Ugrumo. Modeling of the Progressive Degradation of the Nigrostriatal Dopaminergic System in Mice to Study the Mechanisms of Neurodegeneration and Neuroplasticity in Parkinson's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614126. |
this model reproduces the main hallmarks of pd: progressive degeneration of dopaminergic neurons; the appearance of motor disorders with a 70-80% decrease in the level of dopamine in the striatum; an increase in dopamine turnover in the striatum to compensate for dopamine deficiency. |
2023-01-08 |
2023-08-14 |
mouse |
| Heba M Mansour, Ahmed M Fathi, Aiman S El-Khatib, Mahmoud M Khatta. Kinases control of Regulated Cell Death Revealing Druggable Targets for Parkinson's disease. Ageing research reviews. 2023-01-07. PMID:36608709. |
motor impairment seen in pd is associated with dopaminergic neurotoxicity in the striatum, and dopaminergic neuronal death in the substantia nigra pars compacta. |
2023-01-07 |
2023-08-14 |
Not clear |
| Zhaofei Yang, Ying Wang, Min Wei, Song Li, Congcong Jia, Cheng Cheng, Murad Al-Nusaif, Jun Zhang, Cong Liu, Weidong L. Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain. Cell death & disease. vol 14. issue 1. 2023-01-05. PMID:36604420. |
strikingly, such an injection induced dopaminergic neurodegeneration and α-syn depositions in the striatum, substantia nigra, and other brain regions, including the frontal cortex, somatosensory cortex, hypothalamus, brain stem, and cerebellum. |
2023-01-05 |
2023-08-14 |
rat |
| Tamara Marín, Cristian Valls, Carolina Jerez, Tomás Huerta, Daniela Elgueta, René L Vidal, Alejandra R Alvarez, Gonzalo I Cancin. The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model. IBRO neuroscience reports. vol 13. 2023-01-02. PMID:36590096. |
finally, we found that the intraperitoneal administration of imatinib prevented the death of dopaminergic neurons induced by injecting 6-hydroxydopamine stereotaxically in the mice striatum. |
2023-01-02 |
2023-08-14 |
mouse |