Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Julia A K Chartove, Michelle M McCarthy, Benjamin R Pittman-Polletta, Nancy J Kopel. A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control. PLoS computational biology. vol 16. issue 2. 2020-05-27. PMID:32097404. |
local field potential recordings in rodent striatum show dopamine- and reward-dependent transitions between two states: a "spontaneous" state involving β (∼15-30 hz) and low γ (∼40-60 hz), and a state involving θ (∼4-8 hz) and high γ (∼60-100 hz) in response to dopaminergic agonism and reward. |
2020-05-27 |
2023-08-13 |
Not clear |
Brónagh McCoy, Sara Jahfari, Gwenda Engels, Tomas Knapen, Jan Theeuwe. Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson's disease. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31603493. |
reduced levels of dopamine in parkinson's disease contribute to changes in learning, resulting from the loss of midbrain neurons that transmit a dopaminergic teaching signal to the striatum. |
2020-05-26 |
2023-08-13 |
human |
Mingming Zhang, Di Zhao, Zhao Zhang, Xinyu Cao, Lu Yin, Yi Liu, Ti-Fei Yuan, Wenbo Lu. Time perception deficits and its dose-dependent effect in methamphetamine dependents with short-term abstinence. Science advances. vol 5. issue 10. 2020-05-21. PMID:31692967. |
intake of addictive substances acutely modifies dopaminergic transmission in the striatum and prefrontal cortex, which is the neural substrate underlying time processing. |
2020-05-21 |
2023-08-13 |
human |
Liping Zhang, LingYu Zhang, Lin Li, Christian Hölsche. Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 1. 2020-05-20. PMID:30741689. |
in addition, both drugs rescued the decrease of tyrosine hydroxylase (th) levels, reduced the accumulation of α-syn, alleviated the chronic inflammation response in the brain, reduced lipid peroxidation, and inhibited the mitochondrial mitophagy signaling pathway, and furthermore increased expression of the key growth factor gdnf that protects dopaminergic neurons in the substantia nigra (sn) and striatum. |
2020-05-20 |
2023-08-13 |
mouse |
Guanbin Gao, Rui Chen, Meng He, Jing Li, Jing Li, Liyun Wang, Taolei Su. Gold nanoclusters for Parkinson's disease treatment. Biomaterials. vol 194. 2020-05-18. PMID:30576972. |
in addition, immunohistochemical and western blot (wb) analyses indicate that auncs can significantly reverse dopaminergic (da) neuron loss in substantia nigra and striatum of sick mice. |
2020-05-18 |
2023-08-13 |
mouse |
Hye Ryeong Lim, Mai-Tram Vo, Dong Jun Kim, Unn Hwa Lee, Jong Hyuk Yoon, Hyung-Jun Kim, Jeongah Kim, Sang Ryong Kim, Jun Yeon Lee, Chae Ha Yang, Hee Young Kim, June-Seek Choi, Kijeong Kim, Esther Yang, Hyun Kim, Seongsoo Lee, Byung Ju Lee, Kyungjin Kim, Jeong Woo Park, Chang Man H. DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release. International journal of molecular sciences. vol 21. issue 1. 2020-05-15. PMID:31861806. |
drg2 was strongly expressed in the neurons of the dopaminergic system such as those in the striatum (str), ventral tegmental area (vta), and substantia nigra (sn), and on neuronal cell bodies in high-density regions such as the hippocampus (hip), cerebellum, and cerebral cortex in the mouse brain. |
2020-05-15 |
2023-08-13 |
mouse |
Lilian R F Faro, Hanna Tak-Kim, Miguel Alfonso, Rafael Durá. Clothianidin, a neonicotinoid insecticide, activates α4β2, α7 and muscarinic receptors to induce in vivo dopamine release from rat striatum. Toxicology. vol 426. 2020-05-14. PMID:31479693. |
taken together, these results suggest that the stimulatory effect of clo on in vivo dopamine from rat striatum depends on the activation of α4β2 present in dopaminergic terminals and α7 nachrs subtypes expressed in glutamatergic terminals in the striatum. |
2020-05-14 |
2023-08-13 |
rat |
Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
tyrosine hydroxylase staining showed that the hfd resulted in fewer dopaminergic neurons in the substantia nigra (sn), but not the striatum. |
2020-05-14 |
2023-08-13 |
mouse |
Hidaka Haga, Kazuya Matsuo, Yasushi Yabuki, Chen Zhang, Feng Han, Kohji Fukunag. Enhancement of ATP production ameliorates motor and cognitive impairments in a mouse model of MPTP-induced Parkinson's disease. Neurochemistry international. vol 129. 2020-05-11. PMID:31229554. |
administration of ep or sa4503 protected the dopaminergic neurons from mptp-induce toxicity and restored the dopamine levels in the striatum. |
2020-05-11 |
2023-08-13 |
mouse |
Bing Zhu, Ashley Lindsey, Nan Li, Kevin Lee, Veronica Ramirez-Alcantara, Joshua C Canzoneri, Alexandra Fajardo, Luciana Madeira da Silva, Meagan Thomas, John T Piazza, Larry Yet, Brian T Eberhardt, Evrim Gurpinar, Dennis Otali, William Grizzle, Jacob Valiyaveettil, Xi Chen, Adam B Keeton, Gary A Piazz. Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling. Oncotarget. vol 8. issue 41. 2020-04-23. PMID:29050202. |
