| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valeria V Goloborshcheva, Valerian G Kucheryanu, Natalia A Voronina, Ekaterina V Teterina, Aleksey A Ustyugov, Sergei G Morozo. Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140378. |
parkinson's disease (pd) is one of the key neurodegenerative disorders caused by a dopamine deficiency in the striatum due to the death of dopaminergic (da) neurons of the substantia nigra pars compacta. |
2022-09-23 |
2023-08-14 |
Not clear |
| Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Le. Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson's Disease Model. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142491. |
we found that dietary morin prevented mptp-induced motor dysfunction and ameliorated dopaminergic neuronal damage in striatum (str) and substantia nigra (sn) in our mouse model. |
2022-09-23 |
2023-08-14 |
mouse |
| Xinyu Yan, Wenji He, Sanqiang Pa. Amphetamine-induced Neurite Injury in PC12 Cells Through Inhibiting GAP-43 Pathway. Neurotoxicology. 2022-09-23. PMID:36150536. |
we found amph reduced level of gap-43 in the striatum of rats that receives rich dopaminergic terminals. |
2022-09-23 |
2023-08-14 |
rat |
| Michal Rafal Zareba, Wiktoria Furman, Marek Binde. Influence of age and cognitive performance on resting-state functional connectivity of dopaminergic and noradrenergic centers. Brain research. 2022-09-17. PMID:36115586. |
to the best of our knowledge, this work is the first to report the age-related effects on vta local synchronization and its connectivity with key recipients of dopaminergic innervation, such as striatum and mediodorsal thalamus. |
2022-09-17 |
2023-08-14 |
Not clear |
| Jiahui Shao, Xuan Liu, Mengjia Lian, Youbing Ma. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotoxicity research. 2022-09-13. PMID:36097250. |
parkinson disease is a neurodegenerative disorder distinguished by dopaminergic shortage in the striatum and the accumulation of α-synuclein neuronal aggregates in the brains of patients. |
2022-09-13 |
2023-08-14 |
Not clear |
| Nishant Sharma, Ritu Soni, Monika Sharma, Sayan Chatterjee, Nidhi Parihar, Mohd Mukarram, Ruhi Kale, Adil Ali Sayyed, Santosh Kumar Behera, Amit Khairna. Chlorogenic Acid: a Polyphenol from Coffee Rendered Neuroprotection Against Rotenone-Induced Parkinson's Disease by GLP-1 Secretion. Molecular neurobiology. 2022-09-01. PMID:36048341. |
cga treatment ameliorated rotenone-induced dopaminergic nerve degeneration and alpha-synuclein accumulation in substantia nigra and augmented mean density of dopaminergic nerve fibers in striatum. |
2022-09-01 |
2023-08-14 |
mouse |
| Xiaosan Tang, Heng Li, Baozeng An, Haibo Ma, Nana Huang, Xiaohong L. Transplantation of human cord blood-derived multipotent stem cells (CB-SCs) enhances the recovery of Parkinson in rats. Transplant immunology. 2022-08-29. PMID:36038047. |
after being transplanted into the striatum and substantia nigra of pd rats, most of cb-scs (>90%) developed a fate commitment to dopaminergic differentiation, expressed as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2022-08-29 |
2023-08-14 |
human |
| Jannette Rodríguez-Pallares, María García-Garrote, Juan A Parga, José Luis Labandeira-Garcí. Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018150. |
clinical studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum, release dopamine, integrate into the host neural circuits, and improve motor functions. |
2022-08-26 |
2023-08-14 |
human |
| Laszlo G Harsing, Joseph Knoll, Ildiko Mikly. Enhancer Regulation of Dopaminergic Neurochemical Transmission in the Striatum. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955676. |
enhancer regulation of dopaminergic neurochemical transmission in the striatum. |
2022-08-12 |
2023-08-14 |
Not clear |
| Daniele Urso, Daniel J van Wamelen, Lucia Batzu, Valentina Leta, Juliet Staunton, José A Pineda-Pardo, Giancarlo Logroscino, Jagdish Sharma, K Ray Chaudhur. Clinical trajectories and biomarkers for weight variability in early Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-08-02. PMID:35918350. |
presynaptic dopaminergic imaging in the right striatum may serve as a predictor of future weight changes in pd and hc. |
2022-08-02 |
2023-08-14 |
Not clear |
| Xiaojie Liu, Hao Yu, Bixuan Chen, Vladislav Friedman, Lianwei Mu, Thomas J Kelly, Gonzalo Ruiz-Pérez, Li Zhao, Xiaowen Bai, Cecilia J Hillard, Qing-Song Li. CB2 Agonist GW842166x Protected against 6-OHDA-Induced Anxiogenic- and Depressive-Related Behaviors in Mice. Biomedicines. vol 10. issue 8. 2022-07-27. PMID:35892676. |
here, we report that the selective cb2 agonist gw842166x exerted neuroprotective effects against 6-hydroxydopamine (6-ohda)-induced loss of dopaminergic terminals and dopamine release in the striatum, which were blocked by the cb2 antagonist am630. |
2022-07-27 |
2023-08-14 |
mouse |
