| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fanpeng Zhao, Wenzhang Wang, Chunyu Wang, Sandra L Siedlak, Hisashi Fujioka, Beisha Tang, Xiongwei Zh. Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-27. PMID:28215578. |
more importantly, pq-induced oxidative damage and stress signaling as well as selective loss of dopaminergic (da) neurons in the substantia nigra and axonal terminals in striatum was also inhibited in transgenic mice overexpressing hmfn2. |
2018-11-27 |
2023-08-13 |
mouse |
| Mark S Gold, Kenneth Blum, Marcelo Febo, David Baron, Edward Justin Modestino, Igor Elman, Rajendra D Badgaiya. Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems. Frontiers in bioscience (Scholar edition). vol 10. 2018-11-27. PMID:29293435. |
anhedonia may by due to derangements in mesolimbic dopaminergic pathways and their terminal fields (e.g., striatum, amygdala, and prefrontal cortex) that persist long after the traces of the causative drugs are eliminated (pharmacokinetically). |
2018-11-27 |
2023-08-13 |
Not clear |
| J P Kesby, D W Eyles, J J McGrath, J G Scot. Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience. Translational psychiatry. vol 8. issue 1. 2018-11-26. PMID:29382821. |
for example, psychostimulant-induced locomotion, the commonly utilised phenotype for positive symptoms in rodents, is heavily associated with dopaminergic activation in the limbic striatum. |
2018-11-26 |
2023-08-13 |
human |
| Moran Gilat, Kaylena A Ehgoetz Martens, Oscar Miranda-Domínguez, Ishu Arpan, James M Shine, Martina Mancini, Damien A Fair, Simon J G Lewis, Fay B Hora. Dysfunctional Limbic Circuitry Underlying Freezing of Gait in Parkinson's Disease. Neuroscience. vol 374. 2018-11-20. PMID:29408498. |
the present study therefore examined resting-state mri functional connectivity between the amygdala, striatum and frontoparietal attentional control network in pd patients with (freezers: n = 19) and without fog (non-freezers: n = 21) in the dopaminergic 'off' state. |
2018-11-20 |
2023-08-13 |
Not clear |
| Marie A Labouesse, Andrea M Sartori, Oliver Weinmann, Eleanor H Simpson, Christoph Kellendonk, Ulrike Weber-Stadlbaue. Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 41. 2018-11-15. PMID:30254156. |
dopaminergic signaling in the striatum, particularly at dopamine 2 receptors (d2r), has been a topic of active investigation in obesity research in the past decades. |
2018-11-15 |
2023-08-13 |
mouse |
| Rodrigo N Ferreira, Aline S de Miranda, Natalia P Rocha, Ana C Simoes E Silva, Antonio L Teixeira, Elizabeth R da Silva Camargo. Neurotrophic Factors in Parkinson's Disease: What Have we Learned from Pre-Clinical and Clinical Studies? Current medicinal chemistry. vol 25. issue 31. 2018-11-14. PMID:29532753. |
these neurological alterations are probably due to the death of dopaminergic neurons in the substantia nigra pars compacta and consequent reduction of dopamine input into the striatum. |
2018-11-14 |
2023-08-13 |
Not clear |
| Thomas B Stoker, Roger A Barke. Regenerative Therapies for Parkinson's Disease: An Update. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 32. issue 4. 2018-11-13. PMID:30027398. |
therefore, treatment is needed that can restore dopaminergic tone in the striatum in a physiological and targeted manner to avert these side effects. |
2018-11-13 |
2023-08-13 |
Not clear |
| Won-Seok Choi, Hyung-Wook Kim, François Tronche, Richard D Palmiter, Daniel R Storm, Zhengui Xi. Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons. Scientific reports. vol 7. 2018-11-08. PMID:28327638. |
this conditional deletion of ndufs4, which reduces complex i activity in dopamine neurons, did not cause a significant loss of dopaminergic neurons in substantia nigra pars compacta (snpc), and there was no loss of dopaminergic neurites in striatum or amygdala. |
2018-11-08 |
2023-08-13 |
mouse |
| Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michalu. The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:30129004. |
the results obtained from the in vivo microdialysis study as well as from the ex vivo experiments suggest that multiple administration of 1metiq protects dopaminergic neurons against the lactacystin-induced decline in th concentration in the substantia nigra and prevents disturbances of dopamine release in the striatum. |
2018-11-06 |
2023-08-13 |
rat |
| Vincent Chin-Hung Chen, Chun-Ching Chiu, Li-Jeng Chen, Tsai-Ching Hsu, Bor-Show Tzan. Effects of taurine on striatal dopamine transporter expression and dopamine uptake in SHR rats. Behavioural brain research. vol 348. 2018-11-05. PMID:29694913. |
dopaminergic deficits in the prefrontal cortex and striatum have been attributed to the pathogenesis of attention-deficit hyperactivity disorder (adhd). |
