| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle S Antunes, Leandro Cattelan Souza, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Vandreza Cardoso Bortolotto, Márcia Rósula Poetini Silva, Stífani Machado Araújo, Marina Prigol, Cristina Wayne Nogueira, Silvana Peterini Boeir. Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice. Molecular neurobiology. vol 57. issue 7. 2021-05-19. PMID:32458386. |
in conclusion, this study indicated that hesperidin exerts anxiolytic-like and antidepressant-like effect against 6-ohda-induced neurotoxicity through the modulation of cytokine production, neurotrophic factors levels, and dopaminergic innervation in the striatum. |
2021-05-19 |
2023-08-13 |
mouse |
| Arianna Ferrini, Dora Steel, Katy Barwick, Manju A Kuria. An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 5. 2021-05-19. PMID:33934385. |
adcy5 is the most commonly expressed isoform of adenylyl cyclase in medium spiny neurons (msns) of the striatum, and it integrates and controls dopaminergic signaling. |
2021-05-19 |
2023-08-13 |
Not clear |
| Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Yunfei Tan, Xingming Wang, Jiancheng Zhang, Kenji Hashimot. Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP. Neuroscience letters. vol 730. 2021-05-14. PMID:32387710. |
glyphosate exposure for 14 days significantly potentiated mptp-induced dopaminergic neurotoxicity in the striatum and snr of mouse brain. |
2021-05-14 |
2023-08-13 |
mouse |
| Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Yunfei Tan, Xingming Wang, Jiancheng Zhang, Kenji Hashimot. Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP. Neuroscience letters. vol 730. 2021-05-14. PMID:32387710. |
this study suggests that glyphosate exposure might exacerbate mptp-induced dopaminergic neurotoxicity in the striatum and snr of adult mice. |
2021-05-14 |
2023-08-13 |
mouse |
| Yunjeong Song, Sowoon Seo, Santosh Lamichhane, Jungwon Seo, Jin Tae Hong, Hye Jin Cha, Jaesuk Yu. Limonene has anti-anxiety activity via adenosine A2A receptor-mediated regulation of dopaminergic and GABAergic neuronal function in the striatum. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 83. 2021-05-11. PMID:33548867. |
limonene has anti-anxiety activity via adenosine a2a receptor-mediated regulation of dopaminergic and gabaergic neuronal function in the striatum. |
2021-05-11 |
2023-08-13 |
Not clear |
| Jae-Hwan Jang, Mi-Jung Yeom, Sora Ahn, Ju-Young Oh, Suhwan Ji, Tae-Hong Kim, Hi-Joon Par. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32827699. |
next, we found that acupuncture increased the levels of dopaminergic fibers and neurons in the striatum and the substantia nigra, respectively. |
2021-04-27 |
2023-08-13 |
mouse |
| Olle Lindval. Balancing Expectations for Success in Stem Cell-Based Clinical Trials for Parkinson's Disease. Cell stem cell. vol 27. issue 4. 2021-04-27. PMID:33007236. |
upcoming clinical trials assessing transplantation of stem cell-derived dopaminergic neurons into the striatum in patients with parkinson's disease could generate groundbreaking results on neuronal replacement in the human brain. |
2021-04-27 |
2023-08-13 |
human |
| Anastasiia Bohush, Wiesława Leśniak, Serge Weis, Anna Filipe. Calmodulin and Its Binding Proteins in Parkinson's Disease. International journal of molecular sciences. vol 22. issue 6. 2021-04-23. PMID:33809535. |
at the microscopic level it is characterized by formation of specific intraneuronal inclusions, called lewy bodies (lbs), and by a progressive loss of dopaminergic neurons in the striatum and substantia nigra. |
2021-04-23 |
2023-08-13 |
Not clear |
| P A Dionísio, J D Amaral, C M P Rodrigue. Oxidative stress and regulated cell death in Parkinson's disease. Ageing research reviews. vol 67. 2021-04-19. PMID:33540042. |
motor deficits usually associated with pd correlate with dopaminergic axonal neurodegeneration starting at the striatum, which is then followed by dopaminergic neuronal death in the substantia nigra pars compacta (sn), with both events occurring already at the prodromal stage. |
2021-04-19 |
2023-08-13 |
Not clear |
| Tomas Fiala, Jihang Wang, Matthew Dunn, Peter Šebej, Se Joon Choi, Ekeoma C Nwadibia, Eva Fialova, Diana M Martinez, Claire E Cheetham, Keri J Fogle, Michael J Palladino, Zachary Freyberg, David Sulzer, Dalibor Same. Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain. Journal of the American Chemical Society. vol 142. issue 20. 2021-04-16. PMID:32395989. |
dichloropane, a monoamine transporter ligand, enables targeting of dense dopaminergic axons in the mouse striatum and sparse noradrenergic axons in the mouse cortex in acute brain slices. |
2021-04-16 |
2023-08-13 |
mouse |
