| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefanie Seiler, Stefano Di Santo, Lukas Andereggen, Hans R Widme. Antagonization of the Nogo-Receptor 1 Enhances Dopaminergic Fiber Outgrowth of Transplants in a Rat Model of Parkinson's Disease. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28603490. |
in rats without a transplant, the density of dopaminergic fibers in the striatum was analyzed. |
2020-10-01 |
2023-08-13 |
human |
| Francesca Siani, Rosaria Greco, Giovanna Levandis, Cristina Ghezzi, Francesca Daviddi, Chiara Demartini, Elisabetta Vegeto, Marie-Thérèse Fuzzati-Armentero, Fabio Blandin. Influence of Estrogen Modulation on Glia Activation in a Murine Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28620274. |
animals were sacrificed at different time points following 6-ohda injection and brain sections containing striatum and substantia nigra pars compacta (snc) underwent immunohistochemistry for tyrosine hydroxylase (th) (dopaminergic marker), immunofluorescence for iba1 and gfap (markers of microglia and astrocyte activation, respectively) and triple immunoflorescent to identify polarization of microglia toward the cytotoxic m1 (dapi/iba1/tnfα) or cytoprotective m2 (dapi/iba1/cd206) phenotype. |
2020-10-01 |
2023-08-13 |
mouse |
| Sudhakar R Subramaniam, Howard J Federof. Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28642697. |
parkinson's disease (pd) is a chronic and progressive disorder characterized neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular proteinaceous inclusions, reduction of dopaminergic terminals in the striatum, and increased neuroinflammatory cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Alejandra Boronat-García, Magdalena Guerra-Crespo, René Drucker-Colí. Historical perspective of cell transplantation in Parkinson's disease. World journal of transplantation. vol 7. issue 3. 2020-10-01. PMID:28698835. |
the classical motor symptoms of pd are caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrement in dopamine release in the striatum. |
2020-10-01 |
2023-08-13 |
human |
| Florian Brugger, Roberto Erro, Bettina Balint, Georg Kägi, Paolo Barone, Kailash P Bhati. Why is there motor deterioration in Parkinson's disease during systemic infections-a hypothetical view. NPJ Parkinson's disease. vol 1. 2020-10-01. PMID:28725683. |
possible explanations encompass changes in the pharmacodynamics of the dopaminergic drugs, altered dopamine metabolism in the brain, alterations in the dopaminergic transmission in the striatum or an enhancement of neurodegeneration due to remote effects of peripheral inflammatory processes or circulating bacterial toxins. |
2020-10-01 |
2023-08-13 |
Not clear |
| Amy K Reeve, John P Grady, Eve M Cosgrave, Emma Bennison, Chun Chen, Philippa D Hepplewhite, Christopher M Morri. Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson's disease. NPJ Parkinson's disease. vol 4. 2020-10-01. PMID:29872690. |
the loss of dopaminergic substantia nigra neurons in parkinson's disease is associated with loss of synapses within the striatum, and this may precede neuronal loss. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
after the last pole test, dopaminergic neuronal survival in the striatum and the substantia nigra (sn), cell proliferation in the svz and mrna expression of neurotrophic factors and dopamine receptors in the striatum were evaluated. |
2020-10-01 |
2023-08-13 |
mouse |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
krg administration suppressed dopaminergic neuronal death induced by mptp in the striatum as well as the sn, augmented the number of brdu- and brdu/doublecortin (dcx)-positive cells in the svz and enhanced the expression of proliferation cell nuclear antigen, brain derived neurotrophic factor (bdnf), glial cell derived neurotrophic factor (gdnf), cerebral dopamine neurotrophic factor (cdnf), ciliary neurotrophic factor (cntf), dopamine receptor d3 (drd3) and d5 mrnas. |
2020-10-01 |
2023-08-13 |
mouse |
| Elisa Caggiu, Giannina Arru, Sepideh Hosseini, Magdalena Niegowska, GianPietro Sechi, Ignazio Roberto Zarbo, Leonardo A Sech. Inflammation, Infectious Triggers, and Parkinson's Disease. Frontiers in neurology. vol 10. 2020-10-01. PMID:30837941. |
parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons of the substantia nigra pars compacta with a reduction of dopamine concentration in the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Ca. 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents. Parkinson's disease. vol 2019. 2020-10-01. PMID:30944722. |
