| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Tian, Yuwen Cao, Rong Chen, Yufeng Jing, Lin Xia, Shiqing Zhang, Huaxi Xu, Zhaoliang S. HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson's disease model. Clinical science (London, England : 1979). vol 134. issue 15. 2020-12-29. PMID:32706028. |
in the subacute parkinson's disease (pd) mice model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), injection of hmgb1 competitive inhibitor protein hmgb1 a box and the ethyl pyruvate (ep) that inhibit the release of hmgb1 from cells restored the number of dopaminergic neurons and th+ fibers in the sn and striatum. |
2020-12-29 |
2023-08-13 |
mouse |
| Mahboubeh Manouchehrabadi, Mona Farhadi, Zahra Azizi, Anahita Torkaman-Boutorab. Carvacrol Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in In Vivo and In Vitro Models of Parkinson's Disease. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31364033. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons that project from the substantia nigra pars compacta to the striatum. |
2020-12-21 |
2023-08-13 |
human |
| Changliang Li. Targeting the cholinergic system in Parkinson's disease. Acta pharmacologica Sinica. vol 41. issue 4. 2020-12-21. PMID:32132659. |
in addition to dopaminergic innervation, giant aspiny cholinergic interneurons (chis) within the striatum have long been recognized as a critical node for balancing dopamine signaling and regulating movement. |
2020-12-21 |
2023-08-13 |
Not clear |
| Michael Freedberg, Andrew C Toader, Eric M Wassermann, Joel L Vos. Competitive and cooperative interactions between medial temporal and striatal learning systems. Neuropsychologia. vol 136. 2020-12-11. PMID:31733236. |
the involvement of other regions, such as midbrain dopaminergic nuclei and the prefrontal cortex, may promote and mediate cooperation between the striatum and the mtl during learning. |
2020-12-11 |
2023-08-13 |
Not clear |
| Seunghyi Kook, Xuanzhi Zhan, Kimberly Thibeault, Mohamed R Ahmed, Vsevolod V Gurevich, Eugenia V Gurevic. Mdm2 enhances ligase activity of parkin and facilitates mitophagy. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32193420. |
loss-of-function mutations in the e3 ubiquitin ligase parkin have been implicated in the death of dopaminergic neurons in the substantia nigra, which is the root cause of dopamine deficit in the striatum in parkinson's disease. |
2020-12-10 |
2023-08-13 |
Not clear |
| Tommi Kilpeläinen, Ulrika H Julku, Reinis Svarcbahs, Timo T Myöhäne. Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. Scientific reports. vol 9. issue 1. 2020-11-30. PMID:31758049. |
additionally, we found a decreased amphetamine response in locomotor activity and decreased extracellular dopaminergic markers in the striatum and substantia nigra with significantly elevated levels of asyn oligomers. |
2020-11-30 |
2023-08-13 |
mouse |
| D R Belov, E V Efimova, Z S Fesenko, K A Antonova, S F Kolodyazhny, A M Lakstygal, R R Gainetdino. Putative Trace-Amine Associated Receptor 5 (TAAR5) Agonist α-NETA Increases Electrocorticogram Gamma-Rhythm in Freely Moving Rats. Cellular and molecular neurobiology. vol 40. issue 2. 2020-11-18. PMID:31385135. |
administration of α-neta caused significant modulation of dopaminergic system as evidenced by an altered dopamine turnover rate in the striatum. |
2020-11-18 |
2023-08-13 |
mouse |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
based on the knowledge that cocaine induces both addiction and motor stimulation, through its ability to enhance dopaminergic signaling in the corpus striatum, we have now explored the involvement of rhes in the effects associated with this psychostimulant. |
2020-11-05 |
2023-08-13 |
mouse |
| Blenda Hyedra de Campos, Lorena de Jager, Gabriela Souza Reginato, Rito Santo Pereira, Carlos César Crestani, Phileno Pinge-Filho, Marli Cardoso Martins-Ping. Cardiovascular evaluation of female rats with 6-OHDA-induced parkinsonism: Possible protection by ovarian hormones and participation of nitric oxide. Life sciences. vol 259. 2020-11-04. PMID:32795538. |
parkinson's disease (pd) is a neurological disorder caused by environmental and genetic factors, characterized by the death of dopaminergic neurons of the substantia nigra pars compacta (snpc), leading to a decrease of dopamine in the striatum. |
2020-11-04 |
2023-08-13 |
rat |
| E Maruthi Prasad, Shih-Ya Hun. Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 9. issue 10. 2020-11-03. PMID:33081318. |
in pd, continuous loss of dopaminergic neurons in the substantia nigra causes dopamine depletion in the striatum, promotes the primary motor symptoms of resting tremor, bradykinesia, muscle rigidity, and postural instability. |
