| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard L Jayaraj, Rami Beiram, Sheikh Azimullah, Nagoor Meeran M F, Shreesh K Ojha, Abdu Adem, Fakhreya Yousuf Jala. Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways. Molecules (Basel, Switzerland). vol 26. issue 15. 2021-09-17. PMID:34361780. |
parkinson's disease is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta (snpc) and the resultant loss of dopamine in the striatum. |
2021-09-17 |
2023-08-13 |
rat |
| Grego David Apóstol Del Rosal, Ilhuicamina Daniel Limón, Isabel Martínez, Aleidy Patricio-Martíne. The Chronic Oral Administration of Clobenzorex or Amphetamine Decreases Motor Behavior and Induces Glial Activation in the Striatum Without Dopaminergic Degeneration. Neurotoxicity research. vol 39. issue 5. 2021-09-10. PMID:34279823. |
the chronic oral administration of clobenzorex or amphetamine decreases motor behavior and induces glial activation in the striatum without dopaminergic degeneration. |
2021-09-10 |
2023-08-13 |
human |
| Grego David Apóstol Del Rosal, Ilhuicamina Daniel Limón, Isabel Martínez, Aleidy Patricio-Martíne. The Chronic Oral Administration of Clobenzorex or Amphetamine Decreases Motor Behavior and Induces Glial Activation in the Striatum Without Dopaminergic Degeneration. Neurotoxicity research. vol 39. issue 5. 2021-09-10. PMID:34279823. |
various studies have shown that amphetamines induce dopaminergic neurotoxicity and neuroinflammation in the striatum, symptoms which are associated with motor damage. |
2021-09-10 |
2023-08-13 |
human |
| Kaori Masai, Keita Kuroda, Nami Isooka, Ryo Kikuoka, Shinki Murakami, Sunao Kamimai, Dengli Wang, Keyue Liu, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanum. Neuroprotective Effects of Anti-high Mobility Group Box-1 Monoclonal Antibody Against Methamphetamine-Induced Dopaminergic Neurotoxicity. Neurotoxicity research. vol 39. issue 5. 2021-09-10. PMID:34417986. |
meth injections induced hyperthermia, an increase in plasma hmgb1 concentration, degeneration of dopaminergic nerve terminals, accumulation of microglia, and extracellular release of neuronal hmgb1 in the striatum. |
2021-09-10 |
2023-08-13 |
mouse |
| Hayate Javed, M F Nagoor Meeran, Sheikh Azimullah, Lujain Bader Eddin, Vivek Dhar Dwivedi, Niraj Kumar Jha, Shreesh Ojh. α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease. Biomolecules. vol 10. issue 10. 2021-09-06. PMID:33049992. |
bsb treatment significantly prevented rot-induced loss of dopaminergic neurons and fibers in the substantia nigra and striatum respectively. |
2021-09-06 |
2023-08-13 |
rat |
| L C Fernandes, A G Santos, T B Sampaio, Sms Sborgi, Rds Prediger, M M Ferro, Gcn Franco, L Lipinski, E Miyosh. Exposure to paraquat associated with periodontal disease causes motor damage and neurochemical changes in rats. Human & experimental toxicology. vol 40. issue 1. 2021-09-02. PMID:32748713. |
the rats were euthanized and the left hemimandibles and striatum were dissected for the analysis of dopaminergic and inflammatory markers. |
2021-09-02 |
2023-08-13 |
rat |
| L C Fernandes, A G Santos, T B Sampaio, Sms Sborgi, Rds Prediger, M M Ferro, Gcn Franco, L Lipinski, E Miyosh. Exposure to paraquat associated with periodontal disease causes motor damage and neurochemical changes in rats. Human & experimental toxicology. vol 40. issue 1. 2021-09-02. PMID:32748713. |
moreover, only the combination of periodontal disease and paraquat exposure induced the loss of dopaminergic neurons and astrocyte activation in the striatum. |
2021-09-02 |
2023-08-13 |
rat |
| Puneet K Sharma, Lisa Wells, Gaia Rizzo, Joanna L Elson, Jan Passchier, Eugenii A Rabiner, Roger N Gunn, David T Dexter, Ilse S Pienaa. DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 3. 2021-09-01. PMID:31965550. |
by revealing that the improved axial-related motor functions seen in pd patients receiving ppn-dbs may be due to stimulation of remaining ppn cholinergic neurons interacting with dopaminergic ones in both the substantia nigra pars compacta and the striatum, our data strongly favor the ppn cholinergic-midbrain dopaminergic connectome as mechanism for ppn-dbs's therapeutic effects. |
2021-09-01 |
2023-08-13 |
rat |
| Linlin Zhang, Yanan Zheng, Junxia Xie, Limin Sh. Potassium channels and their emerging role in parkinson's disease. Brain research bulletin. vol 160. 2021-08-31. PMID:32305406. |
parkinson's disease (pd) is the second most common neurodegenerative disorder, which is associated with a selective loss of dopaminergic neurons in the substantia nigra (sn) and a reduction of dopamine in the striatum. |
2021-08-31 |
2023-08-13 |
Not clear |
| Chao Ren, Fen Wang, Kai-Jie He, Yu-Ting Zhang, Ling-Xi Li, Jin-Bao Zhang, Jing Chen, Cheng-Jie Mao, Chun-Feng Li. Early-life stress induces prodromal features of Parkinsonian with aging in rats. The journals of gerontology. Series A, Biological sciences and medical sciences. 2021-08-27. PMID:34448826. |
based on neuroimaging and histochemistry, although we found that the dopaminergic system in striatum was impaired after ms, the decrease of striatal dopamine level was ~33%. |
2021-08-27 |
2023-08-13 |
human |
