| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samira Ztaou, Marianne Amalri. Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease. Neurochemistry international. vol 126. 2019-12-10. PMID:30825602. |
parkinson's disease (pd) is a neurodegenerative disorder caused by the loss of nigral dopaminergic neurons innervating the striatum, the main input structure of the basal ganglia. |
2019-12-10 |
2023-08-13 |
Not clear |
| Samira Ztaou, Marianne Amalri. Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease. Neurochemistry international. vol 126. 2019-12-10. PMID:30825602. |
this creates an imbalance between dopaminergic inputs and cholinergic interneurons (chis) within the striatum. |
2019-12-10 |
2023-08-13 |
Not clear |
| Andreas Weihofen, YuTing Liu, Joseph W Arndt, Christian Huy, Chao Quan, Benjamin A Smith, Jean-Luc Baeriswyl, Nicole Cavegn, Luzia Senn, Lihe Su, Galina Marsh, Pavan K Auluck, Fabio Montrasio, Roger M Nitsch, Warren D Hirst, Jesse M Cedarbaum, R Blake Pepinsky, Jan Grimm, Paul H Weinre. Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models. Neurobiology of disease. vol 124. 2019-11-29. PMID:30381260. |
in efficacy studies in three different mouse models with intracerebrally inoculated preformed α-syn fibrils, biib054 treatment attenuated the spreading of α-syn pathology, rescued motor impairments, and reduced the loss of dopamine transporter density in dopaminergic terminals in striatum. |
2019-11-29 |
2023-08-13 |
mouse |
| Xiao-Yan Feng, Jingting Yang, Xiaoli Zhang, Jinxia Zh. Gastrointestinal non-motor dysfunction in Parkinson's disease model rats with 6-hydroxydopamine. Physiological research. vol 68. issue 2. 2019-11-25. PMID:30628835. |
the results indicated that the dopaminergic neurons in sn and fibres in the striatum were markedly reduced in 6-ohda rats. |
2019-11-25 |
2023-08-13 |
rat |
| Orhan Tansel Korkmaz, Neşe Tunçe. Advantages of Vasoactive Intestinal Peptide for the Future Treatment of Parkinson's Disease. Current pharmaceutical design. vol 24. issue 39. 2019-11-21. PMID:30636594. |
the characteristic symptoms of parkinson's disease, such as resting tremor, muscular rigidity, bradykinesia, postural instability and gait imbalance, are thought to be a result of the progressive degeneration of the dopaminergic neurons of the substantia nigra compacta, resulting in insufficient dopamine integrated signalling on gabaergic medium spiny neurons in the striatum. |
2019-11-21 |
2023-08-13 |
Not clear |
| Sawaguch. The role of D1-dopamine receptors in working memory-guided movements mediated by frontal cortical areas. Parkinsonism & related disorders. vol 7. issue 1. 2019-11-20. PMID:11008191. |
like the striatum, the frontal motor cortices receive dopaminergic fibers from midbrain dopamine cells and contain high levels of dopamine receptors. |
2019-11-20 |
2023-08-12 |
monkey |
| M. Morelli, S. Fenu, A. Pinna, A. Cozzolino, A. Carta, G. Di Chiar. "Priming" to dopamine agonist-induced contralateral turning as a model of non-associative sensitization to the expression of the post-synaptic dopamine message. Behavioural pharmacology. vol 4. issue 4. 2019-11-20. PMID:11224207. |
the results of these studies are consistent with the idea that "priming" is an example of non-associative sensitization induced by stimulation of denervated striatal da receptors and expressed as an increased efficiency of post-synaptic dopaminergic transduction in the striatum. |
2019-11-20 |
2023-08-12 |
rat |
| P K. Pal, Z K. Wszolek, A Kishore, R de la Fuente-Fernandez, V Sossi, R J. Uitti, T Dobko, A J. Stoess. Positron emission tomography in pallido-ponto-nigral degeneration (PPND) family (frontotemporal dementia with parkinsonism linked to chromosome 17 and point mutation in tau gene). Parkinsonism & related disorders. vol 7. issue 2. 2019-11-20. PMID:11248587. |
our study showed severe presynaptic dopaminergic dysfunction with intact striatal d2 receptors in ppnd patients, implying that the dopa unresponsiveness is probably a result of pathology downstream to the striatum. |
2019-11-20 |
2023-08-12 |
Not clear |
| S Ferré, P Popoli, L Giménez-Llort, R Rimondini, C E. Müller, I Strömberg, S O. Ögren, K Fux. Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 7. issue 3. 2019-11-20. PMID:11331192. |
evidence for a role of dopaminergic neurotransmission in the motor effects of adenosine antagonists, such as caffeine, is reviewed, based on the existence of specific antagonistic interactions between specific subtypes of adenosine and dopamine receptors in the striatum. |
2019-11-20 |
2023-08-12 |
Not clear |
| S Raypor. Glutamate is a cotransmitter in ventral midbrain dopamine neurons. Parkinsonism & related disorders. vol 7. issue 3. 2019-11-20. PMID:11331197. |
so, in the setting of dopamine neuron demise, there will be a loss of both dopaminergic and glutamatergic inputs to the striatum; furthermore, glutamate released by dopamine neurons may contribute to an excitotoxic cascade and the death of neighboring dopamine neurons. |
2019-11-20 |
2023-08-12 |
rat |
