| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hidetomo Murakami, Tomotaka Shiraishi, Tadashi Umehara, Shusaku Omoto, Maki Takahashi, Haruhiko Motegi, Takahiro Maku, Takeo Sato, Hiroki Takatsu, Teppei Komatsu, Keiko Bono, Kenichiro Sakai, Hidetaka Mitsumura, Yasuyuki Iguch. Face pareidolia is associated with right striatal dysfunction in drug-naïve patients with Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 12. 2021-12-06. PMID:33884529. |
since the striatum is associated with processing of visual information, we investigated correlations of pareidolia with motor symptoms and striatal dopaminergic function. |
2021-12-06 |
2023-08-13 |
Not clear |
| Fernando Castillo Díaz, Lucia Caffino, Fabio Fumagall. Bidirectional role of dopamine in learning and memory-active forgetting. Neuroscience and biobehavioral reviews. vol 131. 2021-12-03. PMID:34655655. |
dopaminergic neurons projecting from the substantia nigra to the striatum play a critical role in motor functions while dopaminergic neurons originating in the ventral tegmental area (vta) and projecting to the nucleus accumbens, hippocampus and other cortical structures regulate rewarding learning. |
2021-12-03 |
2023-08-13 |
Not clear |
| Eva M Szegö, Chris Van den Haute, Lennart Höfs, Veerle Baekelandt, Anke Van der Perren, Björn H Falkenburge. Rab7 reduces α-synuclein toxicity in rats and primary neurons. Experimental neurology. vol 347. 2021-12-03. PMID:34695425. |
in rat brain, wt rab7 reduced αsyn-induced loss of dopaminergic axon terminals in the striatum and the loss of dopaminergic dendrites in the substantia nigra pars reticulata. |
2021-12-03 |
2023-08-13 |
rat |
| Kevin Chen, Tamara Palagashvili, W Hsu, Yibu Chen, Boris Tabakoff, Frank Hong, Abigail T Shih, Jean C Shi. Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice. Brain research. vol 1774. 2021-12-03. PMID:34780749. |
pea and dopamine are both synthesized from phenylalanine by aromatic l-amino acid decarboxylase in dopaminergic neurons in the striatum. |
2021-12-03 |
2023-08-13 |
mouse |
| Kevin Chen, Tamara Palagashvili, W Hsu, Yibu Chen, Boris Tabakoff, Frank Hong, Abigail T Shih, Jean C Shi. Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice. Brain research. vol 1774. 2021-12-03. PMID:34780749. |
a high concentration of pea in the striatum may cause dopaminergic neuronal death in the absence of mao b. |
2021-12-03 |
2023-08-13 |
mouse |
| Esther K Diekhof, Anja Richter, Katja Brodmann, Oliver Grube. Dopamine multilocus genetic profiles predict sex differences in reactivity of the human reward system. Brain structure & function. vol 226. issue 4. 2021-11-30. PMID:33580321. |
participants were genotyped for six key genetic polymorphisms in the dopamine system that have previously been associated with individual differences in reward sensitivity or dopaminergic transmission in the human striatum, such as rs7118900 (dopamine receptor d2 (drd2) taq1a), rs1554929 (drd2 c957t), rs907094 (darpp-32), rs12364283 (drd2), rs6278 (drd2), and rs107656 (drd2). |
2021-11-30 |
2023-08-13 |
human |
| Irene García-Domínguez, Irene Suárez-Pereira, Marti Santiago, Eva M Pérez-Villegas, Lidia Bravo, Carolina López-Martín, María Angustias Roca-Ceballos, Juan García-Revilla, Ana M Espinosa-Oliva, José A Rodríguez-Gómez, Bertrand Joseph, Esther Berrocoso, José Ángel Armengol, José L Venero, Rocío Ruiz, Rocío M de Pablo. Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour. Progress in neuro-psychopharmacology & biological psychiatry. vol 104. 2021-11-29. PMID:32634539. |
in striatum, basal extracellular levels and potassium-evoked da release were significantly reduced in mice lacking casp3, a clear indication of dopaminergic hypofunction in dopaminergic innervating tissues. |
2021-11-29 |
2023-08-13 |
mouse |
| Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids. 2021-11-27. PMID:34837554. |
our study showed that pd mice with tau intervention recovered motor and non-motor functions to some extent, and the number of dopaminergic (dac) neurons in the substantia nigra and the level of dopamine (da) secretion in the striatum were also significantly increased compared with the pq-dyed group, and the protein content of pi3k and pdk-1 and the phosphorylation level of akt were reduced in parallel with the reduction in the expression of microglia and related inflammatory factors. |
2021-11-27 |
2023-08-13 |
mouse |
| Rajeev K Singla, Tanya Agarwal, Xuefei He, Bairong She. Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease. Current drug targets. vol 22. issue 6. 2021-11-26. PMID:33050857. |
parkinson's disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia, and dyskinesia. |
2021-11-26 |
2023-08-13 |
Not clear |
| Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morell. In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice. Neurotoxicology. vol 83. 2021-11-26. PMID:33338551. |
