| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei-Fang Liu, Yan Xue, Cui Liu, Yun-Hai Liu, Hui-Ling Diao, Ying Wang, Yi-Peng Pan, Lei Che. Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson's Disease. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30524223. |
the results from animal experiments demonstrated that orexin-a attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (th) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. |
2020-09-30 |
2023-08-13 |
mouse |
| Haruo Nishijima, Yasuo Miki, Shinya Ueno, Masahiko Tomiyam. Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson's Disease. Parkinson's disease. vol 2018. 2020-09-30. PMID:30662707. |
however, it is still unclear whether the effect of zonisamide is mainly due to dopaminergic modification in the striatum, or if zonisamide works through nondopaminergic pathways. |
2020-09-30 |
2023-08-13 |
rat |
| Eugene Huh, Jin Gyu Choi, Yeomoon Sim, Myung Sook O. An Integrative Approach to Treat Parkinson's Disease: Ukgansan Complements L-Dopa by Ameliorating Dopaminergic Neuronal Damage and L-Dopa-Induced Dyskinesia in Mice. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30666195. |
although l-dopa was found to reduce motor dysfunctions, it failed to decrease the dopaminergic neuronal damage and increased the expression of dopamine receptor 1 (d1r) and 2 (d2r) in the 6-ohda-injected mouse striatum. |
2020-09-30 |
2023-08-13 |
mouse |
| Eugene Huh, Jin Gyu Choi, Yeomoon Sim, Myung Sook O. An Integrative Approach to Treat Parkinson's Disease: Ukgansan Complements L-Dopa by Ameliorating Dopaminergic Neuronal Damage and L-Dopa-Induced Dyskinesia in Mice. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30666195. |
in addition, ugs suppressed the dyskinesia induced by chronic l-dopa treatment while restoring the dopaminergic neurons in the striatum. |
2020-09-30 |
2023-08-13 |
mouse |
| Marjan Khademizadeh, Manoochehr Messripour, Nazem Ghasemi, Fariborz Momen Beik, Ahmad Movahedian Atta. Differentiation of adult human mesenchymal stem cells into dopaminergic neurons. Research in pharmaceutical sciences. vol 14. issue 3. 2020-09-30. PMID:31160898. |
the disease is a progressive degeneration of dopaminergic neurons in the striatum. |
2020-09-30 |
2023-08-13 |
human |
| Biswarup Ghosh, Chen Zhang, Kristine S Ziemba, Anita M Fletcher, David M Yurek, George M Smit. Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway. Molecular therapy. Methods & clinical development. vol 14. 2020-09-30. PMID:31417940. |
the overall goal of our research is to establish a preformed molecular guidance pathway to direct the growth of dopaminergic axons from embryonic ventral mesencephalon (vm), tissue placed within the substantia nigra (sn), into the striatum to reconstruct the nigrostriatal pathway in a hemi-parkinson's disease rat model. |
2020-09-30 |
2023-08-13 |
rat |
| Biswarup Ghosh, Chen Zhang, Kristine S Ziemba, Anita M Fletcher, David M Yurek, George M Smit. Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway. Molecular therapy. Methods & clinical development. vol 14. 2020-09-30. PMID:31417940. |
retrograde tract tracing showed that the dopaminergic axons innervating the striatum were from a9 neurons within the transplant. |
2020-09-30 |
2023-08-13 |
rat |
| Biswarup Ghosh, Chen Zhang, Kristine S Ziemba, Anita M Fletcher, David M Yurek, George M Smit. Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway. Molecular therapy. Methods & clinical development. vol 14. 2020-09-30. PMID:31417940. |
increased dopaminergic innervation of the striatum and improved behavioral recovery were observed with the addition of bdnf. |
2020-09-30 |
2023-08-13 |
rat |
| Sora Ahn, Quan Feng Liu, Jae-Hwan Jang, Jeonghun Park, Ha Jin Jeong, Youngman Kim, Dong-Hee Kim, Guwon Jeong, Seung Tack Oh, Seong-Uk Park, Seung-Yeon Cho, Hi-Joon Park, Songhee Jeo. Gami-Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson's Disease Mouse Model Though DJ-1 and BDNF Expression. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31555122. |
moreover, gcf inhibited the reduction of dopaminergic neurons in the substantia nigra (sn) and fibers in the striatum (st) against mptp/p challenge. |
2020-09-30 |
2023-08-13 |
mouse |
| Chan H Gil, Yu R Kim, Hong J Lee, Da H Jung, Hwa K Shin, Byung T Cho. Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia. Experimental and therapeutic medicine. vol 15. issue 1. 2020-09-29. PMID:29399080. |
apz also attenuated dopaminergic neuronal injury in the striatum. |
2020-09-29 |
2023-08-13 |
mouse |
| Hyunjung Baek, Hyun Il Jang, Hat Nim Jeon, Hyunsu Ba. Comparison of Administration Routes on the Protective Effects of Bee Venom Phospholipase A2 in a Mouse Model of Parkinson's Disease. Frontiers in aging neuroscience. vol 10. 2020-09-29. PMID:29942256. |
