| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Lindroos, Jeanette Hellgren Kotalesk. Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. The European journal of neuroscience. vol 53. issue 7. 2021-06-29. PMID:32609903. |
the two systems are tightly connected, for example, synchronized activity of cholinergic interneurons, leading to increased acetylcholine release, has been shown to directly trigger dopamine release from dopaminergic terminals in striatum. |
2021-06-29 |
2023-08-13 |
Not clear |
| Atsushi Noritake, Taihei Ninomiya, Masaki Isod. Subcortical encoding of agent-relevant associative signals for adaptive social behavior in the macaque. Neuroscience and biobehavioral reviews. vol 125. 2021-06-28. PMID:33609569. |
here, we review the literature supporting the hypothesis that behavioral variables important for decision-making, i.e., stimulus, action, and outcome, are associated with agent information (self and other) in subcortical regions, such as the amygdala, striatum, lateral hypothalamus, and dopaminergic midbrain nuclei. |
2021-06-28 |
2023-08-13 |
monkey |
| Chenyang Han, Heping Shen, Yi Yang, Yongjia Sheng, Jin Wang, Wenyan Li, Xiaohong Zhou, Li Guo, Liping Zhai, Qiaobing Gua. Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation. Brain and behavior. vol 10. issue 11. 2021-06-24. PMID:32902155. |
the main pathological change is the apoptosis of dopaminergic neurons in the substantia nigra pars compacta (snpc), thereby leading to dopamine reduction in nigral striatum. |
2021-06-24 |
2023-08-13 |
mouse |
| Sara R Oliveira, Pedro A Dionísio, Maria M Gaspar, Maria B T Ferreira, Catarina A B Rodrigues, Rita G Pereira, Mónica S Estevão, Maria J Perry, Rui Moreira, Carlos A M Afonso, Joana D Amaral, Cecília M P Rodrigue. Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice. International journal of molecular sciences. vol 22. issue 10. 2021-06-23. PMID:34069782. |
more importantly, mice exposed to mptp and further treated with oxa12 showed protection against mptp-induced dopaminergic neuronal loss in the sn and striatum. |
2021-06-23 |
2023-08-13 |
mouse |
| Ana Clara Cristóvão, Filipa L Campos, Goun Je, Marta Esteves, Subhrangshu Guhathakurta, Lichuan Yang, M Flint Beal, Beatriz M Fonseca, Antonio J Salgado, João Queiroz, Nuno Sousa, Liliana Bernardino, Gilberto Alves, Kyung-Sik Yoon, Yoon-Seong Ki. Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm. The European journal of neuroscience. vol 52. issue 4. 2021-06-21. PMID:31958881. |
the pq exposure paradigm used lead to a rodent model of pd depicting progressive nigrostriatal dopaminergic neurodegeneration, characterized by a 41% significant loss of dopaminergic neuron in the substantia nigra pars compacta (snpc), a significant decrease of 18% and 40% of dopamine levels in striatum at week 5 and 8, respectively, and a significant 1.5-fold decrease in motor performance. |
2021-06-21 |
2023-08-13 |
human |
| Danielle Walu Kasongo, Gioacchino de Leo, Nunzio Vicario, Giampiero Leanza, Giuseppe Legnam. Chronic α-Synuclein Accumulation in Rat Hippocampus Induces Lewy Bodies Formation and Specific Cognitive Impairments. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393581. |
no pathologic α-syn deposits were found within the substantia nigra (sn), the ventral tegmental area (vta), or the striatum, nor was any loss of dopaminergic, noradrenergic, or cholinergic neurons detected in α-syn-injected animals, compared with controls. |
2021-06-18 |
2023-08-13 |
mouse |
| Hye-Sun Lim, Byeong Cheol Moon, Jun Lee, Goya Choi, Gunhyuk Par. The insect molting hormone 20-hydroxyecdysone protects dopaminergic neurons against MPTP-induced neurotoxicity in a mouse model of Parkinson's disease. Free radical biology & medicine. vol 159. 2021-06-18. PMID:32745769. |
a 20e treatment protected against mptp-induced motor incoordination, postural imbalance, and bradykinesia, and significantly reduced dopaminergic neuronal loss in the substantia nigra pars compacta (snpc) and the striatum (st). |
2021-06-18 |
2023-08-13 |
mouse |
| Laura Arroyo, Daniel Valent, Ricard Carreras, Raquel Pato, Josefa Sabrià, Antonio Velarde, Anna Bassol. Neurobiology of environmental enrichment in pigs: hanges in monoaminergic neurotransmitters in several brain areas and in the hippocampal proteome. Journal of proteomics. vol 229. 2021-06-18. PMID:32814107. |
the decrease in noradrenaline in the prefrontal cortex and amygdala, a general decrease in the dopaminergic system and an increase of serotonin in the striatum indicate a lower response to stress in enriched conditions. |
2021-06-18 |
2023-08-13 |
Not clear |
| Dinesh Kumar Verma, Anurupa Ghosh, Lindsey Ruggiero, Etienne Cartier, Eric Janezic, Dionne Williams, Eui-Gil Jung, Michael Moore, Jong Bok Seo, Yong-Hwan Ki. The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models. eNeuro. vol 7. issue 5. 2021-06-18. PMID:32887693. |
in immunohistochemistry, dopaminergic axon tips in the striatum and cell bodies in the substantia nigra from ubc9-overexpressing transgenic mice were protected from mptp toxicities compared with wild-type (wt) siblings. |
2021-06-18 |
2023-08-13 |
mouse |