| Jaron T Colas, Neil M Dundon, Raphael T Gerraty, Natalie M Saragosa-Harris, Karol P Szymula, Koranis Tanwisuth, J Michael Tyszka, Camilla van Geen, Harang Ju, Arthur W Toga, Joshua I Gold, Dani S Bassett, Catherine A Hartley, Daphna Shohamy, Scott T Grafton, John P O'Dohert. Reinforcement learning with associative or discriminative generalization across states and actions: fMRI at 3 T and 7 T. Human brain mapping. 2022-07-21. PMID:35860954. |
with high-resolution high-field fmri targeting the dopaminergic midbrain, the grl model's rpe signals (alongside value and decision signals) were localized within not only the striatum but also the substantia nigra and the ventral tegmental area, including specific effects of generalization that also extend to the hippocampus. |
2022-07-21 |
2023-08-14 |
human |
| Dandan Qian, Wei Li, Jinwen Xue, Yi Wu, Ziling Wang, Tao Shi, Songting Li, Jingxuan Yang, Shi Qiu, Shaoli Wang, Yousheng Shu, Liang Chen, Qiao Wang, Ti-Fei Yuan, Douglas Zhou, Wei L. A striatal SOM-driven ChAT-iMSN loop generates beta oscillations and produces motor deficits. Cell reports. vol 40. issue 3. 2022-07-20. PMID:35858550. |
thus, we reveal a striatal microcircuit motif that underlies beta oscillation generation and accompanied motor deficits upon perturbation of dopaminergic control over the striatum. |
2022-07-20 |
2023-08-14 |
Not clear |
| Juli Jain, Whidul Hasan, Pronit Biswas, Rajesh S Yadav, Deepali Ja. Neuroprotective effect of quercetin against rotenone-induced neuroinflammation and alterations in mice behavior. Journal of biochemical and molecular toxicology. 2022-07-13. PMID:35822592. |
the finding of the study indicated that rotenone 5 mg/kg body weight for 60 days through oral gavage leads to the release of inflammatory markers in blood serum, astrocytes activation in substantia nigra and hippocampus, and subsequently decreased density of dopaminergic fibers in the striatum. |
2022-07-13 |
2023-08-14 |
mouse |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
these processes cause dopamine levels released in structures innervated by midbrain dopaminergic neurons (e.g., the striatum) to oscillate in a circadian fashion. |
2022-07-11 |
2023-08-14 |
human |
| Fengyan Li, Aixia Zhang, Mo Li, Xueyao Wang, Xuan Wang, Yunqian Guan, Jing An, Deqiang Han, Y Alex Zhang, Zhiguo Che. Induced neural stem cells from Macaca fascicularis show potential of dopaminergic neuron specification and efficacy in a mouse Parkinson's disease model. Acta histochemica. vol 124. issue 6. 2022-07-06. PMID:35792494. |
furthermore, inscs could give rise to dopaminergic neural cells in vitro, which showed safety and efficacy after transplantation into the striatum of an immunodeficient mouse parkinson's disease (pd) model. |
2022-07-06 |
2023-08-14 |
mouse |
| José M M Bispo, João E C Melo, Auderlan M Gois, Katty A A L Medeiros, Rodolfo Santos Silva, Pollyana C Leal, Heitor S Franco, Marina F Souza, Lívia C R F Lins, Alessandra M Ribeiro, Regina H Silva, José R Santo. Testosterone Propionate Improves motor alterations and dopaminergic damage in the Reserpine-Induced Progressive Model of Parkinson's Disease. Brain research bulletin. 2022-07-05. PMID:35781030. |
tp at 1.0mg/kg reduced the damages caused by reserpine in the vacuous chewing and tong protrusion behaviors and prevented dopaminergic damage in the snpc, vta, and striatum. |
2022-07-05 |
2023-08-14 |
rat |
| Adriana Castro-Zavala, Laia Alegre-Zurano, Lídia Cantacorps, Ines Gallego-Landin, Patrick-S Welz, Salvador A Benitah, Olga Valverd. Bmal1-knockout mice exhibit reduced cocaine-seeking behaviour and cognitive impairments. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-07-02. PMID:35779420. |
furthermore, bmal1 deletion influenced the expression of other clock-related genes in the mpfc and striatum, as well as alterations in the expression of dopaminergic elements. |
2022-07-02 |
2023-08-14 |
mouse |
| Haley M Geertsma, Konrad M Ricke, Maxime W C Rousseau. Assessment of Dopaminergic Neurodegeneration in Mice. Methods in molecular biology (Clifton, N.J.). vol 2515. 2022-07-01. PMID:35776351. |
in addition, we outline the protocol for the analysis of the dopaminergic terminals in the striatum, the projection area of midbrain dopaminergic neurons, as a readout for the integrity of the nigrostriatal projections. |
2022-07-01 |
2023-08-14 |
mouse |
| Sukhpal Singh, Upasana Ganguly, Soumya Pal, Gourav Chandan, Rahul Thakur, Reena V Saini, Sankha Shubhra Chakrabarti, Bimal K Agrawal, Sasanka Chakrabart. Protective effects of cyclosporine A on neurodegeneration and motor impairment in rotenone-induced experimental models of Parkinson's disease. European journal of pharmacology. 2022-07-01. PMID:35777442. |
cyclosporine a significantly improved the motor deficits and prevented the loss of nigral dopaminergic neurons projecting into the striatum in rotenone-treated rats. |
2022-07-01 |
2023-08-14 |
human |