| Sari Goldstein Ferber, Aron Weller, Gal Yadid, Alexander Friedma. Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico-Striatal Loop That Are Implicated in Major Depression. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33668515. |
these receptors are enriched in the striosomal compartment of striatum that selectively projects to dopaminergic neurons of substantia nigra compacta and is vulnerable to stress. |
2021-04-15 |
2023-08-13 |
Not clear |
| Simeon O A Helgers, Svilen Angelov, Marc A N Muschler, Alexander Glahn, Shadi Al-Afif, Yazeed Al Krinawe, Elvis J Hermann, Joachim K Krauss, Helge Frieling, Kerstin Schwabe, Mathias Rhei. Epigenetic Regulation of Neural Transmission after Cerebellar Fastigial Nucleus Lesions in Juvenile Rats. Cerebellum (London, England). 2021-04-09. PMID:33834423. |
dna methylation was investigated for target genes of the gabaergic, dopaminergic, glutamatergic and oxytocinergic systems in brain regions with anatomic connections to the fastigial nucleus, i.e., medial prefrontal cortex, nucleus accumbens, striatum, thalamus, and sensorimotor cortex. |
2021-04-09 |
2023-08-13 |
rat |
| Ella E Bauer, Trevor J Buhr, Carter H Reed, Peter J Clar. Exercise-Induced Adaptations to the Mouse Striatal Adenosine System. Neural plasticity. vol 2020. 2021-04-07. PMID:32399024. |
exercise can increase adenosine activity in the brain, which may impair dopaminergic functions in the striatum. |
2021-04-07 |
2023-08-13 |
mouse |
| Peipei Mu, Yuting Liu, Shimin Jiang, Jin Gao, Shen Sun, Li Li, Dianshuai Ga. Glial cell line-derived neurotrophic factor alters lipid composition and protein distribution in MPP+-injured differentiated SH-SY5Y cells. Journal of cellular physiology. vol 235. issue 12. 2021-04-06. PMID:32356318. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra and striatum. |
2021-04-06 |
2023-08-13 |
Not clear |
| Zhaohui Liu, Hoi-Hung Cheun. Stem Cell-Based Therapies for Parkinson Disease. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33137927. |
however, proposed cell replacement therapies are promising because midbrain dopaminergic neurons have been shown to restore dopaminergic neurotransmission and functionally rescue the dopamine-depleted striatum. |
2021-03-29 |
2023-08-13 |
Not clear |
| Huanhuan Chen, Xuelian Li, Hui Ma, Wei Zheng, Xiaoli She. Reduction in Nesfatin-1 Levels in the Cerebrospinal Fluid and Increased Nigrostriatal Degeneration Following Ventricular Administration of Anti-nesfatin-1 Antibody in Mice. Frontiers in neuroscience. vol 15. 2021-02-24. PMID:33613183. |
treatment with anti-nesfatin-1 antibody resulted in a substantial loss (23%) of th-positive (th+) dopaminergic neurons in the substantia nigra pars compacta (snpc), as shown by immunofluorescence staining, a depletion in dopamine and its metabolites in the striatum detected by high-performance liquid chromatography (hplc), and obvious nuclear shrinkage and mitochondrial lesions in dopaminergic neurons in the snpc detected by transmission electron microscopy (tem). |
2021-02-24 |
2023-08-13 |
mouse |
| Yanyan Zhang, Jie Li, Xiao Zhang, Dongdong Song, Tian Tia. Advances of Mechanisms-Related Metabolomics in Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-02-23. PMID:33613180. |
parkinson's disease (pd) is a multifactorial disorder characterized by progressively debilitating dopaminergic neurodegeneration in the substantia nigra and the striatum, along with various metabolic dysfunctions and molecular abnormalities. |
2021-02-23 |
2023-08-13 |
human |
| Rafal Bogac. Dopamine role in learning and action inference. eLife. vol 9. 2021-02-22. PMID:32633715. |
in this framework, dopaminergic neurons projecting to different parts of the striatum encode errors in predictions made by the corresponding systems within the basal ganglia. |
2021-02-22 |
2023-08-13 |
Not clear |
| Julia Löser, Julia Luthardt, Michael Rullmann, David Weise, Osama Sabri, Jürgen Meixensberger, Swen Hesse, Dirk Winkle. Striatal dopamine transporter availability and individual clinical course within the 1-year follow-up of deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. Journal of neurosurgery. 2021-02-19. PMID:33607613. |
degeneration of dopaminergic neurons in the substantia nigra projecting to the striatum is responsible for the motor symptoms in parkinson's disease (pd). |
2021-02-19 |
2023-08-13 |
Not clear |
| Darryl S Watkins, Jason D True, Amber L Mosley, Anthony J Baucu. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Proteomes. vol 6. issue 4. 2021-02-18. PMID:30562941. |
glutamatergic projections from the cortex and dopaminergic projections from the substantia nigra or ventral tegmental area synapse on dendritic spines of specific gabaergic medium spiny neurons (msns) in the striatum. |
2021-02-18 |
2023-08-13 |
mouse |