th immunostaining was performed to evaluate rotenone-induced neurotoxicity on substantia nigra (sn) dopaminergic neurons and the da terminals in the striatum. |
2020-10-01 |
2023-08-13 |
rat |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
in parkinson's disease, the degeneration of dopaminergic neurons in substantia nigra leads to a decrease in the physiological levels of dopamine in striatum. |
2020-10-01 |
2023-08-13 |
human |
| Chentao Wen, Yukiko Ogura, Toshiya Matsushim. Striatal and Tegmental Neurons Code Critical Signals for Temporal-Difference Learning of State Value in Domestic Chicks. Frontiers in neuroscience. vol 10. 2020-09-30. PMID:27877100. |
based on the theoretical and neurophysiological studies, together with tract-tracing data, we propose a novel model to explain how the convergence of signals represented in the striatum could lead to the computation of td error in tegmental dopaminergic neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Veronica A Antipova, Carsten Holzmann, Oliver Schmitt, Andreas Wree, Alexander Hawlitschk. Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson's Disease Differently Affects Behavior. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28680396. |
the loss of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic interneurons in the striatum. |
2020-09-30 |
2023-08-13 |
human |
| Juan M Viveros-Paredes, Rocio E González-Castañeda, Juerg Gertsch, Veronica Chaparro-Huerta, Rocio I López-Roa, Eduardo Vázquez-Valls, Carlos Beas-Zarate, Antoni Camins-Espuny, Mario E Flores-Sot. Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP. Pharmaceuticals (Basel, Switzerland). vol 10. issue 3. 2020-09-30. PMID:28684694. |
in the murine model, bcp pretreatment ameliorated motor dysfunction, protected against dopaminergic neuronal losses in the sn and striatum, and alleviated mptp-induced glia activation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Anna M Klawonn, Anna Nilsson, Carl F Rådberg, Sarah H Lindström, Mia Ericson, Björn Granseth, David Engblom, Michael Frit. The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:29066971. |
the sigma-2 receptor selective agonist siramesine (lu 28-179) decreases cocaine-reinforced pavlovian learning and alters glutamatergic and dopaminergic input to the striatum. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mekite Bezu, Jovana Maliković, Martina Kristofova, Ephrem Engidawork, Harald Höger, Gert Lubec, Volker Kor. Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:29081740. |
the dopaminergic system is known to be involved in working memory processed by several brain regions like prefrontal cortex (pfc), hippocampus, striatum. |
2020-09-30 |
2023-08-13 |
rat |
| Rahul Patel, Joshua M Bradner, Kristen A Stout, William Michael Caudl. Alteration to Dopaminergic Synapses Following Exposure to Perfluorooctane Sulfonate (PFOS), in Vitro and in Vivo. Medical sciences (Basel, Switzerland). vol 4. issue 3. 2020-09-30. PMID:29083377. |
using an in vivo model, we did not observe a deficit to dopaminergic terminals in the striatum of mice exposed to 10 mg/kg pfos for 14 days. |
2020-09-30 |
2023-08-13 |
mouse |
| Xiaohan Zhang, Shenquan Liu, Feibiao Zhan, Jing Wang, Xiaofang Jian. The Effects of Medium Spiny Neuron Morphologcial Changes on Basal Ganglia Network under External Electric Field: A Computational Modeling Study. Frontiers in computational neuroscience. vol 11. 2020-09-30. PMID:29123477. |
the damage of dopaminergic neurons that innervate the striatum has been considered to be the proximate cause of parkinson's disease (pd). |
2020-09-30 |
2023-08-13 |
Not clear |
| Bridget Martinez, Philip V Peplo. MicroRNAs in Parkinson's disease and emerging therapeutic targets. Neural regeneration research. vol 12. issue 12. 2020-09-30. PMID:29323027. |
parkinson's disease (pd) is the second most common age-related neurodegenerative disorder, with the clinical main symptoms caused by a loss of dopaminergic neurons in the substantia nigra, corpus striatum and brain cortex. |
2020-09-30 |
2023-08-13 |
mouse |
| David A Vogelsang, Mark D'Esposit. Is There Evidence for a Rostral-Caudal Gradient in Fronto-Striatal Loops and What Role Does Dopamine Play? Frontiers in neuroscience. vol 12. 2020-09-30. PMID:29706863. |
we extend these observations by discussing how such a rostral-caudal gradient may also exist in the striatum and how the dopaminergic system may play an important role in the hierarchical organization of fronto-striatal loops. |
2020-09-30 |
2023-08-13 |
Not clear |