| Mizuho Aoi, Isao Date, Susumu Tomita, Takashi Ohmot. Single administration of GDNF into the striatum induced protection and repair of the nigrostriatal dopaminergic system in the intrastriatal 6-hydroxydopamine injection model of hemiparkinsonism. Restorative neurology and neuroscience. vol 17. issue 1. 2019-11-20. PMID:11490075. |
single administration of gdnf into the striatum induced protection and repair of the nigrostriatal dopaminergic system in the intrastriatal 6-hydroxydopamine injection model of hemiparkinsonism. |
2019-11-20 |
2023-08-12 |
human |
| Mizuho Aoi, Isao Date, Susumu Tomita, Takashi Ohmot. Single administration of GDNF into the striatum induced protection and repair of the nigrostriatal dopaminergic system in the intrastriatal 6-hydroxydopamine injection model of hemiparkinsonism. Restorative neurology and neuroscience. vol 17. issue 1. 2019-11-20. PMID:11490075. |
results: gdnf injected into the striatum before 6-ohda administration potently protected the dopaminergic system, as shown by the numbers of mesencephalic dopaminergie neuron cell bodies and dopaminergic nerve terminal densities in the striatum. |
2019-11-20 |
2023-08-12 |
human |
| L. Kerkerian, P. Salin, A. Nieoullo. Cortical Regulation of Striatal Neuropeptide Y (NPY)-Containing Neurons in the Rat. The European journal of neuroscience. vol 2. issue 3. 2019-11-20. PMID:12106046. |
previous experiments have shown that after unilateral 6-hydroxydopamine (6-ohda)-induced degeneration of nigrostriatal dopaminergic neurons, the mean number of npy-immunoreactive (ir) neurons per frontal section was increased in the striatum ipsilateral to the lesion side and unaltered in the contralateral striatum. |
2019-11-20 |
2023-08-12 |
rat |
| L. Kerkerian, P. Salin, A. Nieoullo. Cortical Regulation of Striatal Neuropeptide Y (NPY)-Containing Neurons in the Rat. The European journal of neuroscience. vol 2. issue 3. 2019-11-20. PMID:12106046. |
the topographical analysis of the cortical lesion effects also revealed an uneven striatal response, but, in contrast to that observed for the 6-ohda lesion, changes were restricted to dorsolateral areas of the striatum in both brain sides, revealing an apparent complementarity of nigral dopaminergic and cortical influences over striatal npy neuronal system. |
2019-11-20 |
2023-08-12 |
rat |
| Alessandro Zuddas, Giovanni U. Corsini, Jeffery L. Barker, Irwin J. Kopin, Umberto Di Porzi. Specific Reinnervation of Lesioned Mouse Striatum by Grafted Mesencephalic Dopaminergic Neurons. The European journal of neuroscience. vol 3. issue 1. 2019-11-20. PMID:12106271. |
specific reinnervation of lesioned mouse striatum by grafted mesencephalic dopaminergic neurons. |
2019-11-20 |
2023-08-12 |
mouse |
| Alessandro Zuddas, Giovanni U. Corsini, Jeffery L. Barker, Irwin J. Kopin, Umberto Di Porzi. Specific Reinnervation of Lesioned Mouse Striatum by Grafted Mesencephalic Dopaminergic Neurons. The European journal of neuroscience. vol 3. issue 1. 2019-11-20. PMID:12106271. |
implants of embryonic mesencephalic dopaminergic neurons functionally reinnervate the striatum and form a dense network of fibres; approximately 20% of the implanted dopaminergic cells survive for several months. |
2019-11-20 |
2023-08-12 |
mouse |
| Nathalie Dourmap, Adina Michael-Titus, Jean Costenti. Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum. The European journal of neuroscience. vol 2. issue 9. 2019-11-20. PMID:12106279. |
acetorphan, an enkephalinase inhibitor, modulates dopaminergic transmission in rat olfactory tubercle, but not in the nucleus accumbens and striatum. |
2019-11-20 |
2023-08-12 |
rat |
| Nathalie Dourmap, Adina Michael-Titus, Jean Costenti. Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum. The European journal of neuroscience. vol 2. issue 9. 2019-11-20. PMID:12106279. |
the present study focused on the effects of acetorphan, a parenterally active enkephalinase inhibitor, on dopaminergic transmission in rat olfactory tubercle, nucleus accumbens and striatum. |
2019-11-20 |
2023-08-12 |
rat |
| M. Chritin, M. Savasta, F. Mennicken, A. Bal, D. N. Abrous, M. Le Moal, C. Feuerstein, J. P. Herma. Intrastriatal Dopamine-rich Implants Reverse the Increase of Dopamine D2 Receptor mRNA Levels Caused by Lesion of the Nigrostriatal Pathway: A Quantitative In Situ Hybridization Study. The European journal of neuroscience. vol 4. issue 7. 2019-11-20. PMID:12106330. |
the influence of embryonic dopaminergic neurons implanted into the dopamine-depleted striatum on the lesion-induced changes was also examined. |
2019-11-20 |
2023-08-12 |
Not clear |
| Jocelyne Caboche, Philippe Vernier, Monique Rogard, Jean-François Julien, Jacques Mallet, Marie-Jo Besso. Role of Dopaminergic D2 Receptors in the Regulation of Glutamic Acid Decarboxylase Messenger RNA in the Striatum of the Rat. The European journal of neuroscience. vol 4. issue 5. 2019-11-20. PMID:12106353. |
role of dopaminergic d2 receptors in the regulation of glutamic acid decarboxylase messenger rna in the striatum of the rat. |
2019-11-20 |
2023-08-12 |
rat |