| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huanhuan Chen, Xuelian Li, Hui Ma, Wei Zheng, Xiaoli She. Reduction in Nesfatin-1 Levels in the Cerebrospinal Fluid and Increased Nigrostriatal Degeneration Following Ventricular Administration of Anti-nesfatin-1 Antibody in Mice. Frontiers in neuroscience. vol 15. 2021-02-24. PMID:33613183. |
treatment with anti-nesfatin-1 antibody resulted in a substantial loss (23%) of th-positive (th+) dopaminergic neurons in the substantia nigra pars compacta (snpc), as shown by immunofluorescence staining, a depletion in dopamine and its metabolites in the striatum detected by high-performance liquid chromatography (hplc), and obvious nuclear shrinkage and mitochondrial lesions in dopaminergic neurons in the snpc detected by transmission electron microscopy (tem). |
2021-02-24 |
2023-08-13 |
mouse |
| Yanyan Zhang, Jie Li, Xiao Zhang, Dongdong Song, Tian Tia. Advances of Mechanisms-Related Metabolomics in Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-02-23. PMID:33613180. |
parkinson's disease (pd) is a multifactorial disorder characterized by progressively debilitating dopaminergic neurodegeneration in the substantia nigra and the striatum, along with various metabolic dysfunctions and molecular abnormalities. |
2021-02-23 |
2023-08-13 |
human |
| Rafal Bogac. Dopamine role in learning and action inference. eLife. vol 9. 2021-02-22. PMID:32633715. |
in this framework, dopaminergic neurons projecting to different parts of the striatum encode errors in predictions made by the corresponding systems within the basal ganglia. |
2021-02-22 |
2023-08-13 |
Not clear |
| Julia Löser, Julia Luthardt, Michael Rullmann, David Weise, Osama Sabri, Jürgen Meixensberger, Swen Hesse, Dirk Winkle. Striatal dopamine transporter availability and individual clinical course within the 1-year follow-up of deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. Journal of neurosurgery. 2021-02-19. PMID:33607613. |
degeneration of dopaminergic neurons in the substantia nigra projecting to the striatum is responsible for the motor symptoms in parkinson's disease (pd). |
2021-02-19 |
2023-08-13 |
Not clear |
| Darryl S Watkins, Jason D True, Amber L Mosley, Anthony J Baucu. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Proteomes. vol 6. issue 4. 2021-02-18. PMID:30562941. |
glutamatergic projections from the cortex and dopaminergic projections from the substantia nigra or ventral tegmental area synapse on dendritic spines of specific gabaergic medium spiny neurons (msns) in the striatum. |
2021-02-18 |
2023-08-13 |
mouse |
| Mehmet Senel, Esma Dervisevic, Sammy Alhassen, Muamer Dervisevic, Amal Alachkar, Victor J Cadarso, Nicolas H Voelcke. Microfluidic Electrochemical Sensor for Cerebrospinal Fluid and Blood Dopamine Detection in a Mouse Model of Parkinson's Disease. Analytical chemistry. vol 92. issue 18. 2021-02-16. PMID:32786441. |
the loss of dopaminergic neurons results in decreased dopamine (da) release in the striatum and thus impaired motor functions. |
2021-02-16 |
2023-08-13 |
mouse |
| Paul F Kramer, Emily L Twedell, Jung Hoon Shin, Renshu Zhang, Zayd M Khali. Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release. eLife. vol 9. 2021-02-16. PMID:32870779. |
axons of dopaminergic neurons innervate the striatum where they contribute to movement and reinforcement learning. |
2021-02-16 |
2023-08-13 |
mouse |
| Ikuko Miyazaki, Nami Isooka, Fuminori Imafuku, Jin Sun, Ryo Kikuoka, Chieko Furukawa, Masato Asanum. Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson's Disease. International journal of molecular sciences. vol 21. issue 9. 2021-02-05. PMID:32375371. |
rotenone treatment decreased the number of dopaminergic neuronal cells in the substantia nigra pars compacta (snpc) and lesioned nerve terminal in the striatum. |
2021-02-05 |
2023-08-13 |
mouse |
| María-de-Los-Angeles Andrade-Oliva, Juan Escamilla-Sánchez, Yazmín Debray-García, Russell A Morales-Rubio, Raúl González-Pantoja, Marisela Uribe-Ramírez, Omar Amador-Muñoz, Raúl V Díaz-Godoy, Andrea De Vizcaya-Ruiz, José-Antonio Arias-Montañ. In vitro exposure to ambient fine and ultrafine particles alters dopamine uptake and release, and D Environmental toxicology and pharmacology. vol 80. 2021-02-03. PMID:32942001. |
the striatum, a neuronal nucleus with extensive dopaminergic afferents, is a target site for particle toxicity, which results in oxidative stress, inflammation, astrocyte activation and modifications in dopamine content and d |
2021-02-03 |
2023-08-13 |
Not clear |
| Babita Singh, Shivani Pandey, Mohammad Rumman, Abbas Ali Mahd. Neuroprotective effects of Bacopa monnieri in Parkinson's disease model. Metabolic brain disease. vol 35. issue 3. 2021-02-02. PMID:31834548. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra region and the presence of α-synuclein aggregates in the striatum and surrounding areas of brain. |
2021-02-02 |
2023-08-13 |
Not clear |
| R N Lippert, S Hess, P Klemm, L M Burgeno, T Jahans-Price, M E Walton, P Kloppenburg, J C Brünin. Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. The Journal of clinical investigation. vol 130. issue 7. 2021-02-02. PMID:32510473. |
