| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Zuddas, Giovanni U. Corsini, Jeffery L. Barker, Irwin J. Kopin, Umberto Di Porzi. Specific Reinnervation of Lesioned Mouse Striatum by Grafted Mesencephalic Dopaminergic Neurons. The European journal of neuroscience. vol 3. issue 1. 2019-11-20. PMID:12106271. |
implants of embryonic mesencephalic dopaminergic neurons functionally reinnervate the striatum and form a dense network of fibres; approximately 20% of the implanted dopaminergic cells survive for several months. |
2019-11-20 |
2023-08-12 |
mouse |
| Nathalie Dourmap, Adina Michael-Titus, Jean Costenti. Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum. The European journal of neuroscience. vol 2. issue 9. 2019-11-20. PMID:12106279. |
acetorphan, an enkephalinase inhibitor, modulates dopaminergic transmission in rat olfactory tubercle, but not in the nucleus accumbens and striatum. |
2019-11-20 |
2023-08-12 |
rat |
| Nathalie Dourmap, Adina Michael-Titus, Jean Costenti. Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum. The European journal of neuroscience. vol 2. issue 9. 2019-11-20. PMID:12106279. |
the present study focused on the effects of acetorphan, a parenterally active enkephalinase inhibitor, on dopaminergic transmission in rat olfactory tubercle, nucleus accumbens and striatum. |
2019-11-20 |
2023-08-12 |
rat |
| M. Chritin, M. Savasta, F. Mennicken, A. Bal, D. N. Abrous, M. Le Moal, C. Feuerstein, J. P. Herma. Intrastriatal Dopamine-rich Implants Reverse the Increase of Dopamine D2 Receptor mRNA Levels Caused by Lesion of the Nigrostriatal Pathway: A Quantitative In Situ Hybridization Study. The European journal of neuroscience. vol 4. issue 7. 2019-11-20. PMID:12106330. |
the influence of embryonic dopaminergic neurons implanted into the dopamine-depleted striatum on the lesion-induced changes was also examined. |
2019-11-20 |
2023-08-12 |
Not clear |
| Jocelyne Caboche, Philippe Vernier, Monique Rogard, Jean-François Julien, Jacques Mallet, Marie-Jo Besso. Role of Dopaminergic D2 Receptors in the Regulation of Glutamic Acid Decarboxylase Messenger RNA in the Striatum of the Rat. The European journal of neuroscience. vol 4. issue 5. 2019-11-20. PMID:12106353. |
role of dopaminergic d2 receptors in the regulation of glutamic acid decarboxylase messenger rna in the striatum of the rat. |
2019-11-20 |
2023-08-12 |
rat |
| J.S. Schneider, David S. Rothbla. Differences in release and clearance of extracellular dopamine in the striatum after spontaneous or GM1-ganglioside-stimulated recovery from experimental Parkinsonism. Restorative neurology and neuroscience. vol 16. issue 2. 2019-11-20. PMID:12671212. |
while the functional significance of this partial restoration of dopaminergic synaptic transmission in the striatum remains to be determined, it may under-lie improved behavioral recovery observed following gm1 treatment. |
2019-11-20 |
2023-08-12 |
Not clear |
| Silvânia M.M. Vasconcelos, Viviane S. Nascimento, Carlos R.A. Nogueira, Carlos M.A.G. Vieira, Franscisca Cléa F. Sousa, Marta M.F. Fonteles, Glauce S.B. Vian. Effects of haloperidol on rat behavior and density of dopaminergic D2-like receptors. Behavioural processes. vol 63. issue 1. 2019-11-20. PMID:12763267. |
the present work shows the effects of a typical neuroleptic drug (haloperidol, hal) on rat behavior (catalepsy and locomotor activity) and dopaminergic d2-like receptor densities in the hippocampus and striatum. |
2019-11-20 |
2023-08-12 |
rat |
| John P Kostrzewa, Rose Anna Kostrzewa, Richard M Kostrzewa, Ryszard Brus, Przemysław Nowa. Perinatal 6-Hydroxydopamine Modeling of ADHD. Current topics in behavioral neurosciences. vol 29. 2019-11-20. PMID:26475157. |
rats so lesioned during postnatal ontogeny are characterized by ~99 % destruction of dopaminergic nerves in pars compacta substantia nigra, with comparable destruction of the nigrostriatal tract and lifelong ~99 % dopaminergic denervation of striatum, with lesser destructive effect on the ventral tegmental nucleus and associated lesser dopaminergic denervation of nucleus accumbens and prefrontal cortex. |
2019-11-20 |
2023-08-13 |
rat |
| John P Kostrzewa, Rose Anna Kostrzewa, Richard M Kostrzewa, Ryszard Brus, Przemysław Nowa. Perinatal 6-Hydroxydopamine Modeling of ADHD. Current topics in behavioral neurosciences. vol 29. 2019-11-20. PMID:26475157. |
as a consequence of striatal dopaminergic denervation, reactive serotoninergic hyperinnervation of striatum ensues. |
2019-11-20 |
2023-08-13 |
rat |
| A Gugliandolo, P Bramanti, E Mazzo. Mesenchymal stem cell therapy in Parkinson's disease animal models. Current research in translational medicine. vol 65. issue 2. 2019-11-20. PMID:28466824. |
parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, and as a consequence, by decreased dopamine levels in the striatum. |
2019-11-20 |
2023-08-13 |
Not clear |
| Panchanan Maiti, Jayeeta Manna, Gary L Dunba. Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments. Translational neurodegeneration. vol 6. 2019-11-20. PMID:29090092. |
gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize parkinson's disease (pd). |
