| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco Molinet-Dronda, Javier Blesa, Natalia López-González Del Rey, Carlos Juri, María Collantes, José Pineda-Pardo, Inés Trigo-Damas, Elena Iglesias, Ledia F Hernández, Rafael Rodríguez-Rojas, Belén Gago, Margarita Ecay, Elena Prieto, Miguel Á García-Cabezas, Carmen Cavada, María C Rodríguez-Oroz, Iván Peñuelas, José A Obes. Cerebral metabolic pattern associated with progressive parkinsonism in non-human primates reveals early cortical hypometabolism. Neurobiology of disease. 2022-02-27. PMID:35219857. |
dopaminergic depletion in the striatum and cerebral metabolic patterns across groups were studied in vivo by positron emission tomography (pet) using monoaminergic ([ |
2022-02-27 |
2023-08-13 |
monkey |
| Olga Bakina, Helmut Kettenmann, Christiane Nolt. Microglia form satellites with different neuronal subtypes in the adult murine central nervous system. Journal of neuroscience research. 2022-02-25. PMID:35213755. |
we quantified satellite microglia associated with gabaergic and glutamatergic neurons in the somatosensory cortex, striatum, and thalamus; with dopaminergic and serotonergic neurons in the basal forebrain and raphe nucleus, respectively; and with cerebellar purkinje cell neurons. |
2022-02-25 |
2023-08-13 |
mouse |
| Huadong Xu, Xu Cheng, Qian Song, Yuxin Yang, Changhe Wang, Xinjiang Kan. Induced Dopaminergic Neurons for Parkinson's Disease Therapy: Targeting the Striatum or Midbrain/Substantia Nigra Pars Compacta? Neuroscience bulletin. 2022-02-23. PMID:35195854. |
induced dopaminergic neurons for parkinson's disease therapy: targeting the striatum or midbrain/substantia nigra pars compacta? |
2022-02-23 |
2023-08-13 |
Not clear |
| Jee-Young Lee, Antonio Martin-Bastida, Ane Murueta-Goyena, Iñigo Gabilondo, Nicolás Cuenca, Paola Piccini, Beomseok Jeo. Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease. Nature reviews. Neurology. 2022-02-18. PMID:35177849. |
pet and single-photon emission ct targeting the presynaptic terminals of dopaminergic neurons can be used for early diagnosis by detecting axonal degeneration in the striatum. |
2022-02-18 |
2023-08-13 |
Not clear |
| Mathias L Heltberg, Hussein N Awada, Alessandra Lucchetti, Mogens H Jensen, Jakob K Dreyer, Rune N Rasmusse. Biophysical modelling of dopaminergic denervation landscapes in the striatum reveals new therapeutic strategy. eNeuro. 2022-02-15. PMID:35165198. |
biophysical modelling of dopaminergic denervation landscapes in the striatum reveals new therapeutic strategy. |
2022-02-15 |
2023-08-13 |
Not clear |
| Mathias L Heltberg, Hussein N Awada, Alessandra Lucchetti, Mogens H Jensen, Jakob K Dreyer, Rune N Rasmusse. Biophysical modelling of dopaminergic denervation landscapes in the striatum reveals new therapeutic strategy. eNeuro. 2022-02-15. PMID:35165198. |
in this study, we investigate this, by characterizing the dopaminergic landscape in healthy and denervated striatum, using biophysical modelling. |
2022-02-15 |
2023-08-13 |
Not clear |
| Marianne Oldehinkel, Alberto Llera, Myrthe Faber, Ismael Huertas, Jan K Buitelaar, Bastiaan R Bloem, Andre F Marquand, Rick Helmich, Koen V Haak, Christian F Beckman. Mapping dopaminergic projections in the human brain with resting-state fMRI. eLife. vol 11. 2022-02-03. PMID:35113016. |
the striatum receives dense dopaminergic projections making it a key region of the dopaminergic system. |
2022-02-03 |
2023-08-13 |
human |
| Marianne Oldehinkel, Alberto Llera, Myrthe Faber, Ismael Huertas, Jan K Buitelaar, Bastiaan R Bloem, Andre F Marquand, Rick Helmich, Koen V Haak, Christian F Beckman. Mapping dopaminergic projections in the human brain with resting-state fMRI. eLife. vol 11. 2022-02-03. PMID:35113016. |
here, we demonstrate that 'connectopic mapping' -a novel approach for characterizing fine-grained, overlapping modes of functional connectivity- can be used to map dopaminergic projections in striatum. |
2022-02-03 |
2023-08-13 |
human |
| Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi She. Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. Molecular medicine reports. vol 25. issue 3. 2022-01-18. PMID:35039876. |
in the mptp group, the loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta, the reduction of the tyrosine hydroxylase content in the sn and striatum and the astrocyte proliferation and microglial activation in the sn were more significant compared with the rotenone group. |
2022-01-18 |
2023-08-13 |
mouse |
| Soraya Lahlou, Ella Gabitov, Lucy Owen, Daphna Shohamy, Madeleine Shar. Preserved motor memory in Parkinson's disease. Neuropsychologia. 2022-01-18. PMID:35041839. |
patients with parkinson's disease, who lose the dopaminergic projections to the striatum, are impaired in certain aspects of motor learning. |
2022-01-18 |
2023-08-13 |
Not clear |
| Antonio Fernández-Pérez, Adrián Sanz-Magro, Rosario Moratalla, Mario Vallej. Restricting feeding to dark phase fails to entrain circadian activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice. Cell reports. vol 38. issue 2. 2022-01-12. PMID:35021074. |
