| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiumin Liu, Weiwei Liu, Chenkang Wang, Yinzhe Chen, Panwen Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Silibinin attenuates motor dysfunction in a mouse model of Parkinson's disease by suppression of oxidative stress and neuroinflammation along with promotion of mitophagy. Physiology & behavior. vol 239. 2021-10-20. PMID:34181930. |
pd is a neurodegenerative disease that causes a debilitating movement disorder, characterized by a progressive loss of nigrostriatal (substantia nigra and striatum) dopaminergic neurons. |
2021-10-20 |
2023-08-13 |
mouse |
| Vicky Katsidoni, Manolis N Tzatzarakis, Vasiliki Karzi, Kyriaki Thermos, Andreas Kastellakis, George Panagi. Differential effects of chronic voluntary wheel-running on morphine induced brain stimulation reward, motor activity and striatal dopaminergic activity. Behavioural brain research. vol 394. 2021-10-19. PMID:32721470. |
lastly, dopaminergic activity was decreased in the striatum of exercised animals under basal conditions, whereas morphine administration led to an increase in dopamine turnover. |
2021-10-19 |
2023-08-13 |
rat |
| Hiram Tendilla-Beltrán, Heriberto Coatl-Cuaya, Silvia Meneses-Prado, Ruben Antonio Vázquez-Roque, Eduardo Brambila, Miguel Tapia-Rodríguez, David Martín-Hernández, Linda Garcés-Ramírez, José L M Madrigal, Juan C Leza, Gonzalo Flore. Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats. Schizophrenia research. vol 235. 2021-10-19. PMID:34298239. |
increased dopaminergic activity in the striatum underlies the neurobiology of psychotic symptoms in schizophrenia (sz). |
2021-10-19 |
2023-08-13 |
rat |
| Rathinasamy Baskaran, Chuan-Ching Lai, Wai-Yu Li, Li-Heng Tuan, Chia-Chuan Wang, Lukas J-H Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Le. Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency. The Journal of comparative neurology. vol 528. issue 7. 2021-10-18. PMID:31721208. |
moreover, amphetamine-induced elevations of c-fos expression and dopamine level in the striatum were greater in het mice than in wt controls, suggesting an altered dopaminergic regulation in the striatum of het mice. |
2021-10-18 |
2023-08-13 |
mouse |
| Jian-Nan Zhang, Yan-Lin Huang, Hui-Min Yang, Yuan Wang, Li Gu, Hong Zhan. Blockade of metabotropic glutamate receptor 5 attenuates axonal degeneration in 6-hydroxydopamine-induced model of Parkinson's disease. Molecular and cellular neurosciences. vol 110. 2021-10-13. PMID:33248235. |
consistent with these in vitro findings, blockade of mglur5 with mpep attenuated the degeneration of dopaminergic axons induced by 6-ohda injection into the striatum prior to soma death in the early stage of pd in an in vivo animal model. |
2021-10-13 |
2023-08-13 |
Not clear |
| Hui He, Huan Cao, Binxin Huang, Manxi He, Chi Ma, Dezhong Yao, Cheng Luo, Gang Yao, Mingjun Dua. Functional abnormalities of striatum are related to the season-specific effect on schizophrenia. Brain imaging and behavior. vol 15. issue 5. 2021-10-12. PMID:33398777. |
decreased bomv in spring-summer while increased in fall-winter were observed within dopaminergic network of schizophrenic subjects, including striatum, thalamus, and hippocampus. |
2021-10-12 |
2023-08-13 |
human |
| Abhishek Kumar Mishra, Anubhuti Dixi. Dopaminergic Axons: Key Recitalists in Parkinson's Disease. Neurochemical research. 2021-10-12. PMID:34637100. |
parkinson's disease (pd) is associated with dopamine depletion in the striatum owing to the selective and progressive loss of the nigrostriatal dopaminergic neurons, which results in motor dysfunction and secondary clinical manifestations. |
2021-10-12 |
2023-08-13 |
Not clear |
| Abhishek Kumar Mishra, Anubhuti Dixi. Dopaminergic Axons: Key Recitalists in Parkinson's Disease. Neurochemical research. 2021-10-12. PMID:34637100. |
the dopamine level in the striatum is preserved because of the innervation of the substantia nigra (sn) dopaminergic neurons into it. |
2021-10-12 |
2023-08-13 |
Not clear |
| Rebecca B Price, Brenden C Tervo-Clemmens, Benjamin Panny, Michelle Degutis, Angela Griffo, Mary Wood. Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34471098. |
normalized t2*-weighted (nt2*w) imaging has been previously investigated as a method to quantify biological properties of tissue in the striatum (e.g., tissue iron), providing a widely available, in vivo marker with potential relevance to dopaminergic function; but no prior study to our knowledge has examined this neuroimaging marker in clinical depression. |
2021-10-11 |
2023-08-13 |
Not clear |
| Alexandre Iarkov, Cristhian Mendoza, Valentina Echeverri. Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-10-08. PMID:34616271. |
