| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Musa Mustapha, Che Norma Mat Tai. MPTP-induced mouse model of Parkinson's disease: A promising direction of therapeutic strategies. Bosnian journal of basic medical sciences. vol 21. issue 4. 2021-08-02. PMID:33357211. |
this neurotoxin exerts it neurotoxicity by causing a barrage of insults, such as oxidative stress, mitochondrial apoptosis, inflammation, excitotoxicity, and formation of inclusion bodies acting singly and in concert, ultimately leading to dopaminergic neuronal damage in the substantia nigra pars compacta and striatum. |
2021-08-02 |
2023-08-13 |
mouse |
| Klara Danielsson, Oona Lagström, Mia Ericson, Bo Söderpalm, Louise Adermar. Subregion-specific effects on striatal neurotransmission and dopamine-signaling by acute and repeated amphetamine exposure. Neuropharmacology. vol 194. 2021-07-28. PMID:34116108. |
to test this theory, acute and long-lasting changes in dopaminergic neurotransmission were assessed in the nucleus accumbens (nac) and the dorsomedial striatum (dms) following amphetamine exposure in wistar rats. |
2021-07-28 |
2023-08-13 |
rat |
| Yukiko Masaki, Yuto Kashiwagi, Takemi Rokugawa, Miwa Ito, Hitoshi Iimori, Kohji Ab. Pharmacological MRI responses of raclopride in rats: The relationship with D2 receptor occupancy and cataleptic behavior. Synapse (New York, N.Y.). vol 74. issue 12. 2021-07-27. PMID:32644234. |
phmri study revealed significant positive responses to raclopride at 200 μg/kg specifically in the striatum and nucleus accumbens, related to dopaminergic system. |
2021-07-27 |
2023-08-13 |
rat |
| Sadaharu Torikoshi, Asuka Morizane, Takafumi Shimogawa, Bumpei Samata, Susumu Miyamoto, Jun Takahash. Exercise Promotes Neurite Extensions from Grafted Dopaminergic Neurons in the Direction of the Dorsolateral Striatum in Parkinson's Disease Model Rats. Journal of Parkinson's disease. vol 10. issue 2. 2021-07-26. PMID:31929121. |
exercise promotes neurite extensions from grafted dopaminergic neurons in the direction of the dorsolateral striatum in parkinson's disease model rats. |
2021-07-26 |
2023-08-13 |
rat |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
the findings from this study revealed that supplementation of α- and γ-t3 was able to ameliorate the motor deficits induced by 6-ohda and improve the neuronal functions by reducing inflammation, reversing the neuronal degradation, and preventing further reduction of dopaminergic neurons in the sn and striatum (str) fibre density. |
2021-07-26 |
2023-08-13 |
rat |
| Debapriya Garabadu, Nidhi Agrawa. Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31916219. |
parkinson's disease (pd) is a neurodegenerative disease that is accompanied with the loss of dopaminergic neurons in the substantia nigra pars compacta which subsequently leads to a reduction in the dopamine level in the striatum. |
2021-07-19 |
2023-08-13 |
rat |
| Debapriya Garabadu, Nidhi Agrawa. Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31916219. |
further, naringin reduced the rotenone-induced dopaminergic toxicity in striatum and snpc the animals. |
2021-07-19 |
2023-08-13 |
rat |
| Yanyun Sun, Xiao-Jun Lu, Xinghui Fu, Ye Zhang, Yan Zhan, Jiabing Liu, Lingxia Zhao, Chun-Lin Xi. Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-19. PMID:33070275. |
parkinson's disease (pd) is a disorder characterized by a progressive loss of the dopaminergic neurons in the substantia nigra and a depletion of the neurotransmitter dopamine in the striatum. |
2021-07-19 |
2023-08-13 |
rat |
| Changlin Lian, Qiongzhen Huang, Xiangyang Zhong, Zhenyan He, Boyang Liu, Huijun Zeng, Ningbo Xu, Zhao Yang, Chenxin Liao, Zhao Fu, Hongbo Gu. Pentraxin 3 secreted by human adipose-derived stem cells promotes dopaminergic neuron repair in Parkinson's disease via the inhibition of apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 7. 2021-07-16. PMID:34152016. |
moreover, we found that human recombinant ptx3 (rhptx3) treatment could rescue the pathophysiological behavior of the pd mice in vivo, prevent dopaminergic neuronal death, and increase neuronal terminals in the ventral tegmental area + substantia nigra pars compacta and striatum in the pd brain slices in vitro. |
2021-07-16 |
2023-08-13 |
mouse |
| Mai Wada, Mary Jasmin Ang, Poornima D E Weerasinghe-Mudiyanselage, Sung-Ho Kim, Jong-Choon Kim, Taekyun Shin, Changjong Moo. Behavioral characterization in MPTP/p mouse model of Parkinson's disease. Journal of integrative neuroscience. vol 20. issue 2. 2021-07-14. PMID:34258929. |
we confirmed dopaminergic degeneration in terms of decreased expression levels of tyrosine hydroxylase in the substantia nigra and striatum of mptp/p-lesioned mice. |
2021-07-14 |
2023-08-13 |
mouse |