cgmp) degrading enzyme highly expressed in the brain striatum where it plays an important role in dopaminergic neurotransmission, but has limited expression and no known physiological function outside the central nervous system. |
2020-04-23 |
2023-08-13 |
human |
Simon Rw Stott, Suzanne J Randle, Sara Al Rawi, Paulina A Rowicka, Rebecca Harris, Bethany Mason, Jing Xia, Jeffrey W Dalley, Roger A Barker, Heike Lama. Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway. The Journal of pathology. vol 249. issue 2. 2020-04-13. PMID:31144295. |
unexpectedly, a later compensatory response led to a near-full restoration of dopaminergic fibre innervation in the striatum, but nigral cell loss was irreversible. |
2020-04-13 |
2023-08-13 |
Not clear |
Hye-Sun Lim, Joong-Sun Kim, Byeong Cheol Moon, Goya Choi, Seung Mok Ryu, Jun Lee, Mary Jasmin Ang, Mijin Jeon, Changjong Moon, Gunhyuk Par. Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2019. 2020-04-10. PMID:31772707. |
parkinson's disease (pd) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta (snpc) and the striatum. |
2020-04-10 |
2023-08-13 |
Not clear |
Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and the reduction of dopamine levels in the striatum. |
2020-04-07 |
2023-08-13 |
mouse |
Chang Shan, Yan-Ling Gong, Qian-Qian Zhuang, Yan-Fang Hou, Shu-Min Wang, Qin Zhu, Guo-Rui Huang, Bei Tao, Li-Hao Sun, Hong-Yan Zhao, Sheng-Tian Li, Jian-Min Li. Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 94. 2020-03-30. PMID:31220519. |
preinjection with nad in the striatum ameliorated motor deficits and dopaminergic neuronal damage in the substantia nigra and striatum of a mouse model of pd. |
2020-03-30 |
2023-08-13 |
mouse |
Edênia Cunha Menezes, Patrícia Rabelo Santos, Tiago Costa Goes, Vanessa Cibelle Barboza Carvalho, Flávia Teixeira-Silva, Hanna E Stevens, Daniel Jr Badauê-Passo. Effects of a rat model of gestational hypothyroidism on forebrain dopaminergic, GABAergic, and serotonergic systems and related behaviors. Behavioural brain research. vol 366. 2020-03-26. PMID:30898681. |
striatum of mmi offspring showed an isolated decrease in the dopaminergic enzyme, tyrosine hydroxylase. |
2020-03-26 |
2023-08-13 |
rat |
Sonia Lavisse, Susannah Williams, Sophie Lecourtois, Nadja van Camp, Martine Guillermier, Pauline Gipchtein, Caroline Jan, Sébastien Goutal, Leopold Eymin, Julien Valette, Thierry Delzescaux, Anselme L Perrier, Philippe Hantraye, Romina Aron Badi. Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates. Neurobiology of disease. vol 130. 2020-03-24. PMID:31132407. |
post-mortem analyses revealed a significant loss of medium-sized spiny neurons in the striatum, a loss of neurons and fibers in the globus pallidus, a unilateral decrease in dopaminergic neurons of the substantia nigra and a loss of neurons in the motor and dorsolateral prefrontal cortex. |
2020-03-24 |
2023-08-13 |
Not clear |
Mark Howe, Imane Ridouh, Anna Letizia Allegra Mascaro, Alyssa Larios, Maite Azcorra, Daniel A Dombec. Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement. eLife. vol 8. 2020-03-20. PMID:30920369. |
coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement. |
2020-03-20 |
2023-08-13 |
mouse |
Mark Howe, Imane Ridouh, Anna Letizia Allegra Mascaro, Alyssa Larios, Maite Azcorra, Daniel A Dombec. Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement. eLife. vol 8. 2020-03-20. PMID:30920369. |
interplay between dopaminergic and cholinergic neuromodulation in the striatum is crucial for movement control, with prominent models proposing pro-kinetic and anti-kinetic effects of dopamine and acetylcholine release, respectively. |
2020-03-20 |
2023-08-13 |
mouse |
Lucas E Cromberg, Trinidad M M Saez, María G Otero, Eugenia Tomasella, Matías Alloatti, Ana Damianich, Victorio Pozo Devoto, Juan Ferrario, Diego Gelman, Marcelo Rubinstein, Tomás L Falzon. Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors. Journal of neurochemistry. vol 149. issue 3. 2020-03-18. PMID:30664247. |
dysfunction in dopaminergic neurotransmission within the striatum leads to movement impairments, gaiting defects, and hypo-locomotion. |
2020-03-18 |
2023-08-13 |
mouse |
Luan Pereira Diniz, Isadora Matias, Ana Paula Bérgamo Araujo, Matheus Nunes Garcia, Fernanda G Q Barros-Aragão, Soniza Vieira Alves-Leon, Jorge Marcondes de Souza, Débora Foguel, Cláudia Pinto Figueiredo, Carolina Braga, Luciana Romão, Flávia Carvalho Alcantara Gome. α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson's disease model. Journal of neurochemistry. vol 150. issue 2. 2020-03-18. PMID:31009074. |
parkinson's disease (pd) is characterized by selective death of dopaminergic neurons in the substantia nigra, degeneration of the nigrostriatal pathway, increases in glutamatergic synapses in the striatum and aggregation of α-synuclein. |
2020-03-18 |
2023-08-13 |
mouse |