| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ju Hwan Kim, Choong-Hyun Lee, Hyung-Gun Kim, Hak Rim Ki. Decreased dopamine in striatum and difficult locomotor recovery from MPTP insult after exposure to radiofrequency electromagnetic fields. Scientific reports. vol 9. issue 1. 2020-08-19. PMID:30718744. |
in summary, our results strongly suggest that exposing the brain to rf-emf can decrease the number of svs and dopaminergic neurons in the striatum. |
2020-08-19 |
2023-08-13 |
mouse |
| Maxime Fouyssac, David Beli. Beyond drug-induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine-dependent intrastriatal functional shifts that underlie the development of drug addiction: A working hypothesis. The European journal of neuroscience. vol 50. issue 6. 2020-08-12. PMID:30968489. |
exposure to drugs of abuse also alters the function of astrocytes in the dorsolateral striatum, wherein dopaminergic mechanisms control drug-seeking habits, associated compulsivity and relapse. |
2020-08-12 |
2023-08-13 |
Not clear |
| Maxime Fouyssac, David Beli. Beyond drug-induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine-dependent intrastriatal functional shifts that underlie the development of drug addiction: A working hypothesis. The European journal of neuroscience. vol 50. issue 6. 2020-08-12. PMID:30968489. |
this suggests that drug-induced alterations in the glutamatergic homeostasis maintained by astrocytes throughout the entire striatum may interact with dopaminergic mechanisms to promote aberrant plasticity processes that contribute to the maintenance of maladaptive drug-seeking habits. |
2020-08-12 |
2023-08-13 |
Not clear |
| Maxime Fouyssac, David Beli. Beyond drug-induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine-dependent intrastriatal functional shifts that underlie the development of drug addiction: A working hypothesis. The European journal of neuroscience. vol 50. issue 6. 2020-08-12. PMID:30968489. |
capitalising on growing evidence that astrocytes play a fundamental regulatory role in glutamate and dopamine transmission in the striatum, we present an innovative model of a quadripartite synaptic microenvironment within which astrocytes channel functional interactions between the dopaminergic and glutamatergic systems that may represent the primary striatal functional unit that undergoes drug-induced adaptations eventually leading to addiction. |
2020-08-12 |
2023-08-13 |
Not clear |
| Anthony Klambatsen, Stephanie K Nygard, Anna J Chang, Vanya Quinones, Shirzad Jena. Sex differences in memory and intracellular signaling after methamphetamine binge treatment. Brain research. vol 1711. 2020-08-04. PMID:30629943. |
methamphetamine is a neurotoxic psychostimulant known to cause cell death and terminal degradation of dopaminergic neurons in the striatum concomitant with memory deficits. |
2020-08-04 |
2023-08-13 |
rat |
| Mikyung Kim, Raly James Custodio, Chrislean Jun Botanas, June Bryan de la Peña, Leandro Val Sayson, Arvie Abiero, Zae Young Ryoo, Jae Hoon Cheong, Hee Jin Ki. The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice. Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30091820. |
the circadian gene, per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice. |
2020-08-03 |
2023-08-13 |
mouse |
| Mikyung Kim, Raly James Custodio, Chrislean Jun Botanas, June Bryan de la Peña, Leandro Val Sayson, Arvie Abiero, Zae Young Ryoo, Jae Hoon Cheong, Hee Jin Ki. The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice. Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30091820. |
taken together, per2 expression levels may influence the addictive effects of meth through the dopaminergic system in the striatum of mice. |
2020-08-03 |
2023-08-13 |
mouse |
| Benjamin N Greenwoo. The role of dopamine in overcoming aversion with exercise. Brain research. vol 1713. 2020-07-20. PMID:30171838. |
the current review summarizes exercise adaptations in dopaminergic circuits that lead to a hyperdopaminergic state; during which dopamine release in the striatum is sensitized during exposure to non-exercise stimuli, even aversive stressors that do not typically activate reward-related dopamine circuits. |
2020-07-20 |
2023-08-13 |
Not clear |
| Krisztina Szalisznyó, David N Silverstein, János Tót. Neural dynamics in co-morbid schizophrenia and OCD: A computational approach. Journal of theoretical biology. vol 473. 2020-07-17. PMID:30738051. |
serotonin reuptake inhibitor treatment) together with dopaminergic input to the striatum (e.g. |
2020-07-17 |
2023-08-13 |
Not clear |
| Jeroen P H Verharen, Roger A H Adan, Louk J M J Vanderschure. Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 13. 2020-07-08. PMID:31254972. |
finally, treatment with most dopaminergic drugs affected response latencies and number of trials completed, which was also seen after infusion of d2, but not d1 receptor-acting drugs into the striatum. |