2018-11-05 |
2023-08-13 |
rat |
| Yasuhiko Izumi, Seiko Wakita, Chisato Kanbara, Toshie Nakai, Akinori Akaike, Toshiaki Kum. Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons. Scientific reports. vol 7. 2018-11-01. PMID:28176845. |
during development, dopaminergic neurons born in the substantia nigra extend their axons toward the striatum. |
2018-11-01 |
2023-08-13 |
Not clear |
| Yasuhiko Izumi, Seiko Wakita, Chisato Kanbara, Toshie Nakai, Akinori Akaike, Toshiaki Kum. Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons. Scientific reports. vol 7. 2018-11-01. PMID:28176845. |
however, the mechanisms by which the dopaminergic axons extend the striatum to innervate their targets remain unclear. |
2018-11-01 |
2023-08-13 |
Not clear |
| G Nagesh Babu, Manjeet Gupta, Vimal K Paliwal, Suruchi Singh, Tanushri Chatterji, Raja Ro. Serum metabolomics study in a group of Parkinson's disease patients from northern India. Clinica chimica acta; international journal of clinical chemistry. vol 480. 2018-10-01. PMID:29474999. |
parkinson's disease (pd) is the result of progressive degeneration of the nigrostriatal dopaminergic pathway and depletion of neurotransmitter dopamine in the striatum. |
2018-10-01 |
2023-08-13 |
Not clear |
| Hui Chen, Huimeng Lei, Qunyuan X. Neuronal activity pattern defects in the striatum in awake mouse model of Parkinson's disease. Behavioural brain research. vol 341. 2018-09-04. PMID:29289596. |
previous studies showed the loss of dopaminergic neurons directly leads to both changes in firing rate and neuronal synchrony in the striatum by pharmacogenetic approach, but physiological observation of striatal neurons in awake animal is rare up to now due to the limitation of recording methods. |
2018-09-04 |
2023-08-13 |
mouse |
| Haixia Liu, Lu Jia, Xiaoyan Chen, Limin Shi, Junxia Xi. The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease. Brain research bulletin. vol 137. 2018-08-31. PMID:29174294. |
the excitability of dopaminergic neurons in the substantia nigra pars compacta (snc) that supply the striatum with dopamine (da) determines the function of the nigrostriatal system for motor coordination. |
2018-08-31 |
2023-08-13 |
rat |
| Adriano D S Targa, Ana Carolina D Noseda, Lais S Rodrigues, Mariana F Aurich, Marcelo M S Lim. REM sleep deprivation and dopaminergic D2 receptors modulation increase recognition memory in an animal model of Parkinson's disease. Behavioural brain research. vol 339. 2018-08-07. PMID:29128393. |
then, we administered a dopaminergic d2 receptor agonist (piribedil, 3μg/μl), antagonist (raclopride, 10μg/μl) or vehicle (dimethylsulfoxide) directly in the striatum and the animals were submitted to the object recognition test (ort). |
2018-08-07 |
2023-08-13 |
rat |
| Ester Nespoli, Francesca Rizzo, Tobias Boeckers, Ulrike Schulze, Bastian Hengere. Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats. PloS one. vol 13. issue 4. 2018-07-31. PMID:29698507. |
the initial observation that dopaminergic antagonists alleviate tics led to the development of a dopaminergic theory of ts etiology which is supported by post mortem and in vivo studies indicating that non-physiological activation of the striatum could generate tics. |
2018-07-31 |
2023-08-13 |
rat |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
furthermore, after chronic agonist treatment, we observed reduced cb1r binding and mrna levels in sn and striatum, providing evidence for a possible regulatory role of the endocannabinoid system on dopaminergic function. |
2018-07-27 |
2023-08-13 |
rat |
| Elisabeth Ruppert, Marc Bataillard, Izzie Jacques Namer, Laurent Tatu, Aurélien Hacquard, Laurence Hugueny, Jeffrey Hubbard, Ulker Kilic-Huck, Valérie Wolff, Patrice Bourgi. Hyperdopaminergism in lenticulostriate stroke-related restless legs syndrome: an imaging study. Sleep medicine. vol 30. 2018-07-25. PMID:28215236. |
given these elements, we studied dopaminergic metabolism in patients with rls secondary to lenticulostriate infarction using structural and nuclear imaging in the striatum ipsilateral to the infarction area, as compared to the contralateral side. |
2018-07-25 |
2023-08-13 |
Not clear |
| Elisabeth Ruppert, Marc Bataillard, Izzie Jacques Namer, Laurent Tatu, Aurélien Hacquard, Laurence Hugueny, Jeffrey Hubbard, Ulker Kilic-Huck, Valérie Wolff, Patrice Bourgi. Hyperdopaminergism in lenticulostriate stroke-related restless legs syndrome: an imaging study. Sleep medicine. vol 30. 2018-07-25. PMID:28215236. |
we hypothesized that dopaminergic metabolism would be impaired in the striatum ipsilateral to stroke. |
2018-07-25 |
2023-08-13 |
Not clear |