since there is a deficit in the nachrs in pd, inhibiting nachrs loss in the striatum may help prevent dopaminergic neurons loss in the striatum and its pathological consequences. |
2021-10-08 |
2023-08-13 |
Not clear |
| Michelle S Antunes, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Silvana Peterini Boeira, Leandro Cattelan Souz. Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:33057922. |
moreover, hesperidin treatment attenuated the loss of dopaminergic neurons (th+ cells) in the snpc and the depletion of dopamine (da) and its metabolities 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum of 6-ohda-lesioned mice. |
2021-10-07 |
2023-08-13 |
mouse |
| Michelle S Antunes, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Silvana Peterini Boeira, Leandro Cattelan Souz. Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:33057922. |
taken together, our findings indicate that hesperidin mitigates the degeneration of dopaminergic neurons in the snpc by preventing mitochondrial dysfunction and modulating apoptotic pathways in the striatum of 6-ohda-treated mice, thus improving behavioral alterations. |
2021-10-07 |
2023-08-13 |
mouse |
| Li Zuo, Chunfang Dai, Lilin Yi, Zhifang Don. 7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson's disease. Cell death discovery. vol 7. issue 1. 2021-10-06. PMID:34545064. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and diminished dopamine content in the striatum. |
2021-10-06 |
2023-08-13 |
mouse |
| Kohei Takahashi, Osamu Nakagawasai, Takeharu Nakajima, Myu Okubo, Yuki Nishimura, Wakana Sakuma, Ryota Yamagata, Wataru Nemoto, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Minoru Tsuji, Hiroshi Takeda, Takeshi Tadano, Koichi Tan-N. Dopamine D Brain research. vol 1746. 2021-10-01. PMID:32673620. |
our previous study suggested that obx alters dopaminergic function in the striatum of mice; however, the effects on dopaminergic function in the hypothalamus is unknown. |
2021-10-01 |
2023-08-13 |
mouse |
| Huiqing Wang, Shanshan Dou, Junge Zhu, Ziqi Shao, Chunmei Wang, Baohua Chen. Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis. Brain research. vol 1746. 2021-10-01. PMID:32710901. |
parkinson's disease (pd) is the second most common progressive neurodegenerative disorder, the important pathology of pd due to the prominent loss of the dopaminergic neurodegeneration in the substantia nigra pars compacta (snpc) and striatum (str). |
2021-10-01 |
2023-08-13 |
mouse |
| In Soo Ryu, Seong Shoon Yoon, Mee Jung Choi, Young Eun Lee, Ji Sun Kim, Woo Hyun Kim, Jae Hoon Cheong, Hee Jin Kim, Choon-Gon Jang, Yong Sup Lee, Scott C Steffensen, Minhan Ka, Dong Ho Woo, Eun Young Jang, Joung-Wook Se. The potent psychomotor, rewarding and reinforcing properties of 3-fluoromethamphetamine in rodents. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31797481. |
3-fluoromethamphetamine (3-fma), a derivative of methamphetamine (meth), produces behavioral impairment and deficits in dopaminergic transmission in the striatum of mice. |
2021-09-28 |
2023-08-13 |
mouse |
| Robert A McCutcheon, Kirsten Brown, Matthew M Nour, Stephen M Smith, Mattia Veronese, Fernando Zelaya, Martin Osugo, Sameer Jauhar, William Hallett, Mitul M Mehta, Oliver D Howe. Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness. Science advances. vol 7. issue 24. 2021-09-25. PMID:34108214. |
dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness. |
2021-09-25 |
2023-08-13 |
human |
| Dennis Kätzel, Amy R Wolff, Alexei M Bygrave, David M Bannerma. Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia. Frontiers in pharmacology. vol 11. 2021-09-24. PMID:33178010. |
the development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. |
2021-09-24 |
2023-08-13 |
Not clear |
| Dennis Kätzel, Amy R Wolff, Alexei M Bygrave, David M Bannerma. Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia. Frontiers in pharmacology. vol 11. 2021-09-24. PMID:33178010. |
the mesolimbic dopaminergic output is modulated by several interconnected brain-wide circuits centrally involving the hippocampus and key relays like the ventral and associative striatum, ventral pallidum, amygdala, bed nucleus of the stria terminalis, nucleus reuniens, lateral and medial septum, prefrontal and cingulate cortex, among others. |
2021-09-24 |
2023-08-13 |
Not clear |
| Vasily Vorobyov, Alexander Deev, Frank Sengpiel, Vladimir Nebogatikov, Aleksey A Ustyugo. Cortical and Striatal Electroencephalograms and Apomorphine Effects in the FUS Mouse Model of Amyotrophic Lateral Sclerosis. Journal of Alzheimer's disease : JAD. vol 81. issue 4. 2021-09-20. PMID:33935079. |
maturation of locomotor networks is supported by dopaminergic (da) projections from substantia nigra to the spinal cord and striatum. |
2021-09-20 |
2023-08-13 |
mouse |