All Relations between dopaminergic and striatum

Publication Sentence Publish Date Extraction Date Species
Yasuhiko Izum. [Establishment of a novel evaluation system for dopaminergic axonal outgrowth and its regulatory factor]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 5. 2019-06-11. PMID:30393256. although several axon guidance cues have been reported to induce dopaminergic axons from the substantia nigra to the striatum, the mechanisms by which the dopaminergic axons extend in the striatum remain unclear. 2019-06-11 2023-08-13 rat
Mohamed Salama, Sara El-Desouky, Aziza Alsayed, Mahmoud El-Hussiny, Abdelrahman Moustafa, Yasmeen Taalab, Wael Mohame. FOXRED1 silencing in mice: a possible animal model for Leigh syndrome. Metabolic brain disease. vol 34. issue 1. 2019-06-06. PMID:30392038. foxred1 blockage could serve as a new animal model for leigh syndrome due to defective ci, which echoes damage to corpus striatum and affection of the central dopaminergic system in this disease. 2019-06-06 2023-08-13 mouse
José Vicente Lafuente, Catalina Requejo, Luisa Uged. Nanodelivery of therapeutic agents in Parkinson's disease. Progress in brain research. vol 245. 2019-06-05. PMID:30961870. parkinson's disease (pd) as a motor disorder is pathologically featured by the loss of dopaminergic neurons of the substantia nigra compacta (snc) and the consequent depletion of dopamine in the striatum. 2019-06-05 2023-08-13 Not clear
Ana-Luisa Gil-Martínez, Cristina Estrada, Lorena Cuenca, Juan-Antonio Cano, Manuel Valiente, Carlos-Manuel Martínez-Cáceres, Emiliano Fernández-Villalba, María-Trinidad Herrer. Local Gastrointestinal Injury Exacerbates Inflammation and Dopaminergic Cell Death in Parkinsonian Mice. Neurotoxicity research. vol 35. issue 4. 2019-05-23. PMID:30796691. the results obtained show a very significant decrease of dopaminergic neurons in the snpc as well as a significant decrease of dopaminergic fibers in the striatum of the mptp+dss-treated group compared with the control animals. 2019-05-23 2023-08-13 mouse
Felipe Patricio, Irving Parra, Isabel Martínez, Francisca Pérez-Severiano, Sergio Montes, José Aguilera, Ilhuicamina Daniel Limón, Yousef Tizabi, Liliana Mendiet. Effectiveness of Fragment C Domain of Tetanus Toxin and Pramipexole in an Animal Model of Parkinson's Disease. Neurotoxicity research. vol 35. issue 3. 2019-05-15. PMID:30607904. at day 31, the animals were sacrificed and the levels of tyrosine hydroxylase (th), reflecting dopaminergic activity in both striatum and substantia nigra, were evaluated. 2019-05-15 2023-08-13 rat
Tim Prorok, Malabendu Jana, Dhruv Patel, Kalipada Paha. Cinnamic Acid Protects the Nigrostriatum in a Mouse Model of Parkinson's Disease via Peroxisome Proliferator-Activated Receptorα. Neurochemical research. vol 44. issue 4. 2019-04-26. PMID:30612307. oral administration of cinnamic acid protected tyrosine hydroxylase (th)-positive dopaminergic neurons in the substantia nigra pars compacta (snpc) and th fibers in the striatum of mptp-insulted mice. 2019-04-26 2023-08-13 mouse
Tiffany C Ho, Anna C Cichocki, Anthony J Gifuni, M Catalina Camacho, Sarah J Ordaz, Manpreet K Singh, Ian H Gotli. Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents. Social cognitive and affective neuroscience. vol 13. issue 11. 2019-04-22. PMID:30256980. while alterations in dopaminergic functioning have been implicated in suicidal acts-particularly in adults-we do not know whether morphological alterations in dopamine-rich regions of the brain, such as the striatum, are vulnerability factors for the emergence of si in adolescents. 2019-04-22 2023-08-13 human
Jose I A Beserra-Filho, Amanda M de Macêdo, Anderson H F F Leão, Jose Marcos M Bispo, José R Santos, Allan John de Oliveira-Melo, Paula Dos Passos Menezes, Marcelo C Duarte, Adriano A de Souza Araújo, Regina H Silva, Lucindo J Quintans-Júnior, Alessandra M Ribeir. Eplingiella fruticosa leaf essential oil complexed with β-cyclodextrin produces a superior neuroprotective and behavioral profile in a mice model of Parkinson's disease. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 124. 2019-04-18. PMID:30481574. epl-βcd also delayed the onset of catalepsy, reduced the frequency of oral diskynesia, restored memory deficit, produced anxiolytic activity and protected against dopaminergic depletion in the striatum and snpc. 2019-04-18 2023-08-13 mouse
Linfang Chen, Liujun Xue, Jinlong Zheng, Xiangyang Tian, Yingdong Zhang, Qiang Ton. PPARß/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson's disease. Behavioural brain research. vol 356. 2019-04-16. PMID:29885849. our results show that gw501516 reduced movement impairment in pd mice; furthermore, it attenuated dopaminergic neurodegeneration in the midbrain and the depletion of dopamine in the striatum and it inhibited inflammatory reactions and nlrp3 inflammasome activation in the midbrain of pd mice. 2019-04-16 2023-08-13 mouse