2020-07-08 |
2023-08-13 |
rat |
| Omar Collazo-Navarrete, David Hernández-García, Gilda Guerrero-Flores, René Drucker-Colín, Magdalena Guerra-Crespo, Luis Covarrubia. The Substantia Nigra Is Permissive and Gains Inductive Signals When Lesioned for Dopaminergic Differentiation of Embryonic Stem Cells. Stem cells and development. vol 28. issue 16. 2020-07-02. PMID:31140356. |
transplantation of dopaminergic (da) cells into the striatum can rescue from dopamine deficiency in a parkinson's disease condition, but this is not a suitable procedure for regaining the full control of motor activity. |
2020-07-02 |
2023-08-13 |
Not clear |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, T Petteri Piepponen, Sari Ahola, Raimo K Tuominen, Christopher Richie, Brandon K Harvey, Mikko Airavaar. Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30548446. |
adeno-associated virus (aav) vector-mediated delivery of human α-synuclein (α-syn) gene in rat substantia nigra (sn) results in increased expression of α-syn protein in the sn and striatum which can progressively degenerate dopaminergic neurons. |
2020-07-01 |
2023-08-13 |
human |
| Huiying Liu, Hao Wu, Ning Zhu, Zijie Xu, Yue Wang, Yan Qu, Jun Wan. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice. Journal of neurochemistry. vol 152. issue 3. 2020-06-30. PMID:31442326. |
its pathological features are dopaminergic neuronal death in the substantia nigra (sn), and significant reduction in dopamine (da) content in the striatum. |
2020-06-30 |
2023-08-13 |
mouse |
| Shenyu Zhai, Weixing Shen, Steven M Graves, D James Surmeie. Dopaminergic modulation of striatal function and Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 4. 2020-06-26. PMID:30937538. |
the striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a diverse array of cellular and synaptic functions that control goal-directed actions and habits. |
2020-06-26 |
2023-08-13 |
Not clear |
| Niamh Moriarty, Sílvia Cabré, Verónica Alamilla, Abhay Pandit, Eilís Dow. Encapsulation of young donor age dopaminergic grafts in a GDNF-loaded collagen hydrogel further increases their survival, reinnervation, and functional efficacy after intrastriatal transplantation in hemi-Parkinsonian rats. The European journal of neuroscience. vol 49. issue 4. 2020-06-22. PMID:30054941. |
we found that, following intrastriatal transplantation to the lesioned striatum, the gdnf-loaded collagen hydrogel significantly increased the survival (4-fold), reinnervation (5.4-fold), and functional efficacy of the embryonic day 12 dopaminergic neurons. |
2020-06-22 |
2023-08-13 |
rat |
| Tilo Kunath, Ammar Natalwala, Claire Chan, Yixi Chen, Benjamin Stecher, Martin Taylor, Sadaquate Khan, Miratul M K Muqi. Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies? The European journal of neuroscience. vol 49. issue 4. 2020-06-22. PMID:30586214. |
transplantation of dopaminergic cells into the putamen of these patients will provide neurons with wild-type parkin expression to re-innervate the striatum. |
2020-06-22 |
2023-08-13 |
Not clear |
| Dandan Yan, Xiaoqi Pan, Jianling Yao, Dun Wang, Xu Wu, Xiaoyi Chen, Nian Shi, Hong Ya. MAPKs and NF-κB-mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5Y. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-19. PMID:30368882. |
acute acr exposure caused dopaminergic neurons loss and apoptosis as revealed by decreased tyrosine hydroxylase (th)-positive cells and th protein level and increased terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel)-positive cells in the striatum. |
2020-06-19 |
2023-08-13 |
human |
| Dongping Huang, Qing Li, Yi Wang, Zhaolin Liu, Zishan Wang, Heng Li, Jinghui Wang, Jing Su, Yuanyuan Ma, Mei Yu, Jian Fei, Fang Huan. Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson's disease. Aging. vol 11. issue 10. 2020-06-17. PMID:31147527. |
degeneration of the dopaminergic neurons in the substantia nigra and the resultant dopamine depletion from the striatum are the hallmarks of parkinson's disease (pd) and are responsible for the disease's cardinal motor symptoms. |
2020-06-17 |
2023-08-13 |
mouse |
| Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhan. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease. Experimental & molecular medicine. vol 51. issue 10. 2020-06-15. PMID:31578315. |
dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of the midbrain and the striatum and is an important pathologic basis of parkinson's disease (pd). |
2020-06-15 |
2023-08-13 |
Not clear |
| Genevieve Beauvais, Jaime L Watson, Jose A Aguirre, Luis Tecedor, Michelle E Ehrlich, Pedro Gonzalez-Alegr. Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo. Brain research. vol 1706. 2020-05-29. PMID:30366018. |
moreover, we found abnormal expression of components of dopaminergic neurotransmission in dyt1 rat striatum, which were not normalized by suppressing mutant torsina expression. |
2020-05-29 |
2023-08-13 |
human |