previously, we reported that pitx3-mutant aphakia mice with altered development of the retinohypothalamic tract and the dopaminergic neurons projecting to the striatum, are resistant to locomotor and metabolic entrainment by time-restricted feeding. |
2022-01-12 |
2023-08-13 |
mouse |
| Viktoriia Bazylianska, Akhil Sharma, Heli Chauhan, Bernard Schneider, Anna Moszczynsk. Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008791. |
methamphetamine (meth) is a highly abused psychostimulant that is neurotoxic to dopaminergic (daergic) nerve terminals in the striatum and increases the risk of developing parkinson's disease (pd). |
2022-01-11 |
2023-08-13 |
rat |
| Fubo Cheng, Wenxu Zheng, Peter Antony Barbuti, Paola Bonsi, Change Liu, Nicolas Casadei, Giulia Ponterio, Maria Meringolo, Jakob Admard, Claire Marie Dording, Libo Yu-Taeger, Huu Phuc Nguyen, Kathrin Grundmann-Hauser, Thomas Ott, Henry Houlden, Antonio Pisani, Rejko Krüger, Olaf Ries. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain : a journal of neurology. 2022-01-11. PMID:35015830. |
comparing global differentially expressed genes detected in thap1 patients' ipscs derived midbrain dopaminergic neurons and thap1 heterozygous knock-out rat striatum, we observed many common dysregulated genes and 61 of them are involved in dystonic syndromes related pathways, like synaptic transmission, nervous system development, and locomotor behavior. |
2022-01-11 |
2023-08-13 |
mouse |
| Monte S Buchsbaum, Serge A Mitelman, Bradley T Christian, Brian M Merrill, Bradley R Buchsbaum, Danielle Mitelman, Jogeshwar Mukherjee, Douglas S Lehre. Four-modality imaging of unmedicated subjects with schizophrenia: Psychiatry research. Neuroimaging. vol 320. 2021-12-26. PMID:34954446. |
four-modality imaging of unmedicated subjects with schizophrenia: diminished prefrontal function, dopaminergic abnormalities in the striatum and thalamus, reductions in white matter integrity and frontotemporal gray matter deficits are the most replicated findings in schizophrenia. |
2021-12-26 |
2023-08-13 |
human |
| Wisberty J Gordián-Vélez, Dimple Chouhan, Rodrigo A España, H Isaac Chen, Jason A Burdick, John E Duda, D Kacy Culle. Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria. Brain research bulletin. vol 175. 2021-12-10. PMID:34332016. |
the death of dopaminergic neurons in the substantia nigra and the axonal fibers that constitute the nigrostriatal pathway leads to a loss of dopamine in the striatum that causes the motor symptoms of this disease. |
2021-12-10 |
2023-08-13 |
human |
| Esther García-García, Nerea Chaparro-Cabanillas, Albert Coll-Manzano, Maria Carreras-Caballé, Albert Giralt, Daniel Del Toro, Jordi Alberch, Mercè Masana, Manuel J Rodrígue. Unraveling the Spatiotemporal Distribution of VPS13A in the Mouse Brain. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884823. |
in vivo pharmacological modulation of the glutamatergic, dopaminergic or cholinergic systems did not modulate vps13a concentration in the hippocampus, cerebral cortex, or striatum. |
2021-12-10 |
2023-08-13 |
mouse |
| Dmitry Troshev, Daniil Berezhnoy, Olga Kulikova, Denis Abaimov, Olga Muzychuk, Denis Nalobin, Sergey Stvolinsky, Tatiana Fedorov. The dynamics of nigrostriatal system damage and neurobehavioral changes in the rotenone rat model of Parkinson's disease. Brain research bulletin. vol 173. 2021-12-09. PMID:33892082. |
the motor stage developed after a decrease in the number of cells in the snpc by more than 30 %, and was characterized by changes in the dopaminergic system, leading up to a 71 % reduction in dopamine levels in the striatum. |
2021-12-09 |
2023-08-13 |
rat |
| Emma Biondetti, Mathieu D Santin, Romain Valabrègue, Graziella Mangone, Rahul Gaurav, Nadya Pyatigorskaya, Matthew Hutchison, Lydia Yahia-Cherif, Nicolas Villain, Marie-Odile Habert, Isabelle Arnulf, Smaranda Leu-Semenescu, Pauline Dodet, Miquel Vila, Jean-Christophe Corvol, Marie Vidailhet, Stéphane Lehéric. The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33978742. |
striatal dopaminergic denervation occurred first followed by abnormal iron metabolism and finally neuromelanin changes in the substantia nigra pars compacta, which followed the same spatial and temporal gradient observed in the striatum but shifted in time. |
2021-12-09 |
2023-08-13 |
Not clear |
| Yan Xu, Shicong Wang, Longmao Chen, Ziqiang Shao, Min Zhang, Shuang Liu, Xinwen Wen, Yangding Li, Wenhan Yang, Fei Tang, Jing Luo, Li Fan, Cui Yan, Jun Liu, Kai Yua. Reduced midbrain functional connectivity and recovery in abstinent heroin users. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34662755. |
dopaminergic pathways from the midbrain to striatum as well as cortex are involved in addiction. |
2021-12-07 |
2023-08-13 |
human |
| Josefine Waldthaler, Lena Stock, Charlotte Krüger-Zechlin, Lars Timmerman. Age at Parkinson's disease onset modulates the effect of levodopa on response inhibition: Support for the dopamine overdose hypothesis from the antisaccade task. Neuropsychologia. vol 163. 2021-12-07. PMID:34728241. |
assuming less dopaminergic loss in ventral parts of the striatum in early compared to late onset pd, these findings support the dopamine overdose hypothesis. |
2021-12-07 |
2023-08-13 |
Not clear |