| Antonio Verduzco-Mendoza, Paul Carrillo-Mora, Alberto Avila-Luna, Arturo Gálvez-Rosas, Adriana Olmos-Hernández, Daniel Mota-Rojas, Antonio Bueno-Nav. Role of the Dopaminergic System in the Striatum and Its Association With Functional Recovery or Rehabilitation After Brain Injury. Frontiers in neuroscience. vol 15. 2021-07-13. PMID:34248494. |
role of the dopaminergic system in the striatum and its association with functional recovery or rehabilitation after brain injury. |
2021-07-13 |
2023-08-13 |
Not clear |
| Antonio Verduzco-Mendoza, Paul Carrillo-Mora, Alberto Avila-Luna, Arturo Gálvez-Rosas, Adriana Olmos-Hernández, Daniel Mota-Rojas, Antonio Bueno-Nav. Role of the Dopaminergic System in the Striatum and Its Association With Functional Recovery or Rehabilitation After Brain Injury. Frontiers in neuroscience. vol 15. 2021-07-13. PMID:34248494. |
this review aims to provide an overview of the functionality of the dopaminergic system in the striatum and its roles in functional recovery or rehabilitation after tbi. |
2021-07-13 |
2023-08-13 |
Not clear |
| Jessica R Zenchak, Brandon Palmateer, Nicolai Dorka, Tariq M Brown, Lina-Marie Wagner, William E Medendorp, Eric D Petersen, Mansi Prakash, Ute Hochgeschwende. Bioluminescence-driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model. Journal of neuroscience research. vol 98. issue 3. 2021-07-12. PMID:29577367. |
neuronal precursor cells were injected bilaterally into the striatum of homozygous aphakia mice, which carry a spontaneous mutation leading to lack of dopaminergic neurons and symptoms of pd. |
2021-07-12 |
2023-08-13 |
mouse |
| Paola Feraco, Cesare Gagliardo, Giuseppe La Tona, Eleonora Bruno, Costanza D'angelo, Maurizio Marrale, Anna Del Poggio, Maria Chiara Malaguti, Laura Geraci, Roberta Baschi, Benedetto Petralia, Massimo Midiri, Roberto Monaster. Imaging of Substantia Nigra in Parkinson's Disease: A Narrative Review. Brain sciences. vol 11. issue 6. 2021-07-05. PMID:34207681. |
parkinson's disease (pd) is a progressive neurodegenerative disorder, characterized by motor and non-motor symptoms due to the degeneration of the pars compacta of the substantia nigra (snc) with dopaminergic denervation of the striatum. |
2021-07-05 |
2023-08-13 |
Not clear |
| Steven Vetel, Laura Foucault-Fruchard, Claire Tronel, Frédéric Buron, Jackie Vergote, Sylvie Bodard, Sylvain Routier, Sophie Sérrière, Sylvie Chalo. Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson's disease. Neural regeneration research. vol 16. issue 6. 2021-07-03. PMID:33269756. |
although no effect was noticed in the amphetamine-induced rotation test, our data has shown that the pha/pre treatment induced partial protection of the dopaminergic neurons (15-20%), assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra. |
2021-07-03 |
2023-08-13 |
rat |
| Zhuang-Yao D Wei, Ashok K Shett. Treating Parkinson's disease by astrocyte reprogramming: Progress and challenges. Science advances. vol 7. issue 26. 2021-07-02. PMID:34162545. |
such in vivo astrocyte reprogramming in the mouse model of pd has successfully added new dopaminergic neurons to the substantia nigra and increased dopamine levels associated with axonal projections into the striatum. |
2021-07-02 |
2023-08-13 |
mouse |
| Khadga Raj, G D Gupta, Shamsher Sing. l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease. Drug and chemical toxicology. 2021-07-02. PMID:34210222. |
parkinson's disease (pd) is the second most prevalent progressive neurodegenerative disease, characterized by loss of dopaminergic neurons in substantia nigra, with deficiency of dopamine in the striatum. |
2021-07-02 |
2023-08-13 |
rat |
| Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A Cour. The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. Cell death and differentiation. vol 27. issue 4. 2021-06-29. PMID:31591470. |
parkinson's disease (pd) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine release in the striatum. |
2021-06-29 |
2023-08-13 |
mouse |
| Cecilia Tubert, Mario Gustavo Mure. What's wrong with the striatal cholinergic interneurons in Parkinson's disease? Focus on intrinsic excitability. The European journal of neuroscience. vol 53. issue 7. 2021-06-29. PMID:32302030. |
parkinson's disease (pd) is characterized by a degeneration of nigrostriatal dopaminergic neurons that results in a hypercholinergic state in the striatum. |
2021-06-29 |
2023-08-13 |
Not clear |
| Cecilia Tubert, Mario Gustavo Mure. What's wrong with the striatal cholinergic interneurons in Parkinson's disease? Focus on intrinsic excitability. The European journal of neuroscience. vol 53. issue 7. 2021-06-29. PMID:32302030. |
the best-established finding is an increase of chis intrinsic membrane excitability after dopaminergic denervation of striatum. |
2021-06-29 |
2023-08-13 |
Not clear |