2019-11-20 |
2023-08-13 |
Not clear |
| Zade R Holloway, Timothy G Freels, Josiah F Comstock, Hunter G Nolen, Helen J Sable, Deranda B Leste. Comparing phasic dopamine dynamics in the striatum, nucleus accumbens, amygdala, and medial prefrontal cortex. Synapse (New York, N.Y.). 2019-11-20. PMID:30317673. |
to summarize results, the present study found that the striatum and nac had increased stimulation-evoked phasic dopamine release, faster dopamine uptake (leading to restricted dopamine diffusion), weaker autoreceptor functioning, greater supply levels of available dopamine, and increased dopaminergic responses to dat blockade compared to the amygdala and mpfc. |
2019-11-20 |
2023-08-13 |
mouse |
| Bing Hu, Qianqian Shi, Yu Guo, Xiyezi Diao, Heng Guo, Jinsong Zhang, Liang Yu, Hao Dai, Luonan Che. The oscillatory boundary conditions of different frequency bands in Parkinson's disease. Journal of theoretical biology. vol 451. 2019-11-18. PMID:29727632. |
the most important pathological change in pd is the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, which results in a decrease in the dopamine (da) content of the striatum. |
2019-11-18 |
2023-08-13 |
Not clear |
| Laura A Struzyna, Kevin D Browne, Zachary D Brodnik, Justin C Burrell, James P Harris, H Isaac Chen, John A Wolf, Kate V Panzer, James Lim, John E Duda, Rodrigo A España, D Kacy Culle. Tissue engineered nigrostriatal pathway for treatment of Parkinson's disease. Journal of tissue engineering and regenerative medicine. vol 12. issue 7. 2019-11-13. PMID:29766664. |
the classic motor deficits of parkinson's disease are caused by degeneration of dopaminergic neurons in the substantia nigra pars compacta, resulting in the loss of their long-distance axonal projections that modulate the striatum. |
2019-11-13 |
2023-08-13 |
human |
| Laura A Struzyna, Kevin D Browne, Zachary D Brodnik, Justin C Burrell, James P Harris, H Isaac Chen, John A Wolf, Kate V Panzer, James Lim, John E Duda, Rodrigo A España, D Kacy Culle. Tissue engineered nigrostriatal pathway for treatment of Parkinson's disease. Journal of tissue engineering and regenerative medicine. vol 12. issue 7. 2019-11-13. PMID:29766664. |
this strategy may improve parkinson's disease treatment by simultaneously replacing lost dopaminergic neurons in the substantia nigra and reconstructing their long-projecting axonal tracts to the striatum. |
2019-11-13 |
2023-08-13 |
human |
| Shaun W Carlson, C Edward Dixo. Lithium Improves Dopamine Neurotransmission and Increases Dopaminergic Protein Abundance in the Striatum after Traumatic Brain Injury. Journal of neurotrauma. vol 35. issue 23. 2019-11-12. PMID:29699444. |
lithium improves dopamine neurotransmission and increases dopaminergic protein abundance in the striatum after traumatic brain injury. |
2019-11-12 |
2023-08-13 |
rat |
| Floris G Wouterlood, Angela Engel, Mariah Daal, Gertjan Houwen, Aileen Meinderts, Tomàs Jordà Siquier, Jeroen A M Beliën, Yvette C van Dongen, Jørgen Scheel-Krüger, Anne-Marie Thierry, Henk J Groenewegen, Jean-Michel Denia. Mesencephalic dopamine neurons interfacing the shell of nucleus accumbens and the dorsolateral striatum in the rat. Journal of neuroscience research. vol 96. issue 9. 2019-11-11. PMID:29696690. |
our results strongly suggest a functional link between ventromedial, emotional-motivational striatum, and the sensorimotor dorsal striatum via dopaminergic nigrostriatal neurons. |
2019-11-11 |
2023-08-13 |
rat |
| Max Kenedy Felix Dos Santos, Elaine C Gavioli, Lorena Santa Rosa, Vanessa de Paula Soares-Rachetti, Bruno Lobão-Soare. Craving espresso: the dialetics in classifying caffeine as an abuse drug. Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 12. 2019-10-31. PMID:30338342. |
thus, based on a classical action on reward system, caffeine only partially fits its mechanism of action as an abuse drug, especially because previous research does not report a clear effect of dopaminergic activity enhance on nucleus accumbens; despite this, there are reports concerning dopaminergic modulation by caffeine on the striatum. |
2019-10-31 |
2023-08-13 |
human |
| Anindita Bose, Gregory A Petsko, David Elieze. Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms. Journal of Parkinson's disease. vol 8. issue 3. 2019-10-15. PMID:29991141. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, depletion of dopamine in the striatum and the presence of lewy bodies. |
2019-10-15 |
2023-08-13 |
Not clear |
| Jin-Zhong Huang, Yi Ren, Yuan Xu, Tao Chen, Terry C Xia, Zhuo-Ri Li, Jian-Nong Zhao, Fei Hua, Shi-Ying Sheng, Ying Xi. The delta-opioid receptor and Parkinson's disease. CNS neuroscience & therapeutics. vol 24. issue 12. 2019-10-14. PMID:30076686. |
although it is known that the major characteristics of pd pathophysiology are the dysfunction of basal ganglia due to injury/loss of dopaminergic neurons in the substantia nigra pars compacta dopaminergic and exhaustion of corpus striatum dopamine, therapeutic modalities for pd are limited in clinical settings up to date. |
2019-10-14 |
2023-08-13 |
Not clear |