2020-11-03 |
2023-08-13 |
Not clear |
| Natalia Ninkina, Tatiana V Tarasova, Kirill D Chaprov, Andrei Yu Roman, Michail S Kukharsky, Larisa G Kolik, Ruslan Ovchinnikov, Aleksey A Ustyugov, Andrey D Durnev, Vladimir L Buchma. Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice. Neurobiology of aging. vol 91. 2020-10-30. PMID:32224067. |
no significant changes of animal balance/coordination, the number of dopaminergic neurons in the snpc and the content of dopamine and its metabolites in the striatum were observed after adult-onset α-synuclein depletion, but in aging (18-month-old) late-onset depleted mice we found a significant reduction of major dopamine metabolites without changes to the content of dopamine itself. |
2020-10-30 |
2023-08-13 |
mouse |
| Paulina Troncoso-Escudero, Denisse Sepulveda, Rodrigo Pérez-Arancibia, Alejandra V Parra, Javiera Arcos, Felipe Grunenwald, Rene L Vida. On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-28. PMID:33101007. |
these symptoms are due to the loss principally of dopaminergic neurons of the substantia nigra (sn) par compacta and the gabaergic neurons of the striatum in pd and hd, respectively. |
2020-10-28 |
2023-08-13 |
Not clear |
| Thomas B Stoker, Roger A Barke. Recent developments in the treatment of Parkinson's Disease. F1000Research. vol 9. 2020-10-27. PMID:32789002. |
treatment options for pd are limited, with most of the current approaches based on restoration of dopaminergic tone in the striatum. |
2020-10-27 |
2023-08-13 |
Not clear |
| Joseph T Coyle, Robert Schwarc. The Discovery and Characterization of Targeted Perikaryal-Specific Brain Lesions With Excitotoxins. Frontiers in neuroscience. vol 14. 2020-10-06. PMID:33013307. |
the coyle laboratory showed that direct injection of the potent glutamate receptor agonist, kainic acid, into the rat striatum caused a rapid degeneration of intrinsic neurons while sparing axons of passage or termination including the unmyelinated dopaminergic terminals. |
2020-10-06 |
2023-08-13 |
mouse |
| Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Justyna Barut, Piotr Chmielarz, Marta Kot, Monika Bagińska, Rosanna Parlato, Władysława Anna Daniel, Irena Nalep. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism. Scientific reports. vol 9. issue 1. 2020-10-05. PMID:30918302. |
the results showed that reboxetine improved the parkinsonian phenotype associated with delayed progression of sn/vta dopaminergic neurodegeneration and higher dopamine content in the striatum. |
2020-10-05 |
2023-08-13 |
mouse |
| Kristin M Andruska, And Brad A Racett. Neuromythology of Manganism. Current epidemiology reports. vol 2. issue 2. 2020-10-01. PMID:26046010. |
here we will review three neurologic "myths" of manganism in the twenty-first century and will provide evidence that mn is associated with a clinical syndrome of parkinsonism that resembles parkinson disease, dopaminergic dysfunction on molecular imaging, and an inflammatory neuropathology in the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |
| Haruo Nishijima, Masahiko Tomiyam. What Mechanisms Are Responsible for the Reuptake of Levodopa-Derived Dopamine in Parkinsonian Striatum? Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28018168. |
when dopaminergic neurons are lost and dopamine transporters decreased, serotonin and norepinephrine transporters compensate by increasing uptake of excessive extracellular dopamine in the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |
| Janina Grosch, Jürgen Winkler, Zacharias Koh. Early Degeneration of Both Dopaminergic and Serotonergic Axons - A Common Mechanism in Parkinson's Disease. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28066188. |
motor symptoms in parkinson's disease (pd) are tightly linked to the degeneration of substantia nigra dopaminergic neurons and their projections into the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Eun-Sang Ji, Baek-Vin Li. Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats. Journal of exercise rehabilitation. vol 13. issue 1. 2020-10-01. PMID:28349030. |
parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. |
2020-10-01 |
2023-08-13 |
rat |
| Yunseon Jang, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Ilhwan Ryu, Xianshu Ju, Min Jeong Ryu, Woosuk Chung, Eungseok Oh, Gi Ryang Kweon, Jun Young He. A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities. Experimental neurobiology. vol 26. issue 2. 2020-10-01. PMID:28442947. |
a dopaminergic neuronal pathway from the substantia nigra (sn) to the striatum is responsible for regulating grip strength and motor initiation through tyrosine hydroxylase (th) activity-dependent dopamine release. |
2020-10-01 |
2023-08-13 |
mouse |