I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. whole-transcriptome analysis (rna-seq) has been used to analyze changes in the expression of dopaminergic genes that encode proteins involved in the synthesis, inactivation, and neurotransmission of dopamine in the striatum, ventral tegmental area, raphe nuclei of the midbrain, hypothalamus, and hippocampus of male mice subjected to chronic social defeat. 2019-04-11 2023-08-13 mouse
Marianna Manes, Mariana de Souza Aranha Garcia-Gomes, Thaísa Meira Sandini, Julia Zaccarelli-Magalhães, Jorge Camilo Florio, Sandra Regina Alexandre-Ribeiro, Danilo Wadt, Maria Martha Bernardi, Silvia Maria Gomes Massironi, Claudia Madalena Cabrera Mor. Behavioral and neurochemical characterization of the mlh mutant mice lacking otoconia. Behavioural brain research. vol 359. 2019-04-03. PMID:29913187. relative to balb/c mice, the mutant mlh mice showed 1) reduced locomotor and rearing behavior, increased auricular and touch reflexes, decreased motor coordination and increased micturition; 2) decreased responses in the t-maze and aversive wooden beam tests; 3) increased time of immobility in the tail suspension test; 4) no effects in the elevated plus maze or object recognition test; 5) an inability to swim; and 6) reduced turnover of dopaminergic system in the cerebellum, striatum, and frontal cortex. 2019-04-03 2023-08-13 mouse
Ming-Chung Chou, Ping-Hong Lai, Jie-Yuan L. Early white matter injuries associated with dopamine transporter dysfunction in patients with acute CO intoxication: A diffusion kurtosis imaging and Tc-99m TRODAT-1 SPECT study. European radiology. vol 29. issue 3. 2019-04-03. PMID:30143836. we aimed to investigate the relationship between wm injuries of dopaminergic pathways and dopamine transporter dysfunctions of the striatum in patients with acute co intoxication using both diffusion kurtosis imaging (dki) and single photon-emission computed tomography (spect). 2019-04-03 2023-08-13 Not clear
Amirah E-E Aly, Brendan T Harmon, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Barbara L Waszcza. Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson's Disease. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29779176. three to four weeks after the lesion, amphetamine-induced rotational behavior was reduced, and dopaminergic fiber density and cell counts in the lesioned substantia nigra and nerve terminal density in the lesioned striatum were significantly preserved in rats given intranasal pgdnf. 2019-04-01 2023-08-13 human
Katarzyna Kuter, Manuela Kratochwil, Klemencja Berghauzen-Maciejewska, Urszula Głowacka, Michiru D Sugawa, Krystyna Ossowska, Norbert A Denche. Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26844379. we observed loss of dopaminergic phenotype in sn and decreased dopamine level in striatum (str) before actual death of neurons in sn. 2019-03-28 2023-08-13 rat
Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. 2019-03-25 2023-08-13 mouse
Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. consequently there is dopaminergic hyperinnervation of the striatum, without an increase in the numbers of midbrain dopaminergic neurons, in conditional zeb2 (nestin-cre based) knockout mice. 2019-03-25 2023-08-13 mouse
Andreia Moreira da Silva Santos, John P Kelly, Peter Dockery, Karen M Doyl. Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30296469. these findings collectively highlight the importance of the dopaminergic system in methamphetamine induced effects, identify the frontal cortex, amygdala and striatum as key regions that undergo early changes in response to binge-like methamphetamine dosing and provide evidence of time-dependent effects on the cell bodies and fibres of tyrosine hydroxylase expressing neurons. 2019-03-25 2023-08-13 rat
Robert McCutcheon, Katherine Beck, Sameer Jauhar, Oliver D Howe. Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis. Schizophrenia bulletin. vol 44. issue 6. 2019-03-19. PMID:29301039. the current article investigates the magnitude of dopaminergic abnormalities in individuals with schizophrenia, and determines how the magnitude of abnormality varies across functional subdivisions of the striatum. 2019-03-19 2023-08-13 Not clear
Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murra. Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30242202. previous research utilising reward learning or anticipation paradigms has demonstrated cortical and subcortical abnormalities in people with psychosis, specifically in the prefrontal cortex, the dopaminergic midbrain and the striatum. 2019-03-14 2023-08-13 human
Lívia Cristina R F Lins, Marina F Souza, José Marcos M Bispo, Auderlan M Gois, Thaís Cristina S Melo, Rayr Antonio S Andrade, Lucindo J Quintans-Junior, Alessandra M Ribeiro, Regina H Silva, José R Santos, Murilo Marchior. Carvacrol prevents impairments in motor and neurochemical parameters in a model of progressive parkinsonism induced by reserpine. Brain research bulletin. vol 139. 2019-03-12. PMID:29378222. parkinson's disease (pd) is a neurodegenerative disease characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra pars compact (snpc), with consequent depletion of dopamine in the striatum, which gives rise to the characteristic motor symptoms of pd. 2019-03-12 2023-08-13 rat