| Livia Tomova, Kay Tye, Rebecca Sax. The neuroscience of unmet social needs. Social neuroscience. vol 16. issue 3. 2021-06-14. PMID:31729923. |
in humans, social rejection can lead to either increased or decreased social motivation, and is associated with activity in the insular cortex; while chronic loneliness is typically associated with decreased social motivation but has been associated with altered dopaminergic responses in the striatum. |
2021-06-14 |
2023-08-13 |
human |
| Marcello Serra, Annalisa Pinna, Giulia Costa, Alessandro Usiello, Massimo Pasqualetti, Luigi Avallone, Micaela Morelli, Francesco Napolitan. Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons' Degeneration: Link to Parkinson's Disease. International journal of molecular sciences. vol 22. issue 10. 2021-06-14. PMID:34070217. |
involvement of the protein ras homolog enriched in the striatum, rhes, in dopaminergic neurons' degeneration: link to parkinson's disease. |
2021-06-14 |
2023-08-13 |
Not clear |
| Silviu I Rusu, Cyriel M A Pennart. Learning, memory and consolidation mechanisms for behavioral control in hierarchically organized cortico-basal ganglia systems. Hippocampus. vol 30. issue 1. 2021-06-11. PMID:31617622. |
the functioning of a connected set of brain structures-prefrontal cortex, hippocampus, striatum, and dopaminergic mesencephalon-is reviewed in relation to two important distinctions: (a) goal-directed as opposed to habitual behavior and (b) model-based and model-free learning. |
2021-06-11 |
2023-08-13 |
Not clear |
| Carl G Gottschalk, Malabendu Jana, Avik Roy, Dhruv R Patel, Kalipada Paha. Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 10. 2021-06-11. PMID:33514677. |
oral administration of the human equivalent dose of gemfibrozil protected tyrosine hydroxylase (th)-positive dopaminergic neurons in the substantia nigra pars compacta and th fibers in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-insulted mice of both sexes. |
2021-06-11 |
2023-08-13 |
mouse |
| Jeroen P H Verharen, Roger A H Adan, Louk J M J Vanderschure. How Reward and Aversion Shape Motivation and Decision Making: A Computational Account. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 26. issue 1. 2021-06-08. PMID:30866712. |
the brain circuits processing these signals are widespread and include the prefrontal cortex, amygdala and striatum, and their dopaminergic innervation. |
2021-06-08 |
2023-08-13 |
Not clear |
| Ting Sun, Zhe-Xu Ding, Xin Luo, Qing-Shan Liu, Yong Chen. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294121. |
results from immunohistochemistry and western blotting indicated that the loss of dopaminergic neurons in substantia nigra and striatum of pd model mice was rescued by the exosome treatment. |
2021-06-08 |
2023-08-13 |
mouse |
| Roberto Limongi, Michael Mackinley, Kara Dempster, Ali R Khan, Joseph S Gati, Lena Palaniyappa. Frontal-striatal connectivity and positive symptoms of schizophrenia: implications for the mechanistic basis of prefrontal rTMS. European archives of psychiatry and clinical neuroscience. vol 271. issue 1. 2021-06-06. PMID:32683527. |
it has been hypothesized that high-frequency rtms of the ldlpfc might increase the dopaminergic neurotransmission by driving the activity of the left striatum in the basal ganglia (lstr)-increasing striatal dopaminergic activity. |
2021-06-06 |
2023-08-13 |
human |
| James P Harris, Justin C Burrell, Laura A Struzyna, H Isaac Chen, Mijail D Serruya, John A Wolf, John E Duda, D Kacy Culle. Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease. NPJ Parkinson's disease. vol 6. 2021-06-05. PMID:31934611. |
the classic motor symptoms of pd result from selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc), resulting in a loss of their long axonal projections to the striatum. |
2021-06-05 |
2023-08-13 |
Not clear |
| James P Harris, Justin C Burrell, Laura A Struzyna, H Isaac Chen, Mijail D Serruya, John A Wolf, John E Duda, D Kacy Culle. Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease. NPJ Parkinson's disease. vol 6. 2021-06-05. PMID:31934611. |
in the upcoming era of restorative neurosurgery, such constructs may directly replace snpc neurons, restore axon-based dopaminergic inputs to the striatum, and ameliorate motor deficits. |
2021-06-05 |
2023-08-13 |
Not clear |
| Lorena Jiménez-Sánchez, Javier Blesa, Natalia L Del Rey, Mariana H G Monje, José A Obeso, Carmen Cavad. Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease. Neuropharmacology. vol 170. 2021-06-03. PMID:31589886. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra and dopamine depletion in the striatum. |
2021-06-03 |
2023-08-13 |
monkey |
| Luis O Soto-Rojas, Irma A Martínez-Dávila, Claudia Luna-Herrera, María E Gutierrez-Castillo, Francisco E Lopez-Salas, Bismark Gatica-Garcia, Guadalupe Soto-Rodriguez, María Elena Bringas Tobon, Gonzalo Flores, America Padilla-Viveros, Cecilia Bañuelos, Víctor Manuel Blanco-Alvarez, José Dávila-Ayala, David Reyes-Corona, Linda Garcés-Ramírez, Oriana Hidalgo-Alegria, Fidel De La Cruz-López, Daniel Martinez-Fon. Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32321590. |
decreased density of dopaminergic fibers and dendritic spines also occurred in the striatum. |
2021-05-31 |
2023-08-13 |
rat |