this translated into silencing of dopaminergic midbrain neurons, reduced connectivity to their downstream targets, and reduced stimulus-evoked dopamine (da) release in the striatum. |
2021-02-02 |
2023-08-13 |
mouse |
| Kathleen Wiencke, Annette Horstmann, David Mathar, Arno Villringer, Jane Neuman. Dopamine release, diffusion and uptake: A computational model for synaptic and volume transmission. PLoS computational biology. vol 16. issue 11. 2021-01-29. PMID:33253315. |
signal variability in target areas of dopaminergic neurons (striatum, cortex) may arise from dopamine concentration variability. |
2021-01-29 |
2023-08-13 |
Not clear |
| Lívia Ferraz D'avila, Verônica Tironi Dias, Laura Hautrive Milanesi, Karine Roversi, Fabíola Trevizol, Luana Haselein Maurer, Tatiana Emanuelli, Marilise Escobar Burger, Hecson Jesser Sega. Interesterified fat consumption since gestation decreases striatal dopaminergic targets levels and gdnf impairing locomotion of adult offspring. Toxicology letters. vol 339. 2021-01-25. PMID:33359558. |
in the adult offspring striatum, dopaminergic targets, glial cell line-derived neurotrophic factor (gdfn) and lipid profile were quantified. |
2021-01-25 |
2023-08-13 |
rat |
| Lívia Ferraz D'avila, Verônica Tironi Dias, Laura Hautrive Milanesi, Karine Roversi, Fabíola Trevizol, Luana Haselein Maurer, Tatiana Emanuelli, Marilise Escobar Burger, Hecson Jesser Sega. Interesterified fat consumption since gestation decreases striatal dopaminergic targets levels and gdnf impairing locomotion of adult offspring. Toxicology letters. vol 339. 2021-01-25. PMID:33359558. |
moreover, if group showed decreased immunoreactivity of all dopaminergic targets evaluated and gdnf, along with important changes in fa composition in striatum. |
2021-01-25 |
2023-08-13 |
rat |
| Yuki Kishimoto, Wandi Zhu, Waki Hosoda, Jyoti M Sen, Mark P Mattso. Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice. Neuromolecular medicine. vol 21. issue 3. 2021-01-22. PMID:31079293. |
levels of the dopaminergic neuron marker tyrosine hydroxylase in the striatum and numbers of dopaminergic neurons in the substantia nigra were reduced in pd mice with gut inflammation. |
2021-01-22 |
2023-08-13 |
mouse |
| Wen-Wen Liu, Shi-Zhuang Wei, Guo-Dong Huang, Lu-Bing Liu, Chao Gu, Yun Shen, Xian-Hui Wang, Shu-Ting Xia, An-Mu Xie, Li-Fang Hu, Fen Wang, Chun-Feng Li. BMAL1 regulation of microglia-mediated neuroinflammation in MPTP-induced Parkinson's disease mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 5. 2021-01-22. PMID:32246801. |
we here showed that inactivation of brain and muscle arnt-like 1 (bmal1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (mptp)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (dans) in the substantia nigra pars compacta (snpc), decrease of dopamine (da) transmitter, and increased activation of microglia and astrocytes in the striatum. |
2021-01-22 |
2023-08-13 |
mouse |
| Ilaria Rosa, Davide Di Censo, Brigida Ranieri, Giuseppe Di Giovanni, Eugenio Scarnati, Marcello Alecci, Angelo Galante, Tiziana Marilena Flori. Comparison between Tail Suspension Swing Test and Standard Rotation Test in Revealing Early Motor Behavioral Changes and Neurodegeneration in 6-OHDA Hemiparkinsonian Rats. International journal of molecular sciences. vol 21. issue 8. 2021-01-22. PMID:32326015. |
here, we investigated whether early motor behavioral deficits can be observed in the first week after the injection of 6-ohda into the right substantia nigra pars compacta (snc), and if they were indicative of the severity of the dopaminergic (daergic) lesion in the snc and the striatum at different time-points (day 1, 3, 5, 7, 14, 21). |
2021-01-22 |
2023-08-13 |
rat |
| Samuel Alberquilla, Aldo Gonzalez-Granillo, Eduardo Daniel Martín, Rosario Moratall. Dopamine regulates spine density in striatal projection neurons in a concentration-dependent manner. Neurobiology of disease. vol 134. 2021-01-13. PMID:31682992. |
dopaminergic afferents innervate spiny projection neurons (spns) in the striatum, maintaining basal ganglia activity. |
2021-01-13 |
2023-08-13 |
mouse |
| Danielle M Giangrasso, Teri M Furlong, Kristen A Keef. Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease. Neurobiology of disease. vol 134. 2021-01-13. PMID:31734455. |
these results suggest that the nigrostriatal dopaminergic and prefrontal serotoninergic systems are altered early in the progression of dj-1 ko pathology, despite no overt loss of the da innervation of the striatum, and thus may be associated with early alterations in the functions of corticostriatal systems. |
2021-01-13 |
2023-08-13 |
rat |
| Haibo Zhou, Jinlin Su, Xinde Hu, Changyang Zhou, He Li, Zhaorong Chen, Qingquan Xiao, Bo Wang, Wenyan Wu, Yidi Sun, Yingsi Zhou, Cheng Tang, Fei Liu, Linhan Wang, Canbin Feng, Mingzhe Liu, Sanlan Li, Yifeng Zhang, Huatai Xu, Haishan Yao, Linyu Shi, Hui Yan. Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice. Cell. vol 181. issue 3. 2021-01-04. PMID:32272060. |
furthermore, this approach also induced neurons with dopaminergic features in the striatum and alleviated motor defects in a parkinson's disease mouse model. |
2021-01-04 |
2023-08-13 |
mouse |