| Chao Ren, Fen Wang, Kai-Jie He, Yu-Ting Zhang, Ling-Xi Li, Jin-Bao Zhang, Jing Chen, Cheng-Jie Mao, Chun-Feng Li. Early-life stress induces prodromal features of Parkinsonian with aging in rats. The journals of gerontology. Series A, Biological sciences and medical sciences. 2021-08-27. PMID:34448826. |
furthermore, using transcriptome sequencing, we discovered many differentially expressed genes (degs) of ms rats in striatum significantly enriched in the pathway of dopaminergic synapse, and the biological process of locomotion and neuromuscular process controlling balance. |
2021-08-27 |
2023-08-13 |
human |
| Blake L Elliott, Kimberlee D'Ardenne, Prerona Mukherjee, Julie B Schweitzer, Samuel M McClur. Limbic and Executive Meso- and Nigrostriatal Tracts Predict Impulsivity Differences in Attention-Deficit/Hyperactivity Disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-08-26. PMID:34051394. |
we tested whether human midbrain pathways (where dopaminergic cell bodies originate) between the substantia nigra (sn) and ventral tegmental area (vta) and the striatum differed between participants with adhd and typically developing adolescent and young adult participants. |
2021-08-26 |
2023-08-13 |
human |
| Yoshifumi Miyawaki, Bumpei Samata, Tetsuhiro Kikuchi, Kaneyasu Nishimura, Jun Takahash. Zonisamide promotes survival of human-induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats. Journal of neuroscience research. vol 98. issue 8. 2021-08-23. PMID:32506530. |
zonisamide promotes survival of human-induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats. |
2021-08-23 |
2023-08-13 |
human |
| Natalie Hong Siu Chang, Yoshitaka Kumakura, Arne Møller, Jakob Linnet, Dirk Bender, Doris J Doudet, Manouchehr Seyedi Vafaee, Albert Gjedd. On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum. Brain imaging and behavior. 2021-08-21. PMID:34417966. |
we previously determined dopaminergic receptor density in striatum, and we now tested the hypothesis that an elevated dopaminergic condition with increased extracellular dopamine and receptor density follows increased dopamine synthesis capacity in highly sensation-seeking individuals, as measured by positron emission tomography of 18 men with tracer fluorodopa (fdopa). |
2021-08-21 |
2023-08-13 |
human |
| Nozomi Asaoka, Masakazu Ibi, Hikari Hatakama, Koki Nagaoka, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Shuji Kaneko, Chihiro Yabe-Nishimur. NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 12. 2021-08-17. PMID:33563722. |
abnormal dopaminergic signaling in the striatum is one of the factors associated with behavioral repetition; however, the molecular mechanisms underlying the induction of repetitive behavior remain unclear. |
2021-08-17 |
2023-08-13 |
mouse |
| Shaozhi Zhang, Sijie Wang, Xingzhu Shi, Xizeng Fen. Polydatin alleviates parkinsonism in MPTP-model mice by enhancing glycolysis in dopaminergic neurons. Neurochemistry international. vol 139. 2021-08-11. PMID:32758587. |
pld reduced the mptp-induced loss of dopaminergic neurons in substantia nigra and striatum, inhibited the occurrence of neural apoptosis, and restored motor function in mice. |
2021-08-11 |
2023-08-13 |
mouse |
| Isaac Deng, Frances Corrigan, Sanjay Garg, Xin-Fu Zhou, Larisa Bobrovskay. Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice. International journal of molecular sciences. vol 22. issue 14. 2021-08-10. PMID:34299000. |
parkinson's disease (pd) is the most common movement disorder, characterized by progressive degeneration of the nigrostriatal pathway, which consists of dopaminergic cell bodies in substantia nigra and their neuronal projections to the striatum. |
2021-08-10 |
2023-08-13 |
mouse |
| Isaac Deng, Frances Corrigan, Sanjay Garg, Xin-Fu Zhou, Larisa Bobrovskay. Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice. International journal of molecular sciences. vol 22. issue 14. 2021-08-10. PMID:34299000. |
lps also induced inflammation in the striatum characterized by increased expression of microglial marker iba-1 and astrocytic marker gfap, with degeneration of dopaminergic neuronal fibres (reduced tyrosine hydroxylase immunoreactivity), and reduction of synaptic proteins and dj-1 protein. |
2021-08-10 |
2023-08-13 |
mouse |
| Isaac Deng, Frances Corrigan, Sanjay Garg, Xin-Fu Zhou, Larisa Bobrovskay. Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice. International journal of molecular sciences. vol 22. issue 14. 2021-08-10. PMID:34299000. |
this model recapitulated the major features of pd such as motor impairment and degeneration of dopaminergic neuronal fibres in the striatum, as well as some pathological changes in the olfactory bulb and colon; thus, this model could be suitable for understanding clinical pd and testing neuroprotective strategies. |
2021-08-10 |
2023-08-13 |
mouse |
| Angel A Robles-Gómez, Ana V Vega, Benjamín Florán, Jaime Barra. Differential calcium channel-mediated dopaminergic modulation in the subthalamonigral synapse. Synapse (New York, N.Y.). vol 74. issue 7. 2021-08-09. PMID:31975491. |
therefore, we set to analyze the dopaminergic modulation occurring in subthalamo-nigral synapse, in both pars compacta (snc) and pars reticulata (snr) neurons, because these synapses are important for the integration of information previously processed in striatum and globus pallidus. |
2021-08-09 |
2023-08-13 |
Not clear |