immunohistochemistry was performed in the substantia nigra pars compacta (snc) and striatum, to evaluate dopaminergic degeneration by measuring tyrosine hydroxylase (th), as well as astrogliosis and microgliosis by measuring glial fibrillary acidic protein (gfap) and ionized calcium-binding adapter molecule 1 (iba-1), respectively. |
2021-11-26 |
2023-08-13 |
mouse |
| Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morell. In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice. Neurotoxicology. vol 83. 2021-11-26. PMID:33338551. |
in utero administration of dex induced dopaminergic damage by decreasing the density of th-positive fibers in the striatum, although only in adult mice. |
2021-11-26 |
2023-08-13 |
mouse |
| Monika Sharma, Jaswinder Kaur, Siddhi Rakshe, Nishant Sharma, Dignesh Khunt, Amit Khairna. Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons. Neurotoxicity research. 2021-11-24. PMID:34817799. |
conversely, after 16 weeks of washout period, rotenone treated mice showed both olfactory and motor impairment, along with α-syn accumulation in the ob and striatum without glial cell activation and loss of dopaminergic neurons. |
2021-11-24 |
2023-08-13 |
mouse |
| Shunsuke Takagi, Matthew D Puhl, Thea Anderson, Darrick T Balu, Joseph T Coyl. Serine Racemase Expression by Striatal Neurons. Cellular and molecular neurobiology. 2021-11-23. PMID:32445040. |
these results indicate that gabaergic medium spiny neurons receiving dopaminergic inputs in striatum robustly and uniformly express sr. |
2021-11-23 |
2023-08-13 |
mouse |
| Hongli Li, Yaru Feng, Ziyu Chen, Xi Jiang, Zhenyu Zhou, Jinfeng Yuan, Fei Li, Yu Zhang, Xingxu Huang, Shengjie Fan, Xiaojun Wu, Cheng Huan. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson's disease in mice and Caenorhabditis elegans. Pharmacological research. vol 163. 2021-11-18. PMID:33007422. |
parkinson's disease (pd) is a progressive neurodegenerative disease resulting from the degeneration of dopaminergic (daergic) neurons in the substantia nigra pars compacta (snpc) and subsequent deficit of dopamine in the striatum. |
2021-11-18 |
2023-08-13 |
mouse |
| Jiajing Shan, Youge Qu, Siming Wang, Yan Wei, Lijia Chang, Li Ma, Kenji Hashimot. Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson's disease mice by gut microbiome. Brain research bulletin. vol 177. 2021-11-18. PMID:34560239. |
the data suggest that mptp-induced increases in colonic p-α-syn expression might be associated with dopaminergic neurotoxicity in the striatum via gut-microbiota-brain axis. |
2021-11-18 |
2023-08-13 |
mouse |
| Nidheesh Thadathil, Jianfeng Xiao, Roderick Hori, Stephen E Alway, Mohammad Moshahid Kha. Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 16. issue 3. 2021-11-17. PMID:33221984. |
mptp injected mice exhibited loss of dopaminergic neurons and fibers in substantia nigra and striatum respectively, along with impaired motor function at day 7 post mptp injection. |
2021-11-17 |
2023-08-13 |
mouse |
| Yasuko Toyoshima, Hitoshi Takahashi, Shinnichi Katada, Naoyuki Kojima, Mari Tada, Takashi Tani, Ryoko Koike, Takanori Nozawa, Izumi Aida, Takashi Nakajima, Osamu Onodera, Akiyoshi Kakit. Parkinson's disease and parkinsonism: Clinicopathological discrepancies on diagnosis in three patients. Neuropathology : official journal of the Japanese Society of Neuropathology. 2021-11-15. PMID:34779072. |
the cardinal neuropathological features of pd include selective and progressive loss of pigmented neurons in the substantia nigra, deficiencies in dopaminergic signaling in the striatum, and occurrence of phosphorylated α-synuclein-identified lewy bodies in the nervous system. |
2021-11-15 |
2023-08-13 |
Not clear |
| Tao-Mian Mi, Wei Zhang, Martin J McKeown, Piu Cha. Impaired Formation and Expression of Goal-Directed and Habitual Control in Parkinson's Disease. Frontiers in aging neuroscience. vol 13. 2021-11-12. PMID:34759813. |
selective depletion of dopaminergic neurotransmission in the caudal sensorimotor striatum, a subdivision implicated in habitual control, is a major pathological feature in parkinson's disease (pd). |
2021-11-12 |
2023-08-13 |
human |
| Serena Venezia, Walter A Kaufmann, Gregor K Wenning, Nadia Stefanov. Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease. Parkinsonism & related disorders. vol 91. 2021-11-11. PMID:34530328. |
the facilitated propagation of α-synuclein is associated with early loss of dopamine transporter (dat) signal in the striatum and loss of dopaminergic neurons in substantia nigra pars compacta of tlr4 deficient mice. |
2021-11-11 |
2023-08-13 |
mouse |
| Natalia Lopez-Gonzalez Del Rey, Tiziano Balzano, Lucia Martin-Rodriguez, Constanza Salinas-Rebolledo, Ines Trigo-Damas, Alejandro Rojas-Fernandez, Lydia Alvarez-Erviti, Javier Bles. Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and Amygdala. Frontiers in aging neuroscience. vol 13. 2021-11-10. PMID:34744683. |
consistent with the behavior and pathological findings, there was no loss of dopaminergic cell bodies in the substantia nigra and terminals in the striatum. |
2021-11-10 |
2023-08-13 |
mouse |