progressive loss of dopaminergic neurons in the substantia nigra (sn) and their synaptic terminal connections in the striatum are main characterizations of pd. |
2020-09-29 |
2023-08-13 |
mouse |
| Ewelina Palasz, Wiktor Niewiadomski, Anna Gasiorowska, Adrianna Wysocka, Anna Stepniewska, Grazyna Niewiadomsk. Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease. Frontiers in neurology. vol 10. 2020-09-29. PMID:31736859. |
a current hypothesis assumes a central role of neurotrophic factors in the neuroprotection of dopaminergic neurons, even though it is still not clear whether increased da level in the nigrostriatal axis results from neurogenesis of dopaminergic neurons in the sn, recovery of the phenotype of dopaminergic neurons, increased sprouting of the residual dopaminergic axons in the striatum, or generation of local striatal neurons from inhibitory interneurons. |
2020-09-29 |
2023-08-13 |
human |
| Qi Chen, Shurong Li, Yuping Han, Xiaohong Wei, Juan Du, Xiaolin Wang, Bingyin Su, Jun L. Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms. The Journal of toxicological sciences. vol 45. issue 7. 2020-09-29. PMID:32612007. |
toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms. |
2020-09-29 |
2023-08-13 |
mouse |
| Kiyoshi Ando, Takashi Inoue, Keigo Hikishima, Yuji Komaki, Kenji Kawai, Ryo Inoue, Chiyoko Nishime, Eiko Nishinaka, Koji Urano, Hideyuki Okan. Measurement of baseline locomotion and other behavioral traits in a common marmoset model of Parkinson's disease established by a single administration regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: providing reference data for efficacious preclinical evaluations. Behavioural pharmacology. vol 31. issue 1. 2020-09-28. PMID:31625972. |
histology was supportive of dopaminergic neural loss in the striatum. |
2020-09-28 |
2023-08-13 |
marmoset |
| Susan R Goulding, Aideen M Sullivan, Gerard W O'Keeffe, Louise M Collin. The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997802. |
the pathological hallmarks of parkinson's disease are the progressive degeneration of dopaminergic neurons in the substantia nigra and their axons which project to the striatum, and the aggregation of α-synuclein; these result in a range of debilitating motor and non-motor symptoms. |
2020-09-28 |
2023-08-13 |
human |
| René A J Crans, Elise Wouters, Marta Valle-León, Jaume Taura, Caio M Massari, Víctor Fernández-Dueñas, Christophe P Stove, Francisco Ciruel. Striatal Dopamine D Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32231561. |
in parallel to dopaminergic denervation, there is an increase of acetylcholine within the striatum, resulting in a striatal dopaminergic-cholinergic neurotransmission imbalance. |
2020-09-28 |
2023-08-13 |
Not clear |
| Pia M Vidal, Rodrigo Pachec. The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32296337. |
current evidence indicates that these alterations involve hyperactive dopaminergic transmission in mesolimbic areas, striatum, and hippocampus, whereas hypoactive dopaminergic transmission has been reported in the prefrontal cortex of schizophrenic patients. |
2020-09-28 |
2023-08-13 |
Not clear |
| Martina Mazzocchi, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. The class II histone deacetylases as therapeutic targets for Parkinson's disease. Neuronal signaling. vol 4. issue 2. 2020-09-28. PMID:32714601. |
the neuropathological hallmarks of pd include progressive degeneration of midbrain dopaminergic neurons, and loss of their axonal projections to the striatum. |
2020-09-28 |
2023-08-13 |
Not clear |
| Daniel Enterría-Morales, Natalia López-González Del Rey, Javier Blesa, Ivette López-López, Sarah Gallet, Vincent Prévot, José López-Barneo, Xavier d'Anglemont de Tassign. Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons. Brain communications. vol 2. issue 2. 2020-09-28. PMID:32954345. |
glial cell line-derived neurotrophic factor is naturally produced in the striatum from where it exerts a trophic action on the nigrostriatal dopaminergic pathway. |
2020-09-28 |
2023-08-13 |
mouse |
| Maria Eleni Karakatsani, Shutao Wang, Gesthimani Samiotaki, Tara Kugelman, Oluyemi O Olumolade, Camilo Acosta, Tao Sun, Yang Han, Hermes A S Kamimura, Vernice Jackson-Lewis, Serge Przedborski, Elisa Konofago. Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease. Journal of controlled release : official journal of the Controlled Release Society. vol 303. 2020-09-25. PMID:30953664. |
herein, we show that neither fus applied over both the striatum and the ventral midbrain, without neurotrophic factors, nor intravenous administration of neurotrophic factors (either through protein or gene delivery) without fus, ameliorates the damage to the nigrostriatal dopaminergic pathway in the sub-acute mptp mouse model of early-stage pd. |
2020-09-25 |